Glenn S Aller

Glenn S Van Aller

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Glenn S Aller

Glenn S Van Aller

Publications by authors named "Glenn S Van Aller"

17Publications

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1PubMed Central Citations

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.

Structure 2016 05 7;24(5):774-781. Epub 2016 Apr 7.

Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.010DOI Listing
May 2016

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.

ACS Chem Biol 2014 Mar 31;9(3):622-9. Epub 2013 Dec 31.

Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D and ‡Platform Technology and Sciences, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, United States.

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http://dx.doi.org/10.1021/cb4008748DOI Listing
March 2014

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.

Nature 2012 Dec 10;492(7427):108-12. Epub 2012 Oct 10.

Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania 19426, USA.

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http://dx.doi.org/10.1038/nature11606DOI Listing
December 2012

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

ACS Med Chem Lett 2012 Dec 19;3(12):1091-6. Epub 2012 Oct 19.

Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States.

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http://dx.doi.org/10.1021/ml3003346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025676PMC
December 2012

Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.

Bioorg Med Chem Lett 2012 Jun 25;22(12):4028-32. Epub 2012 Apr 25.

Infectious Diseases Center of Excellence for Drug Discovery, Antibacterial Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.086DOI Listing
June 2012

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.

Biochem Biophys Res Commun 2011 Mar 15;406(2):194-9. Epub 2011 Feb 15.

Department of Cancer Research, GlaxoSmithKline, Collegeville, PA 19426, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X110019
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http://dx.doi.org/10.1016/j.bbrc.2011.02.010DOI Listing
March 2011

Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.

Anal Biochem 2008 Dec 10;383(2):311-5. Epub 2008 Sep 10.

Department of Enzymology and Mechanistic Pharmacology, Oncology CEDD, GlaxoSmithKline, Collegeville, PA 19426, USA.

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http://dx.doi.org/10.1016/j.ab.2008.08.037DOI Listing
December 2008

Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin.

Biochemistry 2005 Jan;44(1):253-60

Enzymology and Mechanistic Pharmacology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA.

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http://dx.doi.org/10.1021/bi048632bDOI Listing
January 2005