Publications by authors named "Giuseppina De Simone"

100Publications

Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain.

Cell Mol Life Sci 2020 Nov 17. Epub 2020 Nov 17.

Institute of Biostructures and Bioimaging, CNR, via Mezzocannone, 16, 80134, Naples, Italy.

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http://dx.doi.org/10.1007/s00018-020-03697-3DOI Listing
November 2020

Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules.

J Inorg Biochem 2020 Dec 7;213:111274. Epub 2020 Oct 7.

Neurofarba Department, Sezione di Chimica Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Via U. Schiff 6, I-50019 Sesto Fiorentino (Firenze), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111274DOI Listing
December 2020

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

Metabolites 2020 Oct 14;10(10). Epub 2020 Oct 14.

Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/metabo10100412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602163PMC
October 2020

Catechols: a new class of carbonic anhydrase inhibitors.

Chem Commun (Camb) 2020 Nov 1;56(85):13033-13036. Epub 2020 Oct 1.

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.1039/d0cc05172aDOI Listing
November 2020

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms.

ACS Med Chem Lett 2020 May 4;11(5):1000-1005. Epub 2020 Mar 4.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Palatucci, Polo Didattico SS. Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.0c00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236538PMC
May 2020

Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex.

J Mol Biol 2019 12 1;431(24):4910-4921. Epub 2019 Nov 1.

Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, Naples, 80134, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.10.022DOI Listing
December 2019

Recent Advances in the Development of New Therapeutic Tools Against Major Parasitic Diseases.

Curr Med Chem 2018 ;25(39):5238

Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche Napoli, Italy.

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http://dx.doi.org/10.2174/092986732539181119125949DOI Listing
February 2019

Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350.

Expert Opin Ther Pat 2019 Jan 17;29(1):1-6. Epub 2018 Dec 17.

a Istituto di Biostrutture e Bioimmagini-CNR , Naples , Italy.

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https://www.tandfonline.com/doi/full/10.1080/13543776.2019.1
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http://dx.doi.org/10.1080/13543776.2019.1558210DOI Listing
January 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Eur J Med Chem 2019 Feb 1;163:443-452. Epub 2018 Dec 1.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Palatucci, Polo didattico SS, Annunziata, 98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.073DOI Listing
February 2019

Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance.

Oxid Med Cell Longev 2018 5;2018:2018306. Epub 2018 Aug 5.

Institute of Biostructures and Bioimaging, National Research Council, 80134 Naples, Italy.

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http://dx.doi.org/10.1155/2018/2018306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098850PMC
December 2018

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

Med Res Rev 2018 09 10;38(6):1799-1836. Epub 2018 Apr 10.

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.1002/med.21497DOI Listing
September 2018

Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases?

Curr Med Chem 2018 ;25(39):5266-5278

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.2174/0929867325666180326160121DOI Listing
February 2019

Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX.

Cell Mol Life Sci 2018 09 21;75(17):3283-3296. Epub 2018 Mar 21.

Institute of Biostructures and Bioimaging, CNR, via Mezzocannone, 16, 80134, Naples, Italy.

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http://dx.doi.org/10.1007/s00018-018-2798-8DOI Listing
September 2018

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

J Med Chem 2017 05 9;60(10):4316-4326. Epub 2017 May 9.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina , Viale Annunziata, I-98168 Messina, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00264DOI Listing
May 2017

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage.

J Enzyme Inhib Med Chem 2017 Dec 21;32(1):5-12. Epub 2016 Oct 21.

b Institute of Biostructures and Bioimaging, CNR , Naples , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1225046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010095PMC
December 2017

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition.

Chem Commun (Camb) 2016 09;52(80):11983-11986

Institut des Biomolécules Max Mousseron (IBMM) UMR5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.

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http://xlink.rsc.org/?DOI=C6CC06399C
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http://dx.doi.org/10.1039/c6cc06399cDOI Listing
September 2016

Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.

J Enzyme Inhib Med Chem 2016 15;31(sup4):54-59. Epub 2016 Aug 15.

a Istituto di Bioscienze e Biorisorse, CNR , Napoli , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1217856DOI Listing
February 2017

Editorial (Thematic Issue: Bacterial Metallo-Enzymes as Drug Targets).

Curr Top Med Chem 2016 ;16(21):2329

Istituto di Biostrutture e Bioimmagini-CNR via Mezzocannone 16 80134 Napoli Italy.

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http://dx.doi.org/10.2174/156802661621160630185612DOI Listing
February 2017

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.

Bioorg Med Chem 2016 08 4;24(16):3643-8. Epub 2016 Jun 4.

Università degli Studi di Firenze, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.06.005DOI Listing
August 2016

The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies.

Org Biomol Chem 2016 Jun 6;14(21):4853-8. Epub 2016 May 6.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1039/c6ob00803hDOI Listing
June 2016

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

J Med Chem 2015 Nov 4;58(21):8564-72. Epub 2015 Nov 4.

Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma , Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01144DOI Listing
November 2015

Thermostable Carbonic Anhydrases in Biotechnological Applications.

Int J Mol Sci 2015 Jul 8;16(7):15456-80. Epub 2015 Jul 8.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.3390/ijms160715456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519908PMC
July 2015

Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii.

Mar Drugs 2015 Mar 25;13(4):1688-97. Epub 2015 Mar 25.

Institute of Biostructures and Bioimaging-National Research Council (CNR), Via Mezzocannone 16, I-80134 Naples, Italy.

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http://dx.doi.org/10.3390/md13041688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413181PMC
March 2015

The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families.

Bioorg Med Chem Lett 2015 Apr 28;25(7):1385-9. Epub 2015 Feb 28.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche, and Laboratorio di Chimica Bioinorganica, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.02.046DOI Listing
April 2015

Out of the active site binding pocket for carbonic anhydrase inhibitors.

Chem Commun (Camb) 2015 ;51(2):302-5

Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134, Naples, Italy.

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http://dx.doi.org/10.1039/c4cc07320gDOI Listing
August 2015

High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7).

Eur J Endocrinol 2014 Dec 11;171(6):697-704. Epub 2014 Sep 11.

Department of Experimental Medicine'Sapienza' University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Internal MedicineS. Michele Hospital, Cagliari, ItalyEndocrinologyGaribaldi di Nesima Hospital, Catania University, Catania, ItalyDiabetologic CenterDistretto 54 ASL Napoli 3, Naples, ItalyEndocrinology and DiabetesDepartment of Medical Sciences, University of Cagliari, Cagliari, ItalyU.O.C. Diabetologia/Endocrinology'A. Cardarelli' Hospital, Campobasso, ItalyDepartment of Public Health Sciences and Infectious Diseases'Sapienza' University of Rome, Rome, ItalySan Raffaele Scientific InstituteDiabetes Research Institute, Milan, ItalySection of Internal MedicineEndocrinology, Andrology and Metabolic Disease, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Bari, Italy

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http://www.eje-online.org/content/early/2014/09/11/EJE-14-03
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http://www.eje-online.org/content/171/6/697.full.pdf
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http://www.eje-online.org/cgi/doi/10.1530/EJE-14-0342
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http://dx.doi.org/10.1530/EJE-14-0342DOI Listing
December 2014

Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase.

Extremophiles 2014 Mar 5;18(2):219-28. Epub 2013 Dec 5.

Dipartimento di Biologia, Università degli Studi di Napoli ''Federico II'', Complesso Universitario Monte S. Angelo, Via Cinthia, 80126, Naples, Italy.

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http://dx.doi.org/10.1007/s00792-013-0607-8DOI Listing
March 2014

Thermal-stable carbonic anhydrases: a structural overview.

Subcell Biochem 2014 ;75:387-404

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy,

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http://dx.doi.org/10.1007/978-94-007-7359-2_19DOI Listing
May 2014

Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.

J Med Chem 2013 Nov 31;56(21):8512-20. Epub 2013 Oct 31.

Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS-UM1-UM2 Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.

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http://dx.doi.org/10.1021/jm4009532DOI Listing
November 2013

Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".

J Enzyme Inhib Med Chem 2014 Aug 29;29(4):500-4. Epub 2013 Jul 29.

Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16 , 80134 Naples , Italy .

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http://dx.doi.org/10.3109/14756366.2013.813942DOI Listing
August 2014

Anticancer carbonic anhydrase inhibitors: a patent review (2008 - 2013).

Expert Opin Ther Pat 2013 15;23(6):737-49. Epub 2013 May 15.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.1517/13543776.2013.798648DOI Listing
December 2013

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors.

Expert Opin Drug Discov 2013 Jul 30;8(7):793-810. Epub 2013 Apr 30.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.1517/17460441.2013.795145DOI Listing
July 2013

Faox enzymes inhibited Maillard reaction development during storage both in protein glucose model system and low lactose UHT milk.

Amino Acids 2014 Feb 21;46(2):279-88. Epub 2013 Apr 21.

Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli Federico II Via Salute, Parco Gussone Superiore, Portici (Naples), Italy.

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http://dx.doi.org/10.1007/s00726-013-1497-xDOI Listing
February 2014

Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.

Bioorg Med Chem Lett 2013 Mar 30;23(6):1626-30. Epub 2013 Jan 30.

Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2013.01.087DOI Listing
March 2013

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors.

Chem Commun (Camb) 2012 Sep 27;48(70):8838-40. Epub 2012 Jul 27.

Istituto di Biostrutture e Bioimmagini - CNR, Napoli, Italy.

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http://xlink.rsc.org/?DOI=c2cc34275h
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http://dx.doi.org/10.1039/c2cc34275hDOI Listing
September 2012

Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.

J Med Chem 2012 Aug 20;55(15):6776-83. Epub 2012 Jul 20.

Istituto di Biostrutture e Bioimmagini-CNR , via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1021/jm300818kDOI Listing
August 2012

Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?

Chem Rev 2012 Aug 18;112(8):4421-68. Epub 2012 May 18.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://pubs.acs.org/doi/10.1021/cr200176r
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http://dx.doi.org/10.1021/cr200176rDOI Listing
August 2012

Zinc metallo-enzymes as target for drug design.

Curr Med Chem 2012 ;19(6):820

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http://dx.doi.org/10.2174/092986712799034969DOI Listing
June 2012

(In)organic anions as carbonic anhydrase inhibitors.

J Inorg Biochem 2012 Jun 1;111:117-29. Epub 2011 Dec 1.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, Naples, Italy.

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http://dx.doi.org/10.1016/j.jinorgbio.2011.11.017DOI Listing
June 2012

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II.

Chem Commun (Camb) 2011 Nov 26;47(42):11636-8. Epub 2011 Sep 26.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1039/c1cc14575dDOI Listing
November 2011

C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family.

Biochem J 2011 Apr;435(1):157-66

Dipartimento di Biologia Strutturale e Funzionale, Università degli Studi di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia, Naples, Italy.

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http://dx.doi.org/10.1042/BJ20101334DOI Listing
April 2011

Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII.

Curr Pharm Des 2010 ;16(29):3246-54

Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.2174/138161210793429841DOI Listing
April 2011

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide.

Bioorg Med Chem Lett 2010 Sep 16;20(17):5023-6. Epub 2010 Jul 16.

Istituto di Biostrutture e Bioimmagini-CNR, Napoli, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2010.07.051DOI Listing
September 2010

Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus.

Biochimie 2010 Oct 14;92(10):1435-44. Epub 2010 Jul 14.

Dipartimento di Biologia Strutturale e Funzionale, Università degli Studi di Napoli ''Federico II'', Complesso Universitario Monte S. Angelo, Via Cinthia, 80126 Naples, Italy.

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http://dx.doi.org/10.1016/j.biochi.2010.07.006DOI Listing
October 2010

Inhibition of the R1 fragment of the cadmium-containing zeta-class carbonic anhydrase from the diatom Thalassiosira weissflogii with anions.

Bioorg Med Chem Lett 2010 Aug 1;20(16):4745-8. Epub 2010 Jul 1.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.139DOI Listing
August 2010

Multiple catalytically active thioredoxin folds: a winning strategy for many functions.

Cell Mol Life Sci 2010 Nov 13;67(22):3797-814. Epub 2010 Jul 13.

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.1007/s00018-010-0449-9DOI Listing
November 2010

The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex.

Org Biomol Chem 2010 Aug 27;8(15):3528-33. Epub 2010 May 27.

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://xlink.rsc.org/?DOI=b926832d
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http://dx.doi.org/10.1039/b926832dDOI Listing
August 2010

Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125.

Biopolymers 2010 Aug;93(8):669-77

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1002/bip.21420DOI Listing
August 2010

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.

Bioorg Med Chem Lett 2009 Oct 31;19(20):5825-8. Epub 2009 Aug 31.

Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della, Lastruccia 3, I-50019, Sesto Fiorentino (Firenze), Italy.

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http://dx.doi.org/10.1016/j.bmcl.2009.08.088DOI Listing
October 2009

Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?

Chem Biol Drug Des 2009 Sep;74(3):317-21

Istituto di Biostrutture e Bioimmagini-CNR, 80134 Napoli, Italy.

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http://dx.doi.org/10.1111/j.1747-0285.2009.00857.xDOI Listing
September 2009

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

Biochim Biophys Acta 2010 Feb 11;1804(2):404-9. Epub 2009 Aug 11.

Istituto di Biostrutture e Bioimmagini-CNR, 80134 Naples, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390900195
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http://dx.doi.org/10.1016/j.bbapap.2009.07.027DOI Listing
February 2010

Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus.

Proteins 2009 Sep;76(4):995-1006

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.1002/prot.22408DOI Listing
September 2009

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity.

Expert Opin Emerg Drugs 2008 Jun;13(2):383-92

Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.

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http://dx.doi.org/10.1517/14728214.13.2.383DOI Listing
June 2008

Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.

Bioorg Med Chem Lett 2008 Apr 7;18(7):2267-71. Epub 2008 Mar 7.

Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.012DOI Listing
April 2008

Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?

Curr Pharm Des 2008 ;14(7):655-60

Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.2174/138161208783877820DOI Listing
April 2008

Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.

ChemMedChem 2008 Mar;3(3):473-7

Istituto di Biostrutture e Bioimmagini-CNR via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1002/cmdc.200700274DOI Listing
March 2008

Antiobesity carbonic anhydrase inhibitors.

Curr Top Med Chem 2007 ;7(9):879-84

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.2174/156802607780636762DOI Listing
June 2007

Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.

Bioorg Med Chem 2007 Jun 30;15(12):4152-8. Epub 2007 Mar 30.

Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Naples, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.03.070DOI Listing
June 2007