Gleb Kichaev

Gleb Kichaev

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Gleb Kichaev

Gleb Kichaev

Publications by authors named "Gleb Kichaev"

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Probabilistic fine-mapping of transcriptome-wide association studies.

Nat Genet 2019 04 29;51(4):675-682. Epub 2019 Mar 29.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41588-019-0367-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619422PMC
April 2019

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

Am J Hum Genet 2019 Jan 27;104(1):65-75. Epub 2018 Dec 27.

Department of Epidemiology. Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323418PMC
January 2019

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits.

Am J Hum Genet 2018 10;103(4):535-552

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183028
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http://dx.doi.org/10.1016/j.ajhg.2018.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174356PMC
October 2018

Mixed-model association for biobank-scale datasets.

Nat Genet 2018 07;50(7):906-908

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.nature.com/articles/s41588-018-0144-6
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http://dx.doi.org/10.1038/s41588-018-0144-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309610PMC
July 2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Methods for fine-mapping with chromatin and expression data.

PLoS Genet 2018 02 26;14(2):e1007240. Epub 2018 Feb 26.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843356PMC
February 2018

Enhanced methods to detect haplotypic effects on gene expression.

Bioinformatics 2017 Aug;33(15):2307-2313

Bioinformatics IDP, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860109PMC
August 2017

Widespread Allelic Heterogeneity in Complex Traits.

Am J Hum Genet 2017 May;100(5):789-802

Department of Computer Science, University of California, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420356PMC
May 2017

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits.

Am J Hum Genet 2017 Mar 23;100(3):473-487. Epub 2017 Feb 23.

Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339290PMC
March 2017

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data.

Am J Hum Genet 2016 07 23;99(1):139-53. Epub 2016 Jun 23.

Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005444PMC
July 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:
Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms10979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829663PMC
April 2016

Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders.

Eur J Hum Genet 2016 Jan 22;24(1):113-9. Epub 2015 Apr 22.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/ejhg.2015.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795218PMC
January 2016

Leveraging Functional-Annotation Data in Trans-ethnic Fine-Mapping Studies.

Am J Hum Genet 2015 Aug 16;97(2):260-71. Epub 2015 Jul 16.

Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573268PMC
August 2015

Identification of causal genes for complex traits.

Bioinformatics 2015 Jun;31(12):i206-13

Department of Computer Science, Inter-Departmental Program in Bioinformatics, Department of Human Genetics and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA Department of Computer Science, Inter-Departmental Program in Bioinformatics, Department of Human Genetics and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btv240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542778PMC
June 2015

Integrating functional data to prioritize causal variants in statistical fine-mapping studies.

PLoS Genet 2014 Oct 30;10(10):e1004722. Epub 2014 Oct 30.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214605PMC
October 2014

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ.

Vaccines (Basel) 2013 Aug 22;1(3):367-83. Epub 2013 Aug 22.

Novartis Vaccines & Diagnostics, Inc., 350 Massachusetts Ave, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.3390/vaccines1030367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494232PMC
August 2013

Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation.

Mol Ther Nucleic Acids 2012 Feb 14;1:e11. Epub 2012 Feb 14.

Department of Research and Development, Inovio Pharmaceuticals, Blue Bell, Pennsylvania, USA.

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http://dx.doi.org/10.1038/mtna.2012.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381603PMC
February 2012

Weakening of negative relative to positive associations with cocaine-paired cues contributes to cue-induced responding after drug removal.

Pharmacol Biochem Behav 2012 Jan 8;100(3):458-63. Epub 2011 Oct 8.

Behavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.

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http://dx.doi.org/10.1016/j.pbb.2011.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242854PMC
January 2012