Giorgio Stassi

Giorgio Stassi

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Giorgio Stassi

Giorgio Stassi

Publications by authors named "Giorgio Stassi"

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Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance.

Mol Cancer 2019 03 30;18(1):70. Epub 2019 Mar 30.

Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.

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https://molecular-cancer.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12943-019-0994-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441236PMC
March 2019

Meeting the Challenge of Targeting Cancer Stem Cells.

Front Cell Dev Biol 2019 18;7:16. Epub 2019 Feb 18.

Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.3389/fcell.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387961PMC
February 2019

Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models.

Int J Cancer 2019 01 22;144(2):366-371. Epub 2018 Oct 22.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/ijc.31767
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http://dx.doi.org/10.1002/ijc.31767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587871PMC
January 2019

Role of Type I and II Interferons in Colorectal Cancer and Melanoma.

Front Immunol 2017 26;8:878. Epub 2017 Jul 26.

Cellular and Molecular Pathophysiology Laboratory, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.00878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526853PMC
July 2017

IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition.

Cancer Res 2017 06 11;77(12):3268-3279. Epub 2017 Apr 11.

Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3126DOI Listing
June 2017

Betulinic Acid Kills Colon Cancer Stem Cells.

Curr Stem Cell Res Ther 2016 ;11(5):427-33

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

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February 2017

γδ T cell-based anticancer immunotherapy: progress and possibilities.

Immunotherapy 2015 27;7(9):949-51. Epub 2015 Aug 27.

Cellular & Molecular Pathophysiology Laboratory, Department of Surgical & Oncological Sciences, University of Palermo, Via del Vespro 131, Palermo 90134, Italy.

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http://dx.doi.org/10.2217/imt.15.68DOI Listing
August 2016

Epithelial-mesenchymal transition: a new target in anticancer drug discovery.

Nat Rev Drug Discov 2016 05 29;15(5):311-25. Epub 2016 Jan 29.

Scientific Directorate, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy.

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http://dx.doi.org/10.1038/nrd.2015.13DOI Listing
May 2016

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

Oncotarget 2016 Jan;7(2):1675-86

Department of Research, Advanced Diagnostics, and Technological Innovation, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.18632/oncotarget.6423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811489PMC
January 2016

γδ T cells as a potential tool in colon cancer immunotherapy.

Immunotherapy 2014 ;6(9):989-99

Department of Biopathology & Biomedical Methodologies, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.2217/imt.14.59DOI Listing
July 2015

Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging.

Stem Cells 2015 Jan;33(1):35-44

PSE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia; BioNEM Lab, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1002/stem.1837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311668PMC
January 2015

Colorectal cancer stem cells: from the crypt to the clinic.

Cell Stem Cell 2014 Dec;15(6):692-705

Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.11.012DOI Listing
December 2014

Estrogens and stem cells in thyroid cancer.

Front Endocrinol (Lausanne) 2014 25;5:124. Epub 2014 Jul 25.

Department of Surgical and Oncological Sciences, University of Palermo , Palermo , Italy.

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http://dx.doi.org/10.3389/fendo.2014.00124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110518PMC
August 2014

p63 isoforms regulate metabolism of cancer stem cells.

J Proteome Res 2014 Apr 19;13(4):2120-36. Epub 2014 Mar 19.

Department of Experimental and Clinical Sciences, "G. d'Annunzio University" , Via dei Vestini 31, Chieti-Pescara 66100, Italy.

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http://pubs.acs.org/doi/10.1021/pr4012574
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http://dx.doi.org/10.1021/pr4012574DOI Listing
April 2014

Tumor and its microenvironment: a synergistic interplay.

Semin Cancer Biol 2013 Dec 4;23(6 Pt B):522-32. Epub 2013 Sep 4.

University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffrè, 5, 90127 Palermo, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2013.08.007DOI Listing
December 2013

Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy.

Cancer Res 2013 Nov 5;73(21):6393-400. Epub 2013 Sep 5.

Authors' Affiliations: Department of Surgical and Oncological Sciences, University of Palermo, Palermo; Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità; Department of Surgical Sciences, University La Sapienza; and National Cancer Institute Regina Elena, Rome, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0248DOI Listing
November 2013

Combining conventional chemotherapy and γδ T cell-based immunotherapy to target cancer-initiating cells.

Oncoimmunology 2013 Sep 29;2(9):e25821. Epub 2013 Jul 29.

Biomedical Research Centre; University of Palermo; Palermo, Italy ; Department of Surgical and Anatomical Disciplines; University of Palermo; Palermo, Italy.

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http://dx.doi.org/10.4161/onci.25821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825724PMC
September 2013

Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes.

Oncoimmunology 2013 Apr;2(4):e23434

Department of Biopathology and Biotechnology; University of Palermo; Palermo, Italy ; Biomedical Research Centre; University of Palermo; Palermo, Italy.

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http://dx.doi.org/10.4161/onci.23434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654575PMC
April 2013

IL-21 regulates the differentiation of a human γδ T cell subset equipped with B cell helper activity.

PLoS One 2012 25;7(7):e41940. Epub 2012 Jul 25.

Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, Palermo, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041940PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405033PMC
January 2013

Mechanisms underlying lineage commitment and plasticity of human γδ T cells.

Cell Mol Immunol 2013 Jan 22;10(1):30-4. Epub 2012 Oct 22.

Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, Palermo, Italy.

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http://www.nature.com/articles/cmi201242
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http://dx.doi.org/10.1038/cmi.2012.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003171PMC
January 2013

Cancer stem cell definitions and terminology: the devil is in the details.

Nat Rev Cancer 2012 11 11;12(11):767-75. Epub 2012 Oct 11.

The Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna & Ludwig-Boltzmann Cluster Oncology, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1038/nrc3368DOI Listing
November 2012

CD133 as a target for colon cancer.

Expert Opin Ther Targets 2012 Mar 3;16(3):259-67. Epub 2012 Mar 3.

University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Via Liborio Giuffrè, 5. 90127, Palermo, Italy.

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http://www.tandfonline.com/doi/full/10.1517/14728222.2012.66
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http://dx.doi.org/10.1517/14728222.2012.667404DOI Listing
March 2012

Differentiation, phenotype, and function of interleukin-17-producing human Vγ9Vδ2 T cells.

Blood 2011 Jul 19;118(1):129-38. Epub 2011 Apr 19.

Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-01-33
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http://dx.doi.org/10.1182/blood-2011-01-331298DOI Listing
July 2011

Colorectal cancer stem cells and cell death.

Cancers (Basel) 2011 Apr 11;3(2):1929-46. Epub 2011 Apr 11.

Department of Surgical and Oncological Sciences, University of Palermo, Via Liborio Giuffrè 5, 90127 Palermo (PA), Italy.

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http://dx.doi.org/10.3390/cancers3021929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757397PMC
April 2011

Colon Cancer Stem Cells: Bench-to-Bedside-New Therapeutical Approaches in Clinical Oncology for Disease Breakdown.

Cancers (Basel) 2011 Apr 13;3(2):1957-74. Epub 2011 Apr 13.

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy.

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http://dx.doi.org/10.3390/cancers3021957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757399PMC
April 2011

Immunotherapy targeting colon cancer stem cells.

Immunotherapy 2011 Jan;3(1):97-106

Department of Surgical & Oncological Sciences, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.2217/imt.10.87DOI Listing
January 2011

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

Nature 2010 Dec 21;468(7325):824-8. Epub 2010 Nov 21.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

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http://dx.doi.org/10.1038/nature09557DOI Listing
December 2010

Tumorigenic and metastatic activity of human thyroid cancer stem cells.

Cancer Res 2010 Nov 19;70(21):8874-85. Epub 2010 Oct 19.

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1994DOI Listing
November 2010

Colon cancer stem cells: promise of targeted therapy.

Gastroenterology 2010 Jun;138(6):2151-62

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy.

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http://journalsconsultapp.elsevier-eprints.com/uploads/artic
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http://linkinghub.elsevier.com/retrieve/pii/S001650851000167
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http://dx.doi.org/10.1053/j.gastro.2009.12.063DOI Listing
June 2010

Aurora-a is essential for the tumorigenic capacity and chemoresistance of colorectal cancer stem cells.

Cancer Res 2010 Jun 11;70(11):4655-65. Epub 2010 May 11.

Cellular and Molecular Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Salvatore Maugeri, Pavia, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3953DOI Listing
June 2010

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Nat Cell Biol 2010 May 25;12(5):468-76. Epub 2010 Apr 25.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2048DOI Listing
May 2010

Evidences of cervical cancer stem cells derived from established cell lines.

Cell Cycle 2010 Apr 1;9(7):1238-9. Epub 2010 Apr 1.

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April 2010

The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.

Cancer Res 2010 Jan 12;70(2):719-29. Epub 2010 Jan 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, and Department of Pathology, Academic Medical Center, 1105AZ Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1820DOI Listing
January 2010

Therapeutic implications of Cancer Initiating Cells.

Expert Opin Biol Ther 2009 Aug;9(8):1005-16

University of Palermo, Department of Surgical and Oncological Sciences, Laboratory of Cellular and Molecular Pathophysiology, Palermo, Italy.

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http://dx.doi.org/10.1517/14712590903066687DOI Listing
August 2009

Isolation and culture of colon cancer stem cells.

Methods Cell Biol 2008 ;86:311-24

Department of GENURTO, University of Palermo, 129-90127 Palermo, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0091679X0800014
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http://dx.doi.org/10.1016/S0091-679X(08)00014-9DOI Listing
July 2008

Crucial role of interleukin-4 in the survival of colon cancer stem cells.

Cancer Res 2008 Jun;68(11):4022-5

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-6874DOI Listing
June 2008

IL-4-mediated drug resistance in colon cancer stem cells.

Cell Cycle 2008 Feb 30;7(3):309-13. Epub 2007 Nov 30.

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, Palermo, Italy.

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http://dx.doi.org/10.4161/cc.7.3.5389DOI Listing
February 2008

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

Cell Stem Cell 2007 Oct;1(4):389-402

Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy.

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http://dx.doi.org/10.1016/j.stem.2007.08.001DOI Listing
October 2007

Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells.

Cancer Res 2006 Feb;66(3):1491-9

Department of Surgical and Oncological Sciences and Pathology Institute, University of Palermo, Via Liborio Giuffrè 5, 90127 Palermo, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2514DOI Listing
February 2006

PED mediates AKT-dependent chemoresistance in human breast cancer cells.

Cancer Res 2005 Aug;65(15):6668-75

Department of Cellular and Molecular Biology, Federico II University of Naples, Naples.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4009DOI Listing
August 2005

cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes.

J Biol Chem 2004 Dec 30;279(51):52824-34. Epub 2004 Sep 30.

University of Würzburg Medical School, Department of Dermatology, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M409554200DOI Listing
December 2004

Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin.

J Biol Chem 2004 Mar 15;279(10):9199-207. Epub 2003 Dec 15.

Laboratory of Immunology and Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

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http://www.jbc.org/content/early/2003/12/15/jbc.M305561200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M305561200
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http://dx.doi.org/10.1074/jbc.M305561200DOI Listing
March 2004

Role of apoptosis in autoimmunity.

J Clin Immunol 2004 Jan;24(1):1-11

Department of Surgical and Oncological Sciences, Via Liborio Giuffrè 5, 90127 Palermo, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.1023/B:JOCI.0000018057.89066.c6DOI Listing
January 2004

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10.

Cancer Res 2003 Oct;63(20):6784-90

Department of Surgical and Oncological Sciences, University of Palermo, 90127 Palermo, Italy.

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October 2003

High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells.

J Cell Biochem 2002 ;86(1):162-73

Department of Surgical and Oncological Sciences, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.

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http://dx.doi.org/10.1002/jcb.10203DOI Listing
December 2002

Autoimmune thyroid disease: new models of cell death in autoimmunity.

Nat Rev Immunol 2002 Mar;2(3):195-204

Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy.

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http://dx.doi.org/10.1038/nri750DOI Listing
March 2002

Response to 'Thyrocytes - not innocent bystanders in autoimmune disease'

Nat Immunol 2001 Mar;2(3):183

Department of Surgical, Anatomical and Oncological Sciences, Human Anatomy Section, University of Palermo, 90127 Palermo, Italy.

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http://dx.doi.org/10.1038/85226DOI Listing
March 2001