Publications by authors named "Gilles Boschetti"

50Publications

No Difference of Adalimumab Pharmacokinetics When Dosed at 40 mg Every Week or 80 mg Every Other Week in IBD Patients in Clinical Remission After Adalimumab Dose Intensification.

Dig Dis Sci 2020 Sep 16. Epub 2020 Sep 16.

Groupe Immunité des muqueuses et Agents Pathogènes (GIMAP), INSERM U1111- International center for research in infectiology (CIRI), Saint-Etienne, France.

View Article and Find Full Text PDF
September 2020

Infliximab induces clinical resolution of sacroiliitis that coincides with increased circulating FOXP3 T cells in a patient with IPEX syndrome.

Joint Bone Spine 2020 Oct 11;87(5):483-486. Epub 2020 May 11.

University Claude-Bernard Lyon 1, 69007 Lyon, France; Department of rheumatology, Lyon Sud hospital, hospices civils de Lyon, Pierre-Bénite, France; Inserm UMR1033, Lyon, France. Electronic address:

View Article and Find Full Text PDF
October 2020

Regulation of anti-microbial autophagy by factors of the complement system.

Microb Cell 2020 Mar 19;7(4):93-105. Epub 2020 Mar 19.

CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.

View Article and Find Full Text PDF
March 2020

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.

Cell 2019 09 29;178(6):1493-1508.e20. Epub 2019 Aug 29.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article and Find Full Text PDF
September 2019

TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation.

EBioMedicine 2019 Jun 24;44:60-70. Epub 2019 May 24.

CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses Cedex, France; Inserm U967, 92265 Fontenay-aux-Roses Cedex, France; Université Paris-Diderot, Paris 7, France; Université Paris-Sud, Paris 11, France; Equipe labellisée Ligue contre le Cancer, France. Electronic address:

View Article and Find Full Text PDF
June 2019

Concentrations of Ustekinumab During Induction Therapy Associate With Remission in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2019 11 6;17(12):2610-2612. Epub 2019 Mar 6.

Department of Gastroenterology, Lyon-Sud University Hospital, Hospices Civils de Lyon, Pierre Bénite, and University Claude Bernard Lyon 1, Lyon, France; INSERM U1111, International Center for Research in Infectiology, Lyon, France. Electronic address:

View Article and Find Full Text PDF
November 2019

Usefulness of confocal laser endomicroscopy for predicting postoperative recurrence in patients with Crohn's disease: a pilot study.

Gastrointest Endosc 2019 07 5;90(1):151-157. Epub 2019 Mar 5.

Department of Hepato-Gastroenterology, Lyon-Sud Hospital, Hospices Civils of Lyon, Pierre-Bénite and University Claude Bernard Lyon 1, Lyon, France.

View Article and Find Full Text PDF
July 2019

An onco-geriatric approach to select older patients for optimal treatments of pancreatic adenocarcinoma.

J Geriatr Oncol 2018 07 9;9(4):373-381. Epub 2018 Jun 9.

Department of Digestive Oncology, Edouard Herriot University Hospital, Lyon, France; Department of Gastroenterology, Lyon-Sud Hospital, Lyon, France.

View Article and Find Full Text PDF
July 2018

Distinct Thresholds of Infliximab Trough Level Are Associated with Different Therapeutic Outcomes in Patients with Inflammatory Bowel Disease: A Prospective Observational Study.

Inflamm Bowel Dis 2017 11;23(11):2048-2053

*Department of Gastroenterology, University Hospital of Saint Etienne, Saint Etienne, France; †Department of Gastroenterology, Hospices Civils de Lyon, and INSERM U1111, Lyon, France; ‡Department of Statistics, University of Lyon, Lyon, France; §Department of Gastroenterology, University Hospital of Nancy, Nancy, France; and ‖Department of Immunology, CIC1408, GIMAP EA3064, University Hospital of Saint Etienne, Saint Etienne, France.

View Article and Find Full Text PDF
November 2017

Intestinal dendritic cell licensing through Toll-like receptor 4 is required for oral tolerance in allergic contact dermatitis.

J Allergy Clin Immunol 2018 01 22;141(1):163-170. Epub 2017 Mar 22.

Mucosal Immunity, Vaccination & Biotherapies Laboratory, INSERM U1111-CNRS UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Superieure de Lyon, Lyon, France. Electronic address:

View Article and Find Full Text PDF
January 2018

Development and Internal Validation of a Model Using Fecal Calprotectin in Combination with Infliximab Trough Levels to Predict Clinical Relapse in Crohn's Disease.

Inflamm Bowel Dis 2017 01;23(1):126-132

*Department of Gastroenterology, University Hospital of Saint Etienne, France; †Mathematic Unit, University Claude Bernard, Lyon, France; ‡Department of Radiology, University Hospital of Saint Etienne, France; §Department of Gastroenterology, CHU, Lyon Sud, Lyon, France; ‖Department of Gastroenterology and Inserm, University Hospital of Nancy, Lorraine University, Vandoeuvre-les-Nancy, France; and ¶Department of Immunology, University Hospital of Saint Etienne, Saint Etienne, France.

View Article and Find Full Text PDF
January 2017

Association Between Low Trough Levels of Vedolizumab During Induction Therapy for Inflammatory Bowel Diseases and Need for Additional Doses Within 6 Months.

Clin Gastroenterol Hepatol 2017 Nov 24;15(11):1750-1757.e3. Epub 2016 Nov 24.

Department of Gastroenterology, University of Saint-Etienne, Saint-Etienne, France; EA-3064, Groupe Immunité des Muqueuses et Agents Pathogènes, Faculty of Medicine of Saint-Etienne, University of Lyon, Lyon, France.

View Article and Find Full Text PDF
November 2017

Costs of Crohn's Disease According to Severity States in France: A Prospective Observational Study and Statistical Modeling over 10 Years.

Inflamm Bowel Dis 2016 12;22(12):2924-2932

1Service de Gastroentérologie, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France; 2Université Claude Bernard Lyon 1, Lyon, France; 3Service de Gastroentérologie, Hôpital Lariboisière, AP-HP, Paris, France; 4Service de Gastroentérologie, American University of Beirut Medical Center, Beirut, Lebanon; 5Service de Gastroentérologie, Hôpital Claude Huriez, Lille, France; 6Service de Gastroentérologie, Hôpital Charles Nicolle, Rouen, France; 7Service de Gastroentérologie, Hôpital Haute-Pierre, Strasbourg, France; 8Institut des Maladies de l'Appareil Digestif, CHU de Nantes, CIC Inserm 1413, Université de Nantes, Nantes, France; 9Service de Gastroentérologie, Hôpital Robert Debré, Reims, France; 10Service de Gastroentérologie, CHU d'Amiens, Amiens, France; 11Service de Gastroentérologie, Hôpital de Rangueil, Toulouse, France; 12Service d'Hépatologie, AP-HP, Hôpital Saint-Antoine, Paris, France; 13Service de Gastroentérologie, Hôpital Beaujon, AP-HP, Clichy, France; 14Department of Gastroenterology, University Hospital of Liège, Liège, Belgium; and 15Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif, Service de Gastroentérologie, AP-HP, Hôpital Saint-Louis, Paris, France.

View Article and Find Full Text PDF
December 2016

A Perioperative Clinical Pathway Can Dramatically Reduce Failure-to-rescue Rates After Cytoreductive Surgery for Peritoneal Carcinomatosis: A Retrospective Study of 666 Consecutive Cytoreductions.

Ann Surg 2017 Apr;265(4):806-813

*Department of Surgical Oncology, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Pierre Bénite, France †Department of EMR 37-38, Lyon 1 University, Lyon, France ‡Department of Pole IMER, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Pierre Bénite, France §Department of Critical Care and Anesthesiology, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Pierre Bénite, France ¶Department of Gastroenterology, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Pierre Bénite, France ||Department of Radiology, CHU Lyon Sud, Hospices Civils de Lyon, University of Lyon, Pierre Bénite, France.

View Article and Find Full Text PDF
April 2017

Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis.

Dig Liver Dis 2017 Jan 13;49(1):11-16. Epub 2016 Sep 13.

Department of Gastroenterology, Hospices Civils de Lyon, Lyon-Sud Hospital, Pierre-Bénite, France & INSERM U1111, International Center for Research in Infectiology, Lyon, France. Electronic address:

View Article and Find Full Text PDF
January 2017

Mouse and Human Liver Contain Immunoglobulin A-Secreting Cells Originating From Peyer's Patches and Directed Against Intestinal Antigens.

Gastroenterology 2016 08 27;151(2):311-23. Epub 2016 Apr 27.

International Center for Infectiology Research (CIRI), Lyon, France; Inserm U1111, Lyon, France; CNRS UMR5308, Lyon, France; Ecole Normale Superieure, Lyon, France; Universite Claude Bernard Lyon 1, Lyon, France. Electronic address:

View Article and Find Full Text PDF
August 2016

Isolated ileitis associated with primary sclerosing cholangitis in three patients with Crohn's disease.

Scand J Gastroenterol 2016 25;51(6):727-30. Epub 2016 Jan 25.

b Lyon Sud Hospital and University Claude Bernard Lyon , Pierre Béite , France ;

View Article and Find Full Text PDF
November 2016

Enrichment of Circulating and Mucosal Cytotoxic CD8+ T Cells Is Associated with Postoperative Endoscopic Recurrence in Patients with Crohn's Disease.

J Crohns Colitis 2016 Mar 19;10(3):338-45. Epub 2015 Nov 19.

International Center for Infectiology Research, Université de Lyon, Lyon, France INSERM U1111, Team Immunity, Vaccination and Biotherapy, Lyon, France Université Claude Bernard Lyon 1, Lyon, France.

View Article and Find Full Text PDF
March 2016

Response to Dai et al.

Am J Gastroenterol 2015 Aug;110(8):1242

1] Department of Gastroenterology, Hospices Civils de Lyon, Hopital Lyon-Sud, Pierre-Bénite, France [2] INSERM U1111, International Center for Research in Infectiology, Lyon, France.

View Article and Find Full Text PDF
August 2015

Abdominal necrotic abscess from colonic fistula treated endoscopically.

Gastrointest Endosc 2015 Apr;81(4):1026-7

Hepatogastroenterology Department, Lyon Sud Hospital, Pierre Benite, France, Inserm Unit CREATIS - UMR5220 - INSERM1044, Lyon University, Villeurbanne, France.

View Article and Find Full Text PDF
April 2015

Levels of Fecal Calprotectin Are Associated With the Severity of Postoperative Endoscopic Recurrence in Asymptomatic Patients With Crohn's Disease.

Am J Gastroenterol 2015 Jun 17;110(6):865-72. Epub 2015 Mar 17.

1] Hospices Civils de Lyon, Department of Gastroenterology, Hopital Lyon-Sud, Pierre-Bénite, France [2] INSERM U1111, International Center for Research in Infectiology, Lyon, France.

View Article and Find Full Text PDF
June 2015

Endoscopic and histologic characteristics of serrated lesions.

World J Gastroenterol 2015 Mar;21(10):2896-904

Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.

View Article and Find Full Text PDF
March 2015

Accuracies of serum and fecal S100 proteins (calprotectin and calgranulin C) to predict the response to TNF antagonists in patients with Crohn's disease.

Inflamm Bowel Dis 2015 Feb;21(2):331-6

*Department of Gastroenterology, Hospices Civils de Lyon and University Claude Bernard Lyon 1, Lyon, France; †INSERM U1111 (CIRI), Lyon, France; ‡Cisbio Bioassays, Bagnols sur Cèze, France; and §Laboratory of Biochemistry, LyonSud Hospital, Pierre-Benite, France.

View Article and Find Full Text PDF
February 2015

Tacrolimus induction followed by maintenance monotherapy is useful in selected patients with moderate-to-severe ulcerative colitis refractory to prior treatment.

Dig Liver Dis 2014 Oct 8;46(10):875-80. Epub 2014 Jul 8.

INSERM U-1111 CIRI (International Center for Infectiology Research) and University Claude Bernard Lyon 1, Lyon, France; Hospices Civils de Lyon, Department of Gastroenterology, Lyon-Sud Hospital, Pierre-Bénite, France.

View Article and Find Full Text PDF
October 2014

GASTRICHIP: D2 resection and hyperthermic intraperitoneal chemotherapy in locally advanced gastric carcinoma: a randomized and multicenter phase III study.

BMC Cancer 2014 Mar 14;14:183. Epub 2014 Mar 14.

Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Service de Chirurgie Viscérale et Endocrinienne, Pierre-Bénite Cedex 69495, France.

View Article and Find Full Text PDF
March 2014