Publications by authors named "Giovanni Tonon"

66Publications

MSH6 gene pathogenic variant identified in familial pancreatic cancer in the absence of colon cancer.

Eur J Gastroenterol Hepatol 2020 Mar;32(3):345-349

Division of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele Scientific Institute.

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http://dx.doi.org/10.1097/MEG.0000000000001617DOI Listing
March 2020

Big Data in Medicine, the Present and Hopefully the Future.

Front Med (Lausanne) 2019 15;6:263. Epub 2019 Nov 15.

Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3389/fmed.2019.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873822PMC
November 2019

How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription.

Cells 2019 09 17;8(9). Epub 2019 Sep 17.

Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.3390/cells8091098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769540PMC
September 2019

β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer.

Nat Commun 2019 07 19;10(1):3196. Epub 2019 Jul 19.

Preclinical Models and New Therapeutic Agents Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Regina Elena National Cancer Institute, 00144, Rome, Italy.

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http://dx.doi.org/10.1038/s41467-019-11045-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642155PMC
July 2019

Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features.

Dig Liver Dis 2018 06 23;50(6):521-532. Epub 2018 Feb 23.

Functional Genomics of Cancer Unit, Division of Molecular Oncology, IRCCS Ospedale San Raffaele Scientific Institute, Milan, Italy; Center for Translational Genomics and Bioinformatics, IRCCS Ospedale San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.dld.2018.02.009DOI Listing
June 2018

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.

Haematologica 2018 05 15;103(5):865-873. Epub 2018 Feb 15.

Strategic Research Program on CLL and B-cell Neoplasia Unit, Division of Experimental Oncology, Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2017.177212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927998PMC
May 2018

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.

Cell Rep 2017 Oct;21(3):628-640

Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Hematology/Oncology, University of Florida Health Cancer Center, Gainesville, FL 2033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706555PMC
October 2017

Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.

Nucleic Acids Res 2016 Apr 20;44(7):3448-63. Epub 2016 Feb 20.

Biomolecular NMR Unit, Division of Genetics and Cell Biology, IRCCS S. Raffaele Scientific Institute, Milan 20132, Italy

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http://dx.doi.org/10.1093/nar/gkw103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838375PMC
April 2016

Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival.

Oncoimmunology 2015 May 3;4(5):e1005460. Epub 2015 Feb 3.

Tumor Immunology Unit; IRCCS San Raffaele Scientific Institute ; Milan, Italy ; Division of Immunology, Transplantation and Infectious Diseases; IRCCS San Raffaele Scientific Institute ; Milan, Italy.

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http://dx.doi.org/10.1080/2162402X.2015.1005460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485827PMC
May 2015

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma.

Cancer Discov 2015 Sep 16;5(9):972-87. Epub 2015 Jun 16.

Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560623PMC
September 2015

The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.

Nucleic Acids Res 2015 May 29;43(10):5182-93. Epub 2015 Apr 29.

Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, 20133 Milan, Italy Università Vita-Salute San Raffaele, Milan, 20132, Italy

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http://dx.doi.org/10.1093/nar/gkv387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446438PMC
May 2015

p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Proc Natl Acad Sci U S A 2015 Mar 4;112(11):3499-504. Epub 2015 Mar 4.

Biochemistry Laboratory, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata," 00133 Rome, Italy; Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy;

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http://dx.doi.org/10.1073/pnas.1500762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372004PMC
March 2015

H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.

Nucleic Acids Res 2015 Mar 23;43(5):2560-74. Epub 2015 Feb 23.

Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy

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http://dx.doi.org/10.1093/nar/gkv090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357704PMC
March 2015

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.

Nature 2014 Oct 17;514(7523):513-7. Epub 2014 Aug 17.

1] Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA [2] NYU Cancer Institute and Helen L. and Martin S. Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nature13605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209203PMC
October 2014

Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers.

Mol Cell Oncol 2014 Jul-Sep;1(3):e970055. Epub 2014 Dec 23.

Functional Genomics of Cancer Unit; Division of Molecular Oncology; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS); San Raffaele Scientific Institute ; Milan, Italy.

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http://dx.doi.org/10.4161/23723548.2014.970055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904900PMC
June 2016

Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis.

Stem Cell Reports 2014 Jun 15;2(6):794-809. Epub 2014 May 15.

Division of Molecular Oncology, Leukemia Unit, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1016/j.stemcr.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050345PMC
June 2014

Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.

Nat Med 2014 Jun 11;20(6):599-606. Epub 2014 May 11.

1] Functional Genomics of Cancer Unit, Division of Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy. [2] Università Vita-Salute San Raffaele, Milan, Italy. [3] MAGIC (Microenvironment and Genes in Cancers of the blood) Interdivisional Research Program, IRCCS San Raffaele Scientific Institute, Milan, Italy. [4].

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http://dx.doi.org/10.1038/nm.3562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057660PMC
June 2014

Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation.

Cancer Lett 2014 Feb 8;343(2):286-94. Epub 2013 Oct 8.

Medical Oncology, National Center for Tumor Diseases (NCT), University of Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.09.042DOI Listing
February 2014

Iron increases the susceptibility of multiple myeloma cells to bortezomib.

Haematologica 2013 Jun 14;98(6):971-9. Epub 2012 Dec 14.

Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3324/haematol.2012.074872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669455PMC
June 2013

Disentangling the myeloma web.

Clin Cancer Res 2011 Dec 11;17(23):7210-2. Epub 2011 Oct 11.

Functional Genomics of Cancer Unit, Division of Molecular Oncology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2316DOI Listing
December 2011

Pancreatic cancers require autophagy for tumor growth.

Genes Dev 2011 Apr 15;25(7):717-29. Epub 2011 Mar 15.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.2016111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934PMC
April 2011

Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling.

Blood 2009 Feb 18;113(7):1513-21. Epub 2008 Nov 18.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2008-05-157040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644079PMC
February 2009

Somatic mutations affect key pathways in lung adenocarcinoma.

Nature 2008 Oct;455(7216):1069-75

The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1038/nature07423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694412PMC
October 2008

From oncogene to network addiction: the new frontier of cancer genomics and therapeutics.

Authors:
Giovanni Tonon

Future Oncol 2008 Aug;4(4):569-77

Dana Farber Cancer Institute, Harvard Medical School Mayer Building, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.2217/14796694.4.4.569DOI Listing
August 2008

Moving toward individualized cancer therapies.

Clin Cancer Res 2008 Aug;14(15):4682-4

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1134DOI Listing
August 2008

Molecular pathogenesis of multiple myeloma.

Authors:
Giovanni Tonon

Hematol Oncol Clin North Am 2007 Dec;21(6):985-1006, vii

Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Mayer Building, Rm.417, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.hoc.2007.08.004DOI Listing
December 2007

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets.

Nat Rev Cancer 2007 Aug;7(8):585-98

Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://www.nature.com/articles/nrc2189
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http://dx.doi.org/10.1038/nrc2189DOI Listing
August 2007

Karyotypic "state" as a potential determinant for anticancer drug discovery.

Proc Natl Acad Sci U S A 2005 Feb 9;102(8):2964-9. Epub 2005 Feb 9.

Genetics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0405578102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549443PMC
February 2005

A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands.

J Mol Diagn 2004 Aug;6(3):205-10

Departamento de Patologia Morfológica, Instituto Português de Oncologia, Rua Prof. Lima Basto, 1099-023 Lisboa, Portugal.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867632PMC
http://dx.doi.org/10.1016/S1525-1578(10)60511-9DOI Listing
August 2004

Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas.

Cancer Genet Cytogenet 2004 Jul;152(1):15-22

Genetics Branch, National Cancer Institute, NNMC, 8901 Wisconsin Avenue, Bldg. 8, Room 5101, Bethesda, MD 20889-5105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080300460
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http://dx.doi.org/10.1016/j.cancergencyto.2003.10.007DOI Listing
July 2004

Karyotypic complexity of the NCI-60 drug-screening panel.

Cancer Res 2003 Dec;63(24):8634-47

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889-5105, USA.

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December 2003

Weak platelet agonists and U46619 induce apoptosis-like events in platelets, in the absence of phosphatidylserine exposure.

Thromb Res 2002 Sep;107(6):345-50

American Red Cross, Jerome H Holland Laboratories, Rockville, MD 20855, USA.

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http://dx.doi.org/10.1016/s0049-3848(02)00338-9DOI Listing
September 2002

t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.

Nat Genet 2003 Feb 21;33(2):208-13. Epub 2003 Jan 21.

Genetics Branch, Center for Cancer Research, National Cancer Institute and the National Naval Medical Center, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1038/ng1083DOI Listing
February 2003

Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability.

Neoplasia 2002 Jan-Feb;4(1):19-31

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889-5105, USA.

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http://dx.doi.org/10.1038/sj.neo.7900197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1503315PMC
July 2002