Gino Salituro

Gino Salituro

UNVERIFIED PROFILE

Are you Gino Salituro?   Register this Author

Register author
Gino Salituro

Gino Salituro

Publications by authors named "Gino Salituro"

Are you Gino Salituro?   Register this Author

37Publications

2032Reads

47Profile Views

Quantitation of Super Basic Peptides in Biological Matrices by a Generic Perfluoropentanoic Acid-Based Liquid Chromatography-Mass Spectrometry Method.

J Am Soc Mass Spectrom 2019 Sep 27;30(9):1779-1789. Epub 2019 Jun 27.

Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, NJ, 07065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13361-019-02257-9DOI Listing
September 2019

Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery.

Pharm Res 2019 Aug 26;36(10):151. Epub 2019 Aug 26.

Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 East Lincoln Ave, Rahway, New Jersey, 07065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-019-2682-8DOI Listing
August 2019

Development of a Convenient In Vitro Gel Diffusion Model for Predicting the In Vivo Performance of Subcutaneous Parenteral Formulations of Large and Small Molecules.

AAPS PharmSciTech 2017 Aug 9;18(6):2203-2213. Epub 2017 Jan 9.

Preformulation Automation, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey, 07065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-016-0698-5DOI Listing
August 2017

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

ACS Med Chem Lett 2016 Dec 12;7(12):1107-1111. Epub 2016 Oct 12.

Departments of Medicinal Chemistry, Discovery Pharmaceutical Sciences, Pharmacokenetics Pharmacodynamics Drug Metabolism, Diabetes Research, and Cardiometabolic Disease, Merck & Co., Inc., MRL , 126 East Lincoln Avenue, PO Box 2000, Rahway, New Jersey 07065, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.6b00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150677PMC
December 2016

Discovery of benzamides as potent human β3 adrenergic receptor agonists.

Bioorg Med Chem Lett 2016 Jan 11;26(1):55-9. Epub 2015 Nov 11.

Early Development and Discovery Sciences, Merck and Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2015.11.030DOI Listing
January 2016

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

J Med Chem 2015 Dec 20;58(23):9345-53. Epub 2015 Nov 20.

Department of Discovery Chemistry, ‡Chemistry Modeling, and Informatics, §In Vitro Pharmacology, ∥In Vivo Pharmacology, ⊥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Basic Pharmaceutical Sciences, and ○Atherosclerosis, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.5b01345DOI Listing
December 2015

Modulating Drug Release and Enhancing the Oral Bioavailability of Torcetrapib with Solid Lipid Dispersion Formulations.

AAPS PharmSciTech 2015 Oct 18;16(5):1091-100. Epub 2015 Feb 18.

Discovery Pharmaceutical Sciences, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ, 07065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12249-015-0299-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674632PMC
October 2015

A novel series of indazole-/indole-based glucagon receptor antagonists.

Bioorg Med Chem Lett 2015 Oct 8;25(19):4143-7. Epub 2015 Aug 8.

Early Development and Discovery Science, and Preclinical Development, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2015.08.015DOI Listing
October 2015

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes.

ACS Med Chem Lett 2015 Aug 10;6(8):936-41. Epub 2015 Jul 10.

Departments of Medicinal Chemistry, Diabetes Biology, Pharmacology, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Basic Pharmaceutical Sciences, Chemical Modeling and Informatics, and Process Research, Merck Research Laboratories , Rahway, New Jersey 07065, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.5b00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538435PMC
August 2015

Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Drug Metab Dispos 2015 Jun 26;43(6):851-63. Epub 2015 Mar 26.

Merck Sharp & Dohme Corporation, Kenilworth, New Jersey (X.C., G.H.C., K.O., S.W., X.C., D.N., J.C.P., G.S., J.P., A.L., M.J.S., R.E.); Translational Medicine Research Centre, Singapore (S.J.S., R.S., H.H., A.F., C.K.N.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.115.063347DOI Listing
June 2015

Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.

ACS Med Chem Lett 2015 May 13;6(5):553-7. Epub 2015 Mar 13.

Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Thrombosis, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.5b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434479PMC
May 2015

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

J Med Chem 2014 Apr 2;57(8):3205-12. Epub 2014 Apr 2.

Department of Discovery Chemistry, ‡Department of Metabolic Disorders, §Department of Pharmacology, ∥Department of Drug Metabolism, ⊥Basic Pharmaceutical Sciences, and #Department of Safety Assessment and Animal Resources, Merck & Co., Inc. , Whitehouse Station, New Jersey 08889, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm401992eDOI Listing
April 2014

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.

Bioorg Med Chem Lett 2011 Jun 8;21(11):3390-4. Epub 2011 Apr 8.

Merck Research Laboratories, Merck & Co., Inc., 126 E. Lincoln Ave., PO Box 2000, Rahway, NJ 07065-0900, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2011.03.114DOI Listing
June 2011

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.

Nat Med 2002 Feb;8(2):179-83

Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm0202-179DOI Listing
February 2002