Giorgina Mangano

New insights on the arylpiperazinylalkyl pyridazinone ET1 as potent antinociceptive and anti-inflammatory agent.

Authors:

Francesco Μaione Mariantonella Colucci Federica Raucci Giorgina Mangano Francesca Marzoli Nicola Mascolo Letizia Crocetti Maria Paola Giovannoni Amalia Di Giannuario Stefano Pieretti

Eur J Pharmacol 2020 Dec 16;888:173572. Epub 2020 Sep 16.

National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. Electronic address:

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December 2020

Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and Activity in a Mood Disorder Model.

Authors:

Federica Prati Rosa Buonfiglio Guido Furlotti Claudia Cavarischia Giorgina Mangano Rossella Picollo Laura Oggianu Anna di Matteo Silvana Olivieri Graziella Bovi Pier Francesca Porceddu Angelo Reggiani Beatrice Garrone Francesco Paolo Di Giorgio Rosella Ombrato

ACS Med Chem Lett 2020 May 24;11(5):825-831. Epub 2020 Mar 24.

Angelini Pharma S.p.A., Viale Amelia, 70, 00181 Rome, Italy.

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May 2020

Pharmacological Characterization of the Microsomal Prostaglandin E Synthase-1 Inhibitor AF3485 and .

Authors:

Luigia Di Francesco Annalisa Bruno Emanuela Ricciotti Stefania Tacconelli Melania Dovizio Paloma Guillem-Llobat Maria Alessandra Alisi Beatrice Garrone Isabella Coletta Giorgina Mangano Claudio Milanese Garret A FitzGerald Paola Patrignani

Front Pharmacol 2020 2;11:374. Epub 2020 Apr 2.

Department of Neuroscience, Imaging and Clinical Sciences, and Center for Advanced Studies and Technology (CAST), School of Medicine, G. d'Annunzio University, Chieti, Italy.

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April 2020

Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors.

Authors:

Noemi D'Atanasio Alessandra Capezzone de Joannon Laura Di Sante Giorgina Mangano Rosella Ombrato Marco Vitiello Cristina Bartella Gabriele Magarò Federica Prati Claudio Milanese Carla Vignaroli Francesco Paolo Di Giorgio Serena Tongiani

PLoS One 2020 19;15(2):e0228509. Epub 2020 Feb 19.

Angelini RR&D (Regulatory, Research & Development)-Angelini S.p.A., S. Palomba-Pomezia (Rome), Italy.

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May 2020

The Nootropic Drug Α-Glyceryl-Phosphoryl-Ethanolamine Exerts Neuroprotective Effects in Human Hippocampal Cells.

Authors:

Simona Daniele Giorgina Mangano Lucia Durando Lorella Ragni Claudia Martini

Int J Mol Sci 2020 Jan 31;21(3). Epub 2020 Jan 31.

Department of Pharmacy, University of Pisa, via Bonanno Pisano 6, 56126 Pisa, Italy.

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January 2020

Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.

Authors:

Gabriele Magarò Federica Prati Barbara Garofalo Gaia Corso Guido Furlotti Claudia Apicella Giorgina Mangano Noemi D'Atanasio Daniel Robinson Francesco Paolo Di Giorgio Rosella Ombrato

J Med Chem 2019 08 31;62(16):7445-7472. Epub 2019 Jul 31.

Angelini RR&D (Research, Regulatory & Development) , Angelini S.p.A. , Piazzale della Stazione SNC, S. Palomba-Pomezia , Rome 00071 , Italy.

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August 2019

Targeting Serotonin 2A and Adrenergic α Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives.

Authors:

Guido Furlotti Maria Alessandra Alisi Nicola Cazzolla Francesca Ceccacci Beatrice Garrone Tecla Gasperi Angela La Bella Francesca Leonelli Maria Antonietta Loreto Gabriele Magarò Giorgina Mangano Rinaldo Marini Bettolo Emanuela Masini Martina Miceli Luisa Maria Migneco Marco Vitiello

ChemMedChem 2018 08 9;13(15):1597-1607. Epub 2018 Jul 9.

Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A., Piazzale della stazione snc, 00071, S. Palomba-Pomezia (Rome), Italy.

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August 2018

Proneurogenic Effects of Trazodone in Murine and Human Neural Progenitor Cells.

Authors:

Valeria Bortolotto Francesca Mancini Giorgina Mangano Rita Salem Er Xia Erika Del Grosso Michele Bianchi Pier Luigi Canonico Lorenzo Polenzani Mariagrazia Grilli

ACS Chem Neurosci 2017 09 3;8(9):2027-2038. Epub 2017 Jul 3.

Angelini S.p.A , RR&D, Angelini Research Center, Piazzale della Stazione, 00071 S. Palomba-Pomezia, Roma, Italy.

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September 2017

Structure-Based Discovery of 1H-Indazole-3-carboxamides as a Novel Structural Class of Human GSK-3 Inhibitors.

Authors:

Rosella Ombrato Nicola Cazzolla Francesca Mancini Giorgina Mangano

J Chem Inf Model 2015 Dec 16;55(12):2540-51. Epub 2015 Dec 16.

R&D, Computational Chemistry Laboratory, ‡Chemistry Department, and §In Vitro Pharmacology Development, Angelini Research Center, ACRAF S.p.A. , Piazzale della Stazione, snc, I-00071 Santa Palomba, Pomezia (RM), Italy.

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December 2015

Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders.

Authors:

Guido Furlotti Maria Alessandra Alisi Nicola Cazzolla Patrizia Dragone Lucia Durando Gabriele Magarò Francesca Mancini Giorgina Mangano Rosella Ombrato Marco Vitiello Andrea Armirotti Valeria Capurro Massimiliano Lanfranco Giuliana Ottonello Maria Summa Angelo Reggiani

J Med Chem 2015 Nov 13;58(22):8920-37. Epub 2015 Nov 13.

Drug Discovery and Development Department, Istituto Italiano di Tecnologia , Via Morego 30, 16163 Genova, Italy.

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November 2015

A New Acid-oxidizing Solution: Assessment of Its Role on Methicillin-resistant Staphylococcus aureus (MRSA) Biofilm Morphological Changes.

Authors:

Noemi D'Atanasio Alessandra Capezzone de Joannon Giorgina Mangano Marisa Meloni Nadia Giarratana Claudio Milanese Serena Tongiani

Wounds 2015 Oct;27(10):265-73

Angelini Research S.p.A.,Santa Polumba, Rome, Italy.

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October 2015

Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.

Authors:

Guido Furlotti Maria Alessandra Alisi Claudia Apicella Alessandra Capezzone de Joannon Nicola Cazzolla Roberta Costi Giuliana Cuzzucoli Crucitti Beatrice Garrone Alberto Iacovo Gabriele Magarò Giorgina Mangano Gaetano Miele Rosella Ombrato Luca Pescatori Lorenzo Polenzani Federica Rosi Marco Vitiello Roberto Di Santo

J Med Chem 2012 Nov 24;55(22):9446-66. Epub 2012 Oct 24.

Department of Chemistry, Angelini Santa Palomba Research Center, Piazzale della Stazione snc, 00040 Pomezia, Italy.

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November 2012

The monocyte chemotactic protein synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling.

Authors:

Sara Paccosi Claudia Musilli Giorgina Mangano Angelo Guglielmotti Astrid Parenti

Pharmacol Res 2012 Dec 14;66(6):526-35. Epub 2012 Sep 14.

Department of Pharmacology, University of Florence, Florence, Italy.

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December 2012

Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis.

Authors:

Federica Finetti Erika Terzuoli Elena Bocci Isabella Coletta Lorenzo Polenzani Giorgina Mangano Maria Alessandra Alisi Nicola Cazzolla Antonio Giachetti Marina Ziche Sandra Donnini

PLoS One 2012 18;7(7):e40576. Epub 2012 Jul 18.

Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori (ITT), Italy.

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March 2013

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models.

Authors:

Massimo Zollo Valeria Di Dato Daniela Spano Daniela De Martino Lucia Liguori Natascia Marino Viviana Vastolo Luigi Navas Beatrice Garrone Giorgina Mangano Giuseppe Biondi Angelo Guglielmotti

Clin Exp Metastasis 2012 Aug 7;29(6):585-601. Epub 2012 Apr 7.

Centro di Ingegneria Genetica, Biotecnologie Avanzate (CEINGE), Via Gaetano Salvatore 486, 80145, Naples, Italy.

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August 2012

Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.

Authors:

Annalisa Bruno Luigia Di Francesco Isabella Coletta Giorgina Mangano Maria Alessandra Alisi Lorenzo Polenzani Claudio Milanese Paola Anzellotti Emanuela Ricciotti Melania Dovizio Andrea Di Francesco Stefania Tacconelli Marta L Capone Paola Patrignani

Biochem Pharmacol 2010 Apr 27;79(7):974-81. Epub 2009 Nov 27.

Department of Medicine and Center of Excellence on Aging, School of Medicine, G. d'Annunzio University and G. d'Annunzio University Foundation, Ce.S.I., Chieti 66100, Italy.

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April 2010