Giorgio Minotti

Giorgio Minotti

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Giorgio Minotti

Giorgio Minotti

Publications by authors named "Giorgio Minotti"

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Pharmacology of Ranolazine versus Common Cardiovascular Drugs in Patients with Early Diastolic Dysfunction Induced by Anthracyclines or Nonanthracycline Chemotherapeutics: A Phase 2b Minitrial.

J Pharmacol Exp Ther 2019 Aug 17;370(2):197-205. Epub 2019 May 17.

Clinical Pharmacology Unit (G.M., P.M.) and Cardio Center (V.C.), Campus Bio-Medico University Hospital, Rome; Units of Drug Sciences (G.M., E.S.), Radiation Oncology (C.G.), Oncology (G.A.), and Hematology (O.A.), Department of Medicine and Center for Integrated Research, University Campus Bio-Medico, Rome; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome (F.M.); and Mediservice S.r.l., Agrate Brianza (Monza) (G.R.), Italy.

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http://dx.doi.org/10.1124/jpet.119.258178DOI Listing
August 2019

Efficacy and safety of low dose ponatinib in a case of Ph-positive acute lymphoblastic leukaemia.

Br J Haematol 2019 Aug 1. Epub 2019 Aug 1.

Clinical Pharmacology Unit, University Hospital Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1111/bjh.16132DOI Listing
August 2019

Correction to: Cardiotoxicity of Targeted Cancer Drugs: Concerns, "The Cart Before the Horse," and Lessons from Trastuzumab.

Curr Cardiol Rep 2019 Apr 15;21(5):40. Epub 2019 Apr 15.

Department of Medicine, Unit of Drug Sciences and Center for Integrated Research, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1007/s11886-019-1131-yDOI Listing
April 2019

Isavuconazole: Case Report and Pharmacokinetic Considerations.

Chemotherapy 2018 20;63(5):253-256. Epub 2018 Nov 20.

Clinical Pharmacology Unit, University Hospital Campus Bio-Medico of Rome, Rome, Italy,

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https://www.karger.com/Article/FullText/494329
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http://dx.doi.org/10.1159/000494329DOI Listing
March 2019

Cardiotoxicity of Targeted Cancer Drugs: Concerns, "The Cart Before the Horse," and Lessons from Trastuzumab.

Curr Cardiol Rep 2019 Mar 18;21(5):33. Epub 2019 Mar 18.

Department of Medicine, Unit of Drug Sciences and Center for Integrated Research, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1007/s11886-019-1121-0DOI Listing
March 2019

The Endogenous Lusitropic and Chronotropic Agent, B-Type Natriuretic Peptide, Limits Cardiac Troponin Release in Cancer Patients with an Early Impairment of Myocardial Relaxation Induced by Anthracyclines.

J Pharmacol Exp Ther 2018 Dec 1;367(3):518-527. Epub 2018 Oct 1.

Units of Drug Sciences (P.M., E.S., G.M.), Oncology (G.A.), Hematology (O.A.), Radiation Oncology (C.G.), and Cardiovascular Sciences (V.C.), Department of Medicine and Center for Integrated Research, University Campus Bio-Medico, Rome; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome (F.M.); and Mediservice S.r.l., Agrate Brianza (Monza), Italy (G.R.)

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http://dx.doi.org/10.1124/jpet.118.253104DOI Listing
December 2018

Pharmacology of Cardio-Oncology: Chronotropic and Lusitropic Effects of B-Type Natriuretic Peptide in Cancer Patients with Early Diastolic Dysfunction Induced by Anthracycline or Nonanthracycline Chemotherapy.

J Pharmacol Exp Ther 2018 07 2;366(1):158-168. Epub 2018 May 2.

Units of Drug Sciences (P.M., E.S., G.M.), Cardiovascular Sciences (V.C.), Oncology (G.A.), Hematology (O.A.), and Radiation Oncology (C.G.), Department of Medicine and Center for Integrated Research, University Campus Bio-Medico, Rome, Italy; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy, (F.M.); and Mediservice S.r.l., Agrate Brianza, Monza, Italy (G.R.)

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http://dx.doi.org/10.1124/jpet.118.249235DOI Listing
July 2018

The International Cardioncology Society-ONE trial: Not all that glitters is for cardioncologists only.

Authors:
Giorgio Minotti

Eur J Cancer 2018 07 3;97:27-29. Epub 2018 May 3.

Department of Medicine and Unit of Drug Sciences, University Campus Bio-Medico, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.04.003DOI Listing
July 2018

Pixantrone: novel mode of action and clinical readouts.

Expert Rev Hematol 2018 07 18;11(7):587-596. Epub 2018 Jun 18.

d Istituto Oncologico di Ricerca , Università della Svizzera italiana , Bellinzona , Switzerland.

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http://dx.doi.org/10.1080/17474086.2018.1476848DOI Listing
July 2018

Early Diastolic Dysfunction after Cancer Chemotherapy: Primary Endpoint Results of a Multicenter Cardio-Oncology Study.

Chemotherapy 2018 9;63(2):55-63. Epub 2018 Feb 9.

Units of Cardiology, Hematology, Oncology, Radiation Therapy and Clinical Pharmacology, Department of Medicine, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1159/000486761DOI Listing
June 2018

Do You Know Pixantrone?

Chemotherapy 2017 24;62(3):192-193. Epub 2017 Mar 24.

Department of Medicine and Center for Drug Sciences, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1159/000464276DOI Listing
March 2018

Modified Colistin Regimen for Critically Ill Patients with Acute Renal Impairment and Continuous Renal Replacement Therapy.

Chemotherapy 2018 22;63(1):35-38. Epub 2017 Dec 22.

Clinical Pharmacology Unit, University Hospital Campus Bio-Medico of Rome, Rome, Italy.

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http://dx.doi.org/10.1159/000484974DOI Listing
March 2018

Low-Dose Anthracycline and Risk of Heart Failure in a Pharmacokinetic Model of Human Myocardium Exposure: Analog Specificity and Role of Secondary Alcohol Metabolites.

J Pharmacol Exp Ther 2018 02 8;364(2):323-331. Epub 2017 Dec 8.

Drug Sciences (E.S., P.M., G.M.) and Cardiac Surgery (M.C., E.C.), Department of Medicine and Center for Integrated Research, University Campus Bio-Medico, Rome, Italy

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http://dx.doi.org/10.1124/jpet.117.246140DOI Listing
February 2018

Editorial: The Journal Chemotherapy Is for Cardio-Oncologists Too.

Authors:
Giorgio Minotti

Chemotherapy 2018 Feb 9;63(2):53-54. Epub 2018 Feb 9.

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http://dx.doi.org/10.1159/000487055DOI Listing
February 2018

Cancer drugs and QT prolongation: weighing risk against benefit.

Expert Opin Drug Saf 2017 10 20;16(10):1099-1102. Epub 2017 Jul 20.

a Department of Medicine and Unit of Drug Sciences , University Campus Bio-Medico of Rome , Italy.

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http://dx.doi.org/10.1080/14740338.2017.1354987DOI Listing
October 2017

Modeling Human Myocardium Exposure to Doxorubicin Defines the Risk of Heart Failure from Low-Dose Doxorubicin.

J Pharmacol Exp Ther 2017 08 30;362(2):263-270. Epub 2017 May 30.

Drug Sciences (E.S., P.M., G.M.) and Cardiac Surgery (M.C., E.C.), Department of Medicine and Center for Integrated Research, University Campus Bio-Medico, Rome, Italy

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http://dx.doi.org/10.1124/jpet.117.242388DOI Listing
August 2017

Heart Rate reduction by IVabradine for improvement of ENDothELial function in patients with coronary artery disease: the RIVENDEL study.

Clin Res Cardiol 2017 Jan 12;106(1):69-75. Epub 2016 Aug 12.

Unit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128, Rome, Italy.

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http://dx.doi.org/10.1007/s00392-016-1024-7DOI Listing
January 2017

Drug-induced hepatotoxicity in cancer patients - implication for treatment.

Expert Opin Drug Saf 2016 Sep 14;15(9):1219-38. Epub 2016 Jun 14.

a Medical Oncology Department, Campus Bio-Medico , University of Rome , Rome , Italy.

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http://dx.doi.org/10.1080/14740338.2016.1194824DOI Listing
September 2016

Editorial.

Chemotherapy 2016 3;61(1):1-2. Epub 2015 Nov 3.

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http://dx.doi.org/10.1159/000441664DOI Listing
August 2016

Rethinking Drugs from Chemistry to Therapeutic Opportunities: Pixantrone beyond Anthracyclines.

Chem Res Toxicol 2016 08 22;29(8):1270-8. Epub 2016 Jul 22.

Unit of Drug Sciences, Department of Medicine, University Campus Bio-Medico , Via Alvaro del Portillo, 21, 00128 Rome, Italy.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00190DOI Listing
August 2016

The concomitant management of cancer therapy and cardiac therapy.

Biochim Biophys Acta 2015 Oct 14;1848(10 Pt B):2727-37. Epub 2015 Jan 14.

Unit of Drug Sciences, University Campus Bio-Medico of Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.01.003DOI Listing
October 2015

Managing anthracycline-induced cardiotoxicity: beginning with the end in mind.

Future Cardiol 2015 Jul 4;11(4):363-6. Epub 2015 Aug 4.

Unit of Drug Sciences, Department of Medicine, University Campus Bio-Medico, Via Alvaro del Portillo 21, 00128 Rome, Italy.

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http://dx.doi.org/10.2217/FCA.15.35DOI Listing
July 2015

Low level tumor necrosis factor-alpha protects cardiomyocytes against high level tumor necrosis factor-alpha: brief insight into a beneficial paradox.

Cardiovasc Toxicol 2014 Dec;14(4):387-92

Internal Medicine Unit and Rheumatology Outpatients Clinic, "Ninetto Melli" Hospital, 72027, San Pietro V.co, Brindisi, Italy,

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http://dx.doi.org/10.1007/s12012-014-9257-zDOI Listing
December 2014

Development of a tumor-specific photoactivatable doxorubicin prodrug.

Photochem Photobiol 2013 Sep-Oct;89(5):1009-10. Epub 2013 Sep 3.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1111/php.12151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817842PMC
April 2014

Pharmacology at work for cardio-oncology: ranolazine to treat early cardiotoxicity induced by antitumor drugs.

Authors:
Giorgio Minotti

J Pharmacol Exp Ther 2013 Sep 1;346(3):343-9. Epub 2013 Jul 1.

CIR and Drug Sciences, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1124/jpet.113.204057DOI Listing
September 2013

Anthracycline cardiotoxicity.

Top Curr Chem 2008 ;283:21-44

University Campus Bio-Medico of Rome, CIR and Drug Sciences, Via Alvaro del Portillo 21, 00128, Rome, Italy.

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http://dx.doi.org/10.1007/128_2007_11DOI Listing
April 2013

Anthracycline cardiotoxicity.

Expert Opin Drug Saf 2012 May 2;11 Suppl 1:S21-36. Epub 2011 Jun 2.

Campus Bio-Medico University Hospital, CIR and Drug Sciences, Via Alvaro del Portillo, 21, 00128 Rome, Italy.

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http://dx.doi.org/10.1517/14740338.2011.589834DOI Listing
May 2012

Managing cardiac risk factors in oncology clinical trials.

Tex Heart Inst J 2011 ;38(3):266-7

Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113125PMC
October 2011

Cardiovascular safety of anti-TNF-alpha therapies: facts and unsettled issues.

Autoimmun Rev 2011 Aug 22;10(10):631-5. Epub 2011 Apr 22.

Internal Medicine and Rheumatology, "N. Melli" Hospital, Brindisi, Italy.

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http://dx.doi.org/10.1016/j.autrev.2011.04.014DOI Listing
August 2011

Matters of the heart: the case of TNFalpha-targeting drugs.

Mol Interv 2011 Apr;11(2):79-87

Internal Medicine and Rheumatology, N. Melli Hospital, San Pietro Vernotico, Brindisi, Italy.

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http://dx.doi.org/10.1124/mi.11.2.4DOI Listing
April 2011

Iron regulatory proteins: from molecular mechanisms to drug development.

Antioxid Redox Signal 2010 Nov;13(10):1593-616

Department of Human Morphology and Biomedical Sciences Città Studi, University of Milan, Milano, Italy.

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http://dx.doi.org/10.1089/ars.2009.2983DOI Listing
November 2010

Pharmacological foundations of cardio-oncology.

J Pharmacol Exp Ther 2010 Jul 24;334(1):2-8. Epub 2010 Mar 24.

Center for Integrated Research, Drug Sciences, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1124/jpet.110.165860DOI Listing
July 2010

Anthracycline degradation in cardiomyocytes: a journey to oxidative survival.

Chem Res Toxicol 2010 Jan;23(1):6-10

University Campus Bio-Medico, Fondazione Alberto Sordi-Research Institute on Aging, Rome, Italy.

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http://dx.doi.org/10.1021/tx9003424DOI Listing
January 2010

4'-Epidoxorubicin to re-explore anthracycline degradation in cardiomyocytes.

Chem Res Toxicol 2009 Jun;22(6):978-83

Integrated Research Center and Laboratory of Drug Sciences, University Campus Bio-Medico, and Fondazione Alberto Sordi-Research Institute on Aging, 00128 Rome, Italy.

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http://dx.doi.org/10.1021/tx900039pDOI Listing
June 2009

Doxorubicinolone formation and efflux: a salvage pathway against epirubicin accumulation in human heart.

J Pharmacol Exp Ther 2009 Apr 14;329(1):175-84. Epub 2009 Jan 14.

Center for Integrated Research, Drug Sciences, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1124/jpet.108.149260DOI Listing
April 2009

Anthracycline cardiotoxicity: from bench to bedside.

J Clin Oncol 2008 Aug;26(22):3777-84

Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy.

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http://ascopubs.org/doi/10.1200/JCO.2007.14.9401
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http://dx.doi.org/10.1200/JCO.2007.14.9401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018290PMC
August 2008

Cardiotoxicity of antitumor drugs.

Chem Res Toxicol 2008 May 1;21(5):978-89. Epub 2008 Apr 1.

CIR and Drug Sciences, University Campus Bio-Medico of Rome, Department of Drug Sciences, G. d'Annunzio University of Chieti-Pescara, Italy.

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http://dx.doi.org/10.1021/tx800002rDOI Listing
May 2008

Beyond poisons and problems: toxicology in Italy.

Chem Res Toxicol 2008 Apr;21(4):771-4

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http://dx.doi.org/10.1021/tx8000847DOI Listing
April 2008

Anthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanes.

Cardiovasc Toxicol 2007 ;7(2):67-71

Division of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, ViaVenezian 1, Milan 20133, Italy.

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http://dx.doi.org/10.1007/s12012-007-0013-5DOI Listing
October 2007

An introduction to the metabolic determinants of anthracycline cardiotoxicity.

Cardiovasc Toxicol 2007 ;7(2):80-5

Department of Drug Sciences and Center of Excellence on Aging, G. d'Annunzio University School of Medicine, Chieti, Italy.

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http://dx.doi.org/10.1007/s12012-007-0011-7DOI Listing
October 2007

Doxorubicin degradation in cardiomyocytes.

J Pharmacol Exp Ther 2007 Jul 27;322(1):408-19. Epub 2007 Apr 27.

Department of Drug Sciences and Center of Excellence on Aging, G. d'Annunzio University School of Medicine, Via dei Vestini, 66013 Chieti, Italy.

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http://dx.doi.org/10.1124/jpet.107.122820DOI Listing
July 2007

Defective taxane stimulation of epirubicinol formation in the human heart: insight into the cardiac tolerability of epirubicin-taxane chemotherapies.

J Pharmacol Exp Ther 2007 Feb 29;320(2):790-800. Epub 2006 Nov 29.

Department of Drug Sciences and Center of Excellence on Aging, G. d'Annunzio University School of Medicine, Via dei Vestini, 66013 Chieti, Italy.

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http://dx.doi.org/10.1124/jpet.106.116160DOI Listing
February 2007

Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: implications for cardiotoxicity of doxorubicin-taxane chemotherapies.

J Pharmacol Exp Ther 2006 Jul 13;318(1):424-33. Epub 2006 Apr 13.

Department of Drug Sciences and Center of Excellence on Aging, G. d'Annunzio University School of Medicine, Via dei Vestini, 66013 Chieti, Italy.

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http://dx.doi.org/10.1124/jpet.106.103846DOI Listing
July 2006

Anthracyclines.

Cancer Chemother Biol Response Modif 2003 ;21:29-40

Division of Medical Oncology A, Istituto Nazionale Tumori, Milan, Italy.

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September 2004

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity.

Pharmacol Rev 2004 Jun;56(2):185-229

G. d'Annunzio University School of Medicine, Centro Studi sull'Invecchiamento, Room 412, Via dei Vestini, 66013 Chieti, Italy.

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http://dx.doi.org/10.1124/pr.56.2.6DOI Listing
June 2004

Doxorubicin paradoxically protects cardiomyocytes against iron-mediated toxicity: role of reactive oxygen species and ferritin.

J Biol Chem 2004 Apr 22;279(14):13738-45. Epub 2004 Jan 22.

Institute of General Pathology, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy.

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http://dx.doi.org/10.1074/jbc.M310106200DOI Listing
April 2004

Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms.

Methods Enzymol 2004 ;378:340-61

Department of Drug Sciences and Centro Studi Invecchiamento, G. d'Annunzio University School of Medicine, Chieti, Italy.

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http://dx.doi.org/10.1016/S0076-6879(04)78025-8DOI Listing
April 2004

Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes.

Biofactors 2003 ;17(1-4):187-98

Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy.

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February 2004

Anthracycline secondary alcohol metabolite formation in human or rabbit heart: biochemical aspects and pharmacologic implications.

Biochem Pharmacol 2003 Sep;66(6):989-98

Institute of Biochemistry and Clinical Biochemistry, Catholic University School of Medicine, Largo F. Vito 1, 00168 Rome, Italy.

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http://dx.doi.org/10.1016/s0006-2952(03)00442-8DOI Listing
September 2003

Anthracyclines.

Cancer Chemother Biol Response Modif 2002 ;20:59-69

Istituto Nazionale Tumori, Milan, Italy.

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May 2003

Cardiotoxic effects of anthracycline-taxane combinations.

Expert Opin Drug Saf 2003 Jan;2(1):59-71

Division of Medical Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumouri, 20133 Milan, Italy.

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January 2003

Doxorubicin-dependent reduction of ferrylmyoglobin and inhibition of lipid peroxidation: implications for cardiotoxicity of anticancer anthracyclines.

Chem Res Toxicol 2002 Sep;15(9):1179-89

Department of Drug Sciences, G. d'Annunzio University School of Medicine, Chieti, Italy.

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September 2002

Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.

Biochemistry 2002 Jun;41(23):7435-42

Institute of General Pathology, University of Milan, via Mangiagalli 31, 20133 Milan, Italy.

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http://dx.doi.org/10.1021/bi025756kDOI Listing
June 2002

The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.

Free Radic Biol Med 2002 Jun;32(12):1237-43

Institute of General Pathology, Cell Pathology Centre CNR, Milano, Italy.

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http://dx.doi.org/10.1016/s0891-5849(02)00825-0DOI Listing
June 2002