Publications by authors named "Giovanna Zinzalla"

22Publications

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions.

Protein Sci 2020 04 13;29(4):1047-1053. Epub 2020 Jan 13.

Microbiology, Tumor and Cell Biology (MTC) Department, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/pro.3820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096718PMC
April 2020

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.

Biochemistry 2019 07 11;58(29):3144-3154. Epub 2019 Jul 11.

Microbiology, Tumor and Cell Biology (MTC) , Karolinska Institutet , Solnavägen 9 , 171 65 Stockholm , Sweden.

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http://dx.doi.org/10.1021/acs.biochem.9b00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791285PMC
July 2019

Targeting MYC: is it getting any easier?

Future Med Chem 2016 Oct 21;8(16):1899-1902. Epub 2016 Sep 21.

Karolinska Institutet - Microbiology, Tumor & Cell Biology, Nobels väg 16 Stockholm 171 77, Sweden.

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http://dx.doi.org/10.4155/fmc-2016-0119DOI Listing
October 2016

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.

Chembiochem 2016 Apr 28;17(8):677-82. Epub 2016 Jan 28.

Microbiology, Tumour and Cell Biology (MTC), and Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Tomtebodavägen 23A, Stockholm, 171 65, Sweden.

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http://dx.doi.org/10.1002/cbic.201500565DOI Listing
April 2016

Paving the way to targeting HECT ubiquitin ligases.

Future Med Chem 2015 29;7(16):2107-11. Epub 2015 Oct 29.

Microbiology, Tumor and Cell Biology (MTC) Department, and Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Tomtebodavägen 23, Stockholm 171 65, Sweden.

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http://dx.doi.org/10.4155/fmc.15.141DOI Listing
September 2016

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

Prog Biophys Mol Biol 2015 Oct 27;119(1):41-6. Epub 2015 Jun 27.

Department of Microbiology, Cell and Tumour Biology, and Science for Life Laboratory, Karolinska Institutet, Tomtebodavägen 23A, Stockholm 171 65, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2015.06.004DOI Listing
October 2015

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.

Structure 2015 Jul 11;23(7):1344-9. Epub 2015 Jun 11.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509781PMC
July 2015

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

Bioorg Med Chem Lett 2013 Aug 29;23(16):4719-22. Epub 2013 May 29.

University College London School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.066DOI Listing
August 2013

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry.

J Am Chem Soc 2012 Nov 12;134(47):19384-92. Epub 2012 Nov 12.

EastChem School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, UK.

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http://dx.doi.org/10.1021/ja306519hDOI Listing
November 2012

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition.

J Chem Inf Model 2012 May 3;52(5):1179-92. Epub 2012 May 3.

CRUK Biomolecular Structure Group, UCL School of Pharmacy, University College London, WC1N 1AX London, UK.

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http://dx.doi.org/10.1021/ci200625qDOI Listing
May 2012

A novel small-molecule inhibitor of IL-6 signalling.

Bioorg Med Chem Lett 2010 Dec 29;20(23):7029-32. Epub 2010 Sep 29.

Cancer Research UK Protein, The School of Pharmacy, University of London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.117DOI Listing
December 2010

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold.

Org Biomol Chem 2010 Dec 20;8(23):5294-303. Epub 2010 Sep 20.

Cancer Research UK Protein-Protein Interactions Drug Discovery Research Group, School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.

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http://dx.doi.org/10.1039/c0ob00327aDOI Listing
December 2010

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.

Chem Commun (Camb) 2010 Apr 25;46(13):2289-91. Epub 2010 Jan 25.

Cancer Research UK Protein-Protein Interactions Drug Discovery Research Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.

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http://dx.doi.org/10.1039/b924333jDOI Listing
April 2010

Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.

Future Med Chem 2009 Apr;1(1):65-93

The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.

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http://dx.doi.org/10.4155/fmc.09.12DOI Listing
April 2009

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives.

Org Biomol Chem 2006 May 21;4(10):1977-2002. Epub 2006 Apr 21.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.

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http://dx.doi.org/10.1039/b603015gDOI Listing
May 2006

Polymer-supported haloarene chromium dicarbonyl isonitrile complexes: a study of their synthesis and reactivity.

J Comb Chem 2003 Nov-Dec;5(6):809-13

Dipartimento di Chimica Organica e Industriale, Istituto di Scienze e Tecnologie Molecolari, Centro di Eccellenza CISI, University of Milan and CNR, Via C. Golgi 19, I-20133 Milan, Italy.

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http://dx.doi.org/10.1021/cc0340123DOI Listing
January 2004

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction.

Org Lett 2002 Nov;4(24):4341-4

CNR Istituto di Scienze e Tecnologie Molecolari e Dipartimento di Chimica Organica e Industriale, University of Milan, Via C. Golgi 19, I-20133 Milano, Italy.

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http://dx.doi.org/10.1021/ol026994aDOI Listing
November 2002