Publications by authors named "Gillian Griffiths"

80Publications

Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling.

Elife 2020 May 15;9. Epub 2020 May 15.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.53948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308083PMC
May 2020

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.

Nat Commun 2020 01 20;11(1):381. Epub 2020 Jan 20.

Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.

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http://dx.doi.org/10.1038/s41467-019-14123-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971012PMC
January 2020

Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.

Front Immunol 2019 11;10:700. Epub 2019 Apr 11.

Cambridge Institute of Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.00700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470250PMC
September 2020

The Influence of External Focus Instruction Characteristics on Children's Motor Performance.

Res Q Exerc Sport 2018 Dec 26;89(4):418-428. Epub 2018 Sep 26.

b Southern Illinois University.

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http://dx.doi.org/10.1080/02701367.2018.1512075DOI Listing
December 2018

PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.

Immunity 2018 09 11;49(3):427-437.e4. Epub 2018 Sep 11.

Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162341PMC
September 2018

T cell cytolytic capacity is independent of initial stimulation strength.

Nat Immunol 2018 08 16;19(8):849-858. Epub 2018 Jul 16.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41590-018-0160-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300116PMC
August 2018

An early history of T cell-mediated cytotoxicity.

Nat Rev Immunol 2018 08;18(8):527-535

Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, UK.

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http://www.nature.com/articles/s41577-018-0009-3
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http://dx.doi.org/10.1038/s41577-018-0009-3DOI Listing
August 2018

Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Immun Inflamm Dis 2018 06 11;6(2):312-321. Epub 2018 Apr 11.

Immunoregulation Section, Autoimmunity Branch, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/iid3.219
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http://dx.doi.org/10.1002/iid3.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946154PMC
June 2018

Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Proc Natl Acad Sci U S A 2017 08 17;114(32):E6585-E6594. Epub 2017 Jul 17.

National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1710751114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559056PMC
August 2017

Imaging the Effector CD8 Synapse.

Methods Mol Biol 2017 ;1584:473-486

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1007/978-1-4939-6881-7_29DOI Listing
February 2018

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8 CTLs.

J Immunol 2017 04 17;198(7):2699-2711. Epub 2017 Feb 17.

National Human Genome Research Institute, Bethesda, MD 20892; and

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http://dx.doi.org/10.4049/jimmunol.1601202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360469PMC
April 2017

Secretion from Myeloid Cells: Secretory Lysosomes.

Microbiol Spectr 2016 08;4(4)

Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0030-2016DOI Listing
August 2016

The cytotoxic T lymphocyte immune synapse at a glance.

J Cell Sci 2016 08;129(15):2881-6

Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK

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http://dx.doi.org/10.1242/jcs.186205DOI Listing
August 2016

Origins of the cytolytic synapse.

Nat Rev Immunol 2016 07 6;16(7):421-32. Epub 2016 Jun 6.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/nri.2016.54DOI Listing
July 2016

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.

Traffic 2015 Dec 2;16(12):1330-41. Epub 2015 Nov 2.

Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1111/tra.12337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791091PMC
December 2015

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.

Curr Biol 2015 Dec 5;25(24):3239-44. Epub 2015 Dec 5.

Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691242PMC
December 2015

The biogenesis of lysosomes and lysosome-related organelles.

Cold Spring Harb Perspect Biol 2014 Sep 2;6(9):a016840. Epub 2014 Sep 2.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a016840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142962PMC
September 2014

Communication, the centrosome and the immunological synapse.

Philos Trans R Soc Lond B Biol Sci 2014 Sep;369(1650)

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK

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http://dx.doi.org/10.1098/rstb.2013.0463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113107PMC
September 2014

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

J Allergy Clin Immunol 2014 Dec 27;134(6):1381-1387.e7. Epub 2014 Jun 27.

Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jaci.2014.04.043DOI Listing
December 2014

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Elife 2014 Mar 4;3:e01310. Epub 2014 Mar 4.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936284PMC
http://dx.doi.org/10.7554/eLife.01310DOI Listing
March 2014

Hedgehog signaling controls T cell killing at the immunological synapse.

Science 2013 Dec;342(6163):1247-50

Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1126/science.1244689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022134PMC
December 2013

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Proc Natl Acad Sci U S A 2013 Nov 5;110(47):E4482-91. Epub 2013 Nov 5.

Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1313474110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839780PMC
November 2013

The role of the cytoskeleton at the immunological synapse.

Immunol Rev 2013 Nov;256(1):107-17

Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1111/imr.12117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312978PMC
November 2013

Open questions: missing pieces from the immunological jigsaw puzzle.

BMC Biol 2013 Jan 31;11:10. Epub 2013 Jan 31.

Cambridge Institute for Medical Research, Hills Rd, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1186/1741-7007-11-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561189PMC
January 2013

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

Eur J Immunol 2013 Jan 12;43(1):194-208. Epub 2012 Dec 12.

Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany.

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http://dx.doi.org/10.1002/eji.201142343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405866PMC
January 2013

Cell polarisation and the immunological synapse.

Curr Opin Cell Biol 2013 Feb 16;25(1):85-91. Epub 2012 Sep 16.

Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, CB2 0XY, England, UK.

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http://dx.doi.org/10.1016/j.ceb.2012.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712171PMC
February 2013

Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Immunity 2012 Jun 7;36(6):1003-16. Epub 2012 Jun 7.

Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613120023
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http://dx.doi.org/10.1016/j.immuni.2012.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389133PMC
June 2012

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity.

Cell Mol Life Sci 2012 Jan 12;69(1):29-40. Epub 2011 Oct 12.

Dipartimento Oncoematologia Pediatrica e Cure Domiciliari, Azienda Ospedaliero-Universitaria Meyer, Viale Pieraccini, 24, 50139 Florence, Italy.

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http://dx.doi.org/10.1007/s00018-011-0835-yDOI Listing
January 2012

Centrosome docking at the immunological synapse is controlled by Lck signaling.

J Cell Biol 2011 Feb;192(4):663-74

Cambridge Institute for Medical Research, Addenbrooke's Hospital, University of Cambridge, Cambridge, England, UK.

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http://dx.doi.org/10.1083/jcb.201008140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044125PMC
February 2011

The immunological synapse: a focal point for endocytosis and exocytosis.

J Cell Biol 2010 May;189(3):399-406

Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, England, UK.

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http://dx.doi.org/10.1083/jcb.201002027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867296PMC
May 2010

The synapse and cytolytic machinery of cytotoxic T cells.

Curr Opin Immunol 2010 Jun 11;22(3):308-13. Epub 2010 Mar 11.

Cambridge Institute for Medical Research, Addenbrooke's, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.coi.2010.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101800PMC
June 2010

The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

Immunity 2009 Oct;31(4):621-31

Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1016/j.immuni.2009.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791175PMC
October 2009

Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.

Haematologica 2010 Feb 13;95(2):333-7. Epub 2009 Aug 13.

Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.3324/haematol.2009.012286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817039PMC
February 2010

Gaucher disease: forging a new path to the lysosome.

Cell 2007 Nov;131(4):647-9

Cambridge Institute for Medical Research, Wellcome/MRC Building, Box 139, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY.

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http://dx.doi.org/10.1016/j.cell.2007.10.043DOI Listing
November 2007

Secretory mechanisms in cell-mediated cytotoxicity.

Annu Rev Cell Dev Biol 2007 ;23:495-517

Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, England.

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http://www.annualreviews.org/doi/10.1146/annurev.cellbio.23.
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http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123521DOI Listing
December 2007

Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

J Cell Sci 2007 Jan 12;120(Pt 1):191-9. Epub 2006 Dec 12.

Sir William Dunn School of Pathology, South Parks Rd, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1242/jcs.03315DOI Listing
January 2007

Centrosome polarization delivers secretory granules to the immunological synapse.

Nature 2006 Sep;443(7110):462-5

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://www.nature.com/articles/nature05071
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http://dx.doi.org/10.1038/nature05071DOI Listing
September 2006

Regulating secretory lysosomes.

J Biochem 2006 Jul;140(1):7-12

Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1093/jb/mvj126DOI Listing
July 2006

CTL secretory lysosomes: biogenesis and secretion of a harmful organelle.

Semin Immunol 2005 Feb;17(1):87-94

Sir William Dunn School of Pathology, University of Oxford, South Park Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/j.smim.2004.09.007DOI Listing
February 2005

Linking albinism and immunity: the secrets of secretory lysosomes.

Science 2004 Jul;305(5680):55-9

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1126/science.1095291DOI Listing
July 2004

The role of the secretory immunological synapse in killing by CD8+ CTL.

Semin Immunol 2003 Dec;15(6):301-5

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/j.smim.2003.09.003DOI Listing
December 2003

A general role for Rab27a in secretory cells.

Mol Biol Cell 2004 Jan 14;15(1):332-44. Epub 2003 Nov 14.

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e03-07-0452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307551PMC
January 2004

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

Nat Immunol 2003 Nov 19;4(11):1111-20. Epub 2003 Oct 19.

Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK.

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http://dx.doi.org/10.1038/ni1000DOI Listing
November 2003

Lytic granules, secretory lysosomes and disease.

Curr Opin Immunol 2003 Oct;15(5):516-21

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1016/s0952-7915(03)00113-4DOI Listing
October 2003

Delivering the kiss of death.

Nat Immunol 2003 May;4(5):399-403

Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1038/ni0503-399DOI Listing
May 2003

Microtubule-dependent transport of secretory vesicles in RBL-2H3 cells.

Traffic 2003 May;4(5):302-12

Department of Pathology and Cancer Research & Treatment Center, University of New Mexico Health Sciences Center, New Mexico, USA.

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http://dx.doi.org/10.1034/j.1600-0854.2003.00084.xDOI Listing
May 2003

Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.

Science 2003 Mar 13;299(5613):1713-6. Epub 2003 Feb 13.

Department of Immunology, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, UK.

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http://dx.doi.org/10.1126/science.1080115DOI Listing
March 2003

Endocytosing the death sentence.

J Cell Biol 2003 Jan 21;160(2):155-6. Epub 2003 Jan 21.

Sir William Dunn School of Medicine, Oxford OX1 3RE, United Kingdom.

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http://dx.doi.org/10.1083/jcb.200212143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172643PMC
January 2003

The secretory synapse: the secrets of a serial killer.

Immunol Rev 2002 Nov;189:152-60

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1034/j.1600-065x.2002.18913.xDOI Listing
November 2002

What's special about secretory lysosomes?

Semin Cell Dev Biol 2002 Aug;13(4):279-84

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK.

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http://dx.doi.org/10.1016/s1084-9521(02)00057-5DOI Listing
August 2002

Albinism and immunity: what's the link?

Curr Mol Med 2002 Aug;2(5):479-83

Sir William Dunn School of Pathology, Oxford University, UK.

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http://dx.doi.org/10.2174/1566524023362258DOI Listing
August 2002

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.

Traffic 2002 Mar;3(3):193-202

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1034/j.1600-0854.2002.030305.xDOI Listing
March 2002

Secretory lysosomes.

Nat Rev Mol Cell Biol 2002 Feb;3(2):122-31

Sir William Dunn School of Pathology, Oxford University, South Parks Rd, Oxford OX1 3RE, UK.

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http://dx.doi.org/10.1038/nrm732DOI Listing
February 2002