Publications by authors named "Gong Cheng"

432 Publications

Direct and indirect effects of fenoxycarb on freshwater systems dominated by Neocaridina palmata (Decapoda: Atyidae) and macrophyte Ceratophyllum demersum.

Ecotoxicol Environ Saf 2021 May 12;219:112304. Epub 2021 May 12.

Institute of Pesticide and Environmental Toxicology, Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang University, Hangzhou 310058, PR China.

Few studies have been conducted with regard to the effects of insecticides on population dynamics of shrimps and associated groups such as macrophytes, phytoplankton, microorganisms etc. In the present study, effects of a single application of fenoxycarb were tested using indoor freshwater systems dominated by Neocaridina palmata and Ceratophyllum demersum (Dicotyledons: Ceratophyllales). The no observed effect concentration (NOEC) and lowest observed effect concentration (LOEC) for the N. palmata, as scaled by liberated chitobiase, were 6.48 μg/L and 27.76 μg/L, and the dose-related effect lasted for 14 days. Results of principal components analysis (PCA) and that of principal response curves (PRC) method showed that the biomass of C. demersum and concentrations of chlorophyll-a were suppressed, while the concentrations of phycocyanin were promoted. Illumina high-throughput sequencing was adopted to determine the diversity of bacteria and fungi in the media. Result of PCA and PRC showed that the fenoxycarb promoted photosynthetic bacteria (e.g. Cyanobacteria and Rhodobacterales) and suppressed groups involved in nitrogen and sulfur the transformation (e.g. Flavobacterium, hgcI_clade, Cystobasidium, Rhodotorula and Rhizobiales). Promotion in pathogen such as Pseudomonas and Cercozoa and suppression in beneficial taxa such as Novosphingobium and Rhodotorula were also sighted. Result of study suggested a water quality deterioration due to fenoxycarb applications.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112304DOI Listing
May 2021

Self-Organizing Microdroplet Protocells Displaying Light-Driven Oscillatory and Morphological Evolution.

Small 2021 May 12:e2101162. Epub 2021 May 12.

Department of Earth and Planetary Sciences and Origins of Life Initiative, Harvard University, Cambridge, MA, 02138, USA.

The development of synthetic systems that enable the sustained active self-assembly of molecular blocks to mimic the complexity and dynamic behavior of living systems is of great interest in elucidating the origins of life, understanding the basic principles behind biological organization, and designing active materials. However, it remains a challenge to construct microsystems with dynamic behaviors and functions that are connected to molecular self-assembly processes driven by external energy. Here, an active self-assembly of microdroplet protocells with dynamic structure and high structural complexity through living radical polymerization under constant energy flux is reported. The active microdroplet protocells exhibit nonlinear behaviors including oscillatory growth and shrinkage. This relies on the transient stabilization of molecular assembly, which can channel the inflow of energy through noncovalent interactions of pure synthetic components. The intercommunication of microdroplet protocells through stochastic fusion leads to the formation of a variety of dynamic and higher-order biomimetic microstructures. This work constitutes an important step toward the realization of autonomous and dynamic microsystems and active materials with life-like properties.
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http://dx.doi.org/10.1002/smll.202101162DOI Listing
May 2021

Prevalence and Risk Factors for Anxiety and Depression in Patients With COVID-19 in Wuhan, China.

Psychosom Med 2021 05;83(4):368-372

From the Surgery Intensive Care Unit (Li, Liu, Wang, Zhang, Gong, Duan) China-Japan Friendship Hospital; and Peking University Institute of Mental Health (Sun), National Clinical Research Center for Mental Disorders, Beijing, China.

Objective: Infectious diseases can cause psychological changes in patients. This study aimed to evaluate the prevalence and related risk factors for anxiety and depression in patients with COVID-19.

Methods: A cross-sectional study was performed on patients with COVID-19 admitted to the Sino-French New City branch of Wuhan Tongji Hospital from January to February 2020. The Zung Self-Rating Anxiety and Depression Scales were used to evaluate the prevalence of anxiety and depression. Demographic, clinical, and sociological data were also collected. Multivariable logistic regression analysis was used to identify independent risk factors of anxiety and depression in patients with COVID-19.

Results: In the current study, 183 patients were enrolled (mean age = 53 ± 9 years; 41.1% women). The prevalences of anxiety and depression were 56.3% and 39.3%, respectively. Logistic regression analysis revealed that older age, female sex, being divorced or widowed, COVID-19 disease duration, renal disease, and depression were identified as independent risk factors for anxiety in patients with COVID-19. Factors that were associated with depression were female sex, being widowed, COVID-19 disease duration, and anxiety.

Conclusions: This study demonstrates a high prevalence of anxiety and depression in patients with COVID-19 at the peak of the epidemic in Wuhan, China. The identification of demographic, clinical, and social factors may help identify health care professionals to provide psychological care as part of treatment for patients with COVID-19 and other life-threatening infectious diseases.
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http://dx.doi.org/10.1097/PSY.0000000000000934DOI Listing
May 2021

Enhanced degradation of reactive brilliant red X-3B by photocatalysis integrated with micro-electrolysis.

Environ Sci Pollut Res Int 2021 May 4. Epub 2021 May 4.

School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.

The microwave electrodeless lamp UV photocatalysis (MWUV) integrated with iron carbon micro-electrolysis (ME) was applied to degrade reactive brilliant red X-3B. In the present study, the removal rate of X-3B by MWUV/ME was 95%, which was significantly higher than 56% of MWUV and 62% of ME system. The experiment results demonstrated a synergistic effect in MWUV/ME system, wherein the ME system played an important role in color removal and the formation of ·OH in photocatalysis contributed most for the mineralization of X-3B and its intermediates. The removal efficiency of TOC was 32%, 7.5%, and 59.5% under MWUV, ME, and MWUV/ME processes at the end of the reaction, respectively. The Fe existed in the system was an enhancer of producing ·OH via self-generation of ·OH by UV irradiation or improving the separation of electron-hole in photocatalysis by capturing the electrons. Therefore, the combined treatment of MWUV and ME system has the potential of synergistic effect compared to the separate process. Lowering the initial solution pH and increasing the iron filing dosage and dissolved oxygen were beneficial for the enhancement of degradation efficiency. The inorganic anions showed a diversity influencing the degradation of X-3B. NO, CO, and SO (at higher concentration) promoted the degradation reaction, while Cl had non-significant effect.
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http://dx.doi.org/10.1007/s11356-021-14205-wDOI Listing
May 2021

Virtual Angle Boundary-Aware Particle Swarm Optimization to Maximize the Coverage of Directional Sensor Networks.

Sensors (Basel) 2021 Apr 19;21(8). Epub 2021 Apr 19.

School of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing 100083, China.

With the transition of the mobile communication networks, the network goal of the Internet of everything further promotes the development of the Internet of Things (IoT) and Wireless Sensor Networks (WSNs). Since the directional sensor has the performance advantage of long-term regional monitoring, how to realize coverage optimization of Directional Sensor Networks (DSNs) becomes more important. The coverage optimization of DSNs is usually solved for one of the variables such as sensor azimuth, sensing radius, and time schedule. To reduce the computational complexity, we propose an optimization coverage scheme with a boundary constraint of eliminating redundancy for DSNs. Combined with Particle Swarm Optimization (PSO) algorithm, a Virtual Angle Boundary-aware Particle Swarm Optimization (VAB-PSO) is designed to reduce the computational burden of optimization problems effectively. The VAB-PSO algorithm generates the boundary constraint position between the sensors according to the relationship among the angles of different sensors, thus obtaining the boundary of particle search and restricting the search space of the algorithm. Meanwhile, different particles search in complementary space to improve the overall efficiency. Experimental results show that the proposed algorithm with a boundary constraint can effectively improve the coverage and convergence speed of the algorithm.
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http://dx.doi.org/10.3390/s21082868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073300PMC
April 2021

Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes.

Mol Med Rep 2021 Jun 26;23(6). Epub 2021 Apr 26.

Department of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.

As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide a link between these two diseases. The present study compared the content and function of MPs from patients with ACS with or without T2DM. MPs from healthy subjects (n=20), patients with ACS (n=24), patients with T2DM (n=20) and patients with combined ACS and T2DM (n=24) were obtained. After incubating rat thoracic tissue with MPs, the effect of MPs on endothelial‑dependent vasodilatation, expression of caveolin‑1 and endothelial nitric oxide synthase (), phosphorylation of eNOS at the S1177 and T495 sites and its association with heat shock protein 90 (Hsp90), and the generation of NO and superoxide anion (O) were determined. MP concentrations were higher in patients with T2DM and patients with ACS with or without T2DM than in healthy subjects. Moreover, MPs from patients with T2DM or ACS led to impairment in endothelial‑dependent vasodilatation, decreased expression of NO, as well as eNOS and its phosphorylation at Ser1177 and association with Hsp90, but increased eNOS phosphorylation at T495, caveolin‑1 expression and O generation. These effects were strengthened by MPs from patients with ACS combined with T2DM. T2DM not only increased MP content but also resulted in greater vascular impairment effects in ACS. These results may provide novel insight into the treatment of patients with ACS and T2DM.
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http://dx.doi.org/10.3892/mmr.2021.12113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097757PMC
June 2021

Neural network based 3D tracking with a graphene transparent focal stack imaging system.

Nat Commun 2021 04 23;12(1):2413. Epub 2021 Apr 23.

Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.

Recent years have seen the rapid growth of new approaches to optical imaging, with an emphasis on extracting three-dimensional (3D) information from what is normally a two-dimensional (2D) image capture. Perhaps most importantly, the rise of computational imaging enables both new physical layouts of optical components and new algorithms to be implemented. This paper concerns the convergence of two advances: the development of a transparent focal stack imaging system using graphene photodetector arrays, and the rapid expansion of the capabilities of machine learning including the development of powerful neural networks. This paper demonstrates 3D tracking of point-like objects with multilayer feedforward neural networks and the extension to tracking positions of multi-point objects. Computer simulations further demonstrate how this optical system can track extended objects in 3D, highlighting the promise of combining nanophotonic devices, new optical system designs, and machine learning for new frontiers in 3D imaging.
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http://dx.doi.org/10.1038/s41467-021-22696-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065157PMC
April 2021

Weakly Supervised Object Localization and Detection: A Survey.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 20;PP. Epub 2021 Apr 20.

As an emerging and challenging problem in the computer vision community, weakly supervised object localization and detection plays an important role for developing new generation computer vision systems and has received significant attention in the past decade. As methods have been proposed, a comprehensive survey of these topics is of great importance. In this work, we review (1) classic models, (2) approaches with feature representations from off-the-shelf deep networks, (3) approaches solely based on deep learning, and (4) publicly available datasets and standard evaluation metrics that are widely used in this field. We also discuss the key challenges in this field, development history of this field, advantages/disadvantages of the methods in each category, the relationships between methods in different categories, applications of the weakly supervised object localization and detection methods, and potential future directions to further promote the development of this research field.
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http://dx.doi.org/10.1109/TPAMI.2021.3074313DOI Listing
April 2021

Interaction of Viruses with the Insect Intestine.

Annu Rev Virol 2021 Apr 19. Epub 2021 Apr 19.

Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China; email:

In nature, insects face a constant threat of infection by numerous exogeneous viruses, and their intestinal tracts are the predominant ports of entry. Insects can acquire these viruses orally during either blood feeding by hematophagous insects or sap sucking and foliage feeding by insect herbivores. However, the insect intestinal tract forms several physical and immunological barriers to defend against viral invasion, including cell intrinsic antiviral immunity, the peritrophic matrix and the mucin layer, and local symbiotic microorganisms. Whether an infection can be successfully established in the intestinal tract depends on the complex interactions between viruses and those barriers. In this review, we summarize recent progress on virus-intestinal tract interplay in insects, in which various underlying mechanisms derived from nutritional status, dynamics of symbiotic microorganisms, and virus-encoded components play intricate roles in the regulation of virus invasion in the intestinal tract, either directly or indirectly. Expected final online publication date for the , Volume 8 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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http://dx.doi.org/10.1146/annurev-virology-091919-100543DOI Listing
April 2021

Adaptive Neighborhood Metric Learning.

IEEE Trans Pattern Anal Mach Intell 2021 Apr 15;PP. Epub 2021 Apr 15.

This paper proposes a novel distance metric learning algorithm, named adaptive neighborhood metric learning (ANML). In ANML, we design two thresholds to adaptively identify the inseparable similar and dissimilar samples in the training procedure, thus inseparable sample removing and metric parameter learning are implemented in the same procedure. Due to the non-continuity of the proposed ANML, we develop a log-exp mean function to construct a continuous formulation to surrogate it. The proposed method has interesting properties. For example, when ANML is used to learn the linear embedding, current famous metric learning algorithms such as the large margin nearest neighbor (LMNN) and neighbourhood components analysis (NCA) are the special cases of the proposed ANML by setting the parameters different values. Besides, compared with LMNN and NCA, ANML has a broader searching space which may contain better solutions. When it is used to learn deep features, the state-of-the-art deep metric learning algorithms such as Triplet loss, Lifted structure loss, and Multi-similarity loss become the special cases of our method. Furthermore, the proposed log-exp mean function gives a new perspective to review deep metric learning methods such as Prox-NCA and N-pairs loss. Experiments are conducted to demonstrate the effectiveness of the proposed method.
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http://dx.doi.org/10.1109/TPAMI.2021.3073587DOI Listing
April 2021

MiR-33a plays an crucial role in the proliferation of bovine preadipocytes.

Adipocyte 2021 12;10(1):189-200

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, P.R. China.

Preadipocyte proliferation is a critical and precisely orchestrated procedure in adipogenesis, which is highly regulated by microRNAs (miRNAs). A previous study identified that the expression of miR-33a is different in intramuscular fat (IMF) tissues from steers and bulls. In the present study, miR-33a was overexpressed in bovine preadipocytes, and a total of 781 differentialy expressed genes were found, including 348 upregulated and 433 downregulated genes. Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analyses of the differentially expressed genes enriched cell division and cell cycle respectively. MiR-33a overexpression decreased the rate of preadipocyte proliferation. Synchronously, the mRNA and protein expression levels of proliferation-related marker genes, including cyclin B1 (CCNB1) and proliferating cell nuclear antigen (PCNA), were decreased. In contrast, inhibiting miR-33a increased the rate of preadipocyte proliferation, and expression levels of CCNB1 and PCNA. Furthermore, based on luciferase reporter assays, miR-33a targeted directly cyclin-dependent kinase 6 (CDK6)-3'UTR and inhibited CDK6 protein expression. Interestingly, the silencing of CDK6 inhibited bovine preadipocyte proliferation and proliferation-related genes. Therefore, miR-33a inhibits the proliferation of bovine preadipocytes. CDK6 is the target gene of miR-33a and may be involved in the effects of miR-33a on bovine preadipocyte proliferation.
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http://dx.doi.org/10.1080/21623945.2021.1908655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043176PMC
December 2021

Development of a four-gene prognostic model for clear cell renal cell carcinoma based on transcriptome analysis.

Genomics 2021 Apr 7;113(4):1816-1827. Epub 2021 Apr 7.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address:

This study aimed to develop a prognostic model for clear cell renal cell carcinoma (ccRCC) based on transcriptome analysis. We screened Gene Expression Omnibus (GEO) database and the Cancer Genome Atlas (TCGA) database for gene expression data and clinical characteristics of ccRCC. After differentially expression analysis, we identified 533 key genes of the development of ccRCC. Next, a weighted gene co-expression network analysis (WGCNA) was executed to investigate the association between differentially expressed genes and clinical characteristics. Then, based on protein-protein interaction (PPI) network, least absolute shrinkage and selection operator (LASSO) regression and Cox regression, a four-gene (COL4A5, ABCB1, NR3C2 and PLG) prognostic model has been constructed in TCGA training cohort. Finally, we examined the predictive power of this model with survival analysis and receiver operating characteristic (ROC) curve both in training cohort and in validation cohorts. And we found this model was significantly correlated with infiltrating immune cells. The four-gene prognosis model could be a potential prediction tool with high accuracy and reliability for ccRCC patients.
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http://dx.doi.org/10.1016/j.ygeno.2021.04.005DOI Listing
April 2021

Observation of strong excitonic magneto-chiral anisotropy in twisted bilayer van der Waals crystals.

Nat Commun 2021 Apr 7;12(1):2088. Epub 2021 Apr 7.

Nanoscale Science and Engineering Center, University of California, Berkeley, CA, USA.

The interplay between chirality and magnetism generates a distinct physical process, the magneto-chiral effect, which enables one to develop functionalities that cannot be achieved solely by any of the two. Such a process is universal with the breaking of parity-inversion and time-reversal symmetry simultaneously. However, the magneto-chiral effect observed so far is weak when the matter responds to photons, electrons, or phonons. Here we report the first observation of strong magneto-chiral response to excitons in a twisted bilayer tungsten disulfide with the amplitude of excitonic magneto-chiral (ExMCh) anisotropy reaches a value of ~4%. We further found the ExMCh anisotropy features with a spectral splitting of ~7 nm, precisely the full-width at half maximum of the excitonic chirality spectrum. Without an externally applied strong magnetic field, the observed ExMCh effect with a spontaneous magnetic moment from the ferromagnetic substrate of thulium iron garnet at room temperature is favorable for device applications. The unique ExMCh processes provide a new pathway to actively control magneto-chiral applications in photochemical reactions, asymmetric synthesis, and drug delivery.
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http://dx.doi.org/10.1038/s41467-021-22412-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8027870PMC
April 2021

Lycium barbarum Polysaccharide Ameliorates Sjögren's Syndrome in a Murine Model.

Mol Nutr Food Res 2021 Apr 6:e2001118. Epub 2021 Apr 6.

GMH Institute of Central Nervous System Regeneration, Jinan University, Guangzhou, China.

Scope: This study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjögren's syndrome (pSS).

Methods And Results: Non-obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg  d ), high dose LBP (10 mg kg  d ), low dose interleukin (IL)-2 (25 000 IU/d), and control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces the salivary gland inflammation compared with the control group (histological score p vs  = 0.019; foci number: p vs  = 0.038). LBP.L also remarkably reduces the effector follicular helper T (Tfh) cells and the CD4 IL-17A helper T (Th17) cells in both spleen and cervical lymph node (cLN) cells. Additionally, the ratios of regulatory T cell (Treg)/Tfh cells and Treg/Th17 cells are substantially increased in mice treated with LBP.L in both spleen and cLNs. LBP also inhibits Th17 and Tfh cells and markedly increases the Treg/Tfh ratio in human peripheral blood mononuclear cells.

Conclusion: LBP.L inhibits the progression of pSS in mice, associated with modulation of T cell differentiation.
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http://dx.doi.org/10.1002/mnfr.202001118DOI Listing
April 2021

Chest pain showing precordial ST-segment elevation in a 96-year-old woman with right coronary artery occlusion: A case report.

World J Clin Cases 2021 Mar;9(8):1877-1884

Department of Electrocardiology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.

Background: Typically, right coronary artery (RCA) occlusion causes ST-segment elevation in inferior leads. However, it is rarely observed that RCA occlusion causes ST-segment elevation only in precordial leads. In general, an electrocardiogram is considered to be the most important method for determining the infarct-related artery, and recognizing this is helpful for timely discrimination of the culprit artery for reperfusion therapy. In this case, an elderly woman presented with chest pain showing dynamic changes in precordial ST-segment elevation with RCA occlusion.

Case Summary: A 96-year-old woman presented with acute chest pain showing precordial ST-segment elevation with dynamic changes. Myocardial injury markers became positive. Coronary angiography indicated acute total occlusion of the proximal nondominant RCA, mild atherosclerosis of left anterior descending artery and 75% stenosis in the left circumflex coronary artery. Percutaneous coronary intervention was conducted for the RCA. Repeated manual thrombus aspiration was performed, and fresh thrombus was aspirated. A 2 mm × 15 mm balloon was used to dilate the RCA with an acceptable angiographic result. The patient's chest pain was relieved immediately. A postprocedural electrocardiogram showed alleviation of precordial ST-segment elevation. The diagnosis of acute isolated right ventricular infarction caused by proximal nondominant RCA occlusion was confirmed. Echocardiography indicated normal motion of the left ventricular anterior wall and interventricular septum (ejection fraction of 54%), and the right ventricle was slightly dilated. The patient was asymptomatic during the 9-mo follow-up period.

Conclusion: Cardiologists should be conscious that precordial ST-segment elevation may be caused by occlusion of the nondominant RCA.
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http://dx.doi.org/10.12998/wjcc.v9.i8.1877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953383PMC
March 2021

Individual or combined transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma: a time-to-event meta-analysis.

World J Surg Oncol 2021 Mar 19;19(1):81. Epub 2021 Mar 19.

Department of Liver Surgery, Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: There is still some debate as to whether transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA) is better than TACE or RFA alone. This meta-analysis aimed to compare the efficacy and safety of TACE plus RFA for hepatocellular carcinoma (HCC) with RFA or TACE alone.

Methods: We searched PubMed, MEDLINE, Embase, Cochrane Library, and CNKI (China National Knowledge Infrastructure) for all relevant randomized controlled trials and retrospective studies reporting overall survival (OS), recurrence-free survival (RFS), and complications of TACE plus RFA for HCC, compared with RFA or TACE alone.

Results: Twenty-one studies involving 3413 patients were included. TACE combined with RFA was associated with better OS (hazard ratio [HR]=0.62, 95% confidence intervals [CI] = 0.55-0.71, P < 0.001) and RFS (HR = 0.52, 95% CI = 0.39-0.69, P < 0.001) than TACE alone; compared with RFA alone, TACE plus RFA resulted in longer OS (HR = 0.63, 95% CI = 0.53-0.75, P < 0.001) and RFS (HR = 0.60, 95% CI = 0.51-0.71, P < 0.001). Subgroup analyses by tumor size also showed that combined treatment resulted in better OS and RFS compared with RFA alone in patients with HCC larger than 3 cm. Combined treatment resulted in similar rate of major complications compared with TACE or RFA alone (OR = 1.78, 95% CI = 0.99-3.20, P = 0.05; OR = 1.00, 95% CI = 0.42-2.38, P = 1.00, respectively).

Conclusions: TACE combined with RFA was more effective for HCC than TACE alone. For patients with a tumor larger than 3 cm, the combined treatment also achieved a better effect than RFA alone.
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http://dx.doi.org/10.1186/s12957-021-02188-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7980330PMC
March 2021

Analysis of risk factors for determining the need for prostate biopsy in patients with negative MRI.

Sci Rep 2021 Mar 15;11(1):6048. Epub 2021 Mar 15.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.

To analyze the clinical characteristics of patients with negative biparametric magnetic resonance imaging (bpMRI) who didn't need prostate biopsies (PBs). A total of 1,012 male patients who underwent PBs in the First Affiliated Hospital of Nanjing Medical University from March 2018 to November 2019, of 225 had prebiopsy negative bpMRI (defined as Prostate Imaging Reporting and Data System (PI-RADS 2.1) score less than 3). The detection efficiency of clinically significant prostate cancer (CSPCa) was assessed according to age, digital rectal examination (DRE), prostate volume (PV) on bpMRI, prostate-specific antigen (PSA) and PSA density (PSAD). The definition of CSPCa for Gleason score > 6. Univariate and multivariable logistic regression analysis were used to identify predictive factors of absent CSPCa on PBs. Moreover, absent CSPCa contained clinically insignificant prostate cancer (CIPCa) and benign result. The detection rates of present prostate cancer (PCa) and CSPCa were 27.11% and 16.44%, respectively. Patients who were diagnosed as CSPCa had an older age (P < 0.001), suspicious DRE (P < 0.001), a smaller PV (P < 0.001), higher PSA value (P = 0.008) and higher PSAD (P < 0.001) compared to the CIPCa group and benign result group. PSAD < 0.15 ng/ml/cm (P = 0.004) and suspicious DRE (P < 0.001) were independent predictors of absent CSPCa on BPs. The negative forecast value of bpMRI for BP detection of CSPCa increased with decreasing PSAD, mainly in patients with naive PB (P < 0.001) but not in prior negative PB patients. 25.33% of the men had the combination of negative bpMRI, PSAD < 0.15 ng/ml/cm and PB naive, and none had CSPCa on repeat PBs. The incidence of PB was determined, CSPCa was 1.59%, 0% and 16.67% in patients with negative bpMRI and PSAD < 0.15 ng/ml/cm, patients with negative bpMRI, PSAD < 0.15 ng/ml/cm and biopsy naive and patients with negative bpMRI, PSAD < 0.15 ng/ml/cm and prior negative PB, separately. We found that a part of patients with negative bpMRI, a younger age, no suspicious DRE and PSAD < 0.15 ng/ml/cm may securely avoid PBs. Conversely PB should be considered in patients regardless of negative bpMRI, especially who with a greater age, obviously suspicious DRE, significantly increased PSA value, a significantly small PV on MRI and PSAD > 0.15 ng/ml/cm.
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http://dx.doi.org/10.1038/s41598-021-83802-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960992PMC
March 2021

Two Deoxythymidine Triphosphate Synthesis-Related Genes Regulate Obligate Symbiont Density and Reproduction in the Whitefly MED.

Front Physiol 2020 24;11:574749. Epub 2021 Feb 24.

Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.

Deoxythymidine triphosphate (dTTP) is essential for DNA synthesis and cellular growth in all organisms. Here, genetic capacity analysis of the pyrimidine pathway in insects and their symbionts revealed that dTTP is a kind of metabolic input in several host insect/obligate symbiont symbiosis systems, including MED/ (hereafter ). As such, the roles of dTTP on both sides of the symbiosis system were investigated in MED/. Dietary RNA interference (RNAi) showed that suppressing dTTP production significantly reduced the density of , significantly repressed the expression levels of horizontally transferred essential amino acid (EAA) synthesis-related genes, and significantly decreased the reproduction of MED adults as well as the hatchability of their offspring. Our results revealed the regulatory role of dTTP in MED/ and showed that dTTP synthesis-related genes could be potential targets for controlling as well as other sucking pests.
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http://dx.doi.org/10.3389/fphys.2020.574749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943623PMC
February 2021

Anatomic relationship between S2 sacroiliac screws' entry points and pelvic external branches of superior gluteal artery.

Eur J Trauma Emerg Surg 2021 Mar 6. Epub 2021 Mar 6.

Orthopaedics Department, Yantai Shan Hospital, 91#, Jiefang Road, Yantai, 264008, People's Republic of China.

Objective: To study the relationship between the pelvic external branches of the superior gluteal artery and the entry area of the S2 sacroiliac screw to provide the anatomical basis and technical reference for avoiding the superior gluteal artery injury during the clinical screw placement.

Methods: CTA imaging of superior gluteal artery of 74 healthy adults (37 males and 37 females) was randomly selected. The safe bony entry area ('safe area' for abbreviation) of S2 sacroiliac screw in the standard lateral view of the pelvis three-dimensional reconstruction CT image was determined by the CT auxiliary measurement software. The relationship between the pelvic external branches of the superior gluteal artery and the safe area of S2 sacroiliac screw was observed, and the cases in which the artery intersected the safe area were counted. The distance between the safe area and the superior gluteal artery branches closest to it was measured for the cases in which the artery and the safe area did not intersect.

Results: 21 of the 74 cases did not have a bone channel of horizontal S2 sacroiliac screw, so they were excluded from this study. In the remaining 53 cases, 12 cases had the deep superior branch of the superior gluteal artery through the safe area of S2 screw (22.6%), and 16 cases had the superficial branch of the superior gluteal artery through the safe area of S2 screw (30.2%). There was no obvious overlap feature and law between the safe area and the superficial and deep superior branches. In 20 cases of the 53 cases, the safe area of S2 screw was located between the deep superior branch and the superficial branch of superior gluteal artery (37.7%), and in 5 cases, the safe area of S2 screw was located behind the superficial branch of superior gluteal artery (9.4%). In the cases where the superior gluteal artery did not intersect the screw entry bony safe area, the part of superior gluteal artery closest to the safe area was located in front or back of the widest part of the safe area.

Conclusion: The risk of accidental injury of the deep superior branch and superficial branch of the superior gluteal artery is high during the process of S2 sacroiliac screw placement. Even if the screw entry point is located in the bony safe area, the absolute safety of screw placement cannot be guaranteed. We strongly suggest that a careful and thorough plan is needed before surgery.
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http://dx.doi.org/10.1007/s00068-021-01622-2DOI Listing
March 2021

Potential role of specific microRNAs in the regulation of thermal stress response in livestock.

J Therm Biol 2021 Feb 20;96:102859. Epub 2021 Jan 20.

College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. Electronic address:

Thermal stress is known to have harmful effects on livestock productivity and can cause livestock enterprises considerable financial loss. These effects may be aggravated by climate change. Stress responses to nonspecific systemic actions lead to perturbation of molecular pathways in the organism. The molecular response is regulated in a dynamic and synchronized manner that assurances robustness and flexibility for the restoration of functional and structural homeostasis in stressed cells and tissues. MicroRNAs (miRNAs) are micro molecules of small non-coding RNA that control gene expression at the post-transcriptional level. Recently, various studies have discovered precise types of miRNA that regulate cellular machinery and homeostasis under various types of stress, suggesting a significant role of miRNA in thermal stress responses in animals. The miRNAs revealed in this paper could serve as promising candidates and biomarkers for heat stress and could be used as potential pharmacological targets for mitigating the consequences of thermal stress. Stress miRNA pathways may be associated with thermal stress, which offers some potential approaches to combat the negative impacts of thermal stress in livestock. The review provides new data that can assist the elucidation of the miRNA mechanisms that mediate animals' responses to thermal stress.
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http://dx.doi.org/10.1016/j.jtherbio.2021.102859DOI Listing
February 2021

Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation.

PLoS Pathog 2021 Feb 24;17(2):e1009353. Epub 2021 Feb 24.

The State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

Repeated blood meals provide essential nutrients for mosquito egg development and routes for pathogen transmission. The target of rapamycin, the TOR pathway, is essential for vitellogenesis. However, its influence on pathogen transmission remains to be elucidated. Here, we show that rapamycin, an inhibitor of the TOR pathway, effectively suppresses Plasmodium berghei infection in Anopheles stephensi. An. stephensi injected with rapamycin or feeding on rapamycin-treated mice showed increased resistance to P. berghei infection. Exposing An. stephensi to a rapamycin-coated surface not only decreased the numbers of both oocysts and sporozoites but also impaired mosquito survival and fecundity. Transcriptome analysis revealed that the inhibitory effect of rapamycin on parasite infection was through the enhanced activation of immune responses, especially the NF-κB transcription factor REL2, a regulator of the immune pathway and complement system. Knockdown of REL2 in rapamycin-treated mosquitoes abrogated the induction of the complement-like proteins TEP1 and SPCLIP1 and abolished rapamycin-mediated refractoriness to Plasmodium infection. Together, these findings demonstrate a key role of the TOR pathway in regulating mosquito immune responses, thereby influencing vector competence.
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http://dx.doi.org/10.1371/journal.ppat.1009353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7939355PMC
February 2021

Study of changes in rat mandibular condyle under intermittent cyclic and continuous compressive stress.

Arch Oral Biol 2021 Apr 30;124:105066. Epub 2021 Jan 30.

Department of Oral Science, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China. Electronic address:

Objectives: This study aimed to investigate the effects of intermittent and continuous compressive stress on rat mandibular condyles.

Design: Ninety rats were randomly divided into 5 groups: non-loading control groups and 1-day intermittent cyclic loading, 3-day intermittent cyclic loading, 7-day intermittent cyclic loading, continuous loading groups. In the loading groups, compressive mechanical stresses were loaded onto the condyles. The rats were euthanized after one, two, or four weeks. Histomorphometric and immunochemical staining of the cartilage and the micro-CT scanning of subchondral bone were investigated.

Results: Under continuous loading following the first week, cartilage thickness, numbers of chondrocytes, extracellular matrix (Type-II collagen) and proliferation decreased significantly, and there was no apparent repair response after the second and fourth weeks. The cartilage of 1-day and 3-day intermittent cyclic loading groups showed similar pathological changes but better proliferative activity compared with the continuous loading group. The 7-day intermittent loading group had significant recovery after 2 weeks, including the increase of cartilage thickness and the number of chondrocytes, cell swelling and rearranging. However, the remodeling of subchondral bone showed no significant difference between the intermittent and continuous loading stress compared to the control group.

Conclusions: Under moderate mechanical stress, the condylar cartilage actively remodeled, whereas the subchondral bone, as supportive rigid structure, was less sensitive to mechanical pressure. The intermittent compressive stress protects the condylar cartilage from excessive damage, which is different from continuous compressive stress. With longer intervals, the cartilage has the potential capability for recovery as the initial state.
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http://dx.doi.org/10.1016/j.archoralbio.2021.105066DOI Listing
April 2021

Prognostic significance of postoperative complication after curative resection for patients with gastric cancer.

J Cancer Res Ther 2020 ;16(7):1611-1616

Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.

Purposes: To investigate the impact of postoperative complication on long-term survival in gastric cancer patients after curative resection.

Methods: A total 663 gastric cancer patients undergoing potentially curative resection during January 2010 to November 2014 were studied. Complications were classified according to the Clavien-Dindo severity classification.

Results: Postoperative complications occurred in 138 of 663 cases (20.8%). Multivariate analysis identified >65 years old (P = 0.001), male (P = 0.035), and total gastrectomy (P = 0.037) as independent risk factors for postoperative complications. The 5-year overall survival rate was 48.7% in the no complication group, which was significantly better than that in the complication group (42.7%, P = 0.01). Further stratified analysis by cancer staging revealed that decline in 5-year overall survival due to postoperative complication existed among stage I (P = 0.032), II (P = 0.041), and III (P = 0.001) patients. Cox proportional hazards model showed that increasing pT (P = 0.013) and pN (P = 0.001) grade, advanced pTNM (P = 0.001) stage, total gastrectomy (P = 0.001), and postoperative complication (P = 0.006) were independent prognostic factors.

Conclusion: Postoperative complications have a significant negative impact on the long-term survival in gastric cancer patients even if the tumor is resected curatively.
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http://dx.doi.org/10.4103/jcrt.JCRT_856_19DOI Listing
January 2020

Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway.

Biochem Biophys Res Commun 2021 03 6;546:29-34. Epub 2021 Feb 6.

Department of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, China. Electronic address:

Mitochondrial injury plays an essential role in the pathogenesis of diabetic cardiomyopathy (DCM). Previous studies demonstrated that rosmarinic acid (RA) treatment prevented high glucose-induced mitochondrial injury in vitro. However, whether RA can ameliorate cardiac function by preventing mitochondrial injury in DCM is unknown. The SIRT1/PGC-1α pathway has emerged as an important regulator of metabolic control and other mitochondrial functions. The present study was undertaken to determine the effects of RA on mitochondrial and cardiac function in DCM as well as the involvement of the SIRT1/PGC-1α pathway. Our results revealed that RA improved cardiac systolic and diastolic function and prevented mitochondrial injury in DCM, as shown by the reduced blood glucose and lipid levels, increased mitochondrial membrane potential levels, improved adenosine triphosphate synthesis, and inhibited apoptosis (P < 0.05). Moreover, RA upregulated the expression of SIRT1 and PGC-1α in DCM mice and high glucose-treated H9c2 cardiomyocytes (P < 0.05). Further mechanistic studies in H9c2 cardiomyocytes revealed that suppression of SIRT1 by Sh-SIRT1 counteracted the effects of RA on high glucose-induced abnormal metabolism of glucose and lipids, oxidative stress and apoptosis (P < 0.05). Taken together, these data indicate that RA prevented mitochondrial injury and cardiac dysfunction in DCM mice, and the SIRT1/PGC-1α pathway mediated the protective effects of RA.
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http://dx.doi.org/10.1016/j.bbrc.2021.01.086DOI Listing
March 2021

Recurrent Takotsubo cardiomyopathy triggered by emotionally stressful events: A case report.

World J Clin Cases 2021 Jan;9(3):677-684

Department of Electrocardiology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.

Background: Takotsubo cardiomyopathy (TCM) is characterized by reversible left ventricular dysfunction triggered by emotional or physical stress. Only 1%-2% of patients with acute coronary syndrome are diagnosed with TCM. Although obstructive coronary artery disease is frequently considered to be the cause of chest pain, TCM should be considered in some clinical settings. In this case, clinicians did not make a timely and accurate diagnosis for TCM due to a lack of knowledge until the third hospitalization with a left ventriculogram.

Case Summary: A 55-year-old postmenopausal woman had intermittent chest pain following emotionally stressful events three times in the past 3 years. Cardiac troponin levels increased after each instance of symptom onset. A transthoracic echocardiogram showed reversible left ventricular dysfunction. The patient underwent three coronary angiograms without evidence of coronary artery disease. A left ventriculogram was first performed at the third hospitalization and revealed apical akinesia with ballooning of the apical region and consistent hypercontractile basal segments. The diagnosis of TCM was confirmed. The patient was treated with an angiotensin-converting-enzyme inhibitor (perindopril) and a β-blocker (metoprolol). No complications occurred during the patient's hospitalization. The patient was told to avoid stressful events. During the 9-mo follow-up visit, the patient was asymptomatic with an ejection fraction of 55%.

Conclusion: Clinicians should be conscious of the possibility of TCM, especially in postmenopausal women presenting with clinical manifestations similar to acute coronary syndrome without coronary occlusion.
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http://dx.doi.org/10.12998/wjcc.v9.i3.677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829724PMC
January 2021

Family graveyards form underappreciated local plant diversity hotspots in China's agricultural landscapes.

Sci Rep 2021 Jan 21;11(1):2011. Epub 2021 Jan 21.

College of Agricultural Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.

In the intensively farmed, homogenous agricultural landscape of the North China Plain, family graveyards form distinct cultural landscape features. In addition to their cultural value, these graveyards represent semi-natural habitat islands whose potential roles in biodiversity conservation and ecological functioning has remained poorly understood. In this study, we investigated plant species richness on 199 family graveyards of different ages and sizes. In accordance with biogeography theory, both overall and insect-pollinated plant species richness increased with area and age of graveyards. Even small graveyards show a strong potential for conserving local plant richness, and a mosaic of both large and small family graveyards could play an important role in the conservation of farmland biodiversity and related ecosystem functions. The launch of agri-environmental measures that conserve and create semi-natural habitats, in turn benefitting agricultural biodiversity and ecological functioning, has proven difficult in China due to the shortage of dispensable arable land. Given the great value of family graveyards as semi-natural habitats reflected in our study, we propose to focus preliminary efforts on conserving these landscape features as existing, widespread and culturally important semi-natural habitat islands. This would represent an effective, complementary policy to a subsequent re-establishment of other semi-natural habitats for the conservation of biodiversity and ecological functioning in agricultural landscapes.
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http://dx.doi.org/10.1038/s41598-020-80362-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820468PMC
January 2021

Genetic variants in the cholesterol biosynthesis pathway genes and risk of prostate cancer.

Gene 2021 Mar 12;774:145432. Epub 2021 Jan 12.

Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Previous studies have found the relationship between cholesterol biosynthesis pathway genes and the risk or prognosis of prostate cancer (PCa), while there is no definite evidence that genetic variants in the cholesterol biosynthesis pathway gene is related to PCa risk. Consequently, we performed this study to explore the associations of single-nucleotide polymorphisms (SNPs) in the cholesterol biosynthesis pathway with PCa risk. We systematically evaluated the association of SNPs in 21 cholesterol biosynthesis pathway genes with the risk of PCa using the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial database using a logistic regression model. Gene expression data of PCa from Gene Expression Omnibus (GEO) datasets and the Cancer Genome Atlas (TCGA) database were applied for mRNA expression analysis. The TCGA database was used to perform expression quantitative trait loci (eQTL) analysis. The interaction between demographic factors and SNPs was analyzed using two-by-four tables. We found T allele of rs67415672 in HMGCS1 is a significant protective allele of PCa [adjusted odds ratio (OR) = 0.90, 95% confidence interval (CI) = 0.83-0.97, P = 4.16 × 10]. Moreover, rs67415672 was an eQTL for HMGCS1 (P = 2.23 × 10). The expression of HMGCS1 significantly decreased in PCa primary tumors than that in normal tissues. These findings indicated that the HMGCS1 rs67415672 might be possible functional susceptibility loci for PCa.
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http://dx.doi.org/10.1016/j.gene.2021.145432DOI Listing
March 2021

A predictive model for respiratory distress in patients with COVID-19: a retrospective study.

Ann Transl Med 2020 Dec;8(23):1585

Department of Medical Informatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.

Background: Coronavirus disease 2019 (COVID-19), associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global public health crisis. We retrospectively evaluated 863 hospitalized patients with COVID-19 infection, designated IWCH-COVID-19.

Methods: We built a successful predictive model after investigating the risk factors to predict respiratory distress within 30 days of admission. These variables were analyzed using Kaplan-Meier and Cox proportional hazards (PHs) analyses. Hazard ratios (HRs) and performance of the final model were determined.

Results: Neutrophil count >6.3×10/L, D-dimer level ≥1.00 mg/L, and temperature ≥37.3 °C at admission showed significant positive association with the outcome of respiratory distress in the final model. Complement C3 (C3) of 0.9-1.8 g/L, platelet count >350×10/L, and platelet count of 125-350×10/L showed a significant negative association with outcomes of respiratory distress in the final model. The final model had a C statistic of 0.891 (0.867-0.915), an Akaike's information criterion (AIC) of 567.65, and a bootstrap confidence interval (CI) of 0.866 (0.842-0.89). This five-factor model could help in early allocation of medical resources.

Conclusions: The predictive model based on the five factors obtained at admission can be applied for calculating the risk of respiratory distress and classifying patients at an early stage. Accordingly, high-risk patients can receive timely and effective treatment, and health resources can be allocated effectively.
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http://dx.doi.org/10.21037/atm-20-4977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791231PMC
December 2020

Effect of Neudesin Neurotrophic Factor on Differentiation of Bovine Preadipocytes and Myoblasts in a Co-Culture System.

Animals (Basel) 2020 Dec 26;11(1). Epub 2020 Dec 26.

College of Animal Science and Technology, Northwest A&F University, Xianyang 712100, China.

In this study, we successfully established a co-culture system of bovine preadipocytes and myoblasts to explore the effect of exogenous addition of Neudesin neurotrophic factor (NENF) recombinant protein on the differentiation of adipocytes and myoblasts in co-culture. The optimal concentration of NENF recombinant protein was 100 pg/mL. promoted the differentiation of bovine preadipocytes and inhibited the differentiation of bovine myoblasts when the cells were cultured separately. After adding NENF recombinant protein to the co-culture system, the accumulation of lipid droplets in bovine preadipocytes decreased, but the differentiation of bovine myoblasts did not change significantly. The results of real-time quantitative PCR (RT-qPCR) and Western blot showed that the expression levels of adipogenesis-related factors such as , and were significantly down-regulated at the mRNA and protein levels in adipocytes, while myogenic marker genes such as , and had no significant changes at the mRNA or protein levels in myoblasts. This differs from, and potentially conflicts with, the monoculture system, where expression in each cell type changed with the cell microenvironment. Consequently, the molecular mechanism of marbling beef formation cannot be fully revealed using monocultures of adipocytes or myocytes.
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http://dx.doi.org/10.3390/ani11010034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823575PMC
December 2020

Inconsistency of Bone Mineral Density Between Femoral Head and Proximal Femur After Femoral Neck Fracture Surgery Indicates Great Possibility of Femoral Head Necrosis.

Orthopedics 2020 Dec 29:1-6. Epub 2020 Dec 29.

On clinical observation, it was found that the bone mineral density (BMD) of the femoral head and proximal femur was not consistent in some patients with femoral neck fracture after surgery. The current study was performed to explore whether this phenomenon was associated with femoral head necrosis after surgery for femoral neck fracture. Bone mineral density inconsistency is when the difference of the sum of pixel values on both sides of the fracture line has exceeded 30%. Statistical analysis was performed on the clinical characteristics of 271 patients who have received the operation for femoral neck fracture. Chi-square test, Spearman rank correlation, independent sample t test, Kaplan-Meier method, and log-rank test, as well as univariate Cox regression and multivariate Cox regression, were used to analyze the potential relationship among related factors. It was revealed that the incidence of inconsistency in BMD between the femoral head and proximal femur was significantly increased in patients with femoral head necrosis after surgery for femoral neck fracture, and that the consistency was considerably high between BMD inconsistency and femoral head necrosis. The inconsistent BMD occurred 11.1 months earlier than the necrosis of the femoral head. Cox multivariate regression analysis indicated that the inconsistency in BMD between the femoral head and proximal femur after surgery for femoral neck fracture was an independent prognostic factor affecting femoral head necrosis. The inconsistent changes in BMD between the femoral head and proximal femur after surgery for femoral neck fracture indicate a great possibility of femoral head necrosis. [Orthopedics. 2021;44(x):xx-xx.].
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http://dx.doi.org/10.3928/01477447-20201216-06DOI Listing
December 2020