Publications by authors named "Giovanni Cannarozzo"

53 Publications

Is It Possible to Reshape the Body and Tone It at the Same Time? Schwarzy: The New Technology for Body Sculpting.

Bioengineering (Basel) 2022 Jun 28;9(7). Epub 2022 Jun 28.

Department of Biology, University of Florence, 50121 Florence, Italy.

In recent years, a strong desire for slimmer and healthier-looking bodies has grown in the population. The aim of this study was to evaluate the effectiveness and safeness of the new technology Flat Magnetic Stimulation for buttock and abdomen remodeling in athletic subjects. A total of 49 patients (31 females and 18 males) were enrolled. Patients' digital photos and buttocks/abdomen circumference measurements were taken to assess and monitor the effectiveness of treatment on muscle firming. The level of patient satisfaction was evaluated by a questionnaire based on a seven point Likert scale. Average scores were calculated at a 1-month follow-up (FU). A significant increase in the buttocks' mean circumference from 85.5 ± 0.7 cm to 88.5 ± 0.7 cm ( < 0.05) and in the abdomens' mean circumference from 76.5 ± 9.19 cm to 78 ± 9.89 cm ( < 0.05) was observed 1 month after the last treatment. All subjects reported that their buttocks and abdomens felt more lift and toned. The average abdomen and buttocks satisfaction scores improve significantly at 1-month FU. Our data show that FMS treatment could be used as an effective mechanism for muscle toning.
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http://dx.doi.org/10.3390/bioengineering9070284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311856PMC
June 2022

Neck Rejuvenation With a New Infrared Emission.

Dermatol Pract Concept 2022 May 1;12(2):e2022044. Epub 2022 Apr 1.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

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http://dx.doi.org/10.5826/dpc.1202a44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116521PMC
May 2022

Combination of Specific Vascular Lasers and Vascular Intense Pulsed Light Improves Facial Telangiectasias and Redness.

Medicina (Kaunas) 2022 May 11;58(5). Epub 2022 May 11.

Department of Systems Medicine, Tor Vergata University, 00100 Rome, Italy.

Facial telangiectasias are dilated blood vessels that can represent a cosmetic issue for patients. They may be associated with other conditions, such as rosacea. Laser and light treatments are nowadays becoming a cornerstone in the management of these lesions. In total, 68 patients seeking medical treatment for facial telangiectasias were enrolled from 1 March 2019 to 1 March 2020 at the Dermatological Unit of Magna Graecia University (Catanzaro, Italy). A protocol consisting of a 1064 Nd:YAG laser for darker blue telangiectasias and 532 nm Nd:YAG for red lesions followed by intense pulsed light with an optimized spectrum for vascular lesion 3 weeks after the first procedure was proposed. A three-month follow-up visit assessed patient's satisfaction using a visual analog scale (VAS). Two dermatologists measured clinical results using a 4-point scale, comparing pictures before treatment and at follow-up. A total of 68 patients (32 males and 36 females) completed the study, performing all requested treatments. No severe side effects were reported. Patient satisfaction was very high (8.15 ± 1.05 out of a 10-point VAS scale), as well as dermatologists' clinical evaluations (2.19 ± 0.74 out of 3). The combination of vascular lasers and Vascular Intense Pulsed Light acting specifically on small blood vessels may help to improve the aesthetic outcome, reducing side effects. A prospective study with a larger number of participants will be necessary to confirm this study's findings.
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http://dx.doi.org/10.3390/medicina58050651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147706PMC
May 2022

A New Protocol to Treat Abdominal Subcutaneous Fat Combining Microwaves and Flat magnetic stimulation.

Bioengineering (Basel) 2022 Apr 21;9(5). Epub 2022 Apr 21.

Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, 00100 Rome, Italy.

Background: A healthy lifestyle is not always able to improve the abdomen's appearance, especially in those patients who have undergone sudden weight changes.

Objective: We aimed at evaluating the efficacy of combined microwaves and flat magnetic stimulation (FMS) to treat abdominal localized adiposity and laxity.

Methods: Twenty-five patients were subjected to two treatment sessions per month on the abdominal area with microwaves. FMS was also performed twice per week, with a minimum of two days between each session for two months. The technology uses three types of different protocols: massage, muscle definition (shaping), and muscular strengthening. Measurements, including body mass index (BMI) and waist, and abdominal ultrasound were performed at baseline and three months after the last treatment session. Blood examinations were performed, and a 5-Likert scale questionnaire was used to assess patient satisfaction.

Results: At follow-up, three months after the last treatment, the mean waist circumference (WC) was significantly reduced, and skin laxity improved in all patients ( < 0.001). A significant improvement in abdominal muscle tissue thickness was also shown in all abdominal areas, and the thickness of the adipose tissue evaluated by ultrasound was reduced.

Conclusions: This study proves that the combination of microwaves and FMS treatment is secure and efficient for treating abdominal subcutaneous fat and skin laxity.
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http://dx.doi.org/10.3390/bioengineering9050182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137650PMC
April 2022

Clinical Evaluation on the Performance and Safety of a Non-Ablative Fractional 1340 nm Laser for the Treatment of Stretch Marks in Adolescents and Young Adults: A Case Series.

Bioengineering (Basel) 2022 Mar 25;9(4). Epub 2022 Mar 25.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

A large part of the world's population suffers from Striae distensae (SD) or stretch marks, which create physical and psychological discomfort in people. We evaluate the SD clinical improvement by using a non-ablative fractional Nd:YAP 1340 nm laser. The research was performed on 25 patients of both sexes, with a mean age of 31 ± 13.09 years. Each patient underwent from a minimum of 3 to a maximum of 4 treatments, with an Nd:YAP (1340 nm) medical device, every four weeks, with 3- and 6-month follow-up, in these areas: back, abdomen, breast, flanks, lower limbs, buttocks, and thighs. Manchester Scar Scale assessed stretch marks improvement. Side effects, patient pain, and SD overall appearance improvement were also recorded for all patients. Digital photographs measured the aesthetic results. Treatment was well-tolerated (pain score 1.08 ± 0.76) by all patients. There were no long-term side effects, and 88% of patients revealed an SD excellent improvement showing good aesthetic results achieved by the treatment. The total mean pretreatment Manchester Scar Scale score decreased from 13.80 (±1.58) to 10.36 (±1.70) after 3 months ( < 0.01) and to 8.36 (±1.07) after 6 months ( < 0.01). An Nd:YAP (1340 nm) laser seems to be a safe and effective treatment, showing a higher security profile with no side effects.
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http://dx.doi.org/10.3390/bioengineering9040139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027695PMC
March 2022

Non-epidermolytic palmoplantar keratoderma treated with blue LED light.

Photodermatol Photoimmunol Photomed 2022 Apr 1. Epub 2022 Apr 1.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.1111/phpp.12791DOI Listing
April 2022

Microwave Therapy for Cellulite: An Effective Non-Invasive Treatment.

J Clin Med 2022 Jan 20;11(3). Epub 2022 Jan 20.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Background: Cellulite represents a common cosmetic problem that affects nearly all women. This study aimed to evaluate microwave therapy's effectiveness for cellulite treatment.

Methods: In this study, 26 women showing severe or moderate cellulite underwent four sessions of microwave therapy on the buttocks and posterior thighs. The following assessments were performed at baseline and the three-month follow-up after the last treatment: the Cellulite Severity Scale (CSS), Nürnberger-Müller classification scale, photographic evaluation, and buttocks/posterior thighs circumference measurements. A Likert scale questionnaire was used to assess patient satisfaction at the 3-month follow-up.

Results: The treatment positively affected the cellulite severity as confirmed by the Cellulite Severity Scale (CSS) and Nürnberger-Müller classification scale results. CSS showed a significant amelioration in cellulite severity between the initial assessment and the 3-month follow-up for the buttocks and posterior thighs, with total average scores that ranged from 10.7 ± 3.1 to 4.5 ± 1.8 ( < 0.01). The treatment also resulted in a remarkable improvement in comfort/satisfaction and a buttocks and posterior thighs circumference reduction. No serious adverse events were observed.

Conclusions: Microwave therapy has proven to be a safe treatment for improving cellulite appearance and reducing body circumferences.
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http://dx.doi.org/10.3390/jcm11030515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836637PMC
January 2022

Fractional Micro-ablative CO2 Laser as Therapy in Penile Lichen Sclerosus.

J Lasers Med Sci 2021 18;12:e61. Epub 2021 Oct 18.

Department of Health Sciences, Unit of Dermatology, - Magna Graecia University, Catanzaro, Italy.

Topical steroids remain the first-line therapy to treat lichen sclerosus (LS), but circumcision may be curative in most cases. Positive results have been obtained by using a fractional micro-ablative CO2 laser to treat genital LS. This study aims to assess the safety and efficacy of the fractional micro-ablative CO2 laser in the treatment of penile LS. Five treatments with the fractional CO2 laser were performed on one 69-year-old man affected by penile LS. A significant improvement in symptomatology was noted after the first treatment session. Complete clinical remission was achieved 14 weeks after the last treatment. The fractional micro-ablative CO2 laser may represent a practical therapeutic approach in penile LS.
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http://dx.doi.org/10.34172/jlms.2021.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837861PMC
October 2021

Pulsed dye laser prior to CO laser ablation to treat multiple cutaneous neurofibromas in von Recklinghausen's disease: A case report.

Dermatol Ther 2022 04 10;35(4):e15355. Epub 2022 Feb 10.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.1111/dth.15355DOI Listing
April 2022

Sequential Use of CO Laser Prior to Nd:YAG and Dye Laser in the Management of Non-Facial Warts: A Retrospective Study.

Medicina (Kaunas) 2022 Jan 12;58(1). Epub 2022 Jan 12.

Department of Systems Medicine, Tor Vergata University, 00173 Rome, Italy.

: Warts are benign lesions of viral etiology characterized by a hyperkeratotic appearance tending to spread across the skin surface. Various treatments have been proposed to manage this condition, such as acids, imiquimod, photodynamic therapy, cryotherapy, and various lasers. In this paper, we describe a combination protocol using CO laser prior to Nd:YAG laser for lesions interesting the palmoplantar areas or dye laser for lesions on other skin surfaces in the management of non-facial warts resistant to traditional therapies. In total, 34 patients with 103 warts suffering from wart infection resistant to traditional therapies treated from 1 January 2019 to 1 June 2020 were retrospectively enrolled at the Dermatological Unit of Magna Graecia University (Catanzaro, Italy). Two dermatologists measured clinical results, classifying lesions with complete resolution, partial resolution, or non-responding. Patients at four months follow-up were asked to evaluate their degree of satisfaction with a visual analog scale (VAS). Almost all patients reported the complete resolution of lesions, with no patient reporting scarring. Five patients reported hypopigmentation in the treated areas. The mean satisfaction level was high. Only three patients experienced a relapse of the condition. Using a vascular laser following a CO superficial ablation of warts may help reduce the risk of scarring and decrease the incidence of relapses for lesions resistant to traditional therapies. Therefore, more extensive studies will be necessary to confirm the obtained results.
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http://dx.doi.org/10.3390/medicina58010115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780825PMC
January 2022

Erbium Laser for Skin Surgery: A Single-Center Twenty-Five Years' Experience.

Medicines (Basel) 2021 Nov 24;8(12). Epub 2021 Nov 24.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

 (1) Introduction: The Erbium laser is a very versatile laser system used in dermatology. Its ability to be almost selectively absorbed by water makes it a perfect device for managing various cutaneous skin conditions. (2) Methods: In this paper, we report our twenty-five years' experience with the Erbium laser. More than three thousand patients were treated for common skin disorders such as flat warts, seborrheic keratosis, xanthelasmas, and scars. (3) Results: A complete response was observed in 89.6%, without significant side effects. Local anesthesia was used in only a tiny percentage of patients. (4) Conclusions: This study confirms that the Erbium laser is a valuable and flexible procedure for laser surgery with excellent safety and short healing times.
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http://dx.doi.org/10.3390/medicines8120074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705569PMC
November 2021

Combined CO and dye laser technique in the treatment of outcomes due to flap necrosis after surgery for basal cell carcinoma on the nose.

Lasers Surg Med 2022 04 27;54(4):523-529. Epub 2021 Nov 27.

Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Background And Objective: Basal cell carcinoma (BCC) is the most frequent cutaneous cancer worldwide, and the nasal area is the most commonly affected region. Skin flaps are usually performed to achieve radical results, but various adverse events often occur. The necrosis of the skin flap is one of the most frequently observed, resulting in scars and anti-aesthetic outcomes. Ablative and non-ablative lasers have been proposed to improve scars resulting from surgical failure and skin flap necrosis.

Study Design/materials And Methods: This study aims to evaluate a new laser protocol combining ablative CO -laser with flashlamp pulsed dye laser for the treatment of nasal scars resulting from the necrosis of flap that occurred after surgery. Twelve patients were enrolled in the study, and a total of five laser sessions were planned, spaced from 14 days to 1 month apart.

Results: Seven out of 12 patients underwent all the five laser sessions planned, while 5/12 patients achieved optimal cosmetic results within the fourth session. Eighty percent of the patients reported good/optimal cosmetic results, and no significant side effects were observed during the study.

Conclusion: Combining fractionated CO laser with flashlamp pulsed dye laser represents a new effective modality for treating skin flap necrosis after BBC removal, representing a valid alternative to other surgical procedures.
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http://dx.doi.org/10.1002/lsm.23502DOI Listing
April 2022

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study.

Clin Pract 2021 Sep 23;11(4):708-714. Epub 2021 Sep 23.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.
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http://dx.doi.org/10.3390/clinpract11040086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544362PMC
September 2021

A giant epidermal nevus of the face treated with a CO and dye laser combination: a case report and literature review.

J Cosmet Laser Ther 2021 May 20;23(3-4):59-64. Epub 2021 Oct 20.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

Epidermal nevi (EN) are cutaneous hamartomas present at birth, usually occurs in the trunk, the face, or the limbs, appearing as a patch of overgrowing skin. They may be small and localized, but they may interest extensive areas of the body. A 20 years old man came to our attention for an EN interesting all the face. The treatment protocol consisted of a session of CO laser in order to vaporize thicker areas, followed by a session of dye laser on the area to prevent scarring. This treatment was performed under local anesthesia and sedation in three surgical sessions spaced 3 months from each other. Two sessions of dye laser spaced apart 6 months were performed during follow-up to further improve the esthetic outcome. The patient was followed for 2 years with no recurrence. Although surgery is still considered the gold standard in EN management, it is not always feasible. This novel combination technique can obtain optimal cosmetic results with no relapse within the period of follow up. Although further trials on a more significant number of patients are required, the combination of CO and dye laser promises to become a valid therapeutic alternative when treating giant EN of the face.
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http://dx.doi.org/10.1080/14764172.2021.1990962DOI Listing
May 2021

Management of laser treatments during the coronavirus disease 2019 pandemic: The Italian experience.

Clin Dermatol 2021 May-Jun;39(3):521-522. Epub 2021 Feb 16.

Dermatological Unit of "Magna Graecia" University, Catanzaro, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clindermatol.2021.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884231PMC
November 2021

Q-Switched 1064/532 nm Laser with Nanosecond Pulse in Tattoo Treatment: A Double-Center Retrospective Study.

Life (Basel) 2021 Jul 16;11(7). Epub 2021 Jul 16.

Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.

Tattoo removal is a well-established procedure in dermatology. Lasers represent the gold standard in the management of this condition nowadays. In this study, we report our experience on the use of a Q-switched nanosecond source. A total of 52 patients were consecutively enrolled in performing tattoo removal at Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Black and blue tattoos were treated with a 1064 nm laser, with a pulse duration of 6 ns and a fluence up to 10 J/cm, while colored tattoos were treated with sessions of 532 nm laser, with a pulse duration of 6 ns and a fluence up to 5 J/cm. Up to nine treatments with a minimum interval of 8 weeks between each session were performed. A six-month follow-up visit assessed patient satisfaction (Visual Analogue Scale). Overall clinical result was assessed with a clinical evaluation by two blinded dermatologists using a 5-point scale, comparing pictures before treatment and at follow up. A total of 52 patients were included and analyzed: 30 females (57.7%) and 22 males (42.3%). Mean age was 43.7 ± 12.7 years. According to Fitzpatrick's skin classification, 16 individuals (30.8%) were type II, 15 (28.8%) were type III, and 21 (40.4%) were type IV. Most of the treated tattoos were carried out by professionals. The mean number of sessions required to obtain a result was 4.6 ± 2.5, and the final tattoo removal rate was 60% or higher, with 51.9% of the patients reporting highest satisfaction scores Q-Switched 1064/532 nm laser may be considered today as the gold-standard treatment for tattoo removal. Our results confirm literature findings of the safety and effectiveness of these devices.
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http://dx.doi.org/10.3390/life11070699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304052PMC
July 2021

Histological Skin Changes After Treatment with 675 nm Laser.

Photobiomodul Photomed Laser Surg 2021 Sep 25;39(9):617-621. Epub 2021 May 25.

Unit of Dermatology, Department of Health Sciences, Magna Graecia University, Catanzaro, Italy.

To evaluate the histological effects of a new 675-nm laser device on the skin. Innovative technologies based on physical principles have been proposed in recent years to improve the treatment of aging skin. Laser technology is currently being studied for its potential in skin care treatments. A new 675-nm laser device is being used for the treatment of hyperpigmentation, scars, and various types of wrinkles. A 42-year-old man underwent a 675-nm RedTouch laser session for the treatment of aging signs on the neck. Two 2.5-mm biopsies were taken from the treated area and the adjacent area untreated with the laser, 45 days after the procedure. Comparison of the immunohistochemistry findings and assessment of the collagen and elastin fibers were performed by a board-certified dermatopathologist. Skin biopsies revealed histological changes that comprised proliferation of new collagen fibers in the treated area, when compared to that in the untreated areas. Histological analysis suggests that the 675-nm laser has a potential role in stimulating collagen remodeling, with a significant increase in thin and new collagen fibers.
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http://dx.doi.org/10.1089/photob.2020.4927DOI Listing
September 2021

Fractional CO laser-assisted topical rifamycin drug delivery in the treatment of pediatric cutaneous leishmaniasis.

Pediatr Dermatol 2021 May 25;38(3):717-720. Epub 2021 Apr 25.

Department of Health Sciences, University of Magna Graecia, Catanzaro, Italy.

Cutaneous leishmaniasis is challenging to treat. Various drugs have been proposed to manage this condition, with variable results. In this case report, we describe laser-assisted delivery of rifamycin to treat this infection. Two sessions of fractional CO laser were performed one month apart. Each was followed by a topical application of rifamycin for three days. Resolution with minimal scarring was obtained, suggesting this technique might be safe and effective in treating cutaneous leishmaniasis.
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http://dx.doi.org/10.1111/pde.14608DOI Listing
May 2021

Combination of Laser Therapy and Photodynamic Therapy with 5-Aminolevulinic Acid Patch for the Treatment of Actinic Cheilitis.

Photobiomodul Photomed Laser Surg 2021 Apr 16;39(4):303-307. Epub 2021 Mar 16.

Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.

Actinic cheilitis (AC) is a premalignant lesion of the lips that can evolve into squamous cell carcinoma. Among nonsurgical treatments, photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) patch might represent a new noninvasive therapeutic approach for AC. We sought to investigate the potential role of fractional CO laser pretreatment in boosting ALA penetration and distribution into AC treated with PDT. We report a case of a woman with AC on the lower lip, treated with ablative fractional CO laser to boost drug delivery of 5-ALA patch before PDT treatment. Reflectance confocal microscopy was performed to assess diagnosis and treatment response. We detected a good clinical and cosmetic outcome after two applications of combined treatment. Erythema, crust, and edema were reported as side effects. This case report shows that ablative fractional CO laser-assisted PDT might be an effective therapeutic alternative for patients with AC who refuse or are contraindicated for surgical procedures.
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http://dx.doi.org/10.1089/photob.2020.4853DOI Listing
April 2021

Nd:YAG laser in association with pulsed dye laser for the treatment of PHACES syndrome.

Dermatol Reports 2021 Mar 17;13(1):8751. Epub 2021 Mar 17.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

The acronym PHACES stands for posterior fossa malformations, hemangiomas, arterial anomalies (cardiovascular or cerebrovascular), coarctation of the aorta/cardiac defects, eye abnormalities, and sternal defects. The characteristic dermatological clinical manifestation of PHACES syndrome is a segmental and extensive hemangioma, usually on the face. A combined therapy with 1,064 nm Nd-YAG/595-nm pulsed dye laser was performed in a young 15-year-old patient with PHACES syndrome, who presented a hemangioma on the left side of the face, located in the periorbital region. A first session with Nd-YAG laser (2,5 mm spot size, fluence 100 J/cm, pulse duration 7 ms) for the treatment of teleangectasias and subsequently, three treatment sessions with pulsed dye laser (12 mm spot size, fluence 7 J/cm, pulse duration 0,5 ms, repetition rate 0,6 Hz), once every 2 months, were performed. No postoperative complications were recorded, except for transient purpura after the pulsed dye laser sessions. The vascular lesion had a decrease in size bigger than 75%, and these results was maintained 6 months after the last treatment. Combined therapy Nd- YAG/pulsed dye laser is an effective and noninvasive procedure for hemangiomas in patients with PHACES syndrome.
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http://dx.doi.org/10.4081/dr.2021.8751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018255PMC
March 2021

A New 675 nm Laser Device in the Treatment of Facial Aging: A Prospective Observational Study.

Photobiomodul Photomed Laser Surg 2021 Feb 15;39(2):118-122. Epub 2021 Jan 15.

Department of Dermatology, Magna Graecia University, Catanzaro, Italy.

To evaluate the effectiveness and safety of a 675 nm laser device in the treatment of facial aging. Wrinkles represent a major sign of aging skin and are considered a major topic in cosmetic dermatology, representing a common problem that negatively impacts patients' quality of life. Different types of treatments are currently available. The aim of this study was to assess the efficacy and safety of a new 675 nm laser source system on facial wrinkles. A total of 22 consecutive female (age 49.36 ± 8.72) patients, with Fitzpatrick skin types II-IV and facial wrinkles, were treated with three sessions of a 675 nm laser system. Efficacy of treatment was assessed using the Modified Fitzpatrick Wrinkles Scale pre and postoperatively before 3 months. All 22 patients treated with the 675 nm laser had a significant improvement of facial wrinkles according to the FWS (from 1.59 ± 0.80 to 1 ± 0.64;  ≤ 0.001). No side effects occurred except a mild erythematous rash in two patients. This novel 675 nm laser system can be considered a promising and effective tool in patients with facial wrinkles, and it involves a simple post-treatment management.
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http://dx.doi.org/10.1089/photob.2020.4908DOI Listing
February 2021

Combination of Fractional CO Laser and Rhodamine-Intense Pulsed Light in Facial Rejuvenation: A Randomized Controlled Trial.

Photobiomodul Photomed Laser Surg 2021 Feb 15;39(2):113-117. Epub 2021 Jan 15.

Unit of Dermatology, University of Rome, Tor Vergata, Rome, Italy.

This randomized controlled trial aims to verify the efficacy of a combined fractional CO laser and rhodamine-intense pulsed-light (r-IPL) protocol in the photoaging therapy. Skin aging is related to multiple environmental and genetic factors that give rise to different manifestations. In recent years many techniques have been proposed for the rejuvenation of the skin of the face such as ablative and nonablative procedures. Combination of laser or light sources with different wavelengths represents a safe and effective treatment method. r-IPL is a new pulsed-light technique capable to generate wavelengths varying from 550 to 650 nm proposed in nonablative photorejuvenation with a good efficacy and safety profile. Twenty-two patients (skin phototypes II-III, aged 46-67 years) were randomly allocated into two groups: group A was treated only with a therapeutic standard dose of the fractional CO laser, whereas group B was treated with a combined therapy of r-IPL and fractional CO laser. All patients were treated up to three times at a 2-month interval. Efficacy of the procedures was assessed thanks to the Fitzpatrick Wrinkle Severity Scale (scores 1-9) before treatment and at a 4-month follow-up from the last treatment. Patients treated with the combination of r-IPL and fractional CO laser showed better results in terms of wrinkle reduction according to the Fitzpatrick Wrinkle Severity score (2.82 ± 0.87 vs. 3.09 ± 1.14), with a statistically significant reduction in healing times (7.82 ± 0.75 vs. 13.82 ± 1.94 days,  ≤ 0.001) and duration of post-treatment erythema (3.55 ± 0.93 vs. 8.18 ± 1.47 days,  ≤ 0.001). Patient satisfaction was higher after combined fractional CO laser and r-IPL treatment. Our data suggest that combined use of fractional CO laser and r-IPL may lead to excellent results in terms of skin rejuvenation with a simple post-treatment management and an optimal tolerability.
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http://dx.doi.org/10.1089/photob.2020.4876DOI Listing
February 2021

CO Laser Treatment in Idiopathic Scrotal Calcinosis: A Case Series.

J Lasers Med Sci 2020 3;11(4):500-501. Epub 2020 Oct 3.

MD, Department of Dermatology, Magna Graecia University, Catanzaro, Italy 3.

Idiopathic scrotal calcinosis (ISC) is a benign and uncommon condition characterized by the presence of multiple and calcified nodules of the scrotum without disorders in the calcium/ phosphorous metabolism. The condition is usually asymptomatic. Various treatments are available. Surgery is the traditional treatment for ISC, as it allows a histopathological exam. However, newer treatments, such as ablative lasers, have been proposed with very good results. In this article, we report our experience in the treatment of ISC with a CO laser. Five patients affected by ISC were enrolled for CO laser treatment. All patients had excellent healing. Four patients reported minimal scarring. No bleeding was reported after the procedure. Two patients reported itching and were treated with oral antibiotics and antihistamine drugs. The CO super pulsed laser is a fast and effective way to treat ISC and may be an alternative to traditional surgery in this condition.
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http://dx.doi.org/10.34172/jlms.2020.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736950PMC
October 2020

A New 675 nm Laser Device in the Treatment of Melasma: Results of a Prospective Observational Study.

Photobiomodul Photomed Laser Surg 2020 Sep 21;38(9):560-564. Epub 2020 Aug 21.

Unit of Dermatology, University of Rome, Tor Vergata, Rome, Italy.

This study evaluates the efficacy and safety of a new 675 nm laser source system on melasma. Melasma is an acquired circumscribed hyperpigmented disorder that has a negative impact on patients' life quality. Different treatments are currently available. This study evaluates this new 675 nm laser source system, on melasma with the use of established parameters that guarantee minimum pain, the absence of side effects, and simplifying posttreatment management. A total of 25 subjects (all women, 21-50 years old), with facial melasma and Fitzpatrick skin types I-III, were treated with three sessions of a new 675 nm laser system. Efficacy of treatment was evaluated using Melasma Severity Index (MSI) score before and 3 months after the last session. The appearance of side effects has also been monitored to evaluate safety. A preclinical study was executed to evaluate laser effectiveness on sheep skin. All 25 subjects treated with the 675 nm laser had significant improvement in melasma according to MSI score (mean baseline MSI 26.4 ± 19.2; mean 3-month follow-up MSI 17.3 ± 15, : 0.003). Histology in preclinical study showed selective damage of melanin-rich areas. No side effects have been observed except some minor erythematous reactions in two patients. Due to its high affinity with melanin, and its minimal interaction with the vascular component, novel 675 nm laser may be considered promising when treating benign pigmented lesions with a low risk of side effects and simple posttreatment management.
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http://dx.doi.org/10.1089/photob.2020.4850DOI Listing
September 2020

Long-Term Follow-Up for Q-Switched Nd:YAG Treatment of Nevus of Ota: Are High Number of Treatments Really Required? A Case Report.

Photobiomodul Photomed Laser Surg 2021 Feb 5;39(2):137-140. Epub 2020 Aug 5.

Laser Unit, Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.

Q-switched laser is considered a gold standard treatment for Nevus of Ota (NO). We report how few laser sessions in long intervals of time may achieve satisfying outcomes reducing the rate of possible procedure-linked side effects such as burning, cornea injuries, or hyperpigmentation. NO represents a congenital dermal melanocytosis in the trigeminal distribution majorly occurring in Asian individuals. Multiple reports have shown efficacy and safety of Q-switched laser for the treatment of this condition, but they were based on an empiric regimen, often leading to unnecessary overtreatments. At the best of our knowledge, no long-term follow-up observations of single laser sessions have been conducted to assess the proper intervals and number of treatments. A 36-year-old Asian woman, Fitzpatrick skin type IV with clinical diagnosis of NO, was treated with 1064 nm 6 ns Q-switched laser one session per year for a total of two sessions. Clinical result was valued by two physicians independently using standardized and polarized light. No use of general anesthesia or sedation was needed in our experience. Corneal shields have been used. After only two sessions of the Q-switched laser performed 1 year apart, the result was excellent with a 95% of clinical response. No side effect was observed. In our experience, Q-switched Nd:YAG laser is an effective treatment for NO with no necessity of high number of treatments. A larger population is needed to confirm this preliminary result.
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http://dx.doi.org/10.1089/photob.2020.4812DOI Listing
February 2021

A new 675-nm laser device in the treatment of acne scars: an observational study.

Lasers Med Sci 2021 Feb 13;36(1):227-231. Epub 2020 Jun 13.

Unit of Dermatology, Department of Health Science, Magna Graecia University, Catanzaro, Italy.

Purpose: Acne scarring represents a common problem that negatively impacts patients' quality of life. Different types of treatments are currently available for this dermatological condition. This study evaluates the efficacy of a new 675-nm laser source system on acne scars with the use of established parameters that guarantee minimum pain and the absence of side effects such as hyperpigmentation, hypopigmentation, and blistering.

Methods: A total of 24 subjects (all women, aged 21-42 years), with Fitzpatrick skin types I-IV and facial acne scars, were treated with three sessions of a 675-nm laser system. Efficacy of treatment was evaluated using the Goodman and Baron's quantitative grading scale before and 3 months after the last treatment.

Results: All 24 patients treated with this new 675-nm laser had significant improvement of acne scars according to Goodman and Baron's Quantitative Global Acne Scarring Grading System. No side effect has been observed except some minor erythematous reactions in three patients.

Conclusion: The 675-nm laser system we used appears to be effective and well-tolerated in patients with acne scars, and it involves a simple post-treatment management.
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http://dx.doi.org/10.1007/s10103-020-03063-6DOI Listing
February 2021

Daylight photodynamic therapy with 5-aminolevulinic acid 5% gel for the treatment of mild-to-moderate inflammatory acne.

Ital J Dermatol Venerol 2021 02 12;156(1):46-50. Epub 2019 Sep 12.

Department of Health Sciences, Magna Græcia University, Catanzaro, Italy.

Background: Acne vulgaris is a chronic inflammatory disease that frequently occurs in adolescence. This common condition is often treated with topical or systemic therapies according to severity. Photodynamic therapy (PDT) with topical delta-aminolaevulinic acid is a novel drug-sparing, but time-consuming approach. Recently, sunlight exposure has been considered a quicker, safer, cheaper and more agreeable alternative light source for PDT, but efficacy has only been proven in the oncological field. This study aimed to evaluate the efficacy and tolerability of daylight PDT (DL-PDT) for the treatment of inflammatory acne vulgaris of face, chest and trunk lesions.

Methods: Twenty patients with mild-to-moderate acne vulgaris were enrolled and treated with a topical gel based on 5% delta-aminolaevulinic acid, administered 4 times at 14-day intervals. Efficacy was assessed with mean lesion count, Physician Global Assessment (PGA), Investigator's Global Assessment (IGA) and patients' self-assessment (10-point scale).

Results: Compared to T0, mean inflammatory lesions count decreased in all patients at FU1, from 16.7±4.4 to 5.2±3.3 (P). No adverse events were reported, and no patients were lost to follow-up. PGA results of "excellent" or "good" improvement were reported in 95% at T3 and 90% at FU1. Patients' self-assessments was 7.6±1.0 (T3). Discomfort was 0.5±0.2 (T3 and FU1).

Conclusions: DL-PDT seems to be an effective and tolerable therapy for the treatment of mild-to-severe inflammatory acne. This novel regimen seems to be a viable option in the panorama of acne therapies.
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http://dx.doi.org/10.23736/S2784-8671.19.06392-2DOI Listing
February 2021

New Insight in Noninvasive Rejuvenation: The Role of a Rhodamine-Intense Pulsed Light System.

Photobiomodul Photomed Laser Surg 2019 Sep 5;37(9):539-543. Epub 2019 Aug 5.

Department of Health Sciences, University of Catanzaro, Catanzaro, Italy.

Rhodamine-intense pulsed light (r-IPL) is a noncoherent, noncollimated, polychromatic light energy optimized for a double-peak wavelength emission, ranging between 550-680 and 850-1200 nm. Traditional IPL works within visible and infrared spectra, targeting hemoglobin and melanin, are effective to treat rosacea and pigmentary disorders. r-IPL, a new technology in dermatology, emits high-intensity light with a wavelength peak similar to the one of the pulsed dye lasers, showing a good safety and efficacy profile in nonablative photorejuvenation. Assess efficacy and safety of r-IPL on photodamaged facial skin showing hyperpigmentation, telangiectasias, fine lines, and textural changes. Five sessions of r-IPL treatment (fluence ranged between 13.5 and 14 J/cm) have been performed on one 75-year-old lady affected by facial photodamaged skin. Efficacy of treatment was evaluated using the Fitzpatrick Elastosis and Wrinkles Scale (FEWS) and the Global Aesthetic Improvement (GAI) Scale assessed by an investigator, compared with baseline. Treatment safety and tolerance were also evaluated using the Visual Analog Scale (VAS). Photographic and multispectral evaluation demonstrated relevant improvement (vascular, pigment, and texture) of photodamaged facial skin. One month after the last treatment, significant improvement in facial wrinkle and texture was noted. FEWS scores decreased significantly from 7 to 2. According to the GAI scale, the patient had an improvement in skin texture. Immediate response included mild-to-moderate erythema and only trace-mild edema in the treatment area. Pain during the treatment was minimal with a mean VAS pain score of 3/10. No other adverse events were reported. No post-treatment downtime was recorded. r-IPL may represent a valid therapeutic approach in noninvasive photorejuvenation.
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http://dx.doi.org/10.1089/photob.2019.4626DOI Listing
September 2019

Q-switched Nd:YAG laser for cosmetic tattoo removal.

Dermatol Ther 2019 09 23;32(5):e13042. Epub 2019 Aug 23.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

Laser is a widely accepted tool for tattoo removal, with standardized treatment protocols. Nevertheless, cosmetic tattoo removal may be challenging, because tattoos are performed in proximity of "sensitive" areas and because the ink used in cosmetic tattoos may contain substances that are not standardized and may modify their color at a high temperature. In this case series, we aim to evaluate the effectiveness of Q-switched (QS) Nd:YAG laser for cosmetic tattoo removal. Our study included 20 patients with cosmetic tattoos of lips, eyebrows, and eyeliners treated with QS Nd:YAG laser. Before treatment, an accurate preoperative assessment was performed, taking into account both patient and tattoo characteristics. Complete tattoo removal was obtained in all the cases and no major complications occurred. Adverse events were mild, mostly represented by erythema. All patients reported a high level of satisfaction. Selective photothermolysis enables complete tattoo removal, even in the case of cosmetic tattoos. However, cosmetic tattoos require a personalized treatment based on an accurate preoperative assessment which takes into account both patient and tattoo characteristics. QS Nd:YAG laser may be considered a good choice in the treatment of cosmetic tattoos, because it enables complete removal with acceptable secondary effects.
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http://dx.doi.org/10.1111/dth.13042DOI Listing
September 2019
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