Publications by authors named "Giulio Genovese"

62Publications

Monogenic and polygenic inheritance become instruments for clonal selection.

Nature 2020 08 24;584(7819):136-141. Epub 2020 Jun 24.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415571PMC
August 2020

Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort.

J Am Acad Child Adolesc Psychiatry 2020 Aug 14;59(8):964-977. Epub 2019 Aug 14.

Center for Genomic Medicine, Massachusetts General Hospital, Boston; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA; Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408479PMC
August 2020

Contributions of Rare Gene Variants to Familial and Sporadic FSGS.

J Am Soc Nephrol 2019 09 15;30(9):1625-1640. Epub 2019 Jul 15.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts;

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http://www.jasn.org/lookup/doi/10.1681/ASN.2019020152
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http://dx.doi.org/10.1681/ASN.2019020152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727251PMC
September 2019

Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus.

Schizophr Bull 2019 09;45(5):1112-1119

The Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1093/schbul/sby164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737467PMC
September 2019

Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.

Am J Hum Genet 2018 05 26;102(5):760-775. Epub 2018 Apr 26.

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986696PMC
May 2018

modifies -induced kidney disease risk.

Proc Natl Acad Sci U S A 2018 03 12;115(13):3446-3451. Epub 2018 Mar 12.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1716113115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879665PMC
March 2018

The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples.

Twin Res Hum Genet 2017 04 27;20(2):108-118. Epub 2017 Feb 27.

The Stanley Center for Psychiatric Research,Broad Institute of the Massachusetts Institute of Technology and Harvard,Cambridge,MA.

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http://dx.doi.org/10.1017/thg.2017.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357183PMC
April 2017

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Authors:
Christian R Marshall Daniel P Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas S Greer Danny Antaki Aniket Shetty Peter A Holmans Dalila Pinto Madhusudan Gujral William M Brandler Dheeraj Malhotra Zhouzhi Wang Karin V Fuentes Fajarado Michelle S Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu A Bacanu Richard A Belliveau Sarah E Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B Bigdeli Donald W Black Richard Bruggeman Nancy G Buccola Randy L Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J Cairns Dominique Campion Rita M Cantor Vaughan J Carr Noa Carrera Stanley V Catts Kimberley D Chambert Wei Cheng C Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo-Facorro James J Crowley David Curtis Michael Davidson Kenneth L Davis Franziska Degenhardt Jurgen Del Favero Lynn E DeLisi Dimitris Dikeos Timothy Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan Eriksson Valentina Escott-Price Laurent Essioux Ayman H Fanous Kai-How Farh Martilias S Farrell Josef Frank Lude Franke Robert Freedman Nelson B Freimer Joseph I Friedman Andreas J Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S Gershon Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Jacob Gratten Lieuwe de Haan Marian L Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M Hartmann Frans A Henskens Stefan Herms Joel N Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K Kähler René S Kahn Luba Kalaydjieva Juha Karjalainen David Kavanagh Matthew C Keller Brian J Kelly James L Kennedy Yunjung Kim James A Knowles Bettina Konte Claudine Laurent Phil Lee S Hong Lee Sophie E Legge Bernard Lerer Deborah L Levy Kung-Yee Liang Jeffrey Lieberman Jouko Lönnqvist Carmel M Loughland Patrik K E Magnusson Brion S Maher Wolfgang Maier Jacques Mallet Manuel Mattheisen Morten Mattingsdal Robert W McCarley Colm McDonald Andrew M McIntosh Sandra Meier Carin J Meijer Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Younes Mokrab Derek W Morris Bertram Müller-Myhsok Kieran C Murphy Robin M Murray Inez Myin-Germeys Igor Nenadic Deborah A Nertney Gerald Nestadt Kristin K Nicodemus Laura Nisenbaum Annelie Nordin Eadbhard O'Callaghan Colm O'Dushlaine Sang-Yun Oh Ann Olincy Line Olsen F Anthony O'Neill Jim Van Os Christos Pantelis George N Papadimitriou Elena Parkhomenko Michele T Pato Tiina Paunio Diana O Perkins Tune H Pers Olli Pietiläinen Jonathan Pimm Andrew J Pocklington John Powell Alkes Price Ann E Pulver Shaun M Purcell Digby Quested Henrik B Rasmussen Abraham Reichenberg Mark A Reimers Alexander L Richards Joshua L Roffman Panos Roussos Douglas M Ruderfer Veikko Salomaa Alan R Sanders Adam Savitz Ulrich Schall Thomas G Schulze Sibylle G Schwab Edward M Scolnick Rodney J Scott Larry J Seidman Jianxin Shi Jeremy M Silverman Jordan W Smoller Erik Söderman Chris C A Spencer Eli A Stahl Eric Strengman Jana Strohmaier T Scott Stroup Jaana Suvisaari Dragan M Svrakic Jin P Szatkiewicz Srinivas Thirumalai Paul A Tooney Juha Veijola Peter M Visscher John Waddington Dermot Walsh Bradley T Webb Mark Weiser Dieter B Wildenauer Nigel M Williams Stephanie Williams Stephanie H Witt Aaron R Wolen Brandon K Wormley Naomi R Wray Jing Qin Wu Clement C Zai Rolf Adolfsson Ole A Andreassen Douglas H R Blackwood Elvira Bramon Joseph D Buxbaum Sven Cichon David A Collier Aiden Corvin Mark J Daly Ariel Darvasi Enrico Domenici Tõnu Esko Pablo V Gejman Michael Gill Hugh Gurling Christina M Hultman Nakao Iwata Assen V Jablensky Erik G Jönsson Kenneth S Kendler George Kirov Jo Knight Douglas F Levinson Qingqin S Li Steven A McCarroll Andrew McQuillin Jennifer L Moran Bryan J Mowry Markus M Nöthen Roel A Ophoff Michael J Owen Aarno Palotie Carlos N Pato Tracey L Petryshen Danielle Posthuma Marcella Rietschel Brien P Riley Dan Rujescu Pamela Sklar David St Clair James T R Walters Thomas Werge Patrick F Sullivan Michael C O'Donovan Stephen W Scherer Benjamin M Neale Jonathan Sebat

Nat Genet 2017 01 21;49(1):27-35. Epub 2016 Nov 21.

Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737772PMC
January 2017

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.

Am J Hum Genet 2015 Dec 12;97(6):775-89. Epub 2015 Nov 12.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678427PMC
December 2015

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

Am J Hum Genet 2015 Oct;97(4):576-92

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://biorxiv.org/content/biorxiv/early/2015/03/01/015859.f
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http://linkinghub.elsevier.com/retrieve/pii/S000292971500365
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http://dx.doi.org/10.1016/j.ajhg.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596916PMC
October 2015

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.

Cell Rep 2015 Aug 23;12(5):809-20. Epub 2015 Jul 23.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.065DOI Listing
August 2015

Copy Number Variation at the APOL1 Locus.

PLoS One 2015 1;10(5):e0125410. Epub 2015 May 1.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125410PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416782PMC
February 2016

Large multiallelic copy number variations in humans.

Nat Genet 2015 Mar 26;47(3):296-303. Epub 2015 Jan 26.

1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405206PMC
March 2015

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.

Eur J Hum Genet 2015 Apr 5;23(4):555-7. Epub 2014 Nov 5.

1] Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA [2] Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA [4] Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ejhg.2014.228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666583PMC
April 2015

Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.

Kidney Int 2014 Dec 18;86(6):1116-29. Epub 2014 Jun 18.

1] Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Kidney Group, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ki.2014.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245460PMC
December 2014

Evolution of the primate trypanolytic factor APOL1.

Proc Natl Acad Sci U S A 2014 May 7;111(20):E2130-9. Epub 2014 May 7.

Department of Microbiology, New York University School of Medicine, New York, NY 10016;Department of Biological Sciences, Hunter College at City University of New York, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1400699111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034216PMC
May 2014

Mutations in PAX2 associate with adult-onset FSGS.

J Am Soc Nephrol 2014 Sep 27;25(9):1942-53. Epub 2014 Mar 27.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts;

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http://dx.doi.org/10.1681/ASN.2013070686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147972PMC
September 2014

A polygenic burden of rare disruptive mutations in schizophrenia.

Nature 2014 Feb 22;506(7487):185-90. Epub 2014 Jan 22.

1] Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [3] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature12975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136494PMC
February 2014

Increased burden of cardiovascular disease in carriers of APOL1 genetic variants.

Circ Res 2014 Feb 30;114(5):845-50. Epub 2013 Dec 30.

From the Department of Genetics, Harvard Medical School, Boston, MA (K.I., A.G.B., M.G.P., S.R.D., J.N.H., J.G.S., C.S.); Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge (K.I., A.G.B., J.F., G.G., N.G., S.B.G., C.N.-C., S.K., J.N.H., D.M.A., M.R.P., J.G.S., C.S.); Center for Human Genetic Research, Massachusetts General Hospital, Boston (J.F., C.N.-C., S.K., D.M.A.); Division of Nephrology, Department of Medicine (D.J.F., G.G., M.R.P.) and Center for Vascular Biology Research, Department of Medicine (D.J.F.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Departments of Medicine (H.A.T., E.R.F.) and Physiology and Biophysics (J.G.W.), University of Mississippi Medical Center, Jackson; Jackson State University, MS (H.A.T.); Tougaloo College, MS (H.A.T.); Cardiology Division, Massachusetts General Hospital, Boston (C.N.-C., S.K.); Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, MA (J.N.H.); and Howard Hughes Medical Institute and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (C.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982584PMC
February 2014

Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis.

Kidney Int 2014 Jan 18;85(1):124-33. Epub 2013 Sep 18.

1] Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ki.2013.354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068013PMC
January 2014

Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion.

PLoS One 2013 26;8(8):e71885. Epub 2013 Aug 26.

Division of Nephrology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America ; Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071885PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753300PMC
April 2014

Mapping the human reference genome's missing sequence by three-way admixture in Latino genomes.

Am J Hum Genet 2013 Sep 8;93(3):411-21. Epub 2013 Aug 8.

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971454PMC
September 2013

APOL1 variants and kidney disease in people of recent African ancestry.

Nat Rev Nephrol 2013 04 26;9(4):240-4. Epub 2013 Feb 26.

Stanley Center, Broad Institute, Cambridge, MA 02142, USA.

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http://www.nature.com/articles/nrneph.2013.34
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http://dx.doi.org/10.1038/nrneph.2013.34DOI Listing
April 2013

Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.

Kidney Int 2013 Feb 26;83(2):316-22. Epub 2012 Sep 26.

Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ki.2012.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647680PMC
February 2013

APOL1 and kidney disease.

Curr Opin Nephrol Hypertens 2012 Mar;21(2):179-82

Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32835012abDOI Listing
March 2012

Population-based risk assessment of APOL1 on renal disease.

J Am Soc Nephrol 2011 Nov 13;22(11):2098-105. Epub 2011 Oct 13.

Renal Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://jasn.asnjournals.org/content/early/2011/10/06/ASN.201
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http://www.jasn.org/cgi/doi/10.1681/ASN.2011050519
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http://dx.doi.org/10.1681/ASN.2011050519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231785PMC
November 2011

The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.

J Am Soc Nephrol 2010 Sep 5;21(9):1422-6. Epub 2010 Aug 5.

Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, USA.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2010070730
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http://dx.doi.org/10.1681/ASN.2010070730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391383PMC
September 2010

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

Kidney Int 2010 Oct 28;78(7):698-704. Epub 2010 Jul 28.

Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ki.2010.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001190PMC
October 2010

Improved IBD detection using incomplete haplotype information.

BMC Genet 2010 Jun 30;11:58. Epub 2010 Jun 30.

Department of Mathematics, Dartmouth College, Hanover NH 03755, USA.

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https://bmcgenet.biomedcentral.com/articles/10.1186/1471-215
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http://dx.doi.org/10.1186/1471-2156-11-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914765PMC
June 2010

Deviant kinetochore microtubule dynamics underlie chromosomal instability.

Curr Biol 2009 Dec 29;19(22):1937-42. Epub 2009 Oct 29.

Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1016/j.cub.2009.09.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787757PMC
December 2009