Prof.  Giuseppina De Petro, PhD - Division of Biology and Genetics/University of Brescia - Full Professor of Applied Biology

Prof. Giuseppina De Petro

PhD

Division of Biology and Genetics/University of Brescia

Full Professor of Applied Biology

Brescia, Italy/ Lombardia | Italy

Additional Specialties: microRNAs, epigenetics, cancer

ORCID logohttps://orcid.org/0000-0001-9306-0851

Prof.  Giuseppina De Petro, PhD - Division of Biology and Genetics/University of Brescia - Full Professor of Applied Biology

Prof. Giuseppina De Petro

PhD

Introduction

Primary Affiliation: Division of Biology and Genetics/University of Brescia - Brescia, Italy/ Lombardia , Italy

Additional Specialties:

Publications

43Publications

312Reads

65Profile Views

319PubMed Central Citations

Functional Role of microRNA-23b-3p in Cancer Biology.

Microrna 2018 ;7(3):156-166

Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.2174/2211536607666180629155025DOI Listing
December 2018
2 Reads
1 Citation

miRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease.

Mol Neurobiol 2018 Oct 19;55(10):7717-7727. Epub 2018 Feb 19.

Biology and Genetic Division, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.

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http://dx.doi.org/10.1007/s12035-018-0951-xDOI Listing
October 2018
3 Reads
1 Citation
5.140 Impact Factor

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers.

Sci Rep 2018 Jul 10;8(1):10395. Epub 2018 Jul 10.

Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.

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http://dx.doi.org/10.1038/s41598-018-28739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039466PMC
July 2018
4 Reads
5.080 Impact Factor

Study of the in vitro modulation exerted by the antidepressant drug escitalopram on the expression of candidate microRNAs and their target genes.

Mol Cell Neurosci 2017 12 25;85:220-225. Epub 2017 Oct 25.

Faculty of Psychology, eCampus University, Novedrate, Como, Italy; Genetics Unit, IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.10.005DOI Listing
December 2017
9 Reads
3.840 Impact Factor

Biological Function of MicroRNA193a-3p in Health and Disease.

Int J Genomics 2017 5;2017:5913195. Epub 2017 Sep 5.

Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1155/2017/5913195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605928PMC
September 2017
8 Reads
2 Citations

Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells.

Int J Oncol. 2017 Jul;51(1):128-144. doi: 10.3892/ijo.2017.4019. Epub 2017 May 24.

Int J Oncology

Sorafenib is currently used to treat advanced and/or unresectable hepatocellular carcinoma (HCC), but the increase of the median survival was only 3 months. Moreover, sorafenib has severe side effects and patients develop resistance quickly. Epigenetic alterations such as DNA methylation play a decisive role in the development and progression of HCC. To our knowledge, there are no studies that analysed the global DNA methylation changes in HCC cells treated with sorafenib. Using MeDip-chip technologies, we found 1230 differentially methylated genes in HA22T/VGH cells treated with sorafenib compared to untreated cells. Gene ontology and pathway analysis allowed identifying several enriched signaling pathways involved in tumorigenesis and cancer progression. Among the genes differentially methylated we found genes related to apoptosis, angiogenesis and invasion, and genes belonging to pathways known to be deregulated in HCC such as RAF/MEK/ERK, JAK-STAT, PI3K/AKT/mTOR and NF-κB. Generally, we found that oncogenes tended to be hypermethylated and the tumor suppressor genes tended to be hypomethylated after sorafenib treatment. Finally, we validated MeDip-chip results for several genes found differentially methylated such as BIRC3, FOXO3, MAPK3, SMAD2 and TSC2, using both COBRA assay and direct bisulfite sequencing and we evaluated their mRNA expression. Our findings suggest that sorafenib could affect the methylation level of genes associated to cancer-related processes and pathways in HCC cells, some of which have been previously described to be directly targeted by sorafenib.

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July 2017
7 Reads

Environment and bladder cancer: molecular analysis by interaction networks.

Oncotarget. 2017 May 26. doi: 10.18632/oncotarget.18222. [Epub ahead of print]

Oncotarget

Bladder cancer (BC) is the 9th most common cancer worldwide, and the 6th most common cancer in men. Its development is linked to chronic inflammation, genetic susceptibility, smoking, occupational exposures and environmental pollutants. Aim of this work was to identify a sub-network of genes/proteins modulated by environmental or arsenic exposure in BC by computational network approaches. Our studies evidenced the presence of HUB nodes both in "BC and environment" and "BC and arsenicals" networks. These HUB nodes resulted to be correlated to circadian genes and targeted by some miRNAs already reported as involved in BC, thus suggesting how they play an important role in BC development due to environmental or arsenic exposure. Through data-mining analysis related to putative effect of the identified HUB nodes on survival we identified genes/proteins and their mutations on which it will be useful to focus further experimental studies related to the evaluation of their expression in biological matrices and to their utility as biomarkers of BC development.

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May 2017
5 Reads

Clinical and biological significance of miR-23b and miR-193a in human hepatocellular carcinoma.

Oncotarget 2017 Jan;8(4):6955-6969

Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.18632/oncotarget.14332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351682PMC
January 2017
5 Reads
4 Citations
6.360 Impact Factor

Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis.

Int J Mol Med 2016 Nov 19;38(5):1338-1348. Epub 2016 Sep 19.

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Dental Clinic, University of Brescia, I-25123 Brescia, Italy.

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http://dx.doi.org/10.3892/ijmm.2016.2742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065298PMC
November 2016
12 Reads
2 Citations
1.880 Impact Factor

Molecular characterization of LASP-1 expression reveals vimentin as its new partner in human hepatocellular carcinoma cells.

Int J Oncol 2015 May 9;46(5):1901-12. Epub 2015 Mar 9.

Department of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.3892/ijo.2015.2923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383023PMC
May 2015
38 Reads
11 Citations
3.025 Impact Factor

De novo 1Mb interstitial deletion of 8p22 in a patient with slight mental retardation and speech delay.

Mol Cytogenet 2014 15;7:25. Epub 2014 Apr 15.

Biology and Genetics Division, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

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http://dx.doi.org/10.1186/1755-8166-7-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005464PMC
May 2014
9 Reads
1 Citation
2.662 Impact Factor

Effects of miR-193a and sorafenib on hepatocellular carcinoma cells.

Mol Cancer 2013 Dec 13;12:162. Epub 2013 Dec 13.

Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa n, 11, 25123 Brescia, Italy.

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http://dx.doi.org/10.1186/1476-4598-12-162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029516PMC
December 2013
16 Reads
16 Citations
4.260 Impact Factor

Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC.

Int J Oncol 2013 Feb 28;42(2):391-402. Epub 2012 Nov 28.

Department of Biomedical Sciences and Biotechnologies, Division of Biology and Genetics, University of Brescia, I-25123 Brescia, Italy.

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http://dx.doi.org/10.3892/ijo.2012.1716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583619PMC
February 2013
15 Reads
18 Citations
3.025 Impact Factor

The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration.

PLoS One 2011 23;6(5):e20038. Epub 2011 May 23.

Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100319PMC
October 2011
10 Reads
36 Citations
3.234 Impact Factor

MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells.

FEBS J 2009 Jun 16;276(11):2966-82. Epub 2009 Apr 16.

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, IDET Centre of Excellence, University of Brescia, Italy.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07014.xDOI Listing
June 2009
31 Reads
50 Citations
4.001 Impact Factor

Proteomic identification of LASP-1 down-regulation after RNAi urokinase silencing in human hepatocellular carcinoma cells.

Neoplasia 2009 Feb;11(2):207-19

Department of Biomedical Sciences and Biotechnology, Division of Biology and Genetics, IDET Centre of Excellence, University of Brescia, Brescia, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631145PMC
http://dx.doi.org/10.1593/neo.81076DOI Listing
February 2009
17 Reads
13 Citations

Germline and somatic c-met mutations in multifocal/bilateral and sporadic papillary renal carcinomas of selected patients.

Int J Oncol 2008 Aug;33(2):271-6

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, IDET Centre of Excellence, University of Brescia, I-Brescia 25123, Italy.

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August 2008
8 Reads
8 Citations
3.025 Impact Factor

In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells.

Int J Oncol 2007 Aug;31(2):451-60

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, IDET Centre of Excellence, University of Brescia, Brescia I-25123, Italy.

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August 2007
4 Reads
15 Citations
3.025 Impact Factor

Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells.

Mol Cancer Ther 2004 Jun;3(6):671-8

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa n.11, 25123 Brescia, Italy.

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June 2004
11 Reads
13 Citations
5.683 Impact Factor

Telomerase gene expression in intraductal papillary-mucinous tumors (IPMT): preliminary findings.

Acta Biomed 2003 ;74 Suppl 2:59-64

Department of Medical and Surgical Sciences, Surgical Clinic, University of Brescia, Italy.

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May 2004
3 Reads
1 Citation

Matrix assembly induction and cell migration and invasion inhibition by a 13-amino acid fibronectin peptide.

J Biol Chem 2003 Apr 11;278(16):14346-55. Epub 2003 Feb 11.

Division Biology and Genetics, University of Brescia, Italy.

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http://dx.doi.org/10.1074/jbc.M211997200DOI Listing
April 2003
7 Reads
6 Citations
4.573 Impact Factor

Stable expression of antisense urokinase mRNA inhibits the proliferation and invasion of human hepatocellular carcinoma cells.

Cancer Gene Ther 2003 Feb;10(2):112-20

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, IDET Center of Excellence, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1038/sj.cgt.7700533DOI Listing
February 2003
5 Reads
4 Citations
2.420 Impact Factor

Androgen receptor mRNA under-expression in poorly differentiated human hepatocellular carcinoma.

Histol Histopathol 2002 10;17(4):1113-9

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, 19 Valsabbina Street, 25123 Brescia, Italy.

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http://dx.doi.org/10.14670/HH-17.1113DOI Listing
October 2002
1 Read
8 Citations
2.100 Impact Factor

Induction of fibronectin mRNA by urokinase- and tissue-type plasminogen activator in human skin fibroblasts: differential role of u-PA and t-PA at the fibronectin protein level.

Biol Chem 2002 Jan;383(1):177-87

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.

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http://dx.doi.org/10.1515/BC.2002.018DOI Listing
January 2002
5 Reads
3.270 Impact Factor

u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma.

Int J Cancer 2000 Sep;87(5):644-9

Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy.

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September 2000
1 Read
26 Citations
5.085 Impact Factor

Gene response of human skin fibroblasts to urokinase- and tissue-type plasminogen activators.

Growth Factors 2000 ;17(4):249-68

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.

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http://dx.doi.org/10.3109/08977190009028970DOI Listing
July 2000
3.390 Impact Factor

Quantitative in situ hybridization for the evaluation of gene expression in asynchronous and synchronized cell cultures and in tissue sections.

Histol Histopathol 1999 10;14(4):1231-40

Department of Biomedical Sciences and Biotechnology, University of Brescia, Medical Faculty, Italy.

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http://dx.doi.org/10.14670/HH-14.1231DOI Listing
October 1999
2 Citations
2.100 Impact Factor

Expression of urokinase-type plasminogen activator (u-PA), u-PA receptor, and tissue-type PA messenger RNAs in human hepatocellular carcinoma.

Cancer Res 1998 May;58(10):2234-9

Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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May 1998
4 Reads
15 Citations
9.330 Impact Factor

Plasminogen activators in nude mice xenotransplanted with human tumorigenic cells.

Invasion Metastasis 1995 ;15(1-2):22-33

Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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October 1995
1 Read
3 Citations

Phosphorylation of human plasminogen activators and plasminogen.

FEBS Lett 1995 Apr;363(1-2):170-4

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.

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http://dx.doi.org/10.1016/0014-5793(95)00312-wDOI Listing
April 1995
1 Read
2 Citations
3.170 Impact Factor

Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts.

Exp Cell Res 1994 Jul;213(1):286-94

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.

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http://dx.doi.org/10.1006/excr.1994.1200DOI Listing
July 1994
1 Read
10 Citations
3.250 Impact Factor

RT-PCR detection of fibronectin EDA+ and EDB+ mRNA isoforms: molecular markers for hepatocellular carcinoma.

Int J Cancer 1994 Mar;56(6):820-5

Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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http://dx.doi.org/10.1002/ijc.2910560611DOI Listing
March 1994
4 Citations
5.085 Impact Factor

Tyrosine phosphorylation of human urokinase-type plasminogen activator.

FEBS Lett 1991 Apr;281(1-2):137-40

Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy.

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http://dx.doi.org/10.1016/0014-5793(91)80377-fDOI Listing
April 1991
1 Citation
3.170 Impact Factor

Fibronectin and its proteolytic fragments. Potential as cancer markers.

Invasion Metastasis 1983 ;3(3):125-38

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August 1984
2 Reads
2 Citations

Tissue type plasminogen activator, but not urokinase, exerts transformation-enhancing activity.

Int J Cancer 1984 May;33(5):563-7

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http://dx.doi.org/10.1002/ijc.2910330503DOI Listing
May 1984
1 Read
2 Citations
5.085 Impact Factor

Transformation-enhancing activity in plasma of tumor patients: relationship with fibronectin fragments.

Int J Cancer 1983 Feb;31(2):157-62

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http://dx.doi.org/10.1002/ijc.2910310205DOI Listing
February 1983
3 Citations
5.085 Impact Factor

Transformation-enhancing activity of gelatin-binding fragments of fibronectin.

Proc Natl Acad Sci U S A 1981 Aug;78(8):4965-9

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC320310PMC
http://dx.doi.org/10.1073/pnas.78.8.4965DOI Listing
August 1981
1 Read
9 Citations
9.810 Impact Factor

Inhibition of Rous sarcoma-virus-induced transformation by proteins involved in blood coagulation.

Int J Cancer 1980 May;25(5):557-60

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http://dx.doi.org/10.1002/ijc.2910250502DOI Listing
May 1980
1 Read
1 Citation
5.085 Impact Factor

Top co-authors

Giuseppina De Petro
Giuseppina De Petro

Division of Biology and Genetics/University of Brescia

23
S Barlati
S Barlati

University of Brescia

18
Alessandro Salvi
Alessandro Salvi

University of Brescia

18
Sergio Barlati
Sergio Barlati

University of Brescia

13
Nazario Portolani
Nazario Portolani

Brescia University

8
Bruna Arici
Bruna Arici

University of Brescia

7
Ilaria Grossi
Ilaria Grossi

University of Brescia

5
Eleonora Marchina
Eleonora Marchina

University of Brescia

4
Edoardo Abeni
Edoardo Abeni

University of Brescia

4
Daniela Tavian
Daniela Tavian

Catholic University of the Sacred Heart

3