Publications by authors named "Gitte M Knudsen"

100Publications

Change in prefrontal activity and executive functions after action-based cognitive remediation in bipolar disorder: a randomized controlled trial.

Neuropsychopharmacology 2020 Nov 9. Epub 2020 Nov 9.

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41386-020-00901-7DOI Listing
November 2020

Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin.

Neuropsychopharmacology 2020 Aug 25. Epub 2020 Aug 25.

Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41386-020-00823-4DOI Listing
August 2020

Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity-Comparison with other anxiety-related temperamental dimensions.

Mol Genet Genomic Med 2020 08 15;8(8):e1352. Epub 2020 Jun 15.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.

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http://dx.doi.org/10.1002/mgg3.1352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434600PMC
August 2020

Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent.

Neurochem Int 2020 09 25;138:104772. Epub 2020 May 25.

Psychiatric Centre Copenhagen, University Hospital of Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.neuint.2020.104772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452124PMC
September 2020

Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol.

Front Pharmacol 2020 30;11:591. Epub 2020 Apr 30.

Centre for Neuropsychiatric Schizophrenia Research (CNSR), Centre for Clinical Intervention & Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Glostrup, Denmark.

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http://dx.doi.org/10.3389/fphar.2020.00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204912PMC
April 2020

Abnormal prefrontal cortex processing of reward prediction errors in recently diagnosed patients with bipolar disorder and their unaffected relatives.

Bipolar Disord 2020 Apr 16. Epub 2020 Apr 16.

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/bdi.12915DOI Listing
April 2020

A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding.

Eur Neuropsychopharmacol 2020 04 4;33:71-80. Epub 2020 Mar 4.

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2020.02.001DOI Listing
April 2020

Psychometric Properties and Validation of the EMOTICOM Test Battery in a Healthy Danish Population.

Front Psychol 2019 3;10:2660. Epub 2019 Dec 3.

Neurobiology Research Unit, The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fpsyg.2019.02660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901831PMC
December 2019

Radiosynthesis and preclinical evaluation of [ C]Cimbi-701 - Towards the imaging of cerebral 5-HT receptors.

J Labelled Comp Radiopharm 2020 Feb 6;63(2):46-55. Epub 2020 Jan 6.

Neurobiology Research Unit and Center for Integrated Molecular Imaging, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/jlcr.3808DOI Listing
February 2020

Towards selective CNS PET imaging of the 5-HT receptor system: Past, present and future.

Neuropharmacology 2020 08 24;172:107830. Epub 2019 Oct 24.

Neurobiology Research Unit, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark; Department for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetesparken 2, 2100, Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine and PET, University Hospital Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107830DOI Listing
August 2020

Different preprocessing strategies lead to different conclusions: A [C]DASB-PET reproducibility study.

J Cereb Blood Flow Metab 2020 Sep 1;40(9):1902-1911. Epub 2019 Oct 1.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1177/0271678X19880450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446563PMC
September 2020

Human biodistribution and radiation dosimetry of the 5-HT receptor agonist Cimbi-36 labeled with carbon-11 in two positions.

EJNMMI Res 2019 Jul 31;9(1):71. Epub 2019 Jul 31.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Building 6931, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s13550-019-0527-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669221PMC
July 2019

In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates.

J Pharm Pharm Sci 2019 ;22(1):352-364

Department of Psychiatry, Columbia University Medical Center, New York, USA. Area of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, USA.

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http://dx.doi.org/10.18433/jpps30329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453972PMC
August 2020

Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [C]DASB PET study.

Neuroimage 2019 10 1;199:466-479. Epub 2019 Jun 1.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2019.05.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688914PMC
October 2019

Cortical modulation of pupillary function: systematic review.

PeerJ 2019 7;7:e6882. Epub 2019 May 7.

Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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https://peerj.com/articles/6882
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http://dx.doi.org/10.7717/peerj.6882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510220PMC
May 2019

Measuring endogenous changes in serotonergic neurotransmission with [C]Cimbi-36 positron emission tomography in humans.

Transl Psychiatry 2019 04 11;9(1):134. Epub 2019 Apr 11.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging (Cimbi), Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.

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http://dx.doi.org/10.1038/s41398-019-0468-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459901PMC
April 2019

Correction to: Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Trials 2019 04 8;20(1):201. Epub 2019 Apr 8.

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s13063-019-3289-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452507PMC
April 2019

Improved radiosynthesis and preliminary in vivo evaluation of the C-labeled tetrazine [C]AE-1 for pretargeted PET imaging.

Bioorg Med Chem Lett 2019 04 13;29(8):986-990. Epub 2019 Feb 13.

Department for Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine and PET, University Hospital Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.02.014DOI Listing
April 2019

Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study.

Psychopharmacology (Berl) 2019 Jun 8;236(6):1759-1769. Epub 2019 Jan 8.

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark.

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http://link.springer.com/10.1007/s00213-018-5158-3
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http://dx.doi.org/10.1007/s00213-018-5158-3DOI Listing
June 2019

Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex.

Sci Rep 2018 12 17;8(1):17889. Epub 2018 Dec 17.

Danish Research Centre for Magnetic Resonance (DRCMR), Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.1038/s41598-018-36350-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297157PMC
December 2018

Influence of Strategic Cortical Infarctions on Pupillary Function.

Front Neurol 2018 29;9:916. Epub 2018 Oct 29.

Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fneur.2018.00916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215832PMC
October 2018

Evaluation of [ F]2FP3 in pigs and non-human primates.

J Labelled Comp Radiopharm 2019 01 6;62(1):34-42. Epub 2018 Dec 6.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://doi.wiley.com/10.1002/jlcr.3692
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http://dx.doi.org/10.1002/jlcr.3692DOI Listing
January 2019

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.

Curr Biol 2018 10 27;28(19):3065-3074.e6. Epub 2018 Sep 27.

Department of Psychiatry, University of Oxford, Oxford, UK; Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal; Institut d'études avancées de Paris, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609822183104
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http://dx.doi.org/10.1016/j.cub.2018.07.083DOI Listing
October 2018

Pre-intervention test-retest reliability of EEG and ERP over four recording intervals.

Int J Psychophysiol 2018 12 22;134:30-43. Epub 2018 Sep 22.

Department of Clinical Pharmacology, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01678760183006
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http://dx.doi.org/10.1016/j.ijpsycho.2018.09.007DOI Listing
December 2018

Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Trials 2018 Sep 12;19(1):487. Epub 2018 Sep 12.

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s13063-018-2860-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134776PMC
September 2018

Migraine is associated with high brain 5-HT levels as indexed by 5-HT receptor binding.

Cephalalgia 2019 04 8;39(4):526-532. Epub 2018 Aug 8.

1 Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Glostrup, Denmark.

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http://dx.doi.org/10.1177/0333102418793642DOI Listing
April 2019

Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter - A longitudinal combined C-DASB and C-SB207145 PET study.

Eur Neuropsychopharmacol 2018 10 1;28(10):1151-1160. Epub 2018 Aug 1.

Neurobiology Research Unit, Rigshospitalet and Center for Integrated Molecular Brain Imaging, Section 6931, Blegdamsvej 9, 2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2018.06.004DOI Listing
October 2018

Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging.

ACS Chem Neurosci 2018 06 15;9(6):1226-1229. Epub 2018 May 15.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences , University of Copenhagen , Jagtvej 160 , 2100 Copenhagen , Denmark.

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http://dx.doi.org/10.1021/acschemneuro.8b00176DOI Listing
June 2018

Self-perceived personality characteristics in seasonal affective disorder and their implications for severity of depression.

Psychiatry Res 2018 04 6;262:108-114. Epub 2018 Feb 6.

Neurobiology Research Unit, Rigshospitalet, 9 Blegdamsvej, 2100 Copenhagen, Denmark; Center for Integrated Molecular Brain Imaging, the Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2018.02.015DOI Listing
April 2018

High brain serotonin levels in migraine between attacks: A 5-HT receptor binding PET study.

Neuroimage Clin 2018 28;18:97-102. Epub 2018 Jan 28.

Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183001
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http://dx.doi.org/10.1016/j.nicl.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790018PMC
January 2019

Amygdala response to emotional faces in seasonal affective disorder.

J Affect Disord 2018 03 3;229:288-295. Epub 2018 Jan 3.

Neurobiology Research Unit, Rigshospitalet and Center for Integrated Molecular Brain Imaging, Section 6931, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.12.097DOI Listing
March 2018

Amygdala reactivity to fearful faces correlates positively with impulsive aggression.

Soc Neurosci 2019 04 7;14(2):162-172. Epub 2018 Jan 7.

a Neurobiology Research Unit , Copenhagen University Hospital Rigshospitalet , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/17470919.2017.1421262DOI Listing
April 2019

The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [C]Cimbi-36 labeled in two positions.

J Cereb Blood Flow Metab 2018 04 7;38(4):659-668. Epub 2017 Dec 7.

1 Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1177/0271678X17746179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888860PMC
April 2018

Automatic delineation of brain regions on MRI and PET images from the pig.

J Neurosci Methods 2018 01 13;294:51-58. Epub 2017 Nov 13.

Center for Integrated Molecular Brain Imaging (Cimbi) and Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.11.008DOI Listing
January 2018

Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity.

Neuroimage 2018 02 20;166:79-85. Epub 2017 Oct 20.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119173085
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http://dx.doi.org/10.1016/j.neuroimage.2017.10.032DOI Listing
February 2018

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

Int J Neuropsychopharmacol 2017 12;20(12):963-970

Turku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1093/ijnp/pyx071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716061PMC
December 2017

Functional Characterization of 5-HT Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR.

J Neurosci 2017 11 2;37(44):10671-10678. Epub 2017 Oct 2.

Neurobiology Research Unit and NeuroPharm, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1523/JNEUROSCI.1971-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666586PMC
November 2017

Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain.

Int J Neuropsychopharmacol 2017 09;20(9):683-691

Karolinska Institutet and Stockholm County Council, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden; Rigshospitalet, Center for Integrated Molecular Brain Imaging, Copenhagen, Denmark and University of Copenhagen, Faculty of Health and Medicine Sciences, Copenhagen, Denmark; AstraZeneca, PET Science Center at Karolinska Institutet, Personalized Health Care and Biomarkers, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ijnp/pyx051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581490PMC
September 2017

Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT receptor agonists [ F]Cimbi-92 and [ F]Cimbi-150.

J Labelled Comp Radiopharm 2017 10 18;60(12):586-591. Epub 2017 Sep 18.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/jlcr.3557DOI Listing
October 2017

Aggression-related brain function assessed with the Point Subtraction Aggression Paradigm in fMRI.

Aggress Behav 2017 Nov 25;43(6):601-610. Epub 2017 Jul 25.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen O, Denmark.

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http://dx.doi.org/10.1002/ab.21718DOI Listing
November 2017

Low 5-HT receptor binding in the migraine brain: A PET study.

Cephalalgia 2018 03 15;38(3):519-527. Epub 2017 Mar 15.

2 Neurobiology Research Unit and Center for Experimental Medicine Neuropharmacology, Department of Neurology, The Neuroscience Centre, Rigshospitalet, Denmark.

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http://journals.sagepub.com/doi/10.1177/0333102417698708
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http://dx.doi.org/10.1177/0333102417698708DOI Listing
March 2018

Genome-wide-analyses of Listeria monocytogenes from food-processing plants reveal clonal diversity and date the emergence of persisting sequence types.

Environ Microbiol Rep 2017 08 27;9(4):428-440. Epub 2017 Jun 27.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1111/1758-2229.12552DOI Listing
August 2017

Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition.

J Psychiatr Res 2017 09 8;92:199-204. Epub 2017 May 8.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2017.05.003DOI Listing
September 2017

Testosterone levels in healthy men correlate negatively with serotonin 4 receptor binding.

Psychoneuroendocrinology 2017 Jul 22;81:22-28. Epub 2017 Mar 22.

Neurobiology Research Unit, Rigshospitalet, building 6931, Blegdamsvej 9, DK, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2017.03.018DOI Listing
July 2017

Brain serotonin 4 receptor binding is inversely associated with verbal memory recall.

Brain Behav 2017 04 17;7(4):e00674. Epub 2017 Mar 17.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging The Neuroscience Centre Rigshospitalet Copenhagen Denmark.

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http://dx.doi.org/10.1002/brb3.674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390847PMC
April 2017

The Influence of the Toxin/Antitoxin mazEF on Growth and Survival of Listeria monocytogenes under Stress.

Toxins (Basel) 2017 01 13;9(1). Epub 2017 Jan 13.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Matematiktorvet Bldg. 301, DK-2800 Kongens Lyngby, Denmark.

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http://www.mdpi.com/2072-6651/9/1/31
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http://dx.doi.org/10.3390/toxins9010031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308263PMC
January 2017

Radiosynthesis and Evaluation of [C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites.

ACS Chem Neurosci 2017 01 17;8(1):22-27. Epub 2016 Nov 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acschemneuro.6b00335DOI Listing
January 2017

Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands.

J Cereb Blood Flow Metab 2017 Sep 11;37(9):3243-3252. Epub 2017 Jan 11.

3 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/0271678X16686092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584698PMC
September 2017

Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD): Evaluation and comparison to existing practices.

Bioorg Med Chem Lett 2017 01 18;27(2):319-322. Epub 2016 Nov 18.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark; Center for Integrated Molecular Brain Imaging and University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.11.048DOI Listing
January 2017

Convergent F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT receptor PET ligands.

Bioorg Med Chem 2016 11 29;24(21):5353-5356. Epub 2016 Aug 29.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.08.056DOI Listing
November 2016

Sublethal Concentrations of Antibiotics Cause Shift to Anaerobic Metabolism in Listeria monocytogenes and Induce Phenotypes Linked to Antibiotic Tolerance.

Front Microbiol 2016 12;7:1091. Epub 2016 Jul 12.

Department of Bioengineering, Technical University of Denmark Kongens Lyngby, Denmark.

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http://dx.doi.org/10.3389/fmicb.2016.01091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940397PMC
July 2016

The Small Colony Variant of Listeria monocytogenes Is More Tolerant to Antibiotics and Has Altered Survival in RAW 264.7 Murine Macrophages.

Front Microbiol 2016 5;7:1056. Epub 2016 Jul 5.

Gram Lab, Department of Systems Biology, Technical University of Denmark Kongens Lyngby, Denmark.

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http://dx.doi.org/10.3389/fmicb.2016.01056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932272PMC
July 2016

A regularized full reference tissue model for PET neuroreceptor mapping.

Neuroimage 2016 Oct 27;139:405-414. Epub 2016 Jun 27.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.

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http://dx.doi.org/10.1016/j.neuroimage.2016.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192005PMC
October 2016

Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers.

Neuroimage 2016 Oct 16;139:37-43. Epub 2016 Jun 16.

Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.neuroimage.2016.06.024DOI Listing
October 2016

Synthesis and evaluation of (18)F-labeled 5-HT2A receptor agonists as PET ligands.

Nucl Med Biol 2016 08 19;43(8):455-62. Epub 2016 Apr 19.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2016.02.011DOI Listing
August 2016

Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

Eur Neuropsychopharmacol 2016 07 11;26(7):1248-50. Epub 2016 May 11.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.euroneuro.2016.04.008DOI Listing
July 2016

Seasonal difference in brain serotonin transporter binding predicts symptom severity in patients with seasonal affective disorder.

Brain 2016 05 19;139(Pt 5):1605-14. Epub 2016 Mar 19.

Neurobiology Research Unit, Rigshospitalet and Centre for Integrated Molecular Brain Imaging, Section 6931, Blegdamsvej 9, 2100 Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

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http://dx.doi.org/10.1093/brain/aww043DOI Listing
May 2016

Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.

Neuroimage 2016 05 23;132:334-343. Epub 2016 Feb 23.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2016.02.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851886PMC
May 2016

Brain serotonin 4 receptor binding is associated with the cortisol awakening response.

Psychoneuroendocrinology 2016 May 11;67:124-32. Epub 2016 Feb 11.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, DK-2100 Copenhagen, Denmark; Psychiatric Center Copenhagen, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2016.01.032DOI Listing
May 2016

Open and Calm--a randomized controlled trial evaluating a public stress reduction program in Denmark.

BMC Public Health 2015 Dec 16;15:1245. Epub 2015 Dec 16.

Neurobiology Research Unit (NRU) and Center for Integrated Molecular Brain Imaging (Cimbi), The Neuroscience Centre, Rigshospitalet and University of Copenhagen, Juliane Maries Vej 28, 3rd floor, 2100, Copenhagen OE, Denmark.

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http://dx.doi.org/10.1186/s12889-015-2588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682248PMC
December 2015

Metabolic Fate of Hallucinogenic NBOMes.

Chem Res Toxicol 2016 Jan 29;29(1):96-100. Epub 2015 Dec 29.

Department of Drug Design and Pharmacology and ‡Department of Pharmacy, University of Copenhagen , DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00450DOI Listing
January 2016

Development and psychometric validation of the verbal affective memory test.

Memory 2016 10 24;24(9):1208-23. Epub 2015 Sep 24.

a Neurobiology Research Unit (NRU), The Neuroscience Centre, Rigshospitalet , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/09658211.2015.1087573DOI Listing
October 2016

The serotonin transporter in psychiatric disorders: insights from PET imaging.

Lancet Psychiatry 2015 Aug;2(8):743-755

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22150366150023
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http://dx.doi.org/10.1016/S2215-0366(15)00232-1DOI Listing
August 2015

Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward.

Neuropsychopharmacology 2016 Mar 6;41(4):1057-65. Epub 2015 Aug 6.

Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1038/npp.2015.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748430PMC
March 2016

TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging.

J Nucl Med 2015 Sep 16;56(9):1386-90. Epub 2015 Jul 16.

Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark Epilepsy Clinic, Department of Neurology, Rigshospitalet, Copenhagen, Denmark

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http://dx.doi.org/10.2967/jnumed.115.158998DOI Listing
September 2015

Current radiosynthesis strategies for 5-HT2A receptor PET tracers.

J Labelled Comp Radiopharm 2015 Jun 22;58(7):265-73. Epub 2015 May 22.

Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark.

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http://dx.doi.org/10.1002/jlcr.3288DOI Listing
June 2015

Functional connectivity of the dorsal and median raphe nuclei at rest.

Neuroimage 2015 Aug 9;116:187-95. Epub 2015 May 9.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2015.04.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468016PMC
August 2015

Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand.

Eur J Pharmacol 2015 Sep 1;762:35-41. Epub 2015 May 1.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.04.036DOI Listing
September 2015

5-HTTLPR differentially predicts brain network responses to emotional faces.

Hum Brain Mapp 2015 Jul 30;36(7):2842-51. Epub 2015 Apr 30.

Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.

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http://dx.doi.org/10.1002/hbm.22811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869322PMC
July 2015

The Center for Integrated Molecular Brain Imaging (Cimbi) database.

Neuroimage 2016 Jan 17;124(Pt B):1213-1219. Epub 2015 Apr 17.

Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark; Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark; Psychiatric Center Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119150031
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http://dx.doi.org/10.1016/j.neuroimage.2015.04.025DOI Listing
January 2016

Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888.

Bioorg Med Chem Lett 2015 May 21;25(9):1901-4. Epub 2015 Mar 21.

Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.03.039DOI Listing
May 2015

Similar serotonin-2A receptor binding in rats with different coping styles or levels of aggression.

Synapse 2015 Apr 28;69(4):226-32. Epub 2015 Feb 28.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/syn.21810DOI Listing
April 2015

(11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand.

Bioorg Med Chem Lett 2015 Mar 20;25(5):1053-6. Epub 2015 Jan 20.

Center for Integrated Molecular Brain Imaging, University of Copenhagen Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.01.017DOI Listing
March 2015

Familial risk for major depression is associated with lower striatal 5-HT₄ receptor binding.

Int J Neuropsychopharmacol 2014 Oct 31;18(1). Epub 2014 Oct 31.

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (Drs Madsen, Torstensen, Holst, Haahr, Frokjaer, Fisher, and Knudsen); Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (Drs Madsen, Holst, Haahr, Frokjaer, Iversen, Fisher, and Knudsen); Department of Biostatistics, University of Copenhagen, Denmark (Dr Holst); Psychiatric Centre Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (Dr Knorr); PET and Cyclotron Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (Dr Brandt-Larsen); Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark (Dr Iversen).

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http://dx.doi.org/10.1093/ijnp/pyu034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368872PMC
October 2014

The effect of storage conditions on salivary cortisol concentrations using an enzyme immunoassay.

Scand J Clin Lab Invest 2015 Jan 16;75(1):92-5. Epub 2014 Dec 16.

Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging (CIMBI), Copenhagen University Hospital , Rigshospitalet, Section 9201, Copenhagen , Denmark.

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http://dx.doi.org/10.3109/00365513.2014.985252DOI Listing
January 2015

In vivo quantification of cerebral translocator protein binding in humans using 6-chloro-2-(4'-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT.

J Nucl Med 2014 Dec 13;55(12):1966-72. Epub 2014 Nov 13.

Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Epilepsy Clinic, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.2967/jnumed.114.143727DOI Listing
December 2014

BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels.

Hum Brain Mapp 2015 Jan 13;36(1):313-23. Epub 2014 Sep 13.

Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.

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http://dx.doi.org/10.1002/hbm.22630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869129PMC
January 2015

Personality characteristics in surgery seeking and non-surgery seeking obese individuals compared to non-obese controls.

Eat Behav 2014 Dec 28;15(4):595-8. Epub 2014 Aug 28.

Center for Integrated Molecular Brain Imaging, Blegdamsvej 9, 2100 Copenhagen, Rigshospitalet, University of Copenhagen, Denmark; Neurobiology Research Unit, Blegdamsvej 9, 2100Copenhagen, Rigshospitalet, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.eatbeh.2014.08.008DOI Listing
December 2014