Publications by authors named "Gleb K Rystsov"

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Austalides V and W, new meroterpenoids from the fungus Aspergillus ustus and their antitumor activities.

Bioorg Med Chem Lett 2019 11 4;29(22):126708. Epub 2019 Oct 4.

G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS, FSBIS FRC Pushchino Scientific Centre of Biological Research, Russian Academy of Sciences, Pushchino 142290, Russian Federation.

Two new austalide meroterpenoids, named austalides V and W (1 and 2), were isolated from the fungus Aspergillus ustus VKM F-4692. Their structures were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. The main structural feature of both compounds is a tetrahydrofuranyl ring (G), a structural fragment, first found in austalides. Austalides V (1) and W (2) were able to inhibit the propagation of prostate and bladder cancer cells; this biologic activity is possibly related to the inhibition of a number of key pathways regulating cell growth and migration.
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November 2019