Giulio Draetta

Giulio Draetta

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Giulio Draetta

Giulio Draetta

Publications by authors named "Giulio Draetta"

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60Publications

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Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research.

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Genomic Medicine, UT MD Anderson cancer center, Houston, TX 77054, USA.

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http://dx.doi.org/10.3390/cancers11091321DOI Listing
September 2019

Pooled library screening with multiplexed Cpf1 library.

Nat Commun 2019 Jul 17;10(1):3144. Epub 2019 Jul 17.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-10963-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637147PMC
July 2019

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell 2019 Feb;35(2):204-220.e9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.006DOI Listing
February 2019

Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription.

Cancer Discov 2018 01;8(1):17-19

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1245DOI Listing
January 2018

Metabolic Features of Cancer Treatment Resistance.

Recent Results Cancer Res 2016;207:135-56

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/978-3-319-42118-6_6DOI Listing
March 2017

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Cell 2017 02;168(4):579-583

Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.034DOI Listing
February 2017

Identification of potent and selective MTH1 inhibitors.

Bioorg Med Chem Lett 2016 Mar 11;26(6):1503-1507. Epub 2016 Feb 11.

Institute for Applied Cancer Science, MD Anderson Cancer Center, 1901 East Road, Houston (TX) 77054, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.02.026DOI Listing
March 2016

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair.

Cell Rep 2016 Feb 4;14(6):1555-1566. Epub 2016 Feb 4.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.01.019DOI Listing
February 2016

Genetics and biology of pancreatic ductal adenocarcinoma.

Genes Dev 2016 Feb;30(4):355-85

Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.275776.115
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http://dx.doi.org/10.1101/gad.275776.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762423PMC
February 2016

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells.

Cell Metab 2015 Oct;22(4):543-5

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.cmet.2015.09.020DOI Listing
October 2015

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.

Cancer Res 2015 Mar 3;75(6):1091-101. Epub 2015 Mar 3.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446709PMC
March 2015

Oncology drug discovery: planning a turnaround.

Cancer Discov 2014 Apr;4(4):397-404

1Institute for Applied Cancer Science, Departments of 2Genomic Medicine and 3Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 4On-kos, Milan, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0452DOI Listing
April 2014

Cancer drug discovery faces the FACT.

Sci Transl Med 2011 Aug;3(95):95ps34

Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002822DOI Listing
August 2011

Role for histone deacetylase 1 in human tumor cell proliferation.

Mol Cell Biol 2007 Jul 30;27(13):4784-95. Epub 2007 Apr 30.

European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1128/MCB.00494-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951481PMC
July 2007

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

Science 2007 May 26;316(5826):900-4. Epub 2007 Apr 26.

Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.

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http://dx.doi.org/10.1126/science.1141194DOI Listing
May 2007

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.

Biochem Biophys Res Commun 2006 Jun 19;344(3):859-68. Epub 2006 Apr 19.

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0600750
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http://dx.doi.org/10.1016/j.bbrc.2006.03.205DOI Listing
June 2006

Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233].

Authors:
Giulio F Draetta

Biochim Biophys Acta 2005 Sep;1741(3):225

Cancer Research, Merck Research Laboratories, Basic Research, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S092544390500119
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http://dx.doi.org/10.1016/j.bbadis.2005.08.008DOI Listing
September 2005

A mechanism for inhibiting the SUMO pathway.

Mol Cell 2004 Nov;16(4):549-61

European Institute of Oncology, Department of Experimental Oncology, 20141 Milan, Italy.

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http://dx.doi.org/10.1016/j.molcel.2004.11.007DOI Listing
November 2004

Characterization of the BUD31 gene of Saccharomyces cerevisiae.

Biochem Biophys Res Commun 2004 Aug;320(4):1342-50

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.228DOI Listing
August 2004

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.

Oncogene 2004 May;23(25):4454-65

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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http://www.nature.com/articles/1207579
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http://dx.doi.org/10.1038/sj.onc.1207579DOI Listing
May 2004

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation.

Cell Cycle 2004 Apr 1;3(4):469-71. Epub 2004 Apr 1.

European Institute of Oncology, Milan, Italy.

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April 2004

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis.

Oncogene 2004 Mar;23(11):2050-6

European Institute of Oncology, 435 Via Ripamonti, Milan 20141, Italy.

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http://www.nature.com/articles/1207394
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http://dx.doi.org/10.1038/sj.onc.1207394DOI Listing
March 2004

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

Nature 2003 Nov;426(6962):87-91

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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http://dx.doi.org/10.1038/nature02082DOI Listing
November 2003

Regulating mammalian checkpoints through Cdc25 inactivation.

EMBO Rep 2003 Jul;4(7):671-7

European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy.

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http://embor.embopress.org/cgi/doi/10.1038/sj.embor.embor887
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http://dx.doi.org/10.1038/sj.embor.embor887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326326PMC
July 2003

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein.

Oncogene 2003 May;22(17):2541-7

Department of Experimental Oncology, European Institute of Oncology, via Ripamonti, 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1038/sj.onc.1206379DOI Listing
May 2003

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

EMBO Rep 2002 Nov 22;3(11):1062-8. Epub 2002 Oct 22.

European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy.

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http://dx.doi.org/10.1093/embo-reports/kvf213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307602PMC
November 2002

Dual mode of degradation of Cdc25 A phosphatase.

EMBO J 2002 Sep;21(18):4875-84

European Institute of Oncology, 435 Via Ripamonti, I-20141 Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126287PMC
http://dx.doi.org/10.1093/emboj/cdf491DOI Listing
September 2002

Histone deacetylase 1 inactivation by an adenovirus early gene product.

Curr Biol 2002 Apr;12(7):594-8

Department of Experimental Oncology, European Institute of Oncology, 20141, Milan, Italy.

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http://dx.doi.org/10.1016/s0960-9822(02)00720-0DOI Listing
April 2002