Giuseppe Lembo

Giuseppe Lembo

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Giuseppe Lembo

Giuseppe Lembo

Publications by authors named "Giuseppe Lembo"

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PI3Kinases in Diabetes Mellitus and Its Related Complications.

Int J Mol Sci 2018 Dec 18;19(12). Epub 2018 Dec 18.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy.

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http://dx.doi.org/10.3390/ijms19124098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321267PMC
December 2018

Heart, Spleen, Brain.

Circulation 2018 Oct;138(18):1917-1919

Department of Molecular Medicine, Sapienza University of Rome, Italy. Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035628DOI Listing
October 2018

Brain MRI fiber-tracking reveals white matter alterations in hypertensive patients without damage at conventional neuroimaging.

Cardiovasc Res 2018 Sep;114(11):1536-1546

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Via dell'elettronica, Pozzilli (IS), Italy.

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http://dx.doi.org/10.1093/cvr/cvy104DOI Listing
September 2018

Combined bioaugmentation with anaerobic ruminal fungi and fermentative bacteria to enhance biogas production from wheat straw and mushroom spent straw.

Bioresour Technol 2018 Jul 3;260:364-373. Epub 2018 Apr 3.

Department of Civil, Architectural and Environmental Engineering, University of Naples "Federico II", Via Claudio 21, 80125 Naples, Italy.

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http://dx.doi.org/10.1016/j.biortech.2018.03.128DOI Listing
July 2018

Fatty acids are the best fuel for overloaded hearts.

Cardiovasc Res 2018 Jul;114(8):1055-1056

Department of AngioCardioNeurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli (IS), Italy.

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http://dx.doi.org/10.1093/cvr/cvy106DOI Listing
July 2018

The Interactions of the Immune System and the Brain in Hypertension.

Curr Hypertens Rep 2018 02 24;20(1). Epub 2018 Feb 24.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077, Pozzilli, IS, Italy.

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http://dx.doi.org/10.1007/s11906-018-0808-8DOI Listing
February 2018

From clinical observations to molecular mechanisms and back to patients: the successful circuit of the CANTOS study.

Authors:
Giuseppe Lembo

Cardiovasc Res 2018 Jan;114(1):e3-e5

Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.

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http://dx.doi.org/10.1093/cvr/cvx219DOI Listing
January 2018

Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling.

Immunity 2017 11 14;47(5):959-973.e9. Epub 2017 Nov 14.

Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy; Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.10.016DOI Listing
November 2017

The Spleen: A Hub Connecting Nervous and Immune Systems in Cardiovascular and Metabolic Diseases.

Int J Mol Sci 2017 Jun 7;18(6). Epub 2017 Jun 7.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy.

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http://dx.doi.org/10.3390/ijms18061216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486039PMC
June 2017

PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice.

Rev Esp Cardiol (Engl Ed) 2017 Jan 13;70(1):16-24. Epub 2016 Jul 13.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Istituto Neurologico Mediterraneo, Pozzilli, Isernia, Italy; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2016.04.034DOI Listing
January 2017

The Multifaceted Roles of PI3Kγ in Hypertension, Vascular Biology, and Inflammation.

Int J Mol Sci 2016 Nov 8;17(11). Epub 2016 Nov 8.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy.

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http://dx.doi.org/10.3390/ijms17111858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133858PMC
November 2016

Hemorrhagic transformation of acute ischemic stroke is limited in hypertensive patients with cardiac hypertrophy.

Int J Cardiol 2016 Sep 23;219:362-6. Epub 2016 Jun 23.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, IS, Italy; Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.06.060DOI Listing
September 2016

Flavanol-rich cocoa at breakfast: the right remedy after a sleepless night to prevent negative effects on blood pressure and cognition?

J Hypertens 2016 07;34(7):1252-3

aDepartment of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli (IS) bDepartment of Molecular Medicine, 'Sapienza' University of Rome, Rome cDepartment of Medicine and Surgery, University of Milano-Bicocca dIRCCS Multimedica, Sesto San Giovanni, Milan, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000000959DOI Listing
July 2016

Immunological Aspects of Hypertension.

High Blood Press Cardiovasc Prev 2016 Jun 14;23(2):91-5. Epub 2016 Apr 14.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1007/s40292-016-0141-8DOI Listing
June 2016

Pathophysiological Links Among Hypertension and Alzheimer's Disease.

High Blood Press Cardiovasc Prev 2016 Mar 9;23(1):3-7. Epub 2015 Jun 9.

Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1007/s40292-015-0108-1DOI Listing
March 2016

Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship.

Int J Mol Sci 2016 Mar 8;17(3):347. Epub 2016 Mar 8.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli, Italy.

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http://dx.doi.org/10.3390/ijms17030347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813208PMC
March 2016

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.

Mol Metab 2015 Oct 6;4(10):741-52. Epub 2015 Aug 6.

Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy ; Center for Atherosclerosis, Department of Medicine, Policlinico Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1016/j.molmet.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588459PMC
October 2015

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

EMBO Mol Med 2015 Jul;7(7):904-17

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli (IS), Italy Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

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http://dx.doi.org/10.15252/emmm.201404697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520656PMC
July 2015

PlGF, immune system and hypertension.

Oncotarget 2015 Jul;6(21):18246-7

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Isernia, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621886PMC
http://dx.doi.org/10.18632/oncotarget.4914DOI Listing
July 2015

Evaluation of microvascular structure in humans: a 'state-of-the-art' document of the Working Group on Macrovascular and Microvascular Alterations of the Italian Society of Arterial Hypertension.

J Hypertens 2014 Nov;32(11):2120-9; discussion 2129

aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa bDepartment of Clinical and Molecular Medicine, Division of Cardiology, Sant'Andrea Hospital, Sapienza University of Rome, Rome cClinica Medica, University of Milano-Bicocca and IRCCS Multimedica, Sesto San Giovanni, Milan dDepartment of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS) eDepartment of Molecular Medicine, 'Sapienza' University, Rome fDepartment of Medicine and Surgery, University of Salerno, Salerno gIstituto Auxologico Italiano, Ospedale San Luca, Milan hClinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000000322DOI Listing
November 2014

The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension.

Immunity 2014 Nov 7;41(5):737-52. Epub 2014 Nov 7.

Department of Angiocardioneurology and Translational Medicine, Neuro and Cardiovascular Pathophysiology Research Unit, IRCCS Neuromed, 86077 Pozzilli, Italy; Department of Molecular Medicine, "Sapienza" University of Rome, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.11.002DOI Listing
November 2014

Nitroxyl (HNO) for treatment of acute heart failure.

Curr Heart Fail Rep 2014 Sep;11(3):227-35

IRCCS Neuromed, Pozzilli, IS, Italy.

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http://dx.doi.org/10.1007/s11897-014-0210-zDOI Listing
September 2014

G-protein-coupled receptor kinases in hypertension.

High Blood Press Cardiovasc Prev 2013 Mar;20(1):3-4

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http://dx.doi.org/10.1007/s40292-013-0004-5DOI Listing
March 2013

Placental growth factor and cardiac inflammation.

Trends Cardiovasc Med 2012 Nov 25;22(8):209-12. Epub 2012 Aug 25.

Department of Angiocardioneurology and Translational Medicine, IRCCS Neuromed, 86077 Pozzilli (IS), Italy.

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http://dx.doi.org/10.1016/j.tcm.2012.07.022DOI Listing
November 2012

PI3Kγ in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage.

Cardiovasc Res 2012 Sep 19;95(4):403-8. Epub 2012 May 19.

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1093/cvr/cvs166DOI Listing
September 2012

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Cardiovasc Res 2011 Aug 14;91(3):456-64. Epub 2011 Apr 14.

Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, Università di Torino, via Nizza 52, Turin, Italy.

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http://dx.doi.org/10.1093/cvr/cvr103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294280PMC
August 2011

'Alzheimer-like' pathology in a murine model of arterial hypertension.

Biochem Soc Trans 2011 Aug;39(4):939-44

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli (IS), Italy.

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http://dx.doi.org/10.1042/BST0390939DOI Listing
August 2011

Chronic Type A aortic dissection: could surgical intervention be guided by molecular markers?

J Cell Mol Med 2011 Jul;15(7):1615-9

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01314.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823205PMC
July 2011

Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

Hypertension 2009 Nov 21;54(5):1028-34. Epub 2009 Sep 21.

Department of Angio-Cardio-Neurology, Neuromed Institute Istituto Di Ricovero e Cura a Carattere Scientifico, Pozzilli, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.136572DOI Listing
November 2009

Nitric oxide mechanisms of nebivolol.

Ther Adv Cardiovasc Dis 2009 Aug 14;3(4):317-27. Epub 2009 May 14.

Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli (IS), Italy.

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http://dx.doi.org/10.1177/1753944709104496DOI Listing
August 2009

Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension.

Neurobiol Aging 2009 Feb 27;30(2):222-8. Epub 2007 Jul 27.

Department of Angio-Cardio-Neurology, IRCCS Neuromed, 86077 Pozzilli, IS, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.06.005DOI Listing
February 2009

Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.

Blood Press Suppl 2008 Dec;2:31-40

Universitätsklinikum Bonn, Bonn, Germany.

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December 2008

Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs.

Circ Res 2008 Apr 21;102(7):813-22. Epub 2008 Feb 21.

CNR Institute of Neurosciences, Department of Biomedical Sciences, University of Padova, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.163188DOI Listing
April 2008

Resistin impairs insulin-evoked vasodilation.

Diabetes 2008 Mar 7;57(3):577-83. Epub 2007 Dec 7.

Department of Angio-Cardio-Neurology, Neuromed Institute, Pozzilli, Italy.

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http://dx.doi.org/10.2337/db07-0557DOI Listing
March 2008

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation.

Hypertension 2007 Oct 30;50(4):652-6. Epub 2007 Jul 30.

Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.094458DOI Listing
October 2007

Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study.

Clin Drug Investig 2007 ;27(9):623-32

Hypertension Unit, Hospital Clinic (IDIBAPS), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.2165/00044011-200727090-00005DOI Listing
October 2007

Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: the DEFIND study.

Adv Ther 2006 May-Jun;23(3):421-32

Complutense de Madrid-Espana University, Hospital Clinico San Carlos, Madrid, Spain.

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October 2006

Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology.

Trends Cardiovasc Med 2006 Aug;16(6):183-8

Dipartimento di Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Université FEDERICO II Napoli, 80131 Napoli, Italy.

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http://dx.doi.org/10.1016/j.tcm.2006.03.008DOI Listing
August 2006

Integrin signalling: the tug-of-war in heart hypertrophy.

Cardiovasc Res 2006 Jun 8;70(3):422-33. Epub 2006 Feb 8.

Department of Genetics, Biology, and Biochemistry, Turin University, Italy.

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http://dx.doi.org/10.1016/j.cardiores.2005.12.015DOI Listing
June 2006

Acute hypertension induces oxidative stress in brain tissues.

J Cereb Blood Flow Metab 2006 Feb;26(2):253-62

Department of Angio-Cardio-Neurology, IRCCS Neuromed, Pozzilli (IS), Italy.

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http://dx.doi.org/10.1038/sj.jcbfm.9600188DOI Listing
February 2006

Selective Rac-1 inhibition protects from diabetes-induced vascular injury.

Circ Res 2006 Feb 15;98(2):218-25. Epub 2005 Dec 15.

Department of AngioCardioNeurology, IRCCS NEUROMED, Località Camerelle, 86077 Pozzilli, Italy.

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http://dx.doi.org/10.1161/01.RES.0000200440.18768.30DOI Listing
February 2006

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

Thromb Haemost 2006 Jan;95(1):29-35

Dipartimento di Genetica, Biologia e Biochimica, University of Torino, Via Santena 5bis, 10126 Torino, Italy.

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January 2006

Mechanisms of cardiac hypertrophy.

Heart Fail Clin 2005 Jul;1(2):263-73

IRCCS Neuromedicine, Pozzilli, Italy.

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http://dx.doi.org/10.1016/j.hfc.2005.03.006DOI Listing
July 2005

Mechanisms of soluble beta-amyloid impairment of endothelial function.

J Biol Chem 2004 Nov 19;279(46):48135-42. Epub 2004 Aug 19.

Department of Angio-Cardio-Neurology, IRCCS "NEUROMED," Pozzilli (IS), Italy.

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http://dx.doi.org/10.1074/jbc.M407358200DOI Listing
November 2004

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence.

Cardiovasc Res 2004 Aug;63(3):373-80

Department of Angiocardioneurology, I.R.C.C.S. "Neuromed", "La Sapienza" University of Rome, 86077 Pozzilli (IS), Italy.

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http://dx.doi.org/10.1016/j.cardiores.2004.04.031DOI Listing
August 2004

Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy.

Trends Mol Med 2003 Sep;9(9):376-82

Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5bis, 10126 Turin, Italy.

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September 2003

Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity.

J Neurochem 2003 Jul;86(2):413-21

IRCCS Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Italy.

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July 2003