Publications by authors named "Giorgio Inghirami"

100Publications

Peripheral T cell lymphomas: from the bench to the clinic.

Nat Rev Cancer 2020 06 6;20(6):323-342. Epub 2020 Apr 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41568-020-0247-0DOI Listing
June 2020

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.

Cell Rep 2020 01;30(3):755-770.e6

Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68(th) Street, New York, NY 10065, USA; Meyer Cancer Center, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.056DOI Listing
January 2020

Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma.

Am J Pathol 2020 01 11;190(1):2-10. Epub 2019 Oct 11.

Department of Dermatology, Roger Williams Medical Center, Providence, Rhode Island; Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S00029440193075
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http://dx.doi.org/10.1016/j.ajpath.2019.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298558PMC
January 2020

Does Breast Implant-Associated ALCL Begin as a Lymphoproliferative Disorder?

Plast Reconstr Surg 2020 01;145(1):30e-38e

Providence, R.I.; Dallas, Texas; New York, N.Y.; and Rome, Italy From the Department of Dermatology, Boston University School of Medicine and Roger Williams Medical Center; the Department of Plastic Surgery, University of Texas Southwestern Medical School; the Department of Pathology and Laboratory Medicine, Weill Cornell College of Medicine; and the Department of Clinical and Molecular Medicine, Sapienza University, Pathology Unit, Sant'Andrea Hospital.

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http://dx.doi.org/10.1097/PRS.0000000000006390DOI Listing
January 2020

Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets.

Front Genet 2019 10;10:780. Epub 2019 Sep 10.

Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University Medical School, Bologna, Italy.

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http://dx.doi.org/10.3389/fgene.2019.00780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748072PMC
September 2019

Repurposing dasatinib for diffuse large B cell lymphoma.

Proc Natl Acad Sci U S A 2019 08 5;116(34):16981-16986. Epub 2019 Aug 5.

Institute for Cancer Genetics, Columbia University, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1905239116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708382PMC
August 2019

The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.

Cancer Res 2019 Jun 28;79(12):3076-3087. Epub 2019 Jan 28.

Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0359DOI Listing
June 2019

Aptamer-miR-34c Conjugate Affects Cell Proliferation of Non-Small-Cell Lung Cancer Cells.

Mol Ther Nucleic Acids 2018 Dec 27;13:334-346. Epub 2018 Sep 27.

Department of Molecular Medicine and Medical Biotechnology, "Federico II" University of Naples, Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S21622531183026
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http://dx.doi.org/10.1016/j.omtn.2018.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197774PMC
December 2018

Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL.

J Hematol Oncol 2018 08 22;11(1):105. Epub 2018 Aug 22.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10021, USA.

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https://jhoonline.biomedcentral.com/articles/10.1186/s13045-
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http://dx.doi.org/10.1186/s13045-018-0652-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103872PMC
August 2018

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.

J Clin Invest 2018 10 19;128(10):4397-4412. Epub 2018 Jul 19.

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI99436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159983PMC
October 2018

Pathogenesis of Peripheral T Cell Lymphoma.

Annu Rev Pathol 2018 01;13:293-320

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA; email:

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http://dx.doi.org/10.1146/annurev-pathol-020117-043821DOI Listing
January 2018

Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma.

Hum Pathol 2018 05 31;75:167-178. Epub 2018 Jan 31.

Department of Diagnostics and Public Health, University and Hospital Trust of Verona, 37134 Verona, Italy; Department of Pathology, Pederzoli Hospital, 37134 Verona, Italy.

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http://dx.doi.org/10.1016/j.humpath.2018.01.017DOI Listing
May 2018

Diffuse large B cell lymphoma cell of origin by digital expression profiling in the REAL07 Phase 1-2 study.

Br J Haematol 2018 08 24;182(3):453-456. Epub 2017 Jul 24.

USI Università della Svizzera Italiana (USI), Institute of Oncology Research (IOR), Bellinzona.

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http://dx.doi.org/10.1111/bjh.14817DOI Listing
August 2018

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.

Nat Commun 2017 06 9;8:15618. Epub 2017 Jun 9.

Department of Radiation Oncology, Weill Cornell Medicine, 1300 York Avenue, Box 169, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms15618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472757PMC
June 2017

Patient-derived tumor xenografts of lymphoproliferative disorders: are they surrogates for the human disease?

Curr Opin Hematol 2017 Jul;24(4):384-392

aDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USAbSurgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, ItalycDepartment of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino, ItalydDepartment of Pathology, and NYU Cancer Center, New York University School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000349DOI Listing
July 2017

Are we ready to take full advantage of patient-derived tumor xenograft models?

Hematol Oncol 2018 Feb 23;36(1):24-27. Epub 2017 May 23.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1002/hon.2419DOI Listing
February 2018

Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis.

Exp Mol Pathol 2017 04 22;102(2):276-279. Epub 2017 Feb 22.

Departments of Pathology and Pharmacology, Weill Cornell Cancer Center, Weill Cornell Medical College, Cornell University, 10065 New York, NY, USA.

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http://dx.doi.org/10.1016/j.yexmp.2017.02.014DOI Listing
April 2017

The heterogeneous landscape of ALK negative ALCL.

Oncotarget 2017 Mar;8(11):18525-18536

Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy.

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http://dx.doi.org/10.18632/oncotarget.14503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392347PMC
March 2017

Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells.

Cancer Cell 2017 01 15;31(1):110-126. Epub 2016 Dec 15.

Division of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497495PMC
January 2017

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Transposable elements: The enemies within.

Exp Hematol 2016 10 1;44(10):913-6. Epub 2016 Jul 1.

Department of Molecular Biotechnology and Health Sciences; Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.06.251DOI Listing
October 2016

Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma.

Oncotarget 2016 Jul;7(27):41913-41928

Cancer Bio-Immunotherapy Unit, Department of Translational Research, Centro di Riferimento Oncologico, IRCCS-National Cancer Institute, Aviano (PN), Italy.

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http://dx.doi.org/10.18632/oncotarget.9630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173105PMC
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

Oncogenic kinase fusions: an evolving arena with innovative clinical opportunities.

Oncotarget 2016 May;7(18):25064-86

Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041889PMC
http://dx.doi.org/10.18632/oncotarget.7853DOI Listing
May 2016

JAK-STAT in lymphoproliferative disorders.

Oncoscience 2015 11;2(9):737-8. Epub 2015 Aug 11.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606001PMC
http://dx.doi.org/10.18632/oncoscience.189DOI Listing
October 2015

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts.

Blood 2016 Jan 13;127(2):221-32. Epub 2015 Oct 13.

Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy; Department of Pathology, New York University Cancer Center, New York University School of Medicine, New York, NY.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-614503DOI Listing
January 2016

Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma: A Comparison with Real-Time PCR.

J Mol Diagn 2015 Nov 28;17(6):652-60. Epub 2015 Aug 28.

Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino, Torino, Italy; Hematology Division, A.O.S. Antonio, Biagio and Cesare Arrigo, Alessandria, Italy.

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http://dx.doi.org/10.1016/j.jmoldx.2015.05.007DOI Listing
November 2015

Anaplastic lymphoma kinase inhibitors.

Curr Opin Pharmacol 2015 Aug 3;23:39-44. Epub 2015 Jun 3.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Department of Molecular Biotechnology and Health Science, Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino 10126, Italy; Department of Pathology, NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714892150005
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http://dx.doi.org/10.1016/j.coph.2015.05.010DOI Listing
August 2015

Anaplastic lymphoma kinase: activating mechanisms and signaling pathways.

Front Biosci (Schol Ed) 2015 Jun 1;7:283-305. Epub 2015 Jun 1.

Department of Pathology and Laboratory Medicine, Weill Cornell, Medical College, 525 East 68th Street, Starr Pavilion Rm 713, New York, NY 10065 USA,

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June 2015

Epigenomic evolution in diffuse large B-cell lymphomas.

Nat Commun 2015 Apr 20;6:6921. Epub 2015 Apr 20.

1] Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA [2] Institute for Precision Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms7921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411286PMC
April 2015

Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.

Cancer Cell 2015 Apr;27(4):516-32

Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00094-X.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500094
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http://dx.doi.org/10.1016/j.ccell.2015.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898430PMC
April 2015

Stromal contribution to the colorectal cancer transcriptome.

Nat Genet 2015 Apr 23;47(4):312-9. Epub 2015 Feb 23.

1] Candiolo Cancer Institute, Fondazione Piemontese per l'Oncologia'Istituto di Ricovero e Cura a Carattere Scientifico (FRO-IRCCS), Candiolo, Italy. [2] Department of Oncology, University of Torino, Candiolo, Italy.

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http://dx.doi.org/10.1038/ng.3224DOI Listing
April 2015

Advances in understanding the pathogenesis of systemic anaplastic large cell lymphomas.

Br J Haematol 2015 Mar 6;168(6):771-83. Epub 2015 Jan 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA; Department of Pathology, NYU Cancer Center, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/bjh.13265DOI Listing
March 2015

Peripheral T-cell and NK cell lymphoproliferative disorders: cell of origin, clinical and pathological implications.

Immunol Rev 2015 Jan;263(1):124-59

Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino, Italy; Department of Pathology, and NYU Cancer Center, New York University School of Medicine, New York, NY, USA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12248DOI Listing
January 2015

Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells.

Blood 2015 Jan 8;125(5):841-51. Epub 2014 Dec 8.

Neuroimmunomodulation and Molecular Oncology Department, Institute for Biomedical Research (BIOMED), National Research Council of Argentina (CONICET), Catholic University of Argentina (UCA), Buenos Aires, Argentina; Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.1182/blood-2014-07-587337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311229PMC
January 2015

Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications.

Cell Mol Bioeng 2014 Sep;7(3):394-408

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1007/s12195-014-0353-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196273PMC
September 2014

PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas.

Leuk Lymphoma 2015 May 7;56(5):1223-8. Epub 2014 Oct 7.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College , New York, NY , USA.

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http://dx.doi.org/10.3109/10428194.2014.953155DOI Listing
May 2015

ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.

J Thorac Oncol 2014 May;9(5):729-32

Departments of *Pathology and Diagnostics, †Surgery and Oncology, Medical Oncology Unit, University and Hospital Trust of Verona, Verona, Italy; ‡Cytomolecular Lab, Hartmann Institute, University of Helsinki, Finland; §Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies (CeRMS), University of Torino, Torino, Italy; and ‖ARC-NET Research Centre, University and Hospital Trust of Verona, Verona, Italy.

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http://dx.doi.org/10.1097/JTO.0000000000000109DOI Listing
May 2014

Genetics of follicular lymphoma transformation.

Cell Rep 2014 Jan 2;6(1):130-40. Epub 2014 Jan 2.

Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA; Department of Pathology & Cell Biology, Columbia University, New York, NY 10032, USA; Department of Genetics & Development, Columbia University, New York, NY 10032, USA; Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100800PMC
January 2014

Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line.

Genes Chromosomes Cancer 2014 Feb 5;53(2):154-67. Epub 2013 Nov 5.

Department of Clinical Sciences and Community Health, University of Milano and Hematology-CTMO, Fondazione Cà Granda, IRCCS Policlinico, Milano, Italy.

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http://dx.doi.org/10.1002/gcc.22127DOI Listing
February 2014