Publications by authors named "Giovanni Perini"

62Publications

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

Oncotarget 2018 04 17;9(29):20323-20338. Epub 2018 Apr 17.

Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.24859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945521PMC
April 2018

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

Biochim Biophys Acta Gene Regul Mech 2018 Mar 3;1861(3):235-245. Epub 2018 Feb 3.

Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; Health Sciences and Technology - Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Ozzano Emilia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.01.007DOI Listing
March 2018

Transcriptional and epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that govern muscle dystrophin expression.

Biochim Biophys Acta Gene Regul Mech 2017 Nov 1;1860(11):1138-1147. Epub 2017 Sep 1.

Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; CIRI Health Sciences & Technologies (HST), Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2017.08.010DOI Listing
November 2017

Letting the breaks off MYCN.

Cell Death Differ 2016 12 14;23(12):1904-1905. Epub 2016 Oct 14.

Cancer Research, Department of Cell Biology, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/cdd.2016.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136483PMC
December 2016

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Hum Mol Genet 2016 09 27;25(18):3887-3907. Epub 2016 Jul 27.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy

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http://dx.doi.org/10.1093/hmg/ddw231DOI Listing
September 2016

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Cancer Res 2015 Dec 15;75(23):5143-54. Epub 2015 Oct 15.

Children's Cancer Institute Australia, Randwick, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0423DOI Listing
December 2015

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.

Cancer Lett 2015 Jul 2;363(1):37-45. Epub 2015 Apr 2.

Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.044DOI Listing
July 2015

Myc proteins in cell biology and pathology.

Biochim Biophys Acta 2015 May 20;1849(5):467-8. Epub 2014 Dec 20.

Department of Pharmacy and Biotechnology, University of Bologna, via F. Selmi 3, 40126 Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.12.006DOI Listing
May 2015

Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas.

Genes Chromosomes Cancer 2015 Mar 25;54(3):156-67. Epub 2014 Nov 25.

Department of Biology, University of Bari, Bari, Italy; Department of Clinical Genetics, University and Regional Laboratories, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/gcc.22228DOI Listing
March 2015

Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression.

J Natl Cancer Inst 2014 Jul 6;106(7). Epub 2014 Jun 6.

Affiliations of authors: Children's Cancer Institute Australia for Medical Research, Randwick NSW, Australia (PYL, GMM, AET, MW, BL, BBC, MK, TL); Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy (DE, GM, GP); Kids Cancer Centre, Sydney Children's Hospital, Randwick NSW, Australia (GMM); Department of Pathology and Inflammation and Infection Research Centre, University of New South Wales, Kensington 2052, Australia (PP); Institute of Molecular Medicine, Martin Luther University, ZAMED, Halle, Germany (JLB, SH); School of Medicine and Public Health, Priority Research Centre for Cancer Research, University of Newcastle, Callaghan NSW, Australia (XDZ); Harry Perkins Institute of Medical Research, Centre for Medical Research, University of Western Australia, Nedlands WA, Australia (AF); Kinghorn Cancer Centre and Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst NSW, Australia (AS); St Vincent's Clinical School, University of New South Wales, Darlinghurst NSW, Australia (AS, JSM, MED); Australian Centre for Nanomedicine, Randwick NSW, Australia (MK); Garvan Institute of Medical Research, Darlinghurst NSW, Australia (AS, JSM, MED); School of Women's & Children's Health, University of New South Wales, Randwick NSW, Australia (TL).

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/dju113DOI Listing
July 2014

Cancer mortality among psychiatric patients treated in a community-based system of care: a 25-year case register study.

Soc Psychiatry Psychiatr Epidemiol 2014 May 5;49(5):693-701. Epub 2013 Oct 5.

Section of Psychiatry and Section of Clinical Psychology, Department of Public Health and Community Medicine, Policlinico GB Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.

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http://dx.doi.org/10.1007/s00127-013-0765-0DOI Listing
May 2014

Non-coding RNAs in muscle dystrophies.

Int J Mol Sci 2013 Sep 30;14(10):19681-704. Epub 2013 Sep 30.

Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.

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http://dx.doi.org/10.3390/ijms141019681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821580PMC
September 2013

MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin.

Front Oncol 2013 11;3:42. Epub 2013 Mar 11.

Department of Pharmacy and Biotechnology, University of Bologna Bologna, Italy ; Health Sciences and Technologies - Interdepartmental Center for Industrial Research University of Bologna Bologna, Italy.

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http://dx.doi.org/10.3389/fonc.2013.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593680PMC
March 2013

Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications.

J Biol Chem 2013 Mar 28;288(12):8332-41. Epub 2013 Jan 28.

Molecular Haematology and Cancer Biology Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M113.454280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605651PMC
March 2013

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.

Biochim Biophys Acta 2012 Nov-Dec;1819(11-12):1173-85. Epub 2012 Aug 19.

Department of Pharmacy and Biotechnology, University of Bologna, Italy.

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http://dx.doi.org/10.1016/j.bbagrm.2012.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787793PMC
February 2013

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

Cancer Res 2012 Feb 27;72(4):845-53. Epub 2011 Dec 27.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1885DOI Listing
February 2012

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

J Natl Cancer Inst 2011 Aug 28;103(16):1236-51. Epub 2011 Jul 28.

Experimental Therapeutics and Molecular Diagnostics Program, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, P.O. Box 81, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1093/jnci/djr256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156802PMC
August 2011

p53 is a direct transcriptional target of MYCN in neuroblastoma.

Cancer Res 2010 Feb 9;70(4):1377-88. Epub 2010 Feb 9.

Northern Institute for Cancer Research, Newcastle University, Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4H, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-2598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875109PMC
February 2010

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.

Proc Natl Acad Sci U S A 2007 Nov 14;104(47):18682-7. Epub 2007 Nov 14.

Children's Cancer Institute Australia for Medical Research and Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, High Street, Randwick, Sydney, New South Wales 2031, Australia.

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http://dx.doi.org/10.1073/pnas.0705524104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141837PMC
November 2007

In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation.

Proc Natl Acad Sci U S A 2005 Aug 10;102(34):12117-22. Epub 2005 Aug 10.

Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.

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http://dx.doi.org/10.1073/pnas.0409097102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184034PMC
August 2005

In vivo functional dissection of human inner kinetochore protein CENP-C.

J Struct Biol 2002 Oct-Dec;140(1-3):39-48

Department of Biology, University of Bologna, via Selmi 3, Bologna, Italy.

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http://dx.doi.org/10.1016/s1047-8477(02)00506-3DOI Listing
June 2003

Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation.

J Biol Chem 2002 Dec 3;277(51):49896-902. Epub 2002 Oct 3.

Department of Biology, Luigi Galvani Interdepartmental Center, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M206177200
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http://dx.doi.org/10.1074/jbc.M206177200DOI Listing
December 2002

CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains.

J Cell Sci 2002 Jun;115(Pt 11):2317-27

Department of Biology, University of Bologna, via Selmi 3, 40126 Bologna, Italy.

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June 2002