Publications by authors named "Giulio Superti-Furga"

100Publications

A guide to plasma membrane solute carrier proteins.

FEBS J 2020 Aug 18. Epub 2020 Aug 18.

CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1111/febs.15531DOI Listing
August 2020

A substrate-based ontology for human solute carriers.

Mol Syst Biol 2020 Jul;16(7):e9652

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.15252/msb.20209652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374931PMC
July 2020

Caught in the genetic network: a novel regulator of lipid metabolism.

Nat Metab 2020 Jun;2(6):483-484

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s42255-020-0218-5DOI Listing
June 2020

Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis.

Cell Chem Biol 2020 Jun 7;27(6):728-739.e9. Epub 2020 May 7.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303955PMC
June 2020

The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

Authors:
Giulio Superti-Furga Daniel Lackner Tabea Wiedmer Alvaro Ingles-Prieto Barbara Barbosa Enrico Girardi Ulrich Goldmann Bettina Gürtl Kristaps Klavins Christoph Klimek Sabrina Lindinger Eva Liñeiro-Retes André C Müller Svenja Onstein Gregor Redinger Daniela Reil Vitaly Sedlyarov Gernot Wolf Matthew Crawford Robert Everley David Hepworth Shenping Liu Stephen Noell Mary Piotrowski Robert Stanton Hui Zhang Salvatore Corallino Andrea Faedo Maria Insidioso Giovanna Maresca Loredana Redaelli Francesca Sassone Lia Scarabottolo Michela Stucchi Paola Tarroni Sara Tremolada Helena Batoulis Andreas Becker Eckhard Bender Yung-Ning Chang Alexander Ehrmann Anke Müller-Fahrnow Vera Pütter Diana Zindel Bradford Hamilton Martin Lenter Diana Santacruz Coralie Viollet Charles Whitehurst Kai Johnsson Philipp Leippe Birgit Baumgarten Lena Chang Yvonne Ibig Martin Pfeifer Jürgen Reinhardt Julian Schönbett Paul Selzer Klaus Seuwen Charles Bettembourg Bruno Biton Jörg Czech Hélène de Foucauld Michel Didier Thomas Licher Vincent Mikol Antje Pommereau Frédéric Puech Veeranagouda Yaligara Aled Edwards Brandon J Bongers Laura H Heitman Ad P IJzerman Huub J Sijben Gerard J P van Westen Justine Grixti Douglas B Kell Farah Mughal Neil Swainston Marina Wright-Muelas Tina Bohstedt Nicola Burgess-Brown Liz Carpenter Katharina Dürr Jesper Hansen Andreea Scacioc Giulia Banci Claire Colas Daniela Digles Gerhard Ecker Barbara Füzi Viktoria Gamsjäger Melanie Grandits Riccardo Martini Florentina Troger Patrick Altermatt Cédric Doucerain Franz Dürrenberger Vania Manolova Anna-Lena Steck Hanna Sundström Maria Wilhelm Claire M Steppan

Nat Rev Drug Discov 2020 07;19(7):429-430

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http://dx.doi.org/10.1038/d41573-020-00056-6DOI Listing
July 2020

Patient-derived model systems and the development of next-generation anticancer therapeutics.

Curr Opin Chem Biol 2020 Jun 18;56:72-78. Epub 2020 Feb 18.

Allcyte GmbH, 1030, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2020.01.002DOI Listing
June 2020

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.

Sci Rep 2019 10 31;9(1):15751. Epub 2019 Oct 31.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-019-52078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823505PMC
October 2019

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection.

Sci Rep 2019 07 18;9(1):10471. Epub 2019 Jul 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-019-46952-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639343PMC
July 2019

Insights into the transport side of the human SLC38A9 transceptor.

Biochim Biophys Acta Biomembr 2019 09 8;1861(9):1558-1567. Epub 2019 Jul 8.

Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci 4C, 87036 Arcavacata di Rende, Italy; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, via Amendola 165/A, 70126 Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2019.07.006DOI Listing
September 2019

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis.

Leukemia 2019 09 8;33(9):2319-2323. Epub 2019 Apr 8.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41375-019-0468-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756289PMC
September 2019

Prioritization of Transporter-Drug Relationships From Drug Sensitivity Screens.

Front Pharmacol 2018 7;9:1011. Epub 2018 Sep 7.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.3389/fphar.2018.01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137680PMC
September 2018

Recent advances in combinatorial drug screening and synergy scoring.

Curr Opin Pharmacol 2018 10 5;42:102-110. Epub 2018 Sep 5.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17A, 1090 Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714892173020
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http://dx.doi.org/10.1016/j.coph.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219891PMC
October 2018

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.

ACS Chem Biol 2018 06 6;13(6):1480-1486. Epub 2018 Jun 6.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , 1090 Vienna , Austria.

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http://dx.doi.org/10.1021/acschembio.8b00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067815PMC
June 2018

The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.

Cell Host Microbe 2018 06 17;23(6):766-774.e5. Epub 2018 May 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna 1090, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002608PMC
June 2018

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation.

Cell Rep 2018 05;23(7):2157-2167

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972226PMC
May 2018

Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines.

Proteomics 2018 04;18(8):e1700386

Department of Applied Chemistry College of Applied Science, Kyung Hee University, Yongin-si, Republic of Korea.

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http://dx.doi.org/10.1002/pmic.201700386DOI Listing
April 2018

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer.

Oncotarget 2017 Nov 24;8(61):103014-103031. Epub 2017 Aug 24.

Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.18632/oncotarget.20488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732707PMC
November 2017

Next generation of network medicine: interdisciplinary signaling approaches.

Integr Biol (Camb) 2017 02;9(2):97-108

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria and Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.1039/c6ib00215cDOI Listing
February 2017

Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity.

J Biol Chem 2016 Nov 28;291(46):24054-24064. Epub 2016 Sep 28.

From the Department of Biochemistry and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec H3G 0B1, Canada,

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http://dx.doi.org/10.1074/jbc.M116.755801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104931PMC
November 2016

Crystal structure of mammalian acid sphingomyelinase.

Nat Commun 2016 07 20;7:12196. Epub 2016 Jul 20.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 0B1.

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http://dx.doi.org/10.1038/ncomms12196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961792PMC
July 2016

Functional crosstalk between membrane lipids and TLR biology.

Curr Opin Cell Biol 2016 Apr 16;39:28-36. Epub 2016 Feb 16.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.01.010DOI Listing
April 2016

Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A.

J Biol Chem 2016 Mar 20;291(12):6376-85. Epub 2016 Jan 20.

From the Department of Biochemistry and Groupe de Recherche Axe sur la Structure des Proteines, Faculty of Medicine, McGill University, Montreal, Quebec H3G 0B1, Canada and

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http://dx.doi.org/10.1074/jbc.M115.711085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813564PMC
March 2016

Profiling of Small Molecules by Chemical Proteomics.

Methods Mol Biol 2016 ;1394:211-218

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, Vienna, 1090, Austria.

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http://dx.doi.org/10.1007/978-1-4939-3341-9_15DOI Listing
October 2016

A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations.

J Proteome Res 2016 Feb 12;15(2):647-58. Epub 2016 Jan 12.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.jproteome.5b01066DOI Listing
February 2016

Gene essentiality and synthetic lethality in haploid human cells.

Science 2015 Nov 15;350(6264):1092-6. Epub 2015 Oct 15.

Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066CX, Amsterdam, Netherlands.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aac7557
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http://dx.doi.org/10.1126/science.aac7557DOI Listing
November 2015

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1.

Autophagy 2016 06 2;12(6):1061-2. Epub 2015 Oct 2.

a CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , Vienna , Austria.

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http://dx.doi.org/10.1080/15548627.2015.1091143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922434PMC
June 2016

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

Nat Methods 2015 Nov 21;12(11):1055-7. Epub 2015 Sep 21.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/nmeth.3590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629415PMC
November 2015

A Call for Systematic Research on Solute Carriers.

Cell 2015 Jul;162(3):478-87

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.022DOI Listing
July 2015

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Cell Rep 2015 Jun 18;11(12):1919-28. Epub 2015 Jun 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508342PMC
June 2015

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.

Cell 2015 Jul 18;162(1):170-83. Epub 2015 Jun 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523684PMC
July 2015

Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network.

mBio 2015 Jun 2;6(3):e00712. Epub 2015 Jun 2.

CNRS & Aix-Marseille Université, Laboratoire d'Ingénierie des Systèmes Macromoléculaires (UMR7255), Institut de Microbiologie de la Méditerranée, Marseille, France

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http://dx.doi.org/10.1128/mBio.00712-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453011PMC
June 2015

A Modular Synthesis of Modified Phosphoanhydrides.

Chemistry 2015 Jul 1;21(28):10116-22. Epub 2015 Jun 1.

Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich (Switzerland).

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http://dx.doi.org/10.1002/chem.201500838DOI Listing
July 2015

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death.

ACS Chem Biol 2015 Jul 15;10(7):1604-9. Epub 2015 May 15.

∥CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria.

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http://pubs.acs.org/doi/10.1021/acschembio.5b00245
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http://dx.doi.org/10.1021/acschembio.5b00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509420PMC
July 2015

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.

Cell 2015 Apr;161(2):333-47

The David and Janet Polak Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel; Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul 110-799, South Korea; Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 110-799, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.03.001DOI Listing
April 2015

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.

Biochem J 2015 Jun;468(2):283-91

*California Institute for Quantitative Biosciences, University of California at Berkeley, Berkeley, CA 94720, U.S.A.

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http://dx.doi.org/10.1042/BJ20141492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936049PMC
June 2015

The SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motion.

PLoS Comput Biol 2014 Oct 9;10(10):e1003863. Epub 2014 Oct 9.

Institute of Structural and Molecular Biology, University College London, London, United Kingdom; Chemistry Department, University College London (UCL), London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1003863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191882PMC
October 2014

Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics.

Mol Cancer Ther 2014 Nov 4;13(11):2751-62. Epub 2014 Sep 4.

Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM), Vienna, Austria. Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221415PMC
November 2014

Toward effective sharing of high-dimensional immunology data.

Nat Biotechnol 2014 Aug;32(8):755-9

The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/nbt.2974DOI Listing
August 2014

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production.

Virology 2014 Aug 14;462-463:34-41. Epub 2014 Jun 14.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2014.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139193PMC
August 2014

Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics.

ACS Chem Biol 2014 Jul 14;9(7):1490-8. Epub 2014 May 14.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/cb500116cDOI Listing
July 2014

Building and exploring an integrated human kinase network: global organization and medical entry points.

J Proteomics 2014 Jul 3;107:113-27. Epub 2014 Apr 3.

CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH-BT 25.3, 1090, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115268PMC
July 2014

IFITs: Emerging Roles as Key Anti-Viral Proteins.

Front Immunol 2014 10;5:94. Epub 2014 Mar 10.

Laboratory of Giulio Superti-Furga, Center for Molecular Medicine of the Austrian Academy of Sciences , Vienna , Austria.

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http://dx.doi.org/10.3389/fimmu.2014.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948006PMC
June 2014

Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons.

Cell Rep 2013 Dec 19;5(6):1749-62. Epub 2013 Dec 19.

Department of Neuronal Cell Biology, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria; Max-Planck-Institute for Developmental Biology, 72076 Tübingen, Germany; Department for Anatomy & Cell Biology, Ludwig-Maximilians-University, 80336 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130069
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http://dx.doi.org/10.1016/j.celrep.2013.11.023DOI Listing
December 2013

Somatic mutations of calreticulin in myeloproliferative neoplasms.

N Engl J Med 2013 Dec 10;369(25):2379-90. Epub 2013 Dec 10.

From CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (T.K., A.S.H., H.N., J.D.M., N.C.C.T., T.B., D.C., G.I.V., K.B., F.S., C.C., M. Six, A.S., C.B., G.S.-F., R.K.) and the Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna (H.G., B.G., M. Schalling, R.K.) - both in Vienna; and the Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo (E.R., D.P., C.M., I.C.C., E.S., V.F., C.E., L.M., C.P., M.C.), and the Department of Molecular Medicine, University of Pavia (L.M., M.C.) - both in Pavia, Italy.

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http://dx.doi.org/10.1056/NEJMoa1311347DOI Listing
December 2013