Giovanni Maga

Giovanni Maga

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Giovanni Maga

Publications by authors named "Giovanni Maga"

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Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation.

Antiviral Res 2019 Nov 27;171:104593. Epub 2019 Aug 27.

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2019.104593DOI Listing
November 2019

From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.

Future Med Chem 2019 Jun 28;11(11):1357-1381. Epub 2019 Feb 28.

Department of DNA Enzymology & Molecular Virology, Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.4155/fmc-2018-0451DOI Listing
June 2019

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.

J Med Chem 2019 03 21;62(5):2333-2347. Epub 2019 Feb 21.

Dipartimento Biotecnologie, Chimica e Farmacia , Università degli Studi di Siena , Via A. De Gasperi 2 , I-53100 Siena , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01403DOI Listing
March 2019

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.

Bioorg Med Chem Lett 2018 11 20;28(21):3454-3457. Epub 2018 Sep 20.

Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology Temple University, BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, PA 19122, United States; Lead Discovery Siena S.r.l., Via Vittorio Alfieri 31, 53019 Castelnuovo Berardenga, Siena, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183075
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http://dx.doi.org/10.1016/j.bmcl.2018.09.024DOI Listing
November 2018

Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.

ChemMedChem 2018 07 1;13(14):1371-1376. Epub 2018 Jun 1.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy.

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http://dx.doi.org/10.1002/cmdc.201800178DOI Listing
July 2018

Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis.

Chem Res Toxicol 2017 11 8;30(11):1936-1941. Epub 2017 Sep 8.

DNA Enzymology & Molecular Virology and Cell Nucleus & DNA replication Units, Institute of Molecular Genetics IGM-CNR , via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00152DOI Listing
November 2017

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

J Med Chem 2017 08 5;60(15):6528-6547. Epub 2017 Jul 5.

Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma , Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01906DOI Listing
August 2017

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?

Biochem J 2017 04 26;474(10):1559-1577. Epub 2017 Apr 26.

DNA Enzymology & Molecular Virology Unit, Institute of Molecular Genetics - CNR, via Abbiategrasso 207, Pavia 27100, Italy

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http://dx.doi.org/10.1042/BCJ20160772DOI Listing
April 2017

Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.

Nucleic Acids Res 2017 03;45(5):2600-2614

DNA Enzymology & Molecular Virology and Cell Nucleus & DNA replication Units, Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1093/nar/gkw1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389505PMC
March 2017

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma.

Eur J Med Chem 2017 Feb 19;127:369-378. Epub 2016 Dec 19.

Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.12.036DOI Listing
February 2017

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line.

Eur J Med Chem 2016 Nov 19;123:1-13. Epub 2016 Jul 19.

Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2016.07.034DOI Listing
November 2016

The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design.

Bioorg Med Chem 2016 10 2;24(19):4555-4562. Epub 2016 Aug 2.

Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.07.059DOI Listing
October 2016

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.

Bioorg Med Chem Lett 2016 08 18;26(15):3436-40. Epub 2016 Jun 18.

Dipartimento di Farmacia, Università degli Studi di Genova, Viale Benedetto XV, 3, 16132 Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.051DOI Listing
August 2016

DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.

Genes (Basel) 2016 Aug 31;7(9). Epub 2016 Aug 31.

Institute of Molecular Genetics, IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.3390/genes7090057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042388PMC
August 2016

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.

Proc Natl Acad Sci U S A 2016 May 26;113(19):5388-93. Epub 2016 Apr 26.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, I-53100 Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122; Lead Discovery Siena S.r.l., Castelnuovo Berardenga, 53019 Siena, Italy

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http://dx.doi.org/10.1073/pnas.1522987113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868442PMC
May 2016

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.

Nat Commun 2016 Feb 26;7:10805. Epub 2016 Feb 26.

DNA Enzymology &Molecular Virology Unit, Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1038/ncomms10805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773436PMC
February 2016

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors.

J Chem Inf Model 2015 Nov 6;55(11):2443-54. Epub 2015 Nov 6.

Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , Via A. De Gasperi 2, I-53100 Siena, Italy.

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http://pubs.acs.org/doi/10.1021/acs.jcim.5b00419
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http://dx.doi.org/10.1021/acs.jcim.5b00419DOI Listing
November 2015

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.

Eur J Med Chem 2015 Sep 8;102:648-60. Epub 2015 Aug 8.

Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Cagliari, Cittadella Universitaria, s.p. 8, Km 0.700, I-09042 Monserrato, Cagliari, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2015.08.009DOI Listing
September 2015

Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1.

DNA Repair (Amst) 2015 May 29;29:101-11. Epub 2015 Jan 29.

Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, Pavia I-27100, Italy.

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http://dx.doi.org/10.1016/j.dnarep.2015.01.005DOI Listing
May 2015

HCV-targeted antivirals: current status and future challenges.

Curr Pharm Des 2014 ;20(21):3445-64

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università di Siena, via Aldo Moro 2, 53100, Siena (Italy).

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http://dx.doi.org/10.2174/13816128113199990630DOI Listing
March 2015

Foreword: "new targets and new drugs: from in silico planning to in vivo testing".

Authors:
Giovanni Maga

Curr Pharm Biotechnol 2013 ;14(5):475-6

Institute of Molecular Genetics IGM-CNR via Abbiategrasso 207, I-27100, Pavia Italy.

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http://dx.doi.org/10.2174/138920101405131111103331DOI Listing
October 2014

The power of enzyme kinetics in the drug development process.

Curr Pharm Biotechnol 2013 ;14(5):551-60

Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100, Pavia, Italy.

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http://dx.doi.org/10.2174/138920101405131111105023DOI Listing
October 2014

The Arabidopsis STRESS RESPONSE SUPPRESSOR DEAD-box RNA helicases are nucleolar- and chromocenter-localized proteins that undergo stress-mediated relocalization and are involved in epigenetic gene silencing.

Plant J 2014 Jul 27;79(1):28-43. Epub 2014 May 27.

French Associates Institute for Agriculture and Biotechnology of Drylands, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, 84990, Israel.

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http://dx.doi.org/10.1111/tpj.12533DOI Listing
July 2014

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

Eur J Med Chem 2014 Jun 12;80:101-11. Epub 2014 Apr 12.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.027DOI Listing
June 2014

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

ACS Comb Sci 2014 Apr 18;16(4):168-75. Epub 2014 Mar 18.

Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/co500004eDOI Listing
April 2014

DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18850-5. Epub 2013 Nov 4.

Institute of Molecular Genetics-Consiglio Nazionale delle Ricerche, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1073/pnas.1308760110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839753PMC
November 2013

Cytotoxicity of α-dicarbonyl compounds submitted to in vitro simulated digestion process.

Food Chem 2013 Oct 10;140(4):654-9. Epub 2012 Nov 10.

Institute of Molecular Genetics, IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.foodchem.2012.10.063DOI Listing
October 2013

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.

ChemMedChem 2013 Aug 28;8(8):1353-60. Epub 2013 Jun 28.

Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. De Gasperi 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.201300204DOI Listing
August 2013

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.

ACS Med Chem Lett 2013 Jul 20;4(7):622-6. Epub 2013 May 20.

Dipartimentodi Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy ; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University , BioLife Science Building, Suite 333, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, United States.

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http://dx.doi.org/10.1021/ml4000782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027536PMC
July 2013

Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.

ACS Chem Biol 2013 Feb 7;8(2):336-44. Epub 2012 Nov 7.

Institute of Molecular Genetics IGM-CNR , via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1021/cb300542kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574196PMC
February 2013

New in silico and conventional in vitro approaches to advance HIV drug discovery and design.

Expert Opin Drug Discov 2013 Jan 20;8(1):83-92. Epub 2012 Nov 20.

Institute of Molecular Genetics, IGM-CNR, DNA Enzymology & Molecular Virology, Pavia, Italy.

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http://dx.doi.org/10.1517/17460441.2013.741118DOI Listing
January 2013

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.

J Med Chem 2012 Jul 6;55(14):6634-8. Epub 2012 Jul 6.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm300477hDOI Listing
July 2012

2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.

J Med Chem 2012 Apr 26;55(7):3558-62. Epub 2012 Mar 26.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1021/jm201308vDOI Listing
April 2012

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

Bioorg Med Chem 2012 Jan 3;20(2):866-76. Epub 2011 Dec 3.

Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, 06123 Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.11.061DOI Listing
January 2012

A new proofreading mechanism for lesion bypass by DNA polymerase-λ.

EMBO Rep 2011 Dec 23;13(1):68-74. Epub 2011 Dec 23.

Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1038/embor.2011.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246252PMC
December 2011

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.

ChemMedChem 2011 Nov 30;6(11):2009-18. Epub 2011 Aug 30.

Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milan, Via G. Venezian 21, 20133 Milano, Italy.

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http://dx.doi.org/10.1002/cmdc.201100304DOI Listing
November 2011

Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.

Antivir Chem Chemother 2011 Nov 17;22(3):107-18. Epub 2011 Nov 17.

Department of DNA Enzymology and Molecular Virology, Institute of Molecular Genetics-National Research Council, IGM-CNR, Pavia, Italy.

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http://dx.doi.org/10.3851/IMP1855DOI Listing
November 2011

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

Bioorg Med Chem Lett 2011 Oct 29;21(19):5928-33. Epub 2011 Jul 29.

Dipartimento Farmaco Chimico Tecnologico, University of Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2011.07.079DOI Listing
October 2011

DNA replication and repair bypass machines.

Curr Opin Chem Biol 2011 Oct 1;15(5):627-35. Epub 2011 Sep 1.

Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.cbpa.2011.08.009DOI Listing
October 2011

Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents.

Molecules 2011 Sep 16;16(9):7994-8019. Epub 2011 Sep 16.

DNA Enzymology & Molecular Virology, Insititute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.3390/molecules16097994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264456PMC
September 2011

2,3-Dihydro-1,2-Diphenyl-substituted 4H-Pyridinone derivatives as new anti Flaviviridae inhibitors.

Chem Biol Drug Des 2011 Jun 17;77(6):441-9. Epub 2011 Mar 17.

Dipartimento di Chimica, Università di Salerno, Italy Dipartimento di Scienze Farmaceutiche, Università di Salerno, 84084 Fisciano (SA), Italy.

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http://dx.doi.org/10.1111/j.1747-0285.2011.01102.xDOI Listing
June 2011

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.

Bioorg Med Chem Lett 2011 May 6;21(9):2776-9. Epub 2010 Sep 6.

European Research Centre for Drug Discovery and Development, Università di Siena, via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.002DOI Listing
May 2011

Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.

J Med Chem 2011 Apr 25;54(8):3091-6. Epub 2011 Mar 25.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, Roma, Italy.

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http://dx.doi.org/10.1021/jm101626cDOI Listing
April 2011

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.

J Med Chem 2011 Mar 2;54(6):1587-98. Epub 2011 Mar 2.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm101614jDOI Listing
March 2011

DNA polymerases and mutagenesis in human cancers.

Subcell Biochem 2010 ;50:165-88

Istituto di Genetica Molecolare IGM-CNR, Consiglio Nazionale delle Ricerche, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1007/978-90-481-3471-7_9DOI Listing
June 2010

Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation.

Antiviral Res 2010 Jun 20;86(3):268-75. Epub 2010 Mar 20.

Department of DNA Enzymology and Molecular Virology, Institute of Molecular Genetics-National Research Council, IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.antiviral.2010.03.008DOI Listing
June 2010

DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures.

Biochemistry 2010 Jun;49(22):4695-704

Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.

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http://dx.doi.org/10.1021/bi901792cDOI Listing
June 2010

Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms.

Bioorg Med Chem 2010 Jun 18;18(11):3999-4008. Epub 2010 Apr 18.

Institute of Molecular Genetics IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.04.024DOI Listing
June 2010

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate.

Viruses 2010 Apr 30;2(4):880-99. Epub 2010 Mar 30.

Istituto di Genetica Molecolare, IGM-CNR, Via Abiategrasso 207, 27100 Pavia, Italy; E-Mail: (G.M.).

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http://www.mdpi.com/1999-4915/2/4/880
Publisher Site
http://dx.doi.org/10.3390/v2040880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185657PMC
April 2010

Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action.

Angew Chem Int Ed Engl 2010 Mar;49(10):1805-8

Architecture et réactivité de l'ARN, Université de Strasbourg, CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1002/anie.200905651DOI Listing
March 2010

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorg Med Chem 2010 Feb 4;18(4):1702-10. Epub 2010 Jan 4.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1016/j.bmc.2009.12.059DOI Listing
February 2010

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.

Eur J Med Chem 2009 Sep 8;44(9):3712-7. Epub 2009 Apr 8.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S022352340900196
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2009.03.039DOI Listing
September 2009

3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors.

ChemMedChem 2009 Jun;4(6):976-87

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1002/cmdc.200800441DOI Listing
June 2009

The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1.

J Biol Chem 2009 May 27;284(21):14267-75. Epub 2009 Mar 27.

Institute of Molecular Genetics National Research Council, via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1074/jbc.M900759200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682875PMC
May 2009

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor.

J Med Chem 2009 May;52(10):3354-65

Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo, 1, 06123 Perugia, Italy.

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May 2009

Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors.

Bioorg Med Chem Lett 2009 Mar 9;19(5):1512-6. Epub 2009 Jan 9.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2009.01.005DOI Listing
March 2009

Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.

Antiviral Res 2009 Jan 5;81(1):47-55. Epub 2008 Nov 5.

Department of DNA Enzymology and Molecular Virology, Institute of Molecular Genetics, National Research Council, IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.antiviral.2008.09.008DOI Listing
January 2009

Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.

Proc Natl Acad Sci U S A 2008 Dec 22;105(52):20689-94. Epub 2008 Dec 22.

Institute of Molecular Genetics, Consiglio Nazionale delle Ricerche, Via Abbiategrasso 207, I-27100 Pavia, Italy.

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http://dx.doi.org/10.1073/pnas.0811241106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634905PMC
December 2008

AKAP149 binds to HIV-1 reverse transcriptase and is involved in the reverse transcription.

J Mol Biol 2008 Nov 29;383(4):783-96. Epub 2008 Aug 29.

Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.

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http://dx.doi.org/10.1016/j.jmb.2008.08.055DOI Listing
November 2008

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.

Bioorg Med Chem Lett 2008 Nov 23;18(21):5777-80. Epub 2008 Sep 23.

Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.09.070DOI Listing
November 2008

N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.

Bioorg Med Chem Lett 2008 Aug 28;18(15):4328-31. Epub 2008 Jun 28.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, I-53100, Siena, Italy.

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August 2008