Publications by authors named "Giorgio Giaccone"

100Publications

Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances".

Neurol Sci 2020 Oct 2. Epub 2020 Oct 2.

Division of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1007/s10072-020-04774-yDOI Listing
October 2020

Cell-free amplification of prions: Where do we stand?

Prog Mol Biol Transl Sci 2020 9;175:325-358. Epub 2020 Sep 9.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Unit of Neurology 5 and Neuropathology, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2020.08.005DOI Listing
September 2020

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.

Int J Mol Sci 2020 May 13;21(10). Epub 2020 May 13.

Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/ijms21103435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279405PMC
May 2020

PMCA Applications for Prion Detection in Peripheral Tissues of Patients with Variant Creutzfeldt-Jakob Disease.

Biomolecules 2020 03 5;10(3). Epub 2020 Mar 5.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Division of Neurology 5-Neuropathology, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/biom10030405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175161PMC
March 2020

One novel GRN null mutation, two different aphasia phenotypes.

Neurobiol Aging 2020 03 12;87:141.e9-141.e14. Epub 2019 Nov 12.

Division of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.11.008DOI Listing
March 2020

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids.

Sci Rep 2019 12 9;9(1):18595. Epub 2019 Dec 9.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Division of Neurology 5 and Neuropathology, Milano, Italy.

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http://dx.doi.org/10.1038/s41598-019-55078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901582PMC
December 2019

Dreaming of a New World Where Alzheimer's Is a Treatable Disorder.

Front Aging Neurosci 2019 15;11:317. Epub 2019 Nov 15.

Neurology V-Neuropathology Unit and Scientific Directorate, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.3389/fnagi.2019.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873113PMC
November 2019

Prion Efficiently Replicates in α-Synuclein Knockout Mice.

Mol Neurobiol 2019 Nov 30;56(11):7448-7457. Epub 2019 Apr 30.

Unit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1007/s12035-019-1602-6DOI Listing
November 2019

Neuro-Behçet's disease presenting as an isolated progressive cognitive and behavioral syndrome.

Neurocase 2018 Oct - Dec;24(5-6):238-241. Epub 2018 Dec 25.

a Second Division of Neurology , Center for Rare Neurological and Neuromuscular Diseases & Inter University Center for Research in Neurosciences, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli , Naples , Italy.

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http://dx.doi.org/10.1080/13554794.2018.1561898DOI Listing
September 2019

Tau Mutations as a Novel Risk Factor for Cancer-Response.

Cancer Res 2018 11 29;78(22):6525. Epub 2018 Oct 29.

Unit of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2730DOI Listing
November 2018

Synthetic Prion Selection and Adaptation.

Mol Neurobiol 2019 Apr 3;56(4):2978-2989. Epub 2018 Aug 3.

Laboratory of Prion Biology, Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.

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http://link.springer.com/10.1007/s12035-018-1279-2
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http://dx.doi.org/10.1007/s12035-018-1279-2DOI Listing
April 2019

Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation.

J Alzheimers Dis 2018 ;63(1):195-201

Unit of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

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http://dx.doi.org/10.3233/JAD-180018DOI Listing
August 2019

Translational Research in Alzheimer's and Prion Diseases.

J Alzheimers Dis 2018 ;62(3):1247-1259

IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.3233/JAD-170770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869996PMC
May 2019

Towards an early clinical diagnosis of sporadic CJD VV2 (ataxic type).

J Neurol Neurosurg Psychiatry 2017 09 1;88(9):764-772. Epub 2017 Jul 1.

Università di Bologna, Dipartimento di Scienze Biomediche e Neuromotorie, Bologna, Italy.

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http://dx.doi.org/10.1136/jnnp-2017-315942DOI Listing
September 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

An In Vivo C-(R)-PK11195 PET and In Vitro Pathology Study of Microglia Activation in Creutzfeldt-Jakob Disease.

Mol Neurobiol 2018 Apr 28;55(4):2856-2868. Epub 2017 Apr 28.

Vita-Salute San Raffaele University, Via Olgettina 58, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s12035-017-0522-6DOI Listing
April 2018

Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.

Neurobiol Aging 2017 06 20;54:214.e1-214.e6. Epub 2017 Feb 20.

Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.008DOI Listing
June 2017

Measles Inclusion-Body Encephalitis: Neuronal Phosphorylated Tau Protein is Present in the Biopsy but not in the Autoptic Specimens of the Same Patient.

Brain Pathol 2016 09;26(5):673

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

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http://dx.doi.org/10.1111/bpa.12377DOI Listing
September 2016

A 52-Year-Old Man with Myoclonic Jerks.

Brain Pathol 2016 Mar;26(2):291-2

IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.1111/bpa.12359DOI Listing
March 2016

Unusual presentations and intrafamilial phenotypic variability in infantile onset Alexander disease.

Neurol Sci 2016 Jun 7;37(6):973-7. Epub 2016 Jan 7.

Division of Child Neurology, IRCCS-Fondazione Istituto Neurologico Carlo Besta, via Celoria 11, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s10072-015-2466-9DOI Listing
June 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease.

J Alzheimers Dis 2015 ;47(4):877-81

Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.3233/JAD-150179DOI Listing
July 2016

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

Hereditary and sporadic beta-amyloidoses.

Front Biosci (Landmark Ed) 2013 Jun 1;18:1202-26. Epub 2013 Jun 1.

Division of Neurology 5-Neuropathology, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.2741/4173DOI Listing
June 2013

Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice.

Prion 2012 Sep-Oct;6(4):383-90. Epub 2012 Jul 30.

Division of Neuropathology and Neurology 5, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.4161/pri.20197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609068PMC
February 2013

A case of multiple sclerosis with pure, massive superficial demyelination.

Neurology 2012 Jul 11;79(4):384-6. Epub 2012 Jul 11.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1212/WNL.0b013e31826043c2DOI Listing
July 2012

Good gene, bad gene: new APP variant may be both.

Prog Neurobiol 2012 Dec 19;99(3):281-92. Epub 2012 Jun 19.

Neurology V & Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.pneurobio.2012.06.004DOI Listing
December 2012

Variability of the clinical phenotype in an Italian family with dementia associated with an intronic deletion in the GRN gene.

J Alzheimers Dis 2011 ;26(3):583-90

Division of Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy DISM, University of Udine, Udine, Italy.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-2011-110332DOI Listing
January 2012

Lipofuscin hypothesis of Alzheimer's disease.

Dement Geriatr Cogn Dis Extra 2011 Jan 20;1(1):292-6. Epub 2011 Sep 20.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Palermo, Italy.

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http://dx.doi.org/10.1159/000329544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235942PMC
January 2011

APE1/Ref-1 in Alzheimer's disease: an immunohistochemical study.

Neurosci Lett 2009 Dec 25;466(3):124-7. Epub 2009 Sep 25.

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

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http://dx.doi.org/10.1016/j.neulet.2009.09.039DOI Listing
December 2009

A novel Italian presenilin 2 gene mutation with prevalent behavioral phenotype.

J Alzheimers Dis 2009 ;16(3):509-11

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

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http://dx.doi.org/10.3233/JAD-2009-0986DOI Listing
May 2009

Current concepts in Alzheimer's disease: a multidisciplinary review.

Am J Alzheimers Dis Other Demen 2009 Apr-May;24(2):95-121

Science Direction Unit, Fondazione IRCCS Istituto Nazionale Neurologico Carlo Besta, Milano, Italy.

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http://dx.doi.org/10.1177/1533317508328602DOI Listing
June 2009

A new function of microtubule-associated protein tau: involvement in chromosome stability.

Cell Cycle 2008 Jun 25;7(12):1788-94. Epub 2008 Jun 25.

Department of Neuropathology, Neurological Institute Carlo Besta, Milano, Italy.

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http://dx.doi.org/10.4161/cc.7.12.6012DOI Listing
June 2008

Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study.

Brain Pathol 2007 Jul 23;17(3):297-303. Epub 2007 Apr 23.

Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/j.1750-3639.2007.00073.xDOI Listing
July 2007

Cognitive deficits in familial Alzheimer's disease associated with M239V mutation of presenilin 2.

Dement Geriatr Cogn Disord 2006 10;22(3):238-43. Epub 2006 Aug 10.

Division of Neuropathology and Neurology, Carlo Besta National Neurological Institute, Milan, Italy.

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http://dx.doi.org/10.1159/000094972DOI Listing
October 2006

Pathologic prion protein is specifically recognized in situ by a novel PrP conformational antibody.

Neurobiol Dis 2006 Sep 28;23(3):717-24. Epub 2006 Jul 28.

Dipartimento di Scienze Mediche e Chirurgiche, Sezione di Clinica Medica, Università Politecnica delle Marche, Polo Didattico, Via Tronto 10, 60020 Ancona, Italy.

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http://dx.doi.org/10.1016/j.nbd.2006.06.008DOI Listing
September 2006

Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer disease.

J Biol Chem 2005 Dec 27;280(51):42088-96. Epub 2005 Oct 27.

Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, via Balzaretti, 9, 20133 Milan, Italy.

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http://dx.doi.org/10.1074/jbc.M504124200DOI Listing
December 2005