Gilles Defer

Gilles Defer

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Gilles Defer

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Socioeconomic deprivation increases the risk of disability in multiple sclerosis patients.

Mult Scler Relat Disord 2020 Jan 7;40:101930. Epub 2020 Jan 7.

UNICAEN, CHU de Caen Normandie Department of Neurology, MS Expert Center, Normandie University, Caen 14000, France; Réseau Bas-Normand Pour la Prise en Charge de la SEP, Caen, France. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.101930DOI Listing
January 2020

Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial.

Trials 2019 Oct 29;20(1):614. Epub 2019 Oct 29.

MS Expert Centre, Department of Neurology, Caen University Hospital Centre, Avenue de la Côte de Nacre CS 30001, 14033, Caen, Cedex 9, France.

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http://dx.doi.org/10.1186/s13063-019-3715-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819362PMC
October 2019

Comparative effectiveness of teriflunomide vs dimethyl fumarate in multiple sclerosis.

Neurology 2019 08 12;93(7):e635-e646. Epub 2019 Jul 12.

From INSERM (D.-A.L., L.B.), CIC 0004, Nantes; CRTI-INSERM UMR U1064 (D.-A.L.), Université de Nantes; Service de Neurologie (D.-A.L., S.W., L. Michel), CHU Nantes; Centre des Neurosciences de Lyon (R.C., F.R., S.V.), Observatoire Français de la Sclérose en Plaques, INSERM 1028 and CNRS UMR5292, Lyon; Université Claude Bernard Lyon 1 (R.C., F.R., S.V.), Université de Lyon; Department of Neurology (M.D.), Nancy University Hospital; Université de Lorraine (M.D.), EA 4360 APEMAC, Vandoeuvre-Lès-Nancy; Department of Neurology and Clinical Investigation Center (J.D.S.), CHU de Strasbourg, INSERM 1434; Department of Neurology (D.B.), CHU de Toulouse; Service de Neurologie (B. Brochet), CHU de Bordeaux; Service de Neurologie (J.P.), Hôpital de la Timone, CRMBM, CNRS, APHM, Aix Marseille Univ, Marseille; Univ Lille (P.V.), CHU Lille, LIRIC (Lille Inflammation Research International Center), INSERM UMR995; Service de Neurologie (G.E., L. Michel), CHU de Rennes; CRCSEP Nice (C.L.-F.), Neurologie Pasteur 2, Université Nice Cote d'Azur, Nice; Service de Neurologie (P. Clavelou), CHU de Clermont-Ferrand; Service de Neurologie (E.T.), CHU de Nîmes; Department of Neurology (J.-P.C.), Hôpital Nord, CHU Saint-Étienne; Service de Neurologie et Faculté de Médecine de Reims (A.T.), CHU de Reims, URCA; Service de Neurologie (B.S.), CHU Saint-Antoine; Service de Neurologie (A.A.K.), CHU d'Amiens; Service de Neurologie (P. Cabre), CHU de Fort de France; Service de Neurologie (C. Lubetzki, C.P.), CHU Pitié-Salpêtrière; Service de Neurologie (E.B.), CHU de Besançon; Service de Neurologie (O.H.), CH de Poissy; Service de Neurologie (T.D.), CH de Saint-Denis; Service de Neurologie (T.M.), CHU de Dijon; Service de Neurologie (O.G.), Fondation Rothschild; Service de Neurologie (B. Bourre), CHU de Rouen; Department of Neurology (A.W.), Hôpital Henri Mondor, Créteil; Service de Neurologie (P.L.), CHU de Montpellier; Service de Neurologie (L. Magy), CHU de Limoges; Service de Neurologie (G.D.), CHU de Caen; CRC SEP and Department of Neurology (A.-M.G.), CHU Bretonneau, Tours; Department of Neurology (N.M.), CHU La Milétrie, Poitiers; Department of Neurology (C. Labeyrie), CHU Bicêtre, Le Kremlin Bicêtre; Department of Neurology (I.P.), Hôpital Sud Francilien, Corbeil Essonnes; Department of Neurology (C.N.), CHU Versailles; Department of Neurology (O.C.), CHU de Grenoble; Ecole des Hautes Etudes en Santé Publique (E.L.), Rennes; Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation (S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; and INSERM (Y.F.), UMR 1246-SPHERE, Nantes University, Tours University, Nantes, France.

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http://dx.doi.org/10.1212/WNL.0000000000007938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715507PMC
August 2019

Descriptive analysis of the French NS-Park registry: Towards a nation-wide Parkinson's disease cohort?

Parkinsonism Relat Disord 2019 07 25;64:226-234. Epub 2019 Apr 25.

Sorbonne Université, Assistance Publique Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Department of Neurology, Hôpital Pitié-Salpêtrière, F-75013, Paris, France; Center for Interdisciplinary Research in Biology, Collège de France, INSERM U1050, CNRS UMR7241, Labex Memolife, Paris Sciences et Lettres, Paris, France; AP-HP, Department of Neurology, Hôpital Avicenne, Hôpitaux Universitaires de Paris - Seine Saint Denis, Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.04.012DOI Listing
July 2019

Improvement of quality of life and its relationship with neuropsychiatric outcomes in patients with multiple sclerosis starting treatment with natalizumab: A 3-year follow-up multicentric study.

J Neurol Sci 2017 11 6;382:148-154. Epub 2017 Oct 6.

Service de Neurologie, CHU de Clermont-Ferrand, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France; Neuro-Dol, Inserm U1107, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/j.jns.2017.10.008DOI Listing
November 2017

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy.

Neurology 2016 12 4;87(23):2491-2494. Epub 2016 Nov 4.

From the CHU Toulouse Purpan (B.P., F.B., D.B., D.A.-P., D.B.), Pôle Neurosciences; INSERM U1043-CNRS UMR 5282 (B.P., F.B., D.B.), Université Toulouse III, Centre de Physiopathologie Toulouse Purpan, France; University of Münster (N.S., T.S.-H., H.W.), Germany; University of Lille (O.O., H.Z., P.V.); Hôpital Civil (J.-C. Ongagna, J.d.S.), Strasbourg; CHU Pellegrin (B.B., J.-C. Ouallet), Bordeaux; CHU Nancy (M.D., S.P.); CHU Caen (G.D., N.D.); CH St Vincent (P.H.), GHICL, Lille; CHU Reims (A.T.); CHU Montpellier (P.L.); CHU Nîmes (G.C., W.C., O.C.); CHRU Clermont Ferrand (P.C.); CHU Besançon (E.B.); Aix Marseille University (J.P., A.R.), APHM, CHU Timone, Marseille; CHU Nantes (D.L., S.W.); CHU Grenoble (E.T.); CHU Dijon (T.M., A.F.); CHU Lyon (S.V.), Bron; Hôpital de la Salpêtrière (C.P.), Paris, France; Centre d'Esclerosi Múltiple de Catalunya (CEMCAT) (M.C.), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and CHU Nice (C.L.-F.), France.

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http://dx.doi.org/10.1212/WNL.0000000000003401DOI Listing
December 2016

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis.

Expert Opin Drug Metab Toxicol 2016 17;12(3):327-44. Epub 2016 Feb 17.

e Neurology , Centre Hospitalier Universitaire de Caen , Caen , France.

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http://dx.doi.org/10.1517/17425255.2016.1136288DOI Listing
October 2016

[Reporting of harms in clinical trials: Vigilant support to the investigator. A guideline of REVISE' Group].

Therapie 2016 Oct 16;71(5):475-481. Epub 2016 Jun 16.

Délégation à la recherche clinique et à l'innovation, CHU de Caen, 14033 Caen, France. Electronic address:

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http://dx.doi.org/10.1016/j.therap.2016.05.007DOI Listing
October 2016

Influence of education on cognitive performance and dopamine transporter binding in dementia with Lewy bodies.

Clin Neurol Neurosurg 2016 Jul 10;146:138-43. Epub 2016 May 10.

Department of Neurology, University Hospital of Caen, Avenue Cote de Nacre, 14033 Caen, France; Unité INSERM U919, Sérine protéase et physiopathologie de l'Unité Neurovasculaire, GIP Cycéron, Université Caen Basse, Normandie, France.

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http://dx.doi.org/10.1016/j.clineuro.2016.05.009DOI Listing
July 2016

Cutaneous and Mixed Nerve Silent Period Recordings in Symptomatic Paroxysmal Kinesigenic Dyskinesia.

Open Neurol J 2016 26;10:9-14. Epub 2016 May 26.

CHU de Caen, Service de Neurologie, CHU de Caen, Caen, F-14000, France.

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http://dx.doi.org/10.2174/1874205X01610010009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891988PMC
June 2016

Potential diagnostic value of regional myocardial adrenergic imaging using (123)I-MIBG SPECT to identify patients with Lewy body diseases.

Eur J Nucl Med Mol Imaging 2015 Jun 28;42(7):1043-51. Epub 2015 Jan 28.

Department of Nuclear Medicine, University Hospital Center of Caen, Caen, France,

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http://dx.doi.org/10.1007/s00259-015-2989-6DOI Listing
June 2015

Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses.

BMC Neurol 2015 May 15;15:83. Epub 2015 May 15.

Department of Neurology, University Hospital of Caen, Avenue Côte de Nacre, 14033, Caen, Basse Normandie, France.

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http://dx.doi.org/10.1186/s12883-015-0338-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448316PMC
May 2015

Adult-onset genetic leukoencephalopathies: a MRI pattern-based approach in a comprehensive study of 154 patients.

Brain 2015 Feb 19;138(Pt 2):284-92. Epub 2014 Dec 19.

1 Département de Neurologie, CHU de Montpellier, 34295 Montpellier, France

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http://brain.oxfordjournals.org/content/brain/138/2/284.full
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http://www.brain.oxfordjournals.org/cgi/doi/10.1093/brain/aw
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http://dx.doi.org/10.1093/brain/awu353DOI Listing
February 2015

No evidence for genetic association between glutamate transporter EAAT2 and Devic's neuromyelitis optica in caucasians and afro-caribbeans.

Mult Scler Relat Disord 2014 Jan 18;3(1):89-93. Epub 2013 Jul 18.

Caen University Hospital, Department of Neurology, Caen F-14000, France; INSERM U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, Université de Caen Basse-Normandie, Caen F-14000, France.. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2013.06.012DOI Listing
January 2014

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.

Neuroimage 2012 Nov 17;63(2):760-70. Epub 2012 Jul 17.

INSERM, INSERM U919 Serine Protease and Pathophysiology of the Neurovascular Unit, University Caen Basse-Normandie, GIP Cyceron, Bd Becquerel, BP5229, 14074 Caen, France.

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http://dx.doi.org/10.1016/j.neuroimage.2012.07.018DOI Listing
November 2012

Inflammatory-like presentation of CADASIL: a diagnostic challenge.

BMC Neurol 2012 Aug 21;12:78. Epub 2012 Aug 21.

Department of Neurology, Strasbourg University Hospital, 1, Avenue Molière, 67000, Strasbourg, France.

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http://dx.doi.org/10.1186/1471-2377-12-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488471PMC
August 2012

CD49d expression as a promising biomarker to monitor natalizumab efficacy.

J Neurol Sci 2012 Mar 1;314(1-2):138-42. Epub 2011 Nov 1.

CHU de Caen, Department of Neurology, Caen, F-14000, France.

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http://dx.doi.org/10.1016/j.jns.2011.10.005DOI Listing
March 2012

Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.

J Cereb Blood Flow Metab 2011 Nov 31;31(11):2119-34. Epub 2011 Aug 31.

Inserm UMR-S 919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, Université de Caen Basse-Normandie, Caen Cedex, France.

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http://dx.doi.org/10.1038/jcbfm.2011.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210341PMC
November 2011

Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation.

Stroke 2011 Oct 4;42(10):2947-9. Epub 2011 Aug 4.

INSERM U919, University Caen Basse-Normandie, Serine Proteases and Pathophysiology of the Neurovascular Unit, and Department of Neurology, University-Hospital, GIP Cyceron, Bd Becquerel, BP5229, 14074 Caen, France.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.111.620468
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.111.620468DOI Listing
October 2011

Stroke and the immune system: from pathophysiology to new therapeutic strategies.

Lancet Neurol 2011 May;10(5):471-80

Institut National de la Santé et de la Recherche Médicale (INSERM) U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, UMR CNRS 6232 Ci-NAPs, Cyceron, Université de Caen Basse-Normandie, Caen, France.

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http://dx.doi.org/10.1016/S1474-4422(11)70066-7DOI Listing
May 2011

Quantification and clinical relevance of brain atrophy in multiple sclerosis: a review.

J Neurol 2009 Sep 8;256(9):1397-412. Epub 2009 Apr 8.

Département de Neurologie, CHU Côte de Nacre, 14000 Caen, France.

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http://dx.doi.org/10.1007/s00415-009-5108-4DOI Listing
September 2009

Functional imaging of working memory in Parkinson's disease: compensations and deficits.

J Neuroimaging 2007 Oct;17(4):277-85

University of Caen, University Team Executive and Attentional Processes and UPRES-EA 3917, Caen, France.

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http://dx.doi.org/10.1111/j.1552-6569.2007.00152.xDOI Listing
October 2007

[Late onset Rasmussen's syndrome: clinical and therapeutic characteristics].

Rev Neurol (Paris) 2007 May;163(5):573-80

Service de Neurologie, CHU, Caen, Cedex.

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http://dx.doi.org/10.1016/s0035-3787(07)90463-4DOI Listing
May 2007

[Perry and Purdy's syndrome (familial and fatal parkinsonism with hypoventilation and athymhormia)].

Bull Acad Natl Med 2005 Mar;189(3):481-90; discussion 490-2

Service de neurologie et Laboratoire de neuropathologie, CHU de Caen, F. 14000.

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March 2005

Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.

Mov Disord 2003 Aug;18(8):928-32

Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique (CNRS) 2210, Orsay, France.

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http://dx.doi.org/10.1002/mds.10463DOI Listing
August 2003