Gonzalo Gómez-López

Gonzalo Gómez-López

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Gonzalo Gómez-López

Gonzalo Gómez-López

Publications by authors named "Gonzalo Gómez-López"

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In Silico Drug Prescription for Targeting Cancer Patient Heterogeneity and Prediction of Clinical Outcome.

Cancers (Basel) 2019 Sep 13;11(9). Epub 2019 Sep 13.

Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.3390/cancers11091361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769767PMC
September 2019

Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells.

Cell Rep 2019 06;27(12):3500-3510.e4

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057268PMC
June 2019

Precision medicine needs pioneering clinical bioinformaticians.

Brief Bioinform 2019 05;20(3):752-766

Spanish National Cancer Research Centre.

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http://dx.doi.org/10.1093/bib/bbx144DOI Listing
May 2019

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization.

Nat Struct Mol Biol 2018 06 4;25(6):496-504. Epub 2018 Jun 4.

Chromosome Dynamics Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/s41594-018-0070-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122591PMC
June 2018

Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics Perspective.

Public Health Genomics 2017 1;20(2):81-91. Epub 2017 Sep 1.

Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1159/000479812DOI Listing
April 2018

Prediction of miRNA-mRNA Interactions Using miRGate.

Methods Mol Biol 2017 ;1580:225-237

Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1007/978-1-4939-6866-4_15DOI Listing
February 2018

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity.

Cell Rep 2018 01;22(2):396-410

Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Cellular Plasticity and Disease Group, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775503PMC
January 2018

Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer.

Gut 2017 08 6;66(8):1449-1462. Epub 2016 Apr 6.

Department of Cancer Biology, Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, IdiPAZ, Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2015-310977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530491PMC
August 2017

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nature 2017 08 2;548(7666):239-243. Epub 2017 Aug 2.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/nature23297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648056PMC
August 2017

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells.

Mol Cancer Ther 2017 07 10;16(7):1366-1376. Epub 2017 Apr 10.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0104DOI Listing
July 2017

Pax8 controls thyroid follicular polarity through cadherin-16.

J Cell Sci 2017 01 25;130(1):219-231. Epub 2016 Oct 25.

Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomédicas 'Alberto Sols', Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid (CSIC-UAM), Madrid 28029, Spain

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http://dx.doi.org/10.1242/jcs.184291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394772PMC
January 2017

RUbioSeq+: A multiplatform application that executes parallelized pipelines to analyse next-generation sequencing data.

Comput Methods Programs Biomed 2017 Jan 26;138:73-81. Epub 2016 Oct 26.

Higher Technical School of Computer Engineering, University of Vigo, Ourense, Spain; Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S01692607163073
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http://dx.doi.org/10.1016/j.cmpb.2016.10.008DOI Listing
January 2017

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance.

Aging Cell 2016 Dec 1;15(6):1113-1125. Epub 2016 Sep 1.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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http://dx.doi.org/10.1111/acel.12517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114719PMC
December 2016

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.

ESMO Open 2016 6;1(5):e000076. Epub 2016 Sep 6.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO) , Madrid , Spain.

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http://dx.doi.org/10.1136/esmoopen-2016-000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070278PMC
September 2016

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

Cell Rep 2016 06 9;15(12):2705-18. Epub 2016 Jun 9.

Breast Cancer Clinical Research Unit, CNIO-Spanish National Cancer Research Center, Melchor Fernández Almagro, 3, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.052DOI Listing
June 2016

Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.

Gut 2015 Dec 3;64(12):1921-35. Epub 2015 Apr 3.

Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1136/gutjnl-2014-308935DOI Listing
December 2015

miRGate: a curated database of human, mouse and rat miRNA-mRNA targets.

Database (Oxford) 2015 8;2015:bav035. Epub 2015 Apr 8.

Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain and High Technical School of Computer Engineering, University of Vigo, Ourense, Spain.

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http://dx.doi.org/10.1093/database/bav035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390609PMC
December 2015

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.

Genom Data 2015 Dec 3;6:21-4. Epub 2015 Aug 3.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro, 3, E-28029, Madrid, Spain.

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http://dx.doi.org/10.1016/j.gdata.2015.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664675PMC
December 2015

Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis.

Cell Rep 2015 Oct 17;13(4):712-722. Epub 2015 Oct 17.

Tumor Suppression Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid E28029, Spain. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01049-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501049
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http://dx.doi.org/10.1016/j.celrep.2015.09.038DOI Listing
October 2015

DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers.

Breast Cancer Res Treat 2015 Jul 14;152(2):271-82. Epub 2015 Jun 14.

Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1007/s10549-015-3459-3DOI Listing
July 2015

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

Sci Rep 2015 May 19;5:10205. Epub 2015 May 19.

1] Molecular Oncology Unit, CIEMAT, Madrid 28040, Spain [2] Oncogenomic Unit, Institute of Biomedical Research, University Hospital "12 de Octubre", Madrid 28040, Spain.

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http://dx.doi.org/10.1038/srep10205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437308PMC
May 2015

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors.

Genom Data 2015 Mar 22;3:75-9. Epub 2014 Nov 22.

Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain ; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.

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http://dx.doi.org/10.1016/j.gdata.2014.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535901PMC
March 2015

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.

Nat Commun 2013 ;4:2697

1] Telomere and Genome Stability Group, The CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Old Campus Road, Oxford OX3 7DQ, UK [2] [3].

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http://dx.doi.org/10.1038/ncomms3697DOI Listing
July 2014

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.

Cell Rep 2014 Jul 17;8(2):487-500. Epub 2014 Jul 17.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905521PMC
July 2014

New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.

PLoS One 2013 13;8(5):e62849. Epub 2013 May 13.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas, and Universidad Autónoma de Madrid-CSIC-UAM, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062849PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652843PMC
December 2013

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.

Sci Rep 2011 12;1:189. Epub 2011 Dec 12.

Cell Division and Cancer Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

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http://dx.doi.org/10.1038/srep00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240995PMC
September 2013

RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses.

Bioinformatics 2013 Jul 28;29(13):1687-9. Epub 2013 Apr 28.

Structural Computational Biology Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre, 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btt203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694642PMC
July 2013

RAP1 protects from obesity through its extratelomeric role regulating gene expression.

Cell Rep 2013 Jun 20;3(6):2059-74. Epub 2013 Jun 20.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid 28029, Spain.

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http://dx.doi.org/10.1016/j.celrep.2013.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889507PMC
June 2013

Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway.

Breast Cancer Res Treat 2012 Jul 14;134(1):41-51. Epub 2011 Dec 14.

Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Melchor Fernandez Almagro 3, Madrid, 28029, Spain.

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http://link.springer.com/10.1007/s10549-011-1905-4
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http://dx.doi.org/10.1007/s10549-011-1905-4DOI Listing
July 2012

The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer.

EMBO Mol Med 2012 Jul 11;4(7):603-16. Epub 2012 Apr 11.

Genes and Cancer Group, Cancer Epigenetics and Biology Program-PEBC, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1002/emmm.201200236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407948PMC
July 2012

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.

Cell Signal 2012 Jun;24(6):1276-86

Dpto. Biología del Cáncer, Instituto de Investigaciones Biomédicas A. Sols (CSIC/UAM), Arturo Duperier 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.cellsig.2012.02.011DOI Listing
June 2012

The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development.

Cell Cycle 2012 Jun 15;11(12):2233-8. Epub 2012 Jun 15.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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http://www.tandfonline.com/doi/abs/10.4161/cc.20318
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http://dx.doi.org/10.4161/cc.20318DOI Listing
June 2012

A unique role of cohesin-SA1 in gene regulation and development.

EMBO J 2012 May 13;31(9):2090-102. Epub 2012 Mar 13.

Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/emboj.2012.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343463PMC
May 2012

Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.

BMC Genomics 2012 Apr 24;13:147. Epub 2012 Apr 24.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas-CSIC y Universidad Autónoma de Madrid-UAM, C/Arturo Duperier 4, Madrid 28029, Spain.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-13-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403905PMC
April 2012

Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

Cell Cycle 2011 May 1;10(9):1488-98. Epub 2011 May 1.

Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615336PMC
http://dx.doi.org/10.4161/cc.10.9.15658DOI Listing
May 2011

Expression and functional validation of new p38α transcriptional targets in tumorigenesis.

Biochem J 2011 Mar;434(3):549-58

CNIO (Spanish National Cancer Centre), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://biochemj.org/lookup/doi/10.1042/BJ20101410
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http://dx.doi.org/10.1042/BJ20101410DOI Listing
March 2011

PileLine: a toolbox to handle genome position information in next-generation sequencing studies.

BMC Bioinformatics 2011 Jan 24;12:31. Epub 2011 Jan 24.

Higher Technical School of Computer Engineering, University of Vigo, Ourense, Spain.

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http://dx.doi.org/10.1186/1471-2105-12-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037855PMC
January 2011

PathJam: a new service for integrating biological pathway information.

J Integr Bioinform 2010 Oct 28;7(1). Epub 2010 Oct 28.

Escuela Superior de Ingeniería Informática University of Vigo, Edificio Politécnico, Campus Universitario As Lagoas s/n, 32004 Ourense, Spain.

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http://dx.doi.org/10.2390/biecoll-jib-2010-147DOI Listing
October 2010

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites.

Nat Cell Biol 2010 Aug 11;12(8):768-80. Epub 2010 Jul 11.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.

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http://dx.doi.org/10.1038/ncb2081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792482PMC
August 2010

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations.

Proc Natl Acad Sci U S A 2009 Nov 3;106(46):19393-8. Epub 2009 Nov 3.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1073/pnas.0909265106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772818PMC
November 2009

Translational disease interpretation with molecular networks.

Genome Biol 2009 29;10(6):221. Epub 2009 Jun 29.

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1186/gb-2009-10-6-221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718486PMC
September 2009

Functional characterization of E- and P-cadherin in invasive breast cancer cells.

BMC Cancer 2009 Mar 3;9:74. Epub 2009 Mar 3.

Department of Biochemistry UAM, Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain.

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http://dx.doi.org/10.1186/1471-2407-9-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656544PMC
March 2009

Bioinformatics and cancer research: building bridges for translational research.

Clin Transl Oncol 2008 Feb;10(2):85-95

Bioinformatics Unit, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Institute (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1007/s12094-008-0161-5DOI Listing
February 2008

CARGO: a web portal to integrate customized biological information.

Nucleic Acids Res 2007 Jul 5;35(Web Server issue):W16-20. Epub 2007 May 5.

SCOMPBio Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1093/nar/gkm280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933121PMC
July 2007