Glenn S Cowley

Glenn S Cowley

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Glenn S Cowley

Glenn S Cowley

Publications by authors named "Glenn S Cowley"

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42Publications

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PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Cancer Res 2017 09 27;77(17):4613-4625. Epub 2017 Jun 27.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581676PMC
September 2017

Defining a Cancer Dependency Map.

Cell 2017 Jul;170(3):564-576.e16

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667678PMC
July 2017

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell 2016 Apr;165(2):303-16

Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826477PMC
April 2016

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci Data 2014 30;1:140035. Epub 2014 Sep 30.

Broad Institute of Harvard and MIT, 7 Cambridge Center , Cambridge, Massachusetts 02142, USA ; Department of Medical, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Departments of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/sdata201435
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http://dx.doi.org/10.1038/sdata.2014.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432652PMC
February 2016

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.

Mol Cancer Ther 2015 Dec 8;14(12):2700-11. Epub 2015 Sep 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. The Broad Institute, Cambridge, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0136-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674359PMC
December 2015

Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA.

Assay Drug Dev Technol 2015 Jan-Feb;13(1):34-43. Epub 2015 Feb 3.

1 National Emerging Infectious Diseases Laboratory, Boston University School of Medicine , Boston, Massachusetts.

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http://dx.doi.org/10.1089/adt.2014.613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340469PMC
November 2015

The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

Nat Immunol 2015 May 6;16(5):495-504. Epub 2015 Apr 6.

Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406861PMC
May 2015

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):268-72. Epub 2014 Dec 22.

The Broad Institute of MIT and Harvard University, Cambridge, MA 02142; The Picower Institute for Learning and Memory, Cambridge, MA 02139; and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1417231112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291668PMC
January 2015

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.

Proc Natl Acad Sci U S A 2015 Jan 29;112(2):512-7. Epub 2014 Dec 29.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; Broad Institute of MIT and Harvard, Cambridge, MA 02142; Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1413291112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299213PMC
January 2015

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.

Cancer Cell 2013 Dec;24(6):738-50

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910168PMC
December 2013

Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.

Genes Dev 2006 Dec 17;20(23):3311-23. Epub 2006 Nov 17.

Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1466806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1686607PMC
December 2006