Giovanni Cazzaniga

Giovanni Cazzaniga

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Giovanni Cazzaniga

Giovanni Cazzaniga

Publications by authors named "Giovanni Cazzaniga"

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Next-generation sequencing of PTEN mutations for monitoring minimal residual disease in T-cell acute lymphoblastic leukemia.

Pediatr Blood Cancer 2019 Oct 1:e28025. Epub 2019 Oct 1.

Department of Woman's and Child's Health, University-Hospital of Padua, Padua, Italy.

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http://dx.doi.org/10.1002/pbc.28025DOI Listing
October 2019

Activin A contributes to the definition of a pro-oncogenic bone marrow microenvironment in t(12;21) preleukemia.

Exp Hematol 2019 May 28;73:7-12.e4. Epub 2019 Feb 28.

Centro Ricerca Tettamanti, Pediatric Department, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.02.006DOI Listing
May 2019

Engineered T cells towards TNFRSF13C (BAFFR): a novel strategy to efficiently target B-cell acute lymphoblastic leukaemia.

Br J Haematol 2018 09 18;182(6):939-943. Epub 2017 Aug 18.

Centro Ricerca Tettamanti, Clinica Pediatrica, Università degli Studi di Milano-Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza, Italy.

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http://dx.doi.org/10.1111/bjh.14899DOI Listing
September 2018

TNFRSF13C (BAFFR) positive blasts persist after early treatment and at relapse in childhood B-cell precursor acute lymphoblastic leukaemia.

Br J Haematol 2018 08 1;182(3):434-436. Epub 2017 Jun 1.

Centro Ricerca Tettamanti, Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca, Fondazione MBBM, Monza, Italy.

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http://dx.doi.org/10.1111/bjh.14794DOI Listing
August 2018

IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.

J Clin Oncol 2018 04 2;36(12):1240-1249. Epub 2018 Mar 2.

Martin Stanulla, Elif Dagdan, Stefanie V. Junk, Laura Hinze, Norman Klein, Christian P. Kratz, Petra Dörge, Doris Steinemann, and Martin Zimmermann, Hannover Medical School; Petra Dörge, German Center for Infection Research, Hannover; Anja Möricke, Kirsten Bleckmann, Denis Schewe, Gunnar Cario, and Martin Schrappe, University Hospital Schleswig-Holstein; Britt-Sabina Petersen and Andre Franke, Kiel University, Kiel; Cornelia Eckert and Stefanie Groeneveld-Krentz, Charité University Hospital; Wolf-Dieter Ludwig, HELIOS-Clinic Berlin-Buch, Berlin; Rolf Koehler, Claus R. Bartram, Andreas Kulozik, and Martina U. Muckenthaler, University of Heidelberg, Heidelberg; Arndt Borkhardt, Heinrich-Heine University, Düsseldorf, Germany; Marketa Zaliova, Charles University and University Hospital Motol, Prague, Czech Republic; Chiara Palmi, Giovanni Cazzaniga, and Andrea Biondi, Azienda Ospedaliera San Gerardo; Maria Grazia Valsecchi, University of Milano-Bicocca, Monza; Geertruy te Kronnie and Giuseppe Basso, University of Padova, Padua, Italy; Jean-Pierre Bourquin and Beat Bornhauser, University Children's Hospital Zurich, Zurich, Switzerland; Shai Izraeli, Sheba Medical Center Tel-Hashomer and Tel Aviv University, Tel Aviv, Israel; Oskar A. Haas and Renate Panzer-Grümayer, St Anna Kinderkrebsforschung and Medical University Vienna, Vienna, Austria; Hélène Cavé, Robert Debré Hospital and Paris-Diderot University, Paris, France; and Richard S. Houlston, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.74.3617DOI Listing
April 2018

DNA variants in DHFR gene and response to treatment in children with childhood B ALL: revisited in AIEOP-BFM protocol.

Pharmacogenomics 2018 Jan 6;19(2):105-112. Epub 2017 Dec 6.

Charles-Bruneau Cancer Center, CHU Sainte-Justine Research Center, Montreal, QC, H3T1C5, Canada.

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http://dx.doi.org/10.2217/pgs-2017-0153DOI Listing
January 2018

Impairment of Retinoic Acid Signaling in Cornelia de Lange Syndrome Fibroblasts.

Birth Defects Res 2017 Oct 28;109(16):1268-1276. Epub 2017 Jul 28.

Università degli Studi di Milano, Dipartimento di Scienze della Salute, Milan, Italy.

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http://dx.doi.org/10.1002/bdr2.1070DOI Listing
October 2017

Williams syndrome and mature B-Leukemia: A random association?

Eur J Med Genet 2016 Dec 19;59(12):634-640. Epub 2016 Oct 19.

Department of Pediatrics, University of Milan Bicocca, Fondazione MBBM, Monza, Italy; Department of Pediatrics, Presidio S. Fermo, ASST Lariana, Como, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2016.10.007DOI Listing
December 2016

Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia.

J Leukoc Biol 2016 06 1;99(6):1077-87. Epub 2016 Mar 1.

Institute for Research in Biomedicine, Bellinzona, Switzerland; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan, Italy; and Istituto Nazionale di Genetica Molecolare, Milan, Italy

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http://dx.doi.org/10.1189/jlb.5MA0915-394RDOI Listing
June 2016

Hodgkin lymphoma in a patient with mosaic trisomy 18: First clinical observation.

Am J Med Genet A 2016 Mar 24;170(3):777-80. Epub 2015 Dec 24.

Department of Pediatrics, Pediatric Genetic Unit, University of Milano-Bicocca, MBBM Foundation, Monza, Italy.

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http://dx.doi.org/10.1002/ajmg.a.37504DOI Listing
March 2016

Nodal monoclonal CD5-positive B-lymphocytosis and toxoplasma lymphadenitis: another variant in the spectrum of infectious lymphadenitis in patients with chronic leukemia/small lymphocytic lymphoma.

Expert Rev Hematol 2015 Oct 20;8(5):563-5. Epub 2015 Aug 20.

a 1 From the Department of Pathology, University Milan Bicocca, San Gerardo Hospital, Monza, Italy.

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http://dx.doi.org/10.1586/17474086.2015.1061281DOI Listing
October 2015

Risk factors for relapse in childhood acute lymphoblastic leukemia: prediction and prevention.

Expert Rev Hematol 2015 Feb 4;8(1):57-70. Epub 2014 Nov 4.

Division of Haematology/Oncology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1586/17474086.2015.978281DOI Listing
February 2015

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients.

Oncotarget 2015 Jan;6(3):1569-81

Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo/Fondazione MBBM, Monza 20900, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359315PMC
http://dx.doi.org/10.18632/oncotarget.2807DOI Listing
January 2015

Postinduction minimal residual disease monitoring by polymerase chain reaction in children with acute lymphoblastic leukemia.

J Clin Oncol 2014 Nov 6;32(31):3553-8. Epub 2014 Oct 6.

Maddalena Paganin, Giulia Fabbri, Katia Polato, and Giuseppe Basso, Università di Padova, Padova; Valentino Conter, Ospedale San Gerardo; Maria Grazia Valsecchi, Università di Milano Bicocca, Monza; Elena Barisone and Franca Fagioli, Ospedale Infantile Regina Margherita, Torino; Giovanni Cazzaniga, Università di Milano Bicocca, Milan; Eugenia Giraldi and Maurizio Aricò, Ospedale Papa Giovanni XXIII di Bergamo, Italy.

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http://dx.doi.org/10.1200/JCO.2014.56.0698DOI Listing
November 2014

Novel clinical trials for pediatric leukemias: lessons learned from genomic analyses.

Hematology Am Soc Hematol Educ Program 2013 ;2013:612-9

1Department of Pediatrics and Centro Ricerca Tettamanti, University of Milano-Bicocca, S. Gerardo Hospital, Fondazione MBBM, Monza, Italy.

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http://dx.doi.org/10.1182/asheducation-2013.1.612DOI Listing
July 2014

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia.

Blood 2014 Jul 1;124(1):106-10. Epub 2014 May 1.

Childhood Leukemia Research Institute, Edmond and Lily Safra Children Hospital, Sheba Medical Center, Ramat Gan, Israel; Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

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http://dx.doi.org/10.1182/blood-2013-10-529685DOI Listing
July 2014

Occult monoclonal B-cell disorder of hyoid bone.

Hematol Oncol 2014 Jun 20;32(2):107-9. Epub 2013 May 20.

Department of Pathology, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy.

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http://dx.doi.org/10.1002/hon.2077DOI Listing
June 2014

IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

Blood 2014 Mar 23;123(11):1691-8. Epub 2013 Dec 23.

Department of Pediatric Oncology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands;

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http://dx.doi.org/10.1182/blood-2013-06-509794DOI Listing
March 2014

The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia.

Genes Chromosomes Cancer 2013 Oct 26;52(10):954-60. Epub 2013 Jul 26.

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.

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http://dx.doi.org/10.1002/gcc.22090DOI Listing
October 2013

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.

Blood 2013 Jun 14;121(25):5064-7. Epub 2013 May 14.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2013-02-487256DOI Listing
June 2013

Developmental timing of mutations revealed by whole-genome sequencing of twins with acute lymphoblastic leukemia.

Proc Natl Acad Sci U S A 2013 Apr 8;110(18):7429-33. Epub 2013 Apr 8.

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1221099110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645544PMC
April 2013

Defining the correct role of minimal residual disease tests in the management of acute lymphoblastic leukaemia.

Br J Haematol 2011 Oct 4;155(1):45-52. Epub 2011 Aug 4.

M.Tettamanti Research Centre, Paediatric Clinic, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, Monza, Italy.

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http://doi.wiley.com/10.1111/j.1365-2141.2011.08795.x
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http://dx.doi.org/10.1111/j.1365-2141.2011.08795.xDOI Listing
October 2011

Predictive factors of relapse and survival in childhood acute myeloid leukemia: role of minimal residual disease.

Expert Rev Anticancer Ther 2011 Sep;11(9):1391-401

Department of Pediatrics, S. Gerardo Hospital, via Pergolesi 33, Monza, Italy.

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http://www.tandfonline.com/doi/full/10.1586/era.11.37
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http://dx.doi.org/10.1586/era.11.37DOI Listing
September 2011

IGH and IGK gene rearrangements as PCR targets for pediatric Burkitt's lymphoma and mature B-ALL MRD analysis.

Lab Invest 2009 Oct 10;89(10):1182-6. Epub 2009 Aug 10.

Clinica di Oncoematologia Pediatrica, Azienda Ospedaliera-Università di Padova, Padua, Italy.

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http://dx.doi.org/10.1038/labinvest.2009.81DOI Listing
October 2009

ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis.

Cancer Genet Cytogenet 2009 Sep;193(2):86-92

Pediatric Hematology-Oncology Program, National Cancer Institute, INCA, Rua André Cavalcanti, 37, 20231-050 Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.04.021DOI Listing
September 2009

The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.

J Clin Invest 2009 Apr 16;119(4):826-36. Epub 2009 Mar 16.

Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://www.jci.org/articles/view/36428
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http://dx.doi.org/10.1172/JCI36428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662549PMC
April 2009

PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells.

Cancer Res 2008 Jan;68(1):181-9

Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2778DOI Listing
January 2008

Monitoring of minimal residual disease in leukemia, advantages and pitfalls.

Ann Med 2006 ;38(7):512-21

Centro Ricerca M. Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza (Mi), Italy.

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http://dx.doi.org/10.1080/07853890600978123DOI Listing
March 2007

TEL/ARG induces cytoskeletal abnormalities in 293T cells.

Cancer Lett 2006 Sep 28;241(1):79-86. Epub 2005 Nov 28.

Centro Ricerca Tettamanti, Università di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.

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http://dx.doi.org/10.1016/j.canlet.2005.10.017DOI Listing
September 2006

The sensitivity of acute lymphoblastic leukemia cells carrying the t(12;21) translocation to campath-1H-mediated cell lysis.

Haematologica 2006 Mar;91(3):322-30

Laboratory of Cellular and Gene Therapy G. Lanzani, Division of Haematology, Ospedali Riuniti di Bergamo, Bergamo, Italy.

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March 2006

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype.

Blood 2005 Aug 3;106(4):1419-22. Epub 2005 May 3.

Centro Ricerca Tettamanti, Clinica Pediatrica University of Milano-Bicocca, Ospedale San Gerardo, 20052 Monza, Italy.

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http://dx.doi.org/10.1182/blood-2005-03-0899DOI Listing
August 2005