Gilles Vassal

Gilles Vassal

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Gilles Vassal

Publications by authors named "Gilles Vassal"

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A European paediatric cancer mission: aspiration or reality?

Lancet Oncol 2019 Sep;20(9):1200-1202

Department of Pediatrics and Adolescent Medicine, Rigshospitalet University Hospital, and Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/S1470-2045(19)30487-5DOI Listing
September 2019

Long-term efficacy of crizotinib in a metastatic papillary renal carcinoma with MET amplification: a case report and literature review.

BMC Cancer 2018 Nov 22;18(1):1159. Epub 2018 Nov 22.

Department of Medical Oncology, Institut Paoli-Calmettes, 232 Bd de Sainte-Marguerite, 13009, Marseille, France.

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http://dx.doi.org/10.1186/s12885-018-5049-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251103PMC
November 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Efficacy of nivolumab in a patient with systemic refractory ALK+ anaplastic large cell lymphoma.

Pediatr Blood Cancer 2018 04 28;65(4). Epub 2017 Nov 28.

Department of Oncology for Children and Adolescents, Gustave Roussy Caner Campus, Villejuif, France.

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http://dx.doi.org/10.1002/pbc.26902DOI Listing
April 2018

Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma.

J Clin Oncol 2018 04 7;36(10):951-958. Epub 2018 Feb 7.

Jacques Grill, Marie-Cécile Le Deley, and Gilles Vassal, Institut Gustave-Roussy, Villejuif; Marie-Cécile Le Deley, Paris-Saclay and Paris-Sud Universities, CESP, Institut National de la Santé et de la Recherche Médicale, Orsay; Pascale Varlet, Sainte-Anne Hospital, Paris, France; Maura Massimino, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan; Felice Giangaspero, Sapienza University, Rome; Felice Giangaspero, IRCCS Neuromed, Pozzilli, Italy; Eric Bouffet, Hospital for Sick Children, Toronto, Ontario, Canada; Amedeo A. Azizi, Medical University of Vienna, Vienna, Austria; Geoffrey McCowage, Australasian Children's Cancer Trials, Clayton, Victoria, Australia; Adela Cañete, Hospital La Fe, Valencia, Spain; Frank Saran, The Royal Marsden Hospital; Chris Jones, The Institute of Cancer Research; Darren Hargrave, Great Ormond Street Hospital, London; Paul S. Morgan and Tim Jaspan, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, United Kingdom; Helen Smith, Josep Garcia, Markus C. Elze, and Lauren Abrey, F. Hoffmann-La Roche Ltd, Basel, Switzerland; and Raphaël F. Rousseau, Gritstone Oncology, Emeryville, CA.

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http://dx.doi.org/10.1200/JCO.2017.76.0611DOI Listing
April 2018

Outcome of children and adolescents with central nervous system tumors in phase I trials.

J Neurooncol 2018 Mar 13;137(1):83-92. Epub 2017 Dec 13.

Pediatric and Adolescent Drug Development, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust - Paediatric Offices, Downs Road, Sutton, SM2 5PT, UK.

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http://dx.doi.org/10.1007/s11060-017-2698-zDOI Listing
March 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

10-year report on the European Paediatric Regulation and its impact on new drugs for children's cancers.

Lancet Oncol 2018 03;19(3):285-287

Innovative Therapy for Children with Cancer, Europe; SIOPE Brussels, Belgium; Department of Clinical Research, Gustave Roussy, Paris-Saclay University, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30105-0DOI Listing
March 2018

Orphan Drug Regulation: A missed opportunity for children and adolescents with cancer.

Eur J Cancer 2017 10 4;84:149-158. Epub 2017 Sep 4.

Innovative Therapy for Children with Cancer, Villejuif, France; Paediatric Drug Development, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, SM2 5PT, UK; Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research, Sutton, SM2 5NG, UK.

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http://dx.doi.org/10.1016/j.ejca.2017.07.021DOI Listing
October 2017

Roles of Clinical Research Networks in Pediatric Drug Development.

Clin Ther 2017 Oct 22;39(10):1939-1948. Epub 2017 Sep 22.

Department of Women's and Children's Health, University of Padova, Padua, Italy.

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http://dx.doi.org/10.1016/j.clinthera.2017.09.001DOI Listing
October 2017

The right to be forgotten: a change in access to insurance and loans after childhood cancer?

J Cancer Surviv 2017 Aug 27;11(4):431-437. Epub 2017 Jan 27.

Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay, 94807, Villejuif, France.

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http://dx.doi.org/10.1007/s11764-017-0600-9DOI Listing
August 2017

Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.

Cancer Genet 2017 04 22;212-213:32-37. Epub 2017 Mar 22.

Department of Paediatrics and Adolescent Medicine, Neuroscience Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cancergen.2017.03.005DOI Listing
April 2017

Busulfan after HSCT in children and young adults.

Lancet Haematol 2017 03;4(3):e103

Département de Recherche Clinique, Gustave Roussy Cancer Campus, Université Paris Sud, Villejuif, France.

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http://dx.doi.org/10.1016/S2352-3026(16)30189-2DOI Listing
March 2017

Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.

Int J Oncol 2017 Jan 6;50(1):203-211. Epub 2016 Dec 6.

Vectorology and Anticancer Therapies, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.3892/ijo.2016.3792DOI Listing
January 2017

Access to loan-related insurance for French cancer survivors.

Lancet Oncol 2016 10;17(10):1354-1356

Department of Clinical Research, Gustave Roussy, U1018 INSERM, B2M, 114 Rue Edouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(16)30452-1DOI Listing
October 2016

[Not Available].

Therapie 2011 Jul-Aug;66(4):301-7

Roche, Neuilly sur Seine, France.

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http://dx.doi.org/10.2515/therapie/2011049DOI Listing
July 2016

European Survey on Standards of Care in paediatric oncology centres.

Eur J Cancer 2016 07 28;61:11-9. Epub 2016 Apr 28.

Direction of Clinical Research, The Gustave Roussy and Universite Paris-Sud, 114 Rue Edouard Vaillant, Villejuif 94805, France.

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http://dx.doi.org/10.1016/j.ejca.2016.03.073DOI Listing
July 2016

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Clin Cancer Res 2016 06 12;22(12):2960-8. Epub 2016 Jan 12.

Laboratoire de Recherche Translationnelle et Centre de RessourcesBiologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France. INSERM U981, Gustave Roussy, Villejuif, France. Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France. Faculté de Pharmacie, Université Paris Sud, Châtenay-Malabry, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2470DOI Listing
June 2016

Equal access to innovative therapies and precision cancer care.

Nat Rev Clin Oncol 2016 06 22;13(6):385-93. Epub 2016 Mar 22.

Gustave Roussy, 114 rue Edouard Vaillant, F-94805, Villejuif, France and University Paris-SUD, Faculté de Médecine, 63 Rue Gabriel Péri, F-94270 Le Kremlin Bicêtre, France.

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http://dx.doi.org/10.1038/nrclinonc.2016.31DOI Listing
June 2016

Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma.

Am J Pathol 2016 02 12;186(2):435-45. Epub 2015 Dec 12.

Laboratory for Vectorology and Anticancer Therapeutics, Gustave Roussy, Paris-Sud University, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8203, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.10.016DOI Listing
February 2016

Acquired EGFR Mutation as the Potential Resistance Driver to Crizotinib in a MET-Mutated Tumor.

J Thorac Oncol 2016 Feb 18;11(2):e21-3. Epub 2015 Dec 18.

DITEP (Département d'Innovations Thérapeutiques et Essais Précoces), Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médicine Paris-Sud XI, Kremlin-Bicêtre, France; U981 INSERM, Gustave Roussy Cancer Campus, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2015.08.001DOI Listing
February 2016

Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies.

Anticancer Res 2016 Feb;36(2):599-609

Vectorology and Anticancer Therapies, UMR 8203, CNRS, Paris-Sud University, Gustave Roussy Institute, Paris-Saclay University, Villejuif, France

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February 2016

Will the revised class waiver list make it?

Lancet Oncol 2015 Sep;16(9):e425-e426

Institute for Cancer Research, London, UK; European Consortium for Innovative Therapies for Children with Cancer, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(15)00233-8DOI Listing
September 2015

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma.

Neuro Oncol 2015 Jul 21;17(7):953-64. Epub 2014 Dec 21.

CNRS UMR 8203 Vectorology and Anticancer Therapeutics, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (N.T., C.P., F.A., L.G.-R., G.C., L.L.-D., B.G., G.V., J.G.); Functional Genomics Unit, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (C.R.); Translational Research Laboratory and Biobank, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Inserm U981, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Medical Biology and Pathology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (B.G., J.G.); Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden (J.P., A.Ö.); Department of Neurosurgery, Necker-Sick Children Hospital, Paris Descartes University, Paris, France (S.P.).

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http://dx.doi.org/10.1093/neuonc/nou330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654348PMC
July 2015

Patients in pediatric phase I and early phase II clinical oncology trials at Gustave Roussy: a 13-year center experience.

J Pediatr Hematol Oncol 2015 Mar;37(2):e102-10

Departments of *Pediatric and Adolescent Oncology †Biostatistics and Epidemiology ‡Radiology §CNRS UMR 8203 Vectorology and Anticancer Therapeutics, Université Paris-Sud 11, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1097/MPH.0000000000000237DOI Listing
March 2015

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.

Anticancer Drugs 2015 Mar;26(3):272-83

aGustave Roussy, Vectorology and Anticancer Therapeutics, Villejuif bUniversité Paris-Sud cCentre National de Recherche Scientifique (CNRS), Vectorology and Anticancer Therapeutics, UMR 8203, Orsay, France dDepartment of Neurosurgery, Necker Enfants-Malades Hospital, Paris-Descartes University, Paris ePediatric American Memorial Hospital, CHU Reims, Reims, France fHoffmann-La Roche Inc., Nutley, New Jersey, USA.

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http://dx.doi.org/10.1097/CAD.0000000000000190DOI Listing
March 2015

Establishment and characterization of new orthotopic and metastatic neuroblastoma models.

In Vivo 2014 Jul-Aug;28(4):425-34

Vectorology and Anticancer Therapeutics, UMR 8203, University Paris-Sud, Orsay, France CNRS, Orsay, Vectorology and Anticancer Therapeutics, UMR 8203, Orsay, France Gustave Roussy Institute, Vectorology and Anticancer Therapeutics, UMR 8203, Villejuif, France Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France

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February 2015

Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.

J Med Chem 2015 Jan 23;58(2):705-17. Epub 2014 Dec 23.

Université Paris-Sud, Centre National de la Recherche Scientifique (CNRS), and Gustave Roussy Cancer Campus Grand Paris, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203 , Villejuif, France -94805.

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http://dx.doi.org/10.1021/jm501224xDOI Listing
January 2015

Towards reducing inequalities: European Standards of Care for Children with Cancer.

Eur J Cancer 2014 Feb 30;50(3):481-5. Epub 2013 Nov 30.

Institute of Child Health, University College London, UK.

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http://dx.doi.org/10.1016/j.ejca.2013.11.004DOI Listing
February 2014

Need for change in implementation of paediatric regulation.

Lancet Oncol 2013 Nov;14(12):1156-7

Institut Gustave Roussy, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(13)70467-4DOI Listing
November 2013

Is the European pediatric medicine regulation working for children and adolescents with cancer?

Clin Cancer Res 2013 Mar 17;19(6):1315-25. Epub 2013 Jan 17.

Clinical Research Division, Institut Gustave Roussy, Villejuif Cedex, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2551DOI Listing
March 2013

New drugs for children and adolescents with cancer: the need for novel development pathways.

Lancet Oncol 2013 Mar 20;14(3):e117-24. Epub 2013 Feb 20.

Division of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(13)70013-5DOI Listing
March 2013

Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.

PLoS One 2012 20;7(8):e43665. Epub 2012 Aug 20.

Pediatric Oncology Research Unit, Department of Pediatrics, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423387PMC
January 2013

[Precompetitive research, a synergy of public and private resources: for what purpose, how and in what framework?].

Therapie 2011 Jul-Aug;66(4):301-7. Epub 2011 Aug 19.

Direction de la Recherche Clinique, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.2515/therapie/2011049DOI Listing
December 2012

Off-patent oral oncology drugs for kids (O3K FP7-project): from bedside to PUMA.

Int J Pharm 2012 Oct;435(2):148-50

Pharmacology and Drug Analysis Department, Institut de cancérologie Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif cedex, France.

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http://dx.doi.org/10.1016/j.ijpharm.2012.05.061DOI Listing
October 2012

CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway.

Histopathology 2012 Jun 6;60(7):1144-55. Epub 2012 Mar 6.

Department of Pathology and Cytogenetics, CHU Sainte Justine, Université de Montreal Research Center, CHU Sainte Justine, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/j.1365-2559.2012.04191.xDOI Listing
June 2012

Population pharmacokinetics of busulfan in children--letter.

Clin Cancer Res 2012 May;18(9):2715-6; author reply 2717-8

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3297DOI Listing
May 2012

A European Network of Paediatric Research at the European Medicines Agency (Enpr-EMA).

Arch Dis Child 2012 Mar 27;97(3):185-8. Epub 2011 Nov 27.

Pediatric Rheumatology International Trials Organisation (PRINTO) at IRCCS G Gaslini, Pediatria II, Reumatologia, Genova, Italy.

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http://dx.doi.org/10.1136/archdischild-2011-300286DOI Listing
March 2012

Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1.

Hum Pathol 2011 Nov;42(11):1727-39

UPRES EA3535, University of Paris South, Institut Gustave Roussy, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.humpath.2011.01.019DOI Listing
November 2011

The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts.

Int J Cancer 2011 Jun 8;128(11):2748-58. Epub 2010 Oct 8.

UPRES EA 3535, Pharmacology and New Anticancer Treatments, University Paris-Sud, Institut Gustave Roussy, Villejuif, France.

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http://doi.wiley.com/10.1002/ijc.25611
Publisher Site
http://dx.doi.org/10.1002/ijc.25611DOI Listing
June 2011

Quantification of dimethyl-ifosfamide and its N-deschloropropylated metabolites in mouse plasma by liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Apr 13;879(11-12):743-50. Epub 2011 Feb 13.

CNRS UMR 8203, Vectorologie et Thérapeutiques Anticancéreuses, Université Paris XI, Institut de Cancérologie Gustave Roussy, IRCIV, Villejuif, France.

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http://dx.doi.org/10.1016/j.jchromb.2011.02.012DOI Listing
April 2011

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma.

Eur J Cancer 2010 Dec 28;46(18):3251-62. Epub 2010 Jun 28.

UPRES EA 3535, Pharmacology and New Treatments of Cancer, Université Paris-Sud XI, Institut Gustave Roussy, 94805 Villejuif, France.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049100048
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http://dx.doi.org/10.1016/j.ejca.2010.06.005DOI Listing
December 2010

MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.

Cancer Res 2010 Nov 8;70(22):9243-52. Epub 2010 Oct 8.

Paediatric Oncology, and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, and Paediatric Oncology, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-10-1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935452PMC
November 2010

Oxazaphosphorines: new therapeutic strategies for an old class of drugs.

Expert Opin Drug Metab Toxicol 2010 Aug;6(8):919-38

Paris XI University and Integrated Research Cancer Institute Villejuif , France.

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http://dx.doi.org/10.1517/17425255.2010.487861DOI Listing
August 2010

New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future.

Expert Opin Investig Drugs 2010 Jul;19(7):859-74

Translational Research Laboratory, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1517/13543784.2010.487654DOI Listing
July 2010

The role of the 'innovative therapies for children with cancer' (ITCC) European consortium.

Cancer Treat Rev 2010 Jun 15;36(4):328-34. Epub 2010 Mar 15.

Dept. of Ped Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, GJ Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ctrv.2010.02.008DOI Listing
June 2010

Operating characteristics of two independent sample design in phase I trials in paediatric oncology.

Eur J Cancer 2010 May 20;46(8):1392-8. Epub 2010 Feb 20.

Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2010.01.024DOI Listing
May 2010

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

Mol Cancer Ther 2010 May;9(5):1219-33

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875164PMC
May 2010

P53 family: at the crossroads in cancer therapy.

Curr Med Chem 2009 ;16(32):4328-44

UPRESS 3535, Pharmacologie et Nouveaux Traitements des Cancers (IFR 54), Institut de Cancérologie Gustave Roussy, Rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.2174/092986709789578196DOI Listing
January 2010

High levels of circulating VEGFR2+ Bone marrow-derived progenitor cells correlate with metastatic disease in patients with pediatric solid malignancies.

Clin Cancer Res 2009 Jul;15(14):4561-71

Laboratory of Translational Research, University of Paris-Sud, UPRES EA 3535, Pharmacology and New Treatments in Cancer, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2363DOI Listing
July 2009