Publications by authors named "Glenn Heller"

100Publications

The added value of new covariates to the brier score in cox survival models.

Authors:
Glenn Heller

Lifetime Data Anal 2020 Oct 22. Epub 2020 Oct 22.

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering, 485 Lexington Avenue, New York, New York, 10017, USA.

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http://dx.doi.org/10.1007/s10985-020-09509-xDOI Listing
October 2020

CNS Metastases in Patients With Exon 14-Altered Lung Cancers and Outcomes With Crizotinib.

JCO Precis Oncol 2020 27;4. Epub 2020 Jul 27.

Thoracic Oncology and Early Drug Development Services, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center; and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/PO.20.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446485PMC
July 2020

Measuring the temporal prognostic utility of a baseline risk score.

Lifetime Data Anal 2020 10 24;26(4):856-871. Epub 2020 Jul 24.

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/s10985-020-09503-3DOI Listing
October 2020

Reply to C. Ren et al.

J Clin Oncol 2018 08 12;36(22):2354-2356. Epub 2018 Jun 12.

Glenn Heller, Memorial Sloan Kettering Cancer Center, New York, NY; Robert McCormack and Thian Kheoh, Janssen Research & Development, Raritan, NJ; Arturo Molina, Janssen Research & Development, Los Angeles, CA; Matthew R. Smith, Massachusetts General Hospital, Boston, MA; Robert Dreicer, University of Virginia Medical School, Charlottesville, VA; Fred Saad, University of Montreal, Montreal, Quebec, Canada; Ronald de Wit, Erasmus Medical Center, Rotterdam, Netherlands; Dana T. Aftab, Exelixis, South San Francisco, CA; Mohammed Hirmand, Medivation, San Francisco, CA; Ana Limon-Carrera, Takeda Oncology, Cambridge, MA; Karim Fizazi, Institut Gustave Roussy, Villejuif, and University of Paris Sud, Orsay, France; Martin Fleisher, Memorial Sloan Kettering Cancer Center, New York, NY; Johann S. de Bono, The Institute of Cancer Research, and The Royal Marsden Hospital, Sutton, Surrey, United Kingdom; and Howard I. Scher, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2018.78.2672DOI Listing
August 2018

Circulating Tumor Cell Number as a Response Measure of Prolonged Survival for Metastatic Castration-Resistant Prostate Cancer: A Comparison With Prostate-Specific Antigen Across Five Randomized Phase III Clinical Trials.

J Clin Oncol 2018 02 22;36(6):572-580. Epub 2017 Dec 22.

Glenn Heller, Martin Fleisher, and Howard I. Scher, Memorial Sloan Kettering Cancer Center; Howard I. Scher, Weill Cornell Medical College, New York, NY; Robert McCormack, Janssen Research & Development, Raritan, NJ; Thian Kheoh and Arturo Molina, Janssen Research & Development, Los Angeles; Dana T. Aftab, Exelixis, South San Francisco; Mohammad Hirmand, Medivation, San Francisco, CA; Matthew R. Smith, Massachusetts General Hospital, Boston; Ana Limon, Takeda Oncology, Cambridge, MA; Robert Dreicer, University of Virginia Medical School, Charlottesville, VA; Fred Saad, University of Montreal, Montreal, Quebec, Canada; Ronald de Wit, Erasmus Medical Center, Rotterdam, the Netherlands; Karim Fizazi, Institut Gustave Roussy, Villejuif, and University of Paris Sud, Orsay, France; and Johann S. de Bono, The Institute of Cancer Research, and The Royal Marsden Hospital, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.75.2998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815402PMC
February 2018

Human Dendritic Cells Mitigate NK-Cell Dysfunction Mediated by Nonselective JAK1/2 Blockade.

Cancer Immunol Res 2017 01 6;5(1):52-60. Epub 2016 Dec 6.

Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (MSKCC), New York, New York.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335862PMC
January 2017

A Pilot Study of a Multimodal Treatment Paradigm to Accelerate Drug Evaluations in Early-stage Metastatic Prostate Cancer.

Urology 2017 04 22;102:164-172. Epub 2016 Nov 22.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2016.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468169PMC
April 2017

Clinical Validity of Detecting Circulating Tumor Cells by AdnaTest Assay Compared With Direct Detection of Tumor mRNA in Stabilized Whole Blood, as a Biomarker Predicting Overall Survival for Metastatic Castration-Resistant Prostate Cancer Patients.

Cancer J 2016 Sep/Oct;22(5):315-320

From the *Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center; †Department of Medicine, Weill Cornell Medical College; and Departments of ‡Laboratory Medicine and §Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1097/PPO.0000000000000220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108569PMC
August 2017

KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.

J Clin Oncol 2016 07 11;34(21):2443-51. Epub 2016 Apr 11.

Christopher J. Forlenza, Jeanette E. Boudreau, Junting Zheng, Jean-Benoît Le Luduec, Elizabeth Chamberlain, Glenn Heller, Nai-Kong V. Cheung, and Katharine C. Hsu, Memorial Sloan Kettering Cancer Center; and Katharine C. Hsu, Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.64.9558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962735PMC
July 2016

Reply to A. Addeo and A. Bahl.

J Clin Oncol 2016 Feb 23;34(4):387-8. Epub 2015 Nov 23.

The Institute of Cancer Research and The Royal Marsden Hospital, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2015.64.6562DOI Listing
February 2016

Estimating the concordance probability in a survival analysis with a discrete number of risk groups.

Lifetime Data Anal 2016 Apr 29;22(2):263-79. Epub 2015 May 29.

Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10985-015-9330-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886856PMC
April 2016

Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer.

J Clin Oncol 2015 Apr 23;33(12):1348-55. Epub 2015 Mar 23.

Howard I. Scher, Glenn Heller, Daniel C. Danila, and Martin Fleisher, Memorial Sloan Kettering Cancer Center; Howard I. Scher and Daniel C. Danila, Weill Cornell Medical College; Xiaoyu Jia, Columbia University, New York, NY; Arturo Molina, Janssen Research & Development, Menlo Park; Weimin Peng, Janssen Research & Development, Los Angeles; Thian Kheoh, Janssen Research & Development, San Diego, CA; Gerhardt Attard, Shahneen K. Sandhu, David Olmos, Ruth Riisnaes, and Johann S. de Bono, Institute of Cancer Research; Gerhardt Attard, Shahneen K. Sandhu, David Olmos, and Johann S. de Bono, Royal Marsden Hospital, Sutton, United Kingdom; Robert McCormack, Janssen Research & Development, Raritan, NJ; and Tomasz Burzykowski and Marc Buyse, International Drug Development Institute, Louvain-la-Neuve, Belgium.

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http://jco.ascopubs.org/content/early/2015/03/23/JCO.2014.55
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.55.3487
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http://dx.doi.org/10.1200/JCO.2014.55.3487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397279PMC
April 2015

Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival.

Eur Urol 2014 Jun 26;65(6):1191-7. Epub 2013 Jul 26.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2013.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113474PMC
June 2014

Repetitively dosed docetaxel and ¹⁵³samarium-EDTMP as an antitumor strategy for metastatic castration-resistant prostate cancer.

Cancer 2013 Sep 13;119(17):3186-94. Epub 2013 Jun 13.

Genitourinary Oncology Service, Sidney Kimmel Center for Prostate and Urologic Cancers, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/cncr.28103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775970PMC
September 2013

Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumors.

Leuk Res 2013 Jul 6;37(7):790-4. Epub 2013 Mar 6.

Leukemia Service, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/j.leukres.2013.02.005DOI Listing
July 2013

Validation and clinical utility of prostate cancer biomarkers.

Nat Rev Clin Oncol 2013 Apr 5;10(4):225-34. Epub 2013 Mar 5.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/nrclinonc.2013.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790270PMC
April 2013

Prevalence of vitamin D insufficiency in survivors of childhood cancer.

Pediatr Blood Cancer 2013 Jul 28;60(7):1237-9. Epub 2012 Nov 28.

Department of Pediatrics, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA.

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http://dx.doi.org/10.1002/pbc.24403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006112PMC
July 2013

The use of back-up units to enhance the safety of unrelated donor cord blood transplantation.

Biol Blood Marrow Transplant 2012 Apr 11;18(4):648-51. Epub 2012 Jan 11.

Adult Bone Marrow Transplantation, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1016/j.bbmt.2011.12.588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303962PMC
April 2012

A measure of explained risk in the proportional hazards model.

Authors:
Glenn Heller

Biostatistics 2012 Apr 21;13(2):315-25. Epub 2011 Dec 21.

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63 Street, New York, NY 10065, USA.

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https://academic.oup.com/biostatistics/article-lookup/doi/10
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http://dx.doi.org/10.1093/biostatistics/kxr047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297826PMC
April 2012

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen.

Blood 2011 Nov 13;118(19):5330-9. Epub 2011 Sep 13.

Laboratory of Cellular Immunobiology, Immunology Program, Sloan-Kettering Institute for Cancer Research, New York, NY 10065, USA.

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http://dx.doi.org/10.1182/blood-2011-06-363408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217413PMC
November 2011

End points and outcomes in castration-resistant prostate cancer: from clinical trials to clinical practice.

J Clin Oncol 2011 Sep 22;29(27):3695-704. Epub 2011 Aug 22.

Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.

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http://ascopubs.org/doi/10.1200/JCO.2011.35.8648
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http://dx.doi.org/10.1200/JCO.2011.35.8648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675708PMC
September 2011

Proportional hazards regression with interval censored data using an inverse probability weight.

Authors:
Glenn Heller

Lifetime Data Anal 2011 Jul 30;17(3):373-85. Epub 2010 Dec 30.

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://link.springer.com/10.1007/s10985-010-9191-8
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http://dx.doi.org/10.1007/s10985-010-9191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499516PMC
July 2011

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts.

Blood 2011 Mar 13;117(12):3277-85; quiz 3478. Epub 2010 Dec 13.

Department of Medicine, Adult Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-08-30
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http://dx.doi.org/10.1182/blood-2010-08-300491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069669PMC
March 2011

An in vivo model of double-unit cord blood transplantation that correlates with clinical engraftment.

Blood 2010 Nov 29;116(19):3999-4006. Epub 2010 Jun 29.

Allogeneic Bone Marrow Transplantation, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1182/blood-2010-03-276212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981548PMC
November 2010

Lehmann family of ROC curves.

Med Decis Making 2010 Jul-Aug;30(4):509-17. Epub 2010 Mar 30.

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63 Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1177/0272989X09360067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590288PMC
November 2010

Hypothyroidism after 131I-monoclonal antibody treatment of neuroblastoma.

Pediatr Blood Cancer 2010 Jul;55(1):76-80

Department of Pediatrics, New York Presbyterian-Weill Cornell Medical College, New York, New York, USA.

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http://dx.doi.org/10.1002/pbc.22452DOI Listing
July 2010

Analytical strategies for characterizing chemotherapy diffusion with patient-level population-based data.

Appl Health Econ Health Policy 2010 ;8(1):37-51

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1007/BF03256164DOI Listing
April 2010

Adverse symptom event reporting by patients vs clinicians: relationships with clinical outcomes.

J Natl Cancer Inst 2009 Dec 17;101(23):1624-32. Epub 2009 Nov 17.

Health Outcomes Group, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63rd St, New York, NY 10065, USA.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djp386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786917PMC
December 2009

A "no-wash" albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactions.

Biol Blood Marrow Transplant 2009 Dec 25;15(12):1596-602. Epub 2009 Sep 25.

Department of Medicine, Allogeneic Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105472PMC
December 2009

Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease.

Biol Blood Marrow Transplant 2010 Mar 24;16(3):435-40. Epub 2009 Oct 24.

Allogeneic Bone Marrow Transplantation Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S108387910900493
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http://dx.doi.org/10.1016/j.bbmt.2009.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096002PMC
March 2010

Hematologic safety profile of linezolid in the early periengraftment period after allogeneic stem cell transplantation.

Biol Blood Marrow Transplant 2009 Oct 26;15(10):1337-41. Epub 2009 Jul 26.

Department of Medicine, Infectious Disease, New York, New York, USA.

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http://dx.doi.org/10.1016/j.bbmt.2009.05.021DOI Listing
October 2009

Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer.

Clin Cancer Res 2009 Mar 10;15(6):2091-7. Epub 2009 Mar 10.

Molecular Cytogenetics Core Laboratory, Department of Medicine, Memorial Sloan-kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875199PMC
March 2009

Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data.

Lancet Oncol 2009 Mar 11;10(3):233-9. Epub 2009 Feb 11.

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1016/S1470-2045(08)70340-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774131PMC
March 2009

Assessing outcomes in prostate cancer clinical trials: a twenty-first century tower of Babel.

Cancer 2008 Sep;113(5):966-74

Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1002/cncr.23719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708077PMC
September 2008

Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib.

J Clin Oncol 2008 Mar;26(9):1472-8

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Howard Building, Room 1012, 1275 York Ave, New York, NY 10021, USA.

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http://dx.doi.org/10.1200/JCO.2007.13.0062DOI Listing
March 2008

Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer.

Clin Cancer Res 2007 Dec;13(23):7053-8

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-1506DOI Listing
December 2007

T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection.

Nat Med 2007 Dec 18;13(12):1440-9. Epub 2007 Nov 18.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nm1676DOI Listing
December 2007

A phase II trial of bortezomib and prednisone for castration resistant metastatic prostate cancer.

J Urol 2007 Dec 22;178(6):2378-83; discussion 2383-4. Epub 2007 Oct 22.

Department of Medicine (Genitourinary Oncology Service), Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.juro.2007.08.015DOI Listing
December 2007

Improving the decision to pursue a phase 3 clinical trial by adjusting for patient-specific factors in evaluating phase 2 treatment efficacy data.

Med Decis Making 2007 Jul-Aug;27(4):380-6

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://journals.sagepub.com/doi/10.1177/0272989X07303826
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http://dx.doi.org/10.1177/0272989X07303826DOI Listing
September 2007

Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications.

J Immunother 2007 Sep;30(6):634-43

Laboratory of Cellular Immunobiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1097/CJI.0b013e31804efc8bDOI Listing
September 2007

Inference on the limiting false discovery rate and the p-value threshold parameter assuming weak dependence between gene expression levels within subject.

Stat Appl Genet Mol Biol 2007 21;6:Article14. Epub 2007 May 21.

Memorial Sloan-Kettering Cancer Center, USA.

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http://dx.doi.org/10.2202/1544-6115.1285DOI Listing
June 2007

The association between measures of progression and survival in castrate-metastatic prostate cancer.

Clin Cancer Res 2007 Mar;13(5):1488-92

Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1885DOI Listing
March 2007

Rapid androgen cycling as treatment for patients with prostate cancer.

Clin Cancer Res 2006 Dec;12(24):7414-21

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1496DOI Listing
December 2006

Post-therapy changes in PSA as an outcome measure in prostate cancer clinical trials.

Nat Clin Pract Oncol 2006 Dec;3(12):658-67

Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancer, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/ncponc0664DOI Listing
December 2006