Giuseppe Gerna

Giuseppe Gerna

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Giuseppe Gerna

Giuseppe Gerna

Publications by authors named "Giuseppe Gerna"

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Determination of anti-p52 IgM and anti-gB IgG by ELISA as a novel diagnostic tool for detection of early and late phase of primary human cytomegalovirus infections during pregnancy.

J Clin Virol 2019 Nov 13;120:38-43. Epub 2019 Sep 13.

Laboratorio Genetica - Trapiantologia e Malattie cardiovascolari, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Laboratorio Biochimica-Biotecnologie e Diagnostica avanzata, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2019.09.006DOI Listing
November 2019

Brief molecular diagnostic criteria for human cytomegalovirus infection/disease.

Expert Rev Mol Diagn 2019 Sep 22;19(9):773-775. Epub 2019 Aug 22.

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo , Pavia , Italy.

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http://dx.doi.org/10.1080/14737159.2019.1657010DOI Listing
September 2019

An overview of letermovir: a cytomegalovirus prophylactic option.

Expert Opin Pharmacother 2019 Aug 8;20(12):1429-1438. Epub 2019 Jul 8.

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo , Pavia , Italy.

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http://dx.doi.org/10.1080/14656566.2019.1637418DOI Listing
August 2019

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Vaccines (Basel) 2019 Jul 22;7(3). Epub 2019 Jul 22.

Laboratories of Genetics, Transplantology and Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.3390/vaccines7030070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789482PMC
July 2019

Human cytomegalovirus (HCMV) infection/re-infection: development of a protective HCMV vaccine.

New Microbiol 2019 Jan 21;42(1):1-20. Epub 2019 Jan 21.

Laboratorio di Genetica, Trapiantologia e Malattie cardiovascolari and Laboratorio di Biochimica- Biotecnologie e Diagnostica avanzata, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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January 2019

Comparison of the T-cell response to human cytomegalovirus (HCMV) as detected by cytokine flow cytometry and QuantiFERON-CMV assay in HCMV-seropositive kidney transplant recipients.

New Microbiol 2018 07 20;41(3):195-202. Epub 2018 Jul 20.

Laboratorio Genetica - Trapiantologia e Malattie cardiovascolari, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2018

The pentameric complex of human Cytomegalovirus: cell tropism, virus dissemination, immune response and vaccine development.

J Gen Virol 2017 Sep 15;98(9):2215-2234. Epub 2017 Aug 15.

Experimental Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1099/jgv.0.000882DOI Listing
September 2017

Maternal immune correlates of protection from human cytomegalovirus transmission to the fetus after primary infection in pregnancy.

Rev Med Virol 2017 03 23;27(2). Epub 2016 Dec 23.

Experimental Research Laboratories, Transplantation Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1002/rmv.1921DOI Listing
March 2017

Predictive value of human cytomegalovirus (HCMV) T-cell response in the control of HCMV infection by seropositive solid-organ transplant recipients according to different assays and stimuli.

New Microbiol 2016 Oct 13;39(4):247-258. Epub 2016 Sep 13.

Laboratori Sperimentali di Ricerca, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico S. Matteo, Pavia, Italy.

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October 2016

Strategies to control human cytomegalovirus infection in adult hematopoietic stem cell transplant recipients.

Immunotherapy 2016 09;8(9):1135-49

Laboratori Sperimentali di Ricerca-Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.2217/imt-2015-0028DOI Listing
September 2016

Reconstitution of Human Cytomegalovirus-Specific CD4+ T Cells is Critical for Control of Virus Reactivation in Hematopoietic Stem Cell Transplant Recipients but Does Not Prevent Organ Infection.

Biol Blood Marrow Transplant 2015 Dec 8;21(12):2192-2202. Epub 2015 Aug 8.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2015.08.002DOI Listing
December 2015

Primary human cytomegalovirus infections: kinetics of ELISA-IgG and neutralizing antibody in pauci/asymptomatic pregnant women vs symptomatic non-pregnant subjects.

J Clin Virol 2015 Mar 6;64:45-51. Epub 2015 Jan 6.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2015.01.004DOI Listing
March 2015

Differential kinetics of human cytomegalovirus load and antibody responses in primary infection of the immunocompetent and immunocompromised host.

J Gen Virol 2015 Feb 14;96(Pt 2):360-9. Epub 2014 Oct 14.

Struttura Complessa Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1099/vir.0.070441-0DOI Listing
February 2015

Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies.

Proc Natl Acad Sci U S A 2014 Dec 1;111(50):17965-70. Epub 2014 Dec 1.

Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland

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http://dx.doi.org/10.1073/pnas.1415310111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273412PMC
December 2014

Cytomegalovirus DNAemia in pregnant women.

J Clin Virol 2014 Dec 18;61(4):590-2. Epub 2014 Oct 18.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2014.10.002DOI Listing
December 2014

Polyfunctional analysis of human cytomegalovirus (HCMV)-specific CD4(+) and CD8 (+) memory T-cells in HCMV-seropositive healthy subjects following different stimuli.

J Clin Immunol 2014 Nov 18;34(8):999-1008. Epub 2014 Sep 18.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy,

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http://dx.doi.org/10.1007/s10875-014-0093-5DOI Listing
November 2014

Hyperimmune globulin to prevent congenital CMV infection.

N Engl J Med 2014 06;370(26):2544-5

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http://dx.doi.org/10.1056/NEJMc1405377DOI Listing
June 2014

Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus.

J Med Virol 2013 Nov 25;85(11):1960-7. Epub 2013 Jul 25.

SS Virologia Molecolare, SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1002/jmv.23691DOI Listing
November 2013

Systemic and local human cytomegalovirus-specific T-cell response in lung transplant recipients.

New Microbiol 2013 Jul 30;36(3):267-77. Epub 2013 Jun 30.

Laboratori Sperimentali di Ricerca, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2013

Antibodies against neutralization epitopes of human cytomegalovirus gH/gL/pUL128-130-131 complex and virus spreading may correlate with virus control in vivo.

J Clin Immunol 2012 Dec 27;32(6):1324-31. Epub 2012 Jul 27.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

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http://www.cdfound.it/documenti/Antibodies_against_neutraliz
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http://link.springer.com/10.1007/s10875-012-9739-3
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http://dx.doi.org/10.1007/s10875-012-9739-3DOI Listing
December 2012

Human cytomegalovirus end-organ disease is associated with high or low systemic viral load in preemptively treated solid-organ transplant recipients.

New Microbiol 2012 Jul 30;35(3):279-87. Epub 2012 Jun 30.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2012

Human rhinovirus and human respiratory enterovirus (EV68 and EV104) infections in hospitalized patients in Italy, 2008-2009.

Diagn Microbiol Infect Dis 2012 Jun 10;73(2):162-7. Epub 2012 Apr 10.

S.S. Virologia Molecolare, S.C. Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S073288931200084
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http://dx.doi.org/10.1016/j.diagmicrobio.2012.02.019DOI Listing
June 2012

Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010.

J Med Virol 2012 Apr;84(4):686-90

Virology and Microbiology Department, Molecular Virology Unit, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1002/jmv.23197DOI Listing
April 2012

Endothelial cells and CMV dissemination.

Authors:
Giuseppe Gerna

Future Microbiol 2012 Apr;7(4):441-4

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.2217/fmb.12.12DOI Listing
April 2012

Heart rate and cardiac allograft vasculopathy in heart transplant recipients.

J Heart Lung Transplant 2011 Dec 15;30(12):1368-73. Epub 2011 Aug 15.

Divisione di Cardiologia, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, Montescano, (Pavia), Italy.

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http://dx.doi.org/10.1016/j.healun.2011.07.009DOI Listing
December 2011

Kinetics of effector functions and phenotype of virus-specific and γδ T lymphocytes in primary human cytomegalovirus infection during pregnancy.

J Clin Immunol 2011 Dec 17;31(6):1054-64. Epub 2011 Aug 17.

Experimental Research Laboratories, Transplantation Area, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

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http://link.springer.com/content/pdf/10.1007/s10875-011-9577
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http://link.springer.com/10.1007/s10875-011-9577-8
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http://dx.doi.org/10.1007/s10875-011-9577-8DOI Listing
December 2011

Management of human cytomegalovirus infection in transplantation: validation of virologic cut-offs for preemptive therapy and immunological cut-offs for protection.

New Microbiol 2011 Jul 30;34(3):229-54. Epub 2011 Jul 30.

Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2011

Phylogenetic patterns of human respiratory picornavirus species, including the newly identified group C rhinoviruses, during a 1-year surveillance of a hospitalized patient population in Italy.

J Clin Microbiol 2011 Jan 10;49(1):373-6. Epub 2010 Nov 10.

S.S. Virologia Molecolare, S.C. Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://jcm.asm.org/cgi/doi/10.1128/JCM.01814-10
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http://dx.doi.org/10.1128/JCM.01814-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020431PMC
January 2011

Comparative evaluation of eight commercial human cytomegalovirus IgG avidity assays.

J Clin Virol 2010 Aug 18;48(4):255-9. Epub 2010 Jun 18.

SC Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S138665321000199
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http://dx.doi.org/10.1016/j.jcv.2010.05.004DOI Listing
August 2010

Enterovirus genotype EV-104 in humans, Italy, 2008-2009.

Emerg Infect Dis 2010 Jun;16(6):1018-21

Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico, San Matteo, Pavia, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086237PMC
http://dx.doi.org/10.3201/eid1606.091533DOI Listing
June 2010

Human cytomegalovirus tropism for endothelial/epithelial cells: scientific background and clinical implications.

Rev Med Virol 2010 May;20(3):136-55

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy.

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http://dx.doi.org/10.1002/rmv.645DOI Listing
May 2010

Surveillance of influenza virus B circulation in Northern Italy: summer-fall 2008 isolation of three strains and phylogenetic analysis.

New Microbiol 2009 Oct;32(4):405-10

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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October 2009

Multicenter quality control study for human cytomegalovirus DNAemia quantification.

New Microbiol 2009 Jul;32(3):245-53

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2009

Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host.

Clin Immunol 2009 Jun 5;131(3):395-403. Epub 2009 Mar 5.

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1016/j.clim.2009.02.002DOI Listing
June 2009

Are human P[14] rotavirus strains the result of interspecies transmissions from sheep or other ungulates that belong to the mammalian order Artiodactyla?

J Virol 2009 Apr 19;83(7):2917-29. Epub 2009 Jan 19.

Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1128/JVI.02246-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655590PMC
April 2009

Human cytomegalovirus-specific T cell reconstitution in young patients receiving T cell-depleted, allogeneic hematopoietic stem cell transplantation.

J Infect Dis 2009 Mar;199(6):829-36

Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Università di Pavia, Pavia, Italy.

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http://dx.doi.org/10.1086/597123DOI Listing
March 2009

Human cytomegalovirus load measurement and its applications for pre-emptive therapy in patients undergoing hematopoietic stem cell transplantation.

Hematol Oncol 2008 Sep;26(3):123-30

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1002/hon.856DOI Listing
September 2008

Comparison of a new Light Diagnostics and the CMV Brite to an in-house developed human cytomegalovirus antigenemia assay.

J Clin Virol 2008 Sep 12;43(1):13-7. Epub 2008 May 12.

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.jcv.2008.03.028DOI Listing
September 2008

Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families.

J Med Virol 2008 Aug;80(8):1415-25

Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1002/jmv.21243DOI Listing
August 2008

Human cytomegalovirus-specific memory CD8+ and CD4+ T cell differentiation after primary infection.

J Infect Dis 2008 Aug;198(4):536-43

Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1086/590118DOI Listing
August 2008

Rapid typing, subtyping and RNA quantification of influenza virus type A strains in respiratory secretions.

New Microbiol 2008 Jul;31(3):319-27

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2008

Maternal, fetal and neonatal diagnosis of congenital human cytomegalovirus infection.

Expert Opin Med Diagn 2008 May;2(5):547-63

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy +39 0382502644 ; +39 0382502599 ;

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http://dx.doi.org/10.1517/17530059.2.5.547DOI Listing
May 2008

Monitoring human cytomegalovirus infection in transplant recipients.

J Clin Virol 2008 Mar 18;41(3):237-41. Epub 2008 Jan 18.

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.jcv.2007.12.001DOI Listing
March 2008

Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection.

Haematologica 2008 Feb;93(2):248-56

Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.3324/haematol.11912DOI Listing
February 2008

Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia.

Blood 2007 Oct 19;110(7):2757-60. Epub 2007 Jun 19.

Servizio di Virologia, Università di Pavia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2007-03-080820DOI Listing
October 2007

The human bocavirus role in acute respiratory tract infections of pediatric patients as defined by viral load quantification.

New Microbiol 2007 Oct;30(4):383-92

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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October 2007

Development of human cytomegalovirus-specific T cell immunity during primary infection of pregnant women and its correlation with virus transmission to the fetus.

J Infect Dis 2007 Apr 20;195(7):1062-70. Epub 2007 Feb 20.

Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1086/512245DOI Listing
April 2007

Quantification and identification of polyomavirus DNA in blood and urine of renal transplant recipients.

Diagn Microbiol Infect Dis 2007 Mar 20;57(3):301-7. Epub 2006 Sep 20.

Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.diagmicrobio.2006.08.006DOI Listing
March 2007

Prospective simultaneous quantification of human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in young recipients of allogeneic hematopoietic stem cell transplants.

Blood 2006 Aug 13;108(4):1406-12. Epub 2006 Apr 13.

Servizio di Virologia, Instituto di Ricovero e Cura a Carattere Scientifico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2005-11-012864DOI Listing
August 2006

Monitoring transplant patients for human cytomegalovirus: Diagnostic update.

Herpes 2006 May;13(1):4-11

Virology Service, IRCCS Policlinico San Matteo, Pavia, Italy.

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May 2006

Amino acid insertions at position 35 of HIV-1 protease interfere with virus replication without modifying antiviral drug susceptibility.

Antiviral Res 2006 Mar 20;69(3):181-5. Epub 2006 Jan 20.

Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.antiviral.2005.12.005DOI Listing
March 2006

Preconceptional primary human cytomegalovirus infection and risk of congenital infection.

J Infect Dis 2006 Mar 9;193(6):783-7. Epub 2006 Feb 9.

Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1086/500509DOI Listing
March 2006

Lymphoproliferative response in primary human cytomegalovirus (HCMV) infection is delayed in HCMV transmitter mothers.

J Infect Dis 2006 Jan 9;193(2):269-76. Epub 2005 Dec 9.

Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1086/498872DOI Listing
January 2006

Rising antigenemia levels may be misleading in pre-emptive therapy of human cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients.

Haematologica 2005 Apr;90(4):526-33

Servizio di Virologia, Oncoematologia Pediatrica, and Centro Trapianti di Midollo Osseo, Divisione di Ematologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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April 2005

Assays for determination of HIV resistance to antiviral drugs.

Curr Drug Metab 2004 Aug;5(4):317-9

Servizio di Virologia IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

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http://dx.doi.org/10.2174/1389200043335496DOI Listing
August 2004

Dissociation of serum and liver hepatitis C virus RNA levels in patients coinfected with human immunodeficiency virus and treated with antiretroviral drugs.

J Clin Microbiol 2004 Jul;42(7):3012-6

Servizio di Virologia, Laboratori di Ricerca, Area Infettivologica, IRCCS Policlinico San Matteo and Università degli Studi di Pavia, via Taramelli 5, 27100 Pavia, Italy.

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http://dx.doi.org/10.1128/JCM.42.7.3012-3016.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC446282PMC
July 2004

Pathogenesis of human cytomegalovirus infection and cellular targets.

Hum Immunol 2004 May;65(5):381-6

Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1016/j.humimm.2004.02.009DOI Listing
May 2004

Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs.

Hum Immunol 2004 May;65(5):403-9

Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1016/j.humimm.2004.02.007DOI Listing
May 2004