Gilles P van Wezel

Gilles P van Wezel

UNVERIFIED PROFILE

Are you Gilles P van Wezel?   Register this Author

Register author
Gilles P van Wezel

Gilles P van Wezel

Publications by authors named "Gilles P van Wezel"

Are you Gilles P van Wezel?   Register this Author

100Publications

2051Reads

27Profile Views

Spatial structure increases the benefits of antibiotic production in Streptomyces.

Evolution 2019 Aug 8. Epub 2019 Aug 8.

Institute of Biology, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/evo.13817DOI Listing
August 2019

Streptomyces coelicolor.

Trends Microbiol 2019 May 6;27(5):468-469. Epub 2019 Jan 6.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tim.2018.12.008DOI Listing
May 2019

Phylogenomic analyses and distribution of terpene synthases among .

Beilstein J Org Chem 2019 29;15:1181-1193. Epub 2019 May 29.

Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3762/bjoc.15.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604706PMC
May 2019

Polyphasic classification of the gifted natural product producer Streptomyces roseifaciens sp. nov.

Int J Syst Evol Microbiol 2019 Apr 21;69(4):899-908. Epub 2019 Jan 21.

1​Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/ijsem.0.003215DOI Listing
April 2019

Structural and Proteomic Changes in Viable but Non-culturable .

Front Microbiol 2019 17;10:793. Epub 2019 Apr 17.

Department of Microbial Biotechnology & Health, Institute of Biology Leiden, Leiden University, Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479200PMC
April 2019

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

J Ind Microbiol Biotechnol 2019 Mar 7;46(3-4):483-492. Epub 2019 Feb 7.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-019-02140-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403205PMC
March 2019

Lugdunomycin, an Angucycline-Derived Molecule with Unprecedented Chemical Architecture.

Angew Chem Int Ed Engl 2019 Feb 29;58(9):2809-2814. Epub 2019 Jan 29.

Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201814581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519343PMC
February 2019

Detection and identification of antibacterial proteins in snake venoms using at-line nanofractionation coupled to LC-MS.

Toxicon 2018 Dec 31;155:66-74. Epub 2018 Aug 31.

Animal Sciences and Health, Institute of Biology Leiden, University of Leiden, Sylviusweg 72, 2333BE, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2018.08.009DOI Listing
December 2018

Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes.

Nat Commun 2018 12 4;9(1):5164. Epub 2018 Dec 4.

Molecular Biotechnology, Institute of Biology, Leiden University, P.O. Box 9505, 2300 RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-07560-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279842PMC
December 2018

Healthy scents: microbial volatiles as new frontier in antibiotic research?

Curr Opin Microbiol 2018 10 12;45:84-91. Epub 2018 Mar 12.

Netherlands Institute of Ecology, Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mib.2018.02.011DOI Listing
October 2018

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

J Bacteriol 2018 10 24;200(20). Epub 2018 Sep 24.

Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://jb.asm.org/lookup/doi/10.1128/JB.00290-18
Publisher Site
http://dx.doi.org/10.1128/JB.00290-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153666PMC
October 2018

Editorial overview: Antimicrobials.

Curr Opin Microbiol 2018 10 31;45:iii-v. Epub 2018 Aug 31.

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mib.2018.08.001DOI Listing
October 2018

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.

Proteomics 2018 09 10;18(18):e1700332. Epub 2018 Jun 10.

Microbial Biotechnology & Health Programme Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201700332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175363PMC
September 2018

Production of Prodiginines Is Part of a Programmed Cell Death Process in .

Front Microbiol 2018 6;9:1742. Epub 2018 Aug 6.

InBioS - Centre for Protein Engineering, Institut de Chimie B6a, University of Liège, Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.01742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087738PMC
August 2018

Cracking the regulatory code of biosynthetic gene clusters as a strategy for natural product discovery.

Biochem Pharmacol 2018 07 5;153:24-34. Epub 2018 Jan 5.

Molecular Biotechnology, Institute of Biology, Sylvius Laboratories, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2018.01.007DOI Listing
July 2018

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era.

Nat Prod Rep 2018 06;35(6):575-604

Leiden University, Leiden Institute of Chemistry, 2300 RA Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8np00012cDOI Listing
June 2018

Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity.

Antonie Van Leeuwenhoek 2018 May 15;111(5):679-690. Epub 2018 Jan 15.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-018-1014-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913384PMC
May 2018

Dispatches from the land of the morning calm: special issue papers from the 18th International Symposium on the Biology of Actinomycetes.

Antonie Van Leeuwenhoek 2018 05;111(5):639

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-018-1077-xDOI Listing
May 2018

Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD.

Sci Rep 2018 05 9;8(1):7328. Epub 2018 May 9.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-25782-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943314PMC
May 2018

Morphology-driven downscaling of Streptomyces lividans to micro-cultivation.

Antonie Van Leeuwenhoek 2018 Mar 1;111(3):457-469. Epub 2017 Nov 1.

Molecular Biotechnology, Institute of Biology, Leiden University, PO Box 9505, 2300RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-017-0967-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816114PMC
March 2018

Microencapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production.

BMC Biotechnol 2018 03 12;18(1):13. Epub 2018 Mar 12.

Microbial Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12896-018-0425-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848461PMC
March 2018

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures.

Antonie Van Leeuwenhoek 2018 Feb 15;111(2):171-182. Epub 2017 Sep 15.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10482-017-0939-y
Publisher Site
http://dx.doi.org/10.1007/s10482-017-0939-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772119PMC
February 2018

Production of poly-β-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by .

Microb Cell 2018 Feb 12;5(6):269-279. Epub 2018 Feb 12.

Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15698/mic2018.06.635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972031PMC
February 2018

Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.

ACS Chem Biol 2017 11 2;12(11):2756-2766. Epub 2017 Oct 2.

Molecular Biotechnology, Institute of Biology, Leiden University , Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.7b00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696649PMC
November 2017

Aromatic Polyketide GTRI-02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2).

Chembiochem 2017 07 7;18(14):1428-1434. Epub 2017 Jun 7.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201700107DOI Listing
July 2017

Chemical ecology of antibiotic production by actinomycetes.

FEMS Microbiol Rev 2017 05;41(3):392-416

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/femsre/fux005DOI Listing
May 2017

Distance-dependent danger responses in bacteria.

Curr Opin Microbiol 2017 Apr 1;36:95-101. Epub 2017 Mar 1.

Institute of Biology, Leiden University, Sylvius Laboratory, Sylviusweg 72, 2300 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mib.2017.02.002DOI Listing
April 2017

Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow.

J Nat Prod 2017 02 27;80(2):269-277. Epub 2017 Jan 27.

Molecular Biotechnology, Institute of Biology, Leiden University , Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jnatprod.6b00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373568PMC
February 2017

Genome Sequence of the Filamentous Actinomycete .

Genome Announc 2017 Feb 9;5(6). Epub 2017 Feb 9.

Sylvius Laboratories, Molecular Biotechnology, Leiden University, Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/genomeA.01560-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331497PMC
February 2017

Structural and functional characterization of the alanine racemase from Streptomyces coelicolor A3(2).

Biochem Biophys Res Commun 2017 01 29;483(1):122-128. Epub 2016 Dec 29.

Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.12.183DOI Listing
January 2017

Correction for Barka et al., Taxonomy, Physiology, and Natural Products of Actinobacteria.

Microbiol Mol Biol Rev 2016 12 9;80(4):iii. Epub 2016 Nov 9.

Molecular Biotechnology, Institute of Biology, Sylvius Laboratories, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MMBR.00044-16DOI Listing
December 2016

Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces.

Mol Microbiol 2016 10 9;102(2):183-195. Epub 2016 Aug 9.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, Leiden, 2333BE, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/mmi.13464DOI Listing
October 2016

Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner.

Antimicrob Agents Chemother 2016 08 22;60(8):4930-9. Epub 2016 Jul 22.

Molecular Biotechnology, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands Department of Microbial Ecology, Netherlands Institute for Ecology (NIOO-KNAW), Wageningen, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00276-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958238PMC
August 2016

Modestobacter caceresii sp. nov., novel actinobacteria with an insight into their adaptive mechanisms for survival in extreme hyper-arid Atacama Desert soils.

Syst Appl Microbiol 2016 Jun 24;39(4):243-251. Epub 2016 Mar 24.

School of Biology, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.syapm.2016.03.007DOI Listing
June 2016

Cross-membranes orchestrate compartmentalization and morphogenesis in Streptomyces.

Nat Commun 2016 06 13;7:ncomms11836. Epub 2016 Jun 13.

Department of Molecular Biotechnology, Institute of Biology Leiden, Leiden University, PO Box 9505, 2300 AB Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms11836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909990PMC
June 2016

Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces.

Sci Rep 2016 05 31;6:27045. Epub 2016 May 31.

Microbial Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep27045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886682PMC
May 2016

SepG coordinates sporulation-specific cell division and nucleoid organization in Streptomyces coelicolor.

Open Biol 2016 Apr;6(4):150164

Molecular Biotechnology, Institute of Biology, Leiden University, PO Box 9505, 2300RA Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.150164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852450PMC
April 2016

Metabolic profiling as a tool for prioritizing antimicrobial compounds.

J Ind Microbiol Biotechnol 2016 Mar 3;43(2-3):299-312. Epub 2015 Sep 3.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-015-1666-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752588PMC
March 2016

Taxonomy, Physiology, and Natural Products of Actinobacteria.

Microbiol Mol Biol Rev 2016 03 25;80(1):1-43. Epub 2015 Nov 25.

Molecular Biotechnology, Institute of Biology, Sylvius Laboratories, Leiden University, Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MMBR.00019-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711186PMC
March 2016

Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era".

J Ind Microbiol Biotechnol 2016 Mar;43(2-3):109

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-015-1715-5DOI Listing
March 2016

Metabolomics-guided analysis of isocoumarin production by species MBT76 and biotransformation of flavonoids and phenylpropanoids.

Metabolomics 2016 30;12:90. Epub 2016 Mar 30.

Natural Products Laboratory, Institute of Biology, Leiden University, Sylviusweg, 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-016-1025-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819732PMC
March 2016

Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66.

ACS Chem Biol 2016 Feb 24;11(2):478-90. Epub 2015 Dec 24.

Molecular Biotechnology, Institute of Biology, Leiden University , Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00801DOI Listing
February 2016

New approaches to achieve high level enzyme production in Streptomyces lividans.

Microb Cell Fact 2016 Feb 4;15:28. Epub 2016 Feb 4.

Instituto de Biología Funcional y Genómica/Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, C/Zacarías González nº 2, 37007, Salamanca, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12934-016-0425-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743123PMC
February 2016

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces.

Open Biol 2016 Jan;6(1):150149

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.150149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736821PMC
January 2016

Goodbye to brute force in antibiotic discovery?

Nat Microbiol 2016 01 27;1:15020. Epub 2016 Jan 27.

Department of Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands, and the Department of Microbial Ecology, Netherlands Institute for Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmicrobiol.2015.20DOI Listing
January 2016

Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced by Streptomyces Species MBT28.

J Nat Prod 2015 Oct 6;78(10):2355-63. Epub 2015 Oct 6.

Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, 2333 CC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jnatprod.5b00276DOI Listing
October 2015

Diversity and functions of volatile organic compounds produced by Streptomyces from a disease-suppressive soil.

Front Microbiol 2015 9;6:1081. Epub 2015 Oct 9.

Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW) Wageningen, Netherlands ; Molecular Biotechnology, Institute of Biology, Leiden University Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2015.01081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598592PMC
October 2015

Socially mediated induction and suppression of antibiosis during bacterial coexistence.

Proc Natl Acad Sci U S A 2015 Sep 27;112(35):11054-9. Epub 2015 Jul 27.

Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1504076112
Publisher Site
http://dx.doi.org/10.1073/pnas.1504076112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568218PMC
September 2015

Minimum Information about a Biosynthetic Gene cluster.

Authors:
Marnix H Medema Renzo Kottmann Pelin Yilmaz Matthew Cummings John B Biggins Kai Blin Irene de Bruijn Yit Heng Chooi Jan Claesen R Cameron Coates Pablo Cruz-Morales Srikanth Duddela Stephanie Düsterhus Daniel J Edwards David P Fewer Neha Garg Christoph Geiger Juan Pablo Gomez-Escribano Anja Greule Michalis Hadjithomas Anthony S Haines Eric J N Helfrich Matthew L Hillwig Keishi Ishida Adam C Jones Carla S Jones Katrin Jungmann Carsten Kegler Hyun Uk Kim Peter Kötter Daniel Krug Joleen Masschelein Alexey V Melnik Simone M Mantovani Emily A Monroe Marcus Moore Nathan Moss Hans-Wilhelm Nützmann Guohui Pan Amrita Pati Daniel Petras F Jerry Reen Federico Rosconi Zhe Rui Zhenhua Tian Nicholas J Tobias Yuta Tsunematsu Philipp Wiemann Elizabeth Wyckoff Xiaohui Yan Grace Yim Fengan Yu Yunchang Xie Bertrand Aigle Alexander K Apel Carl J Balibar Emily P Balskus Francisco Barona-Gómez Andreas Bechthold Helge B Bode Rainer Borriss Sean F Brady Axel A Brakhage Patrick Caffrey Yi-Qiang Cheng Jon Clardy Russell J Cox René De Mot Stefano Donadio Mohamed S Donia Wilfred A van der Donk Pieter C Dorrestein Sean Doyle Arnold J M Driessen Monika Ehling-Schulz Karl-Dieter Entian Michael A Fischbach Lena Gerwick William H Gerwick Harald Gross Bertolt Gust Christian Hertweck Monica Höfte Susan E Jensen Jianhua Ju Leonard Katz Leonard Kaysser Jonathan L Klassen Nancy P Keller Jan Kormanec Oscar P Kuipers Tomohisa Kuzuyama Nikos C Kyrpides Hyung-Jin Kwon Sylvie Lautru Rob Lavigne Chia Y Lee Bai Linquan Xinyu Liu Wen Liu Andriy Luzhetskyy Taifo Mahmud Yvonne Mast Carmen Méndez Mikko Metsä-Ketelä Jason Micklefield Douglas A Mitchell Bradley S Moore Leonilde M Moreira Rolf Müller Brett A Neilan Markus Nett Jens Nielsen Fergal O'Gara Hideaki Oikawa Anne Osbourn Marcia S Osburne Bohdan Ostash Shelley M Payne Jean-Luc Pernodet Miroslav Petricek Jörn Piel Olivier Ploux Jos M Raaijmakers José A Salas Esther K Schmitt Barry Scott Ryan F Seipke Ben Shen David H Sherman Kaarina Sivonen Michael J Smanski Margherita Sosio Evi Stegmann Roderich D Süssmuth Kapil Tahlan Christopher M Thomas Yi Tang Andrew W Truman Muriel Viaud Jonathan D Walton Christopher T Walsh Tilmann Weber Gilles P van Wezel Barrie Wilkinson Joanne M Willey Wolfgang Wohlleben Gerard D Wright Nadine Ziemert Changsheng Zhang Sergey B Zotchev Rainer Breitling Eriko Takano Frank Oliver Glöckner

Nat Chem Biol 2015 Sep;11(9):625-31

1] Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen, Germany. [2] Jacobs University Bremen gGmbH, Bremen, Germany.

View Article

Download full-text PDF

Source
http://orbit.dtu.dk/files/115504295/Minimum_Information_abou
Web Search
http://www.nature.com/doifinder/10.1038/nchembio.1890
Publisher Site
http://dx.doi.org/10.1038/nchembio.1890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714517PMC
September 2015

Multiple allosteric effectors control the affinity of DasR for its target sites.

Biochem Biophys Res Commun 2015 Aug 26;464(1):324-9. Epub 2015 Jun 26.

Center for Protein Engineering, Institut de chimie B6a, University of Liège, B-4000 Liège, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2015.06.152DOI Listing
August 2015

Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

J Antibiot (Tokyo) 2015 Jul 18;68(7):445-52. Epub 2015 Feb 18.

Natural Products Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ja.2015.14DOI Listing
July 2015

Transcriptional analysis of the cell division-related ssg genes in Streptomyces coelicolor reveals direct control of ssgR by AtrA.

Antonie Van Leeuwenhoek 2015 Jul 23;108(1):201-13. Epub 2015 May 23.

School of Chemical and Biological Engineering and Institute of Molecular Biology and Genetics, Seoul National University, Kwanak-gu, Seoul, 151-744, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-015-0479-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457907PMC
July 2015

Correlative cryo-fluorescence light microscopy and cryo-electron tomography of Streptomyces.

Methods Cell Biol 2014 ;124:217-39

Department of Molecular Cell Biology, Section Electron Microscopy, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-801075-4.00010-0DOI Listing
June 2015

Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation.

Sci Rep 2015 Jun 4;5:10868. Epub 2015 Jun 4.

Natural Products Laboratory, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep10868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455117PMC
June 2015

Metabolomics in the natural products field--a gateway to novel antibiotics.

Drug Discov Today Technol 2015 Jun 14;13:11-7. Epub 2015 Feb 14.

Natural Products Laboratory, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ddtec.2015.01.004DOI Listing
June 2015

A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories.

Microb Cell Fact 2015 Apr 1;14:44. Epub 2015 Apr 1.

Molecular Biotechnology, Institute of Biology, Leiden University, PO Box 9505, 2300RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12934-015-0224-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391728PMC
April 2015

Morphogenesis of Streptomyces in submerged cultures.

Adv Appl Microbiol 2014 ;89:1-45

Molecular Biotechnology, Institute Biology Leiden, Leiden University, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-800259-9.00001-9DOI Listing
November 2014

Off the wall.

Elife 2014 Nov 26;3. Epub 2014 Nov 26.

Gilles P van Wezel is in the Institute of Biology, Leiden University, Leiden, Netherlands and Microbial Ecology, NIOO-KNAW, Wageningen, Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.05427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244568PMC
November 2014

Altered desferrioxamine-mediated iron utilization is a common trait of bald mutants of Streptomyces coelicolor.

Metallomics 2014 Aug;6(8):1390-9

Centre for Protein Engineering, University of Liège, Institut de Chimie B6a, B-4000 Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c4mt00068dDOI Listing
August 2014

Eliciting antibiotics active against the ESKAPE pathogens in a collection of actinomycetes isolated from mountain soils.

Microbiology 2014 Aug 2;160(Pt 8):1714-25. Epub 2014 May 2.

Molecular Biotechnology, Institute of Biology, Molecular Biotechnology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/mic.0.078295-0DOI Listing
August 2014

Analysis of novel kitasatosporae reveals significant evolutionary changes in conserved developmental genes between Kitasatospora and Streptomyces.

Antonie Van Leeuwenhoek 2014 Aug 24;106(2):365-80. Epub 2014 Jun 24.

Molecular Biotechnology, Institute of Biology, Leiden University, PO Box 9505, 2300 RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-014-0209-1DOI Listing
August 2014

Streptomyces leeuwenhoekii sp. nov., the producer of chaxalactins and chaxamycins, forms a distinct branch in Streptomyces gene trees.

Antonie Van Leeuwenhoek 2014 May 7;105(5):849-61. Epub 2014 Mar 7.

School of Biology, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-014-0139-yDOI Listing
May 2014

Triggers and cues that activate antibiotic production by actinomycetes.

J Ind Microbiol Biotechnol 2014 Feb 2;41(2):371-86. Epub 2013 Aug 2.

Molecular Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10295-013-1309-zDOI Listing
February 2014

Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies.

Nat Rev Microbiol 2014 Feb 2;12(2):115-24. Epub 2014 Jan 2.

Molecular Biotechnology, Institute of Biology Leiden, Leiden University, Sylviusweg 72, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrmicro3178
Publisher Site
http://dx.doi.org/10.1038/nrmicro3178DOI Listing
February 2014

A novel taxonomic marker that discriminates between morphologically complex actinomycetes.

Open Biol 2013 Oct 23;3(10):130073. Epub 2013 Oct 23.

Molecular Biotechnology, Institute of Biology, Leiden University, PO Box 9505, 2300 RA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.130073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814722PMC
October 2013

Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence.

Sci Rep 2013 23;3:1109. Epub 2013 Jan 23.

Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep01109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552289PMC
September 2013

Single particle tracking of dynamically localizing TatA complexes in Streptomyces coelicolor.

Biochem Biophys Res Commun 2013 Aug 15;438(1):38-42. Epub 2013 Jul 15.

Molecular Biotechnology, Institute of Biology Leiden, Sylvius Laboratories, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2013.07.016DOI Listing
August 2013

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.

Nat Protoc 2013 Jun 23;8(6):1155-68. Epub 2013 May 23.

Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2013.065DOI Listing
June 2013

Multidimensional view of the bacterial cytoskeleton.

J Bacteriol 2013 Apr 15;195(8):1627-36. Epub 2013 Feb 15.

Molecular Biotechnology, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://jb.asm.org/content/195/8/1627.full.pdf
Web Search
http://jb.asm.org/cgi/doi/10.1128/JB.02194-12
Publisher Site
http://dx.doi.org/10.1128/JB.02194-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624557PMC
April 2013

Analysis of two distinct mycelial populations in liquid-grown Streptomyces cultures using a flow cytometry-based proteomics approach.

Appl Microbiol Biotechnol 2012 Dec 16;96(5):1301-12. Epub 2012 Oct 16.

Department of Microbiology, Institute of Biomembranes, University of Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00253-012-4490
Web Search
http://link.springer.com/10.1007/s00253-012-4490-5
Publisher Site
http://dx.doi.org/10.1007/s00253-012-4490-5DOI Listing
December 2012

Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics.

Mol Microbiol 2012 12 5;86(6):1490-507. Epub 2012 Nov 5.

Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300RA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/mmi.12072DOI Listing
December 2012

Dynamic localization of Tat protein transport machinery components in Streptomyces coelicolor.

J Bacteriol 2012 Nov 21;194(22):6272-81. Epub 2012 Sep 21.

Molecular Biotechnology, Institute of Biology, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.01425-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486365PMC
November 2012

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach.

Org Biomol Chem 2012 Nov;10(43):8677-83

Leiden Institute of Chemistry and Netherlands Proteomics Centre, Gorlaeus Laboratories, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2ob26050fDOI Listing
November 2012

Structured morphological modeling as a framework for rational strain design of Streptomyces species.

Antonie Van Leeuwenhoek 2012 Oct 21;102(3):409-23. Epub 2012 Jun 21.

Molecular Biotechnology, Institute of Biology, Leiden University, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-012-9760-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456926PMC
October 2012

Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?

Mol Microbiol 2012 Aug 11;85(3):393-404. Epub 2012 Jun 11.

FacUniversity of Wroclaw, Ul. Tamka 2, 50-137 Wroclaw, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2958.2012.08107.xDOI Listing
August 2012

The tmRNA-tagging mechanism and the control of gene expression: a review.

Wiley Interdiscip Rev RNA 2011 Mar-Apr;2(2):233-46. Epub 2010 Sep 27.

ProteoNic, Niels Bohrweg 11-13, 2333 CA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/wrna.48DOI Listing
March 2012

A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor.

Antonie Van Leeuwenhoek 2012 Mar 29;101(3):479-92. Epub 2011 Oct 29.

Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-011-9657-zDOI Listing
March 2012

Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor.

Antonie Van Leeuwenhoek 2012 Mar 24;101(3):619-32. Epub 2011 Nov 24.

Molecular Biotechnology, LIC, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10482-011-9678-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278627PMC
March 2012

Functional analysis of the N-acetylglucosamine metabolic genes of Streptomyces coelicolor and role in control of development and antibiotic production.

J Bacteriol 2012 Mar 22;194(5):1136-44. Epub 2011 Dec 22.

Molecular Biotechnology, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JB.06370-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294797PMC
March 2012

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances.

Nat Prod Rep 2011 Jul 25;28(7):1311-33. Epub 2011 May 25.

Leiden University, Leiden Institute of Chemistry, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c1np00003aDOI Listing
July 2011

Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces.

Genes Dev 2011 Jan;25(1):89-99

Molecular Biotechnology, Gorlaeus Laboratories, Leiden University, Leiden 2300RA, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.600211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012939PMC
January 2011

The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control.

Mol Microbiol 2010 Mar;75(5):1133-44

Department of Biological Sciences and the Alberta Ingenuity Centre for Carbohydrate Science, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2958.2009.07020.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2009.07020.xDOI Listing
March 2010