Giuseppe Tosto

Giuseppe Tosto

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Giuseppe Tosto

Giuseppe Tosto

Publications by authors named "Giuseppe Tosto"

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Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease.

JAMA Neurol 2019 May 6. Epub 2019 May 6.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2019.1066DOI Listing
May 2019

Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools.

Front Genet 2019 3;10:239. Epub 2019 Apr 3.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.

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https://www.frontiersin.org/article/10.3389/fgene.2019.00239
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http://dx.doi.org/10.3389/fgene.2019.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456789PMC
April 2019

Prosodic Impairment in Dementia: Review of the Literature.

Curr Alzheimer Res 2018 ;15(2):157-163

G.H. Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY. United States.

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http://dx.doi.org/10.2174/1567205014666171030115624DOI Listing
March 2019

An MRI measure of degenerative and cerebrovascular pathology in Alzheimer disease.

Neurology 2018 Oct 14;91(15):e1402-e1412. Epub 2018 Sep 14.

From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.M.B., G.T., H.A., Y.G., A.N., B.R., V.G., J.J.M., J.P.V., N.S., R.M.), The Gertrude H. Sergievsky Center (A.M.B., G.T., H.A., Y.G., J.J.M., N.S., R.M.), and the Departments of Neurology (A.M.B., G.T., J.G., Y.G., J.J.M., N.S., R.M.), Pathology and Cell Biology (J.P.V.), and Psychiatry (R.M.), College of Physicians and Surgeons, and Departments of Biostatistics (H.A.) and Epidemiology (N.S., R.M.), Mailman School of Public Health, Columbia University, New York, NY.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177275PMC
October 2018

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Authors:
Joshua C Bis Xueqiu Jian Brian W Kunkle Yuning Chen Kara L Hamilton-Nelson William S Bush William J Salerno Daniel Lancour Yiyi Ma Alan E Renton Edoardo Marcora John J Farrell Yi Zhao Liming Qu Shahzad Ahmad Najaf Amin Philippe Amouyel Gary W Beecham Jennifer E Below Dominique Campion Camille Charbonnier Jaeyoon Chung Paul K Crane Carlos Cruchaga L Adrienne Cupples Jean-François Dartigues Stéphanie Debette Jean-François Deleuze Lucinda Fulton Stacey B Gabriel Emmanuelle Genin Richard A Gibbs Alison Goate Benjamin Grenier-Boley Namrata Gupta Jonathan L Haines Aki S Havulinna Seppo Helisalmi Mikko Hiltunen Daniel P Howrigan M Arfan Ikram Jaakko Kaprio Jan Konrad Amanda Kuzma Eric S Lander Mark Lathrop Terho Lehtimäki Honghuang Lin Kari Mattila Richard Mayeux Donna M Muzny Waleed Nasser Benjamin Neale Kwangsik Nho Gaël Nicolas Devanshi Patel Margaret A Pericak-Vance Markus Perola Bruce M Psaty Olivier Quenez Farid Rajabli Richard Redon Christiane Reitz Anne M Remes Veikko Salomaa Chloe Sarnowski Helena Schmidt Michael Schmidt Reinhold Schmidt Hilkka Soininen Timothy A Thornton Giuseppe Tosto Christophe Tzourio Sven J van der Lee Cornelia M van Duijn Badri Vardarajan Weixin Wang Ellen Wijsman Richard K Wilson Daniela Witten Kim C Worley Xiaoling Zhang Celine Bellenguez Jean-Charles Lambert Mitja I Kurki Aarno Palotie Mark Daly Eric Boerwinkle Kathryn L Lunetta Anita L Destefano Josée Dupuis Eden R Martin Gerard D Schellenberg Sudha Seshadri Adam C Naj Myriam Fornage Lindsay A Farrer

Mol Psychiatry 2018 Aug 14. Epub 2018 Aug 14.

Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41380-018-0112-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375806PMC
August 2018

Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease.

Ann Clin Transl Neurol 2018 Jul 24;5(7):832-842. Epub 2018 May 24.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University The New York Presbyterian Hospital New York New York.

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http://dx.doi.org/10.1002/acn3.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043775PMC
July 2018

The effect of white matter hyperintensities on cognition is mediated by cortical atrophy.

Neurobiol Aging 2018 04 16;64:25-32. Epub 2017 Dec 16.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831564PMC
April 2018

Clinical Experience with Cerebrospinal Fluid Aβ42, Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia.

J Alzheimers Dis 2018 ;65(4):1417-1425

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-180548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218126PMC
January 2018

Promising Therapies for Alzheimer's Disease.

Curr Pharm Des 2016 ;22(14):2050-6

Dipartmento Biologia e Biotecnologie Charles Darwin, Centro di ricerca in Neurobiologia Daniel Bovet, "Sapienza", Università di Roma, P.le A. Moro, 5 - 00185 Roma, Italy.

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November 2017

Ultra-rare mutations in segregate in Caribbean Hispanic families with Alzheimer disease.

Neurol Genet 2017 Oct 24;3(5):e178. Epub 2017 Aug 24.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain (B.N.V., G.T., R. Lefort, P.L.D.J., S.B., D.R.-D., J.H.L., R.C., R. Lantigua, R.M.); Gertrude H. Sergievsky Center (B.N.V., G.T., S.B., D.R.-D., J.H.L., R.C., R.M.); Department of Neurology (P.L.D.J., S.B., R.M.), Department of Psychiatry (R.M.), Department of Systems Biology (B.N.V.), Department of Medicine (R. Lantigua), and Department of Pathology and Cell Biology (R. Lefort, P.L.N.), College of Physicians and Surgeons, Columbia University, New York Presbyterian Hospital; Department of Epidemiology (J.H.L., R.M.), School of Public Health, Columbia University, New York; Tanz Centre for Research in Neurodegenerative Diseases (E.R., P.S.G.-H.) and Department of Medicine (E.R., P.S.G.-H.), University of Toronto, Krembil Discovery Tower, ON, Canada; Department of Clinical Neurosciences (P.S.G.-H.), Cambridge Institute for Medical Research, University of Cambridge, UK; Rush Alzheimer's Disease Center (L.Y., D.A.B.), Rush University Medical Center, Chicago, IL; Program in Medical and Population Genetics (P.L.D.J.), Broad Institute, Cambridge, MA; and School of Medicine (M.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic.

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http://dx.doi.org/10.1212/NXG.0000000000000178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570674PMC
October 2017

Genetics of Alzheimer's Disease: the Importance of Polygenic and Epistatic Components.

Curr Neurol Neurosci Rep 2017 Aug 21;17(10):78. Epub 2017 Aug 21.

The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, 622 W. 168th Street PH 19-314, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s11910-017-0787-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699909PMC
August 2017

Polygenic risk scores in familial Alzheimer disease.

Neurology 2017 Mar 17;88(12):1180-1186. Epub 2017 Feb 17.

From the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (G.T., J.M., R.O., N.S., Y.S., R.M.), Gertrude H. Sergievsky Center (G.T., J.M., N.S., Y.S., R.M.), and Department of Neurology (G.T., J.M., R.O., N.S., Y.S.), Columbia University College of Physicians and Surgeons, New York; New York Presbyterian Hospital (G.T., J.M., R.O., N.S., Y.S.), NY; Departments of Neurology and Medicine (T.D.B., D.T.), University of Washington, Seattle; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (B.F.B.), Mayo Clinic, Rochester, MN; Hope Center for Neurological Disorders (C.C.), Washington University, St Louis, MO; Department of Medical and Molecular Genetics (K.F., T.M.F.), Indiana University; Department of Neurology (M.F.), Indiana University Center for Alzheimer's Disease and Related Disorders, Indianapolis; Department of Neuroscience (A.M.G., S.B.), Mount Sinai School of Medicine, New York, NY; Department of Neurology (N.R.G.-R.), Mayo Clinic, Jacksonville, FL; School of Medicine (M.M., R.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; Department of Medicine (R.L.) and Department of Epidemiology, Mailman School of Public Health (R.O., N.S.), Columbia University, New York; Division of Epidemiology (R.O.), New York State Psychiatric Institute, New York; Department of Neurology and Neurotherapeutics (R.R.), The University of Texas Southwestern Medical Center, Dallas; Department of Health Sciences Research (D.J.S.), Mayo Clinic, Rochester, MN; and Department of Psychiatry, Neurology and Epidemiology (R.A.S.), University of Pittsburgh, PA.

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http://dx.doi.org/10.1212/WNL.0000000000003734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373783PMC
March 2017

Association of Cardiovascular Risk Factors and Stroke With Alzheimer Disease-Reply.

JAMA Neurol 2017 Jan;74(1):129-130

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York2The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York3Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York4New York Presbyterian Hospital, New York5Department of Epidemiology, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2016.4384DOI Listing
January 2017

Genomics of Alzheimer's disease: Value of high-throughput genomic technologies to dissect its etiology.

Mol Cell Probes 2016 12 13;30(6):397-403. Epub 2016 Sep 13.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; The Department of Neurology, Columbia University, New York, NY, USA; The Dept. of Epidemiology, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcp.2016.09.001DOI Listing
December 2016

Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates.

J Alzheimers Dis 2016 ;49(4):1085-93

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-150244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779642PMC
October 2016

The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease.

JAMA Neurol 2016 Oct;73(10):1231-1237

Taub Institute for Research on Alzheimer's Disease, The Aging Brain and the Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York2Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York3New York Presbyterian Hospital in New York City14Department of Epidemiology, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2016.2539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155512PMC
October 2016

The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment.

Alzheimers Dement 2015 Dec 13;11(12):1510-1519. Epub 2015 Jun 13.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677059PMC
December 2015

Sociodemographic and Clinical Changes Over Time of Individuals Evaluated for Cognitive Disturbances: Good or Bad News?

J Am Med Dir Assoc 2015 Dec;16(12):1095-6

Memory Clinic, Department of Neurology and Psychiatry, "Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.1016/j.jamda.2015.09.013DOI Listing
December 2015

Pattern of extrapyramidal signs in Alzheimer's disease.

J Neurol 2015 Nov 4;262(11):2548-56. Epub 2015 Sep 4.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1007/s00415-015-7886-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776751PMC
November 2015

F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.

Ann Clin Transl Neurol 2015 Aug 18;2(8):810-20. Epub 2015 Jun 18.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, School of Public Health, Columbia University New York, New York ; The Gertrude H. Sergievsky Center, School of Public Health, Columbia University New York, New York ; Department of Neurology, Columbia University New York, New York ; Department of Psychiatry, School of Public Health, Columbia University New York, New York ; Department of Epidemiology, School of Public Health, Columbia University New York, New York.

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http://dx.doi.org/10.1002/acn3.223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554442PMC
August 2015

Predicting aggressive decline in mild cognitive impairment: the importance of white matter hyperintensities.

JAMA Neurol 2014 Jul;71(7):872-7

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2014.667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107926PMC
July 2014

Rivastigmine in the treatment of hypersexuality in Alzheimer disease.

Alzheimer Dis Assoc Disord 2013 Jul-Sep;27(3):287-8

Department of Neurology and Psychiatry, Memory Clinic, University Sapienza, Viale dell'Università, Rome, Italy.

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https://insights.ovid.com/crossref?an=00002093-201307000-000
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http://dx.doi.org/10.1097/WAD.0b013e31825c85aeDOI Listing
March 2014

Genome-wide association studies in Alzheimer's disease: a review.

Curr Neurol Neurosci Rep 2013 Oct;13(10):381

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1007/s11910-013-0381-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809844PMC
October 2013

Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.

PLoS One 2012 12;7(12):e50354. Epub 2012 Dec 12.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050354PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520931PMC
June 2013

White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?

JAMA Neurol 2013 Apr;70(4):455-61

Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/jamaneurol.2013.1321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124641PMC
April 2013

Presenilin 2 mutation R71W in an Italian early-onset sporadic Alzheimer's disease case.

J Neurol 2011 Nov 5;258(11):2043-7. Epub 2011 May 5.

Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1007/s00415-011-6066-1DOI Listing
November 2011

Prosodic impairment in Alzheimer's disease: assessment and clinical relevance.

J Neuropsychiatry Clin Neurosci 2011 ;23(2):E21-3

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http://dx.doi.org/10.1176/jnp.23.2.jnpe21DOI Listing
September 2011

Emerging oral drugs for multiple sclerosis.

Expert Opin Emerg Drugs 2008 Sep;13(3):465-77

S Camillo-Forlanini Hospital, Department of Neuroscience, Viale dell'Università 30, 00185 Rome, Italy.

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http://dx.doi.org/10.1517/14728214.13.3.465 DOI Listing
September 2008

Effect of citalopram in treating hypersexuality in an Alzheimer's disease case.

Neurol Sci 2008 Sep 20;29(4):269-70. Epub 2008 Sep 20.

Clinica della Memoria, Department of Neurological Science La Sapienza Rome, Rome, Italy.

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http://dx.doi.org/10.1007/s10072-008-0979-1DOI Listing
September 2008