Gilles de Keulenaer

Gilles de Keulenaer

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Gilles de Keulenaer

Gilles de Keulenaer

Publications by authors named "Gilles de Keulenaer"

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Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity.

Clin Exp Pharmacol Physiol 2018 Sep 23. Epub 2018 Sep 23.

Department of Surgery and Physiology, UnIC-Cardiovascular Research Centre, Faculty of Medicine, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1111/1440-1681.13036DOI Listing
September 2018

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1.

Circ Res 2018 Jul 14;123(3):342-355. Epub 2018 May 14.

From the Medical Faculty, Department of Cardiovascular Physiology, Heinrich-Heine-University, Düsseldorf, Germany (A.-E.H., C.A., S.K., M.I., S.S., S.B., M.K.)

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312166DOI Listing
July 2018

Neuregulin-1 attenuates stress-induced vascular senescence.

Cardiovasc Res 2018 Jun;114(7):1041-1051

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.1093/cvr/cvy059DOI Listing
June 2018

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO.

Front Physiol 2018 11;9:382. Epub 2018 Apr 11.

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3389/fphys.2018.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904256PMC
April 2018

The future of pleiotropic therapy in heart failure. Lessons from the benefits of exercise training on endothelial function.

Eur J Heart Fail 2017 05 19;19(5):603-614. Epub 2017 Jan 19.

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1002/ejhf.735DOI Listing
May 2017

ErbB2 signaling at the crossing between heart failure and cancer.

Basic Res Cardiol 2016 11 5;111(6):60. Epub 2016 Sep 5.

Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00395-016-0576-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011481PMC
November 2016

A novel set-up for the ex vivo analysis of mechanical properties of mouse aortic segments stretched at physiological pressure and frequency.

J Physiol 2016 11 2;594(21):6105-6115. Epub 2016 Aug 2.

University of Antwerp, Department of Pharmaceutical Sciences, Laboratory of Physiopharmacology, Campus Drie Eiken, Universiteitsplein 1, B-2610, Antwerp, Belgium.

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http://dx.doi.org/10.1113/JP272623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088227PMC
November 2016

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction.

JACC Heart Fail 2016 Apr 9;4(4):312-24. Epub 2015 Dec 9.

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands; Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1016/j.jchf.2015.10.007DOI Listing
April 2016

Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.

Am J Physiol Endocrinol Metab 2016 Apr 19;310(7):E495-504. Epub 2016 Jan 19.

Laboratory of Physiopharmacology, University of Antwerp, Wilrijk, Belgium; and

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http://dx.doi.org/10.1152/ajpendo.00432.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824141PMC
April 2016

Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries.

Pflugers Arch 2016 Feb 3;468(2):257-67. Epub 2015 Oct 3.

Department of Pharmaceutical Sciences, Physiopharmacology, Campus Drie Eiken, University of Antwerp, T2, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00424-015-1737-xDOI Listing
February 2016

Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension.

Cardiovasc Res 2016 Jan 26;109(1):44-54. Epub 2015 Oct 26.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Cardiovascular Research and Development Centre, University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal

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http://dx.doi.org/10.1093/cvr/cvv244DOI Listing
January 2016

Cardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction.

Eur Heart J 2015 Aug 23;36(31):2050-2060. Epub 2015 Apr 23.

Laboratory of Physiopharmacology (Building T2), University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium

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http://dx.doi.org/10.1093/eurheartj/ehv132DOI Listing
August 2015

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

Cardiovasc Res 2014 Dec 23;104(3):423-31. Epub 2014 Oct 23.

Laboratory of Physiopharmacology (Building T2), University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium

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http://dx.doi.org/10.1093/cvr/cvu223DOI Listing
December 2014

Applanation tonometry in mice: a novel noninvasive technique to assess pulse wave velocity and arterial stiffness.

Hypertension 2014 Jul 21;64(1):195-200. Epub 2014 Apr 21.

From the Laboratories of Physiopharmacology Department of Pharmaceutical Sciences (A.J.A.L., P.F., M.D., G.W.D.K., D.M.S.) and Pharmacology Faculty of Medicine (C.E.V.H.), University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03312DOI Listing
July 2014

Is overemphasizing diastolic dysfunction in heart failure with a preserved ejection fraction too narrow minded?

J Cardiovasc Med (Hagerstown) 2014 Feb;15(2):107-9

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.2459/JCM.0b013e3283654cc0DOI Listing
February 2014

Therapeutic potential of neuregulin-1 in cardiovascular disease.

Drug Discov Today 2013 Sep 4;18(17-18):836-42. Epub 2013 Feb 4.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.

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http://dx.doi.org/10.1016/j.drudis.2013.01.010DOI Listing
September 2013

Pathophysiology of diastolic dysfunction in chronic heart failure.

Future Cardiol 2013 Sep;9(5):711-20

University of Antwerp, Universiteitsplein 1, Campus Drie Eiken, Bldg T, 2nd Floor, 2610 Wilrijk, Belgium.

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http://dx.doi.org/10.2217/fca.13.53DOI Listing
September 2013

Cardiotoxicity associated with cancer therapy: pathophysiology and prevention strategies.

Rev Port Cardiol 2013 May 24;32(5):395-409. Epub 2013 Apr 24.

Departamento de Fisiologia e Cirurgia Cardiotorácica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.repc.2012.11.002DOI Listing
May 2013

Impact of radiofrequency characteristics on acute pulmonary vein reconnection and clinical outcome after PVAC ablation.

J Cardiovasc Electrophysiol 2013 Mar 30;24(3):290-6. Epub 2012 Oct 30.

Department of Cardiology, Antwerp Cardiovascular Institute Middelheim, Antwerpen, Belgium.

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http://dx.doi.org/10.1111/jce.12021DOI Listing
March 2013

Molecular mechanisms of cardiotoxicity induced by ErbB receptor inhibitor cancer therapeutics.

Int J Mol Sci 2012 Sep 26;13(10):12268-86. Epub 2012 Sep 26.

Laboratory of Physiopharmacology (Building T2), University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.3390/ijms131012268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497272PMC
September 2012

Pulmonary hypertension and right heart failure in heart failure with preserved left ventricular ejection fraction: pathophysiology and natural history.

Curr Opin Cardiol 2012 May;27(3):273-80

University of Antwerp, Laboratory of Physiology and Pharmacology, Antwerp, Belgium.

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http://dx.doi.org/10.1097/HCO.0b013e3283512035DOI Listing
May 2012

Prevalence, characteristics, and predictors of pulmonary vein narrowing after isolation using the pulmonary vein ablation catheter.

Circ Arrhythm Electrophysiol 2012 Feb 7;5(1):52-60. Epub 2011 Nov 7.

Department of Cardiology, Cardiovascular Institute Middelheim, Antwerp, Belgium.

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http://dx.doi.org/10.1161/CIRCEP.111.961888DOI Listing
February 2012

[Neuregulin1/ErbB system: importance in the control of cardiovascular function].

Acta Med Port 2011 Dec 31;24 Suppl 4:1009-20. Epub 2011 Dec 31.

Serviço de Fisiologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

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December 2011

Effects of nebivolol on vascular endothelial and myocardial function in diabetes mellitus.

J Cardiovasc Pharmacol 2011 Jul;58(1):56-64

From the Laboratory of Physiology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1097/FJC.0b013e31821c4974DOI Listing
July 2011

Systolic and diastolic heart failure are overlapping phenotypes within the heart failure spectrum.

Circulation 2011 May;123(18):1996-2004; discussion 2005

Center for Heart Failure and Cardiac Rehabilitation, AZ Middelheim, University of Antwerp, Belgium.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.981431DOI Listing
May 2011

Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.

Am J Physiol Heart Circ Physiol 2011 Mar 24;300(3):H931-42. Epub 2010 Dec 24.

Laboratory of Physiology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1152/ajpheart.00385.2010DOI Listing
March 2011

Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries.

Biol Chem 2011 Mar;392(3):189-98

Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk (Antwerp), Belgium.

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http://dx.doi.org/10.1515/BC.2011.002DOI Listing
March 2011

Role of autophagy in heart failure associated with aging.

Heart Fail Rev 2010 Sep;15(5):423-30

Division of Pharmacology, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.1007/s10741-010-9166-6DOI Listing
September 2010

Pulmonary vein stenosis after pulmonary vein ablation catheter-guided pulmonary vein isolation.

Heart Rhythm 2010 Sep 12;7(9):1306-8. Epub 2010 Apr 12.

Department of Cardiology, Antwerp Cardiovascular Institute, Middelheim, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S154752711000356
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http://dx.doi.org/10.1016/j.hrthm.2010.04.011DOI Listing
September 2010

The heart failure spectrum: time for a phenotype-oriented approach.

Circulation 2009 Jun 8;119(24):3044-6. Epub 2009 Jun 8.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.870006DOI Listing
June 2009

Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure.

J Mol Cell Cardiol 2009 Jan 28;46(1):33-8. Epub 2008 Oct 28.

Laboratory of Physiology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.yjmcc.2008.10.010DOI Listing
January 2009

Endothelial function in aorta segments of apolipoprotein E-deficient mice before development of atherosclerotic lesions.

Pflugers Arch 2008 Feb 27;455(5):811-8. Epub 2007 Sep 27.

Division of Pharmacology, Faculties of Medicine and Pharmaceutical Sciences, University of Antwerp, Campus Drie Eiken, Gebouw T, Universiteitsplein 1, Wilrijk, 2610, Belgium.

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http://dx.doi.org/10.1007/s00424-007-0337-9DOI Listing
February 2008

Evidence that intracoronary-injected CD133+ peripheral blood progenitor cells home to the myocardium in chronic postinfarction heart failure.

Exp Hematol 2007 Dec 17;35(12):1884-90. Epub 2007 Oct 17.

Department of Clinical Hematology and Stem Cell Laboratory, Universitair Ziekenhuis Brussel, Belgium.

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http://dx.doi.org/10.1016/j.exphem.2007.07.012DOI Listing
December 2007

Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure.

Circulation 2007 Aug;116(8):954-60

University of Antwerp, Laboratory of Physiology, Universiteitsplein 1, Bldg T, 2nd Floor, 2610 Wilrijk, Belgium.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.690487DOI Listing
August 2007

Endogenous inhibitors of hypertrophy in concentric versus eccentric hypertrophy.

Eur J Heart Fail 2007 Apr 28;9(4):352-6. Epub 2006 Nov 28.

University of Antwerp, Laboratory of Physiology, Groenenborgerlaan 171, 2020 Antwerp, and Department of Cardiac Surgery, Middelheim Hospital, Belgium.

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http://dx.doi.org/10.1016/j.ejheart.2006.10.002DOI Listing
April 2007

Systolic and diastolic heart failure: different phenotypes of the same disease?

Eur J Heart Fail 2007 Feb 1;9(2):136-43. Epub 2006 Aug 1.

Department of Physiology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.ejheart.2006.05.014DOI Listing
February 2007

Diastolic heart failure: a separate disease or selection bias?

Prog Cardiovasc Dis 2007 Jan-Feb;49(4):275-83

Department of Physiology, University of Antwerp, and Division of Cardiology, Middelheim Hospital, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.pcad.2006.08.002DOI Listing
February 2007

Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk.

J Biol Chem 2006 Jul 11;281(28):19469-77. Epub 2006 May 11.

Department of Physiology, University of Antwerp, Antwerp 2020, Belgium.

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http://dx.doi.org/10.1074/jbc.M600399200DOI Listing
July 2006

Diastolic heart failure: a myth.

Curr Opin Cardiol 2006 May;21(3):240-8

Middelheim Hospital, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1097/01.hco.0000221587.02114.daDOI Listing
May 2006

Cardiomyopathy and thyrotoxicosis: tachycardiomyopathy or thyrotoxic cardiomyopathy?

Acta Cardiol 2006 Feb;61(1):115-7

Department of Cardiology, AZ Middelheim, Antwerp, Belgium.

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http://dx.doi.org/10.2143/AC.61.1.2005149DOI Listing
February 2006

Inhibition of heme oxygenase-1 impairs cardiac muscle sensitivity to beta-adrenergic stimulation.

Basic Res Cardiol 2005 May 5;100(3):224-30. Epub 2005 Jan 5.

Laboratory of Physiology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00395-005-0510-7DOI Listing
May 2005

Urgent need to reorganize heart failure management: from paradoxes to heart failure clinics.

Acta Cardiol 2005 Apr;60(2):179-84

Center for Heart Failure and Cardiac Rehabilitation, Department of Cardiology, AZ Middelheim, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.2143/AC.60.2.2005029DOI Listing
April 2005

Molecular diversity of cardiac endothelial cells in vitro and in vivo.

Physiol Genomics 2004 Oct 10;19(2):198-206. Epub 2004 Aug 10.

Laboratory for Physiology, Department of Pharmacology, University of Antwerp, Antwerp, Belgium.

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http://physiolgenomics.physiology.org/content/physiolgenomic
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http://physiolgenomics.physiology.org/lookup/doi/10.1152/phy
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http://dx.doi.org/10.1152/physiolgenomics.00143.2004DOI Listing
October 2004

Endocardial endothelium modulates subendocardial pH(i) of rabbit papillary muscles: role of transendothelial HCO(3)(-) transport.

Cardiovasc Res 2004 Sep;63(4):700-8

Department of Pharmacology, University of Antwerp, Groenenborgerlaan 171, Antwerp B-2020, Belgium.

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http://dx.doi.org/10.1016/j.cardiores.2004.05.017DOI Listing
September 2004

The endocardial endothelial Na+/K+ ATPase and cardiac contraction.

Adv Exp Med Biol 2003 ;538:43-56; discussion 56

Department of Pharmacology, University of Antwerp, Groenenborgerlaan, 171, B-2020 Antwerpen, Belgium.

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May 2004

Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase.

Circulation 2004 Jan 19;109(3):324-6. Epub 2004 Jan 19.

Laboratory of Physiology, University of Antwerp, Groenenborgerlaan 171, Building V, 6th Floor, 2020 Antwerp, Belgium.

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http://dx.doi.org/10.1161/01.CIR.0000114521.88547.5EDOI Listing
January 2004

Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation.

Circ Res 2003 Dec 30;93(12):1210-7. Epub 2003 Oct 30.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02139, USA.

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http://dx.doi.org/10.1161/01.RES.0000103635.38096.2FDOI Listing
December 2003

Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction.

Circulation 2002 Dec;106(23):2961-6

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Mass 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1460012PMC
December 2002

Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin.

Circ Res 2002 Oct;91(8):689-95

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.

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October 2002

Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes.

Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H533-9

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Partners Research Facility, 65 Lansdowne Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/ajpheart.00002.2002DOI Listing
August 2002

Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin.

J Biol Chem 2002 Jul 14;277(29):26496-500. Epub 2002 May 14.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/jbc.M202133200DOI Listing
July 2002

Identification of IEX-1 as a biomechanically controlled nuclear factor-kappaB target gene that inhibits cardiomyocyte hypertrophy.

Circ Res 2002 Apr;90(6):690-6

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, USA.

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April 2002