Giles S H Yeo

Giles S H Yeo

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Giles S H Yeo

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Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment.

Mol Metab 2019 Aug 18;26:5-17. Epub 2019 May 18.

Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667392PMC
August 2019

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.

Cell Metab 2019 Aug 19. Epub 2019 Aug 19.

Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.013DOI Listing
August 2019

GDF15 and energy balance: homing in on a mechanism.

Nat Med 2017 10;23(10):1119-1120

MRC Metabolic Diseases Unit and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nm.4414DOI Listing
October 2017

Obesity-associated gene has a role in the central control of appetite and body weight regulation.

Proc Natl Acad Sci U S A 2017 08 15;114(35):9421-9426. Epub 2017 Aug 15.

University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1707310114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584443PMC
August 2017

Genetics of obesity: can an old dog teach us new tricks?

Authors:
Giles S H Yeo

Diabetologia 2017 05 24;60(5):778-783. Epub 2016 Dec 24.

Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

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http://link.springer.com/10.1007/s00125-016-4187-x
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http://dx.doi.org/10.1007/s00125-016-4187-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518377PMC
May 2017

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Mol Metab 2017 05 1;6(5):383-392. Epub 2017 Mar 1.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404100PMC
May 2017

Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.

Hypertension 2016 12 24;68(6):1424-1431. Epub 2016 Oct 24.

From the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Clinical Pharmacology Unit, Department of Medicine, University of Cambridge (J.Z.), University of Cambridge Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science (B.L., G.S.H.Y.), Cambridge University Hospitals NHS Foundation Trust (S.G.N.), Addenbrooke's Hospital, United Kingdom; and Department of Medicine, Faculty of Medicine, The National University of Malaysia (UKM) Medical Centre, Kuala Lumpur (E.A.B.A.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100803PMC
December 2016

Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring.

Endocrinology 2016 Nov 1;157(11):4246-4256. Epub 2016 Sep 1.

Metabolic Research Laboratories and Medical Research Council (M.Z.A., L.C.K., D.S.F.-T., L.C.P., S.K.C., G.S.H.Y., S.E.O.), Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 0QQ, UK; and Medical Research Council Toxicology Unit (D.F.-M.), University of Leicester, Leicester, LE1 9HN, UK.

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http://dx.doi.org/10.1210/en.2016-1314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086532PMC
November 2016

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Diabetologia 2016 10 7;59(10):2156-65. Epub 2016 Jul 7.

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00125-016-4033-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016554PMC
October 2016

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Cell Metab 2016 May 28;23(5):821-36. Epub 2016 Apr 28.

Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Experimental Therapeutics, Clinical Science Group, New Medicines, UCB Pharma S.A., Slough, Berkshire SL1 3WE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873618PMC
May 2016

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Dis Model Mech 2016 Apr 14;9(4):401-12. Epub 2016 Jan 14.

University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1242/dmm.023903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852506PMC
April 2016

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells.

Peptides 2016 Mar 3;77:21-7. Epub 2015 Jul 3.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2015.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788507PMC
March 2016

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Diabetologia 2016 Mar 23;59(3):502-11. Epub 2015 Dec 23.

Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 OQQ, UK.

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http://dx.doi.org/10.1007/s00125-015-3837-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742511PMC
March 2016

FTO Obesity Variant and Adipocyte Browning in Humans.

N Engl J Med 2016 01;374(2):191

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http://dx.doi.org/10.1056/NEJMc1513316DOI Listing
January 2016

Tachykinin-1 in the central nervous system regulates adiposity in rodents.

Endocrinology 2015 May 9;156(5):1714-23. Epub 2015 Mar 9.

Metabolic Diseases Institute (C.T., D.K., J.H., S.A., K.H., H.K., D.P.-T.), Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45237; Department of Pharmacology and Toxicology, Zydus Research Centre, Cadila Healthcare Ltd. (C.T.), Ahmedabab 382210, India; and Medical Research Council (MRC) Metabolic Diseases Unit (X.S., Y.-C.L.T., G.S.H.Y.), University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/en.2014-1781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398763PMC
May 2015

FTO is necessary for the induction of leptin resistance by high-fat feeding.

Mol Metab 2015 Apr 7;4(4):287-98. Epub 2015 Feb 7.

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1016/j.molmet.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354923PMC
April 2015

The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.

Authors:
Giles S H Yeo

Mol Cell Endocrinol 2014 Nov 16;397(1-2):34-41. Epub 2014 Sep 16.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.09.012DOI Listing
November 2014

Obesity and FTO: Changing Focus at a Complex Locus.

Cell Metab 2014 Nov 23;20(5):710-718. Epub 2014 Oct 23.

Medical Research Council Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.09.010DOI Listing
November 2014

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

Biosci Rep 2014 Oct 22;34(5). Epub 2014 Oct 22.

‡Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.1042/BSR20140111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206862PMC
October 2014

Low circulating levels of IGF-1 in healthy adults are associated with reduced β-cell function, increased intramyocellular lipid, and enhanced fat utilization during fasting.

J Clin Endocrinol Metab 2014 Jun 11;99(6):2198-207. Epub 2014 Mar 11.

Department of Paediatrics (A.T., D.C., M.L.M., K.M., D.B.D.) and Wolfson Brain Imaging Centre (A.S.), University of Cambridge, CB2 0QQ, Cambridge, United Kingdom; Medical Research Council (MRC) Metabolic Diseases Unit (G.S.H.Y.), University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom; MRC Human Nutrition Research of Growth and Reproduction (L.B.); and National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre (D.B.D.), Cambridge, CB1 9NL, United Kingdom; Department of Endocrinology (S.W.J., A.V.), Rigshospitalet and Copenhagen University, DK-2100 Denmark; Oxford Centre for Diabetes, Endocrinology, and Metabolism (N.R.H.), University of Oxford, Oxford, OX3 7LE, United Kingdom; and Department of Growth and Reproduction (A.J.), Rigshospitalet, Faculty of Health and Medical Sciences, DK-2100 Denmark.

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http://dx.doi.org/10.1210/jc.2013-4542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413372PMC
June 2014

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

FASEB J 2014 May 30;28(5):2191-201. Epub 2014 Jan 30.

1University of Cambridge Metabolic Research Laboratories, MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke's Hospital, Cambridge CB2 OQQ, UK.

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http://dx.doi.org/10.1096/fj.13-242727DOI Listing
May 2014

DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification.

Int J Mol Sci 2014 May 13;15(5):8491-508. Epub 2014 May 13.

Kolling Institute of Medical Research, Royal North Shore Hospital, Pacific Hwy, St Leonards, NSW 2065, Australia.

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http://dx.doi.org/10.3390/ijms15058491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057744PMC
May 2014

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system.

Biomaterials 2014 Apr 11;35(13):3919-25. Epub 2014 Feb 11.

Cavendish Laboratory, Physics Department, University of Cambridge, UK; Biotechnology Center, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.038DOI Listing
April 2014

The bigger picture of FTO: the first GWAS-identified obesity gene.

Nat Rev Endocrinol 2014 Jan 19;10(1):51-61. Epub 2013 Nov 19.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/nrendo.2013.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188449PMC
January 2014

The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.

Curr Opin Pharmacol 2013 Dec 24;13(6):970-6. Epub 2013 Sep 24.

University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2013.09.010DOI Listing
December 2013

PP2Ce: Fat and stressed out?

Mol Metab 2013 7;2(4):325-6. Epub 2013 Sep 7.

University of Cambridge School of Clinical Medicine, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.molmet.2013.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854984PMC
December 2013

The biology of FTO: from nucleic acid demethylase to amino acid sensor.

Diabetologia 2013 Oct 30;56(10):2113-21. Epub 2013 Jul 30.

MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Box 289, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00125-013-2999-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764322PMC
October 2013

Uncovering the biology of FTO.

Mol Metab 2012 3;1(1-2):32-6. Epub 2012 Aug 3.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.molmet.2012.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757649PMC
September 2013

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Proc Natl Acad Sci U S A 2013 Feb 28;110(7):2557-62. Epub 2013 Jan 28.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1222796110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574930PMC
February 2013

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice.

Mol Cell 2012 Oct 13;48(1):39-51. Epub 2012 Sep 13.

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765120069
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http://dx.doi.org/10.1016/j.molcel.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473360PMC
October 2012

Unraveling the brain regulation of appetite: lessons from genetics.

Nat Neurosci 2012 Oct 25;15(10):1343-9. Epub 2012 Sep 25.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1038/nn.3211DOI Listing
October 2012

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

Front Endocrinol (Lausanne) 2011 22;2. Epub 2011 Feb 22.

Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Cambridge, UK.

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http://dx.doi.org/10.3389/fendo.2011.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355857PMC
August 2012

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

Endocrinology 2012 Jul 8;153(7):3054-65. Epub 2012 Jun 8.

Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Addenbrooke's Hospital, Box 139, Hills Road, Cambridge, CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1210/en.2011-2170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440453PMC
July 2012

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate.

Biochem J 2012 Jun;444(2):183-7

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20120065
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http://dx.doi.org/10.1042/BJ20120065DOI Listing
June 2012

FTO and obesity: a problem for a billion people.

Authors:
Giles S H Yeo

J Neuroendocrinol 2012 Feb;24(2):393-4

Metabolic Research Labs, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1365-2826.2011.02254.xDOI Listing
February 2012

Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain.

Rev Endocr Metab Disord 2011 Sep;12(3):197-209

University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1007/s11154-011-9171-7DOI Listing
September 2011

From GWAS to biology: lessons from FTO.

Ann N Y Acad Sci 2011 Mar;1220:162-71

University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05903.xDOI Listing
March 2011

Where next for GWAS?

Authors:
Giles S H Yeo

Brief Funct Genomics 2011 Mar;10(2):51

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http://dx.doi.org/10.1093/bfgp/elr011DOI Listing
March 2011

Where to go with FTO?

Trends Endocrinol Metab 2011 Feb 4;22(2):53-9. Epub 2010 Dec 4.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.tem.2010.11.001DOI Listing
February 2011

Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.

J Neurosci 2010 Nov;30(46):15464-78

Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

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http://dx.doi.org/10.1523/JNEUROSCI.1800-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683943PMC
November 2010

Central leptin signalling: beyond the arcuate nucleus.

Auton Neurosci 2010 Aug 13;156(1-2):8-14. Epub 2010 Jun 13.

University of Cambridge Metabolic Research Labs, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.autneu.2010.05.008DOI Listing
August 2010

Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespan.

Clin Sci (Lond) 2010 Jul 23;119(9):373-84. Epub 2010 Jul 23.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://clinsci.org/lookup/doi/10.1042/CS20100230
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http://dx.doi.org/10.1042/CS20100230DOI Listing
July 2010

Central melanocortin signaling regulates cholesterol.

Nat Neurosci 2010 Jul;13(7):779-80

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http://dx.doi.org/10.1038/nn0710-779DOI Listing
July 2010

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

PLoS One 2010 Jan 19;5(1):e8771. Epub 2010 Jan 19.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808248PMC
January 2010

Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.

Endocrinology 2009 Jan 18;150(1):114-25. Epub 2008 Sep 18.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Box 289, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2008-0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732289PMC
January 2009

Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus.

J Neurosci 2008 Nov;28(47):12419-26

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.3412-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650686PMC
November 2008

SnapShot: the hormonal control of food intake.

Cell 2008 Oct;135(3):572.e1-2

Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1016/j.cell.2008.10.014DOI Listing
October 2008

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Endocrinology 2008 Mar 26;149(3):1323-8. Epub 2007 Nov 26.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2007-1321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275368PMC
March 2008

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids.

Diabetes 2005 Aug;54(8):2269-76

University Department of Medicine,Addenbrooke's Hospital, Cambridge CB2 2QR, UK.

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http://dx.doi.org/10.2337/diabetes.54.8.2269DOI Listing
August 2005

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.

Nat Neurosci 2004 Nov 24;7(11):1187-9. Epub 2004 Oct 24.

University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/nn1336DOI Listing
November 2004

The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin.

Endocrinology 2004 Oct 1;145(10):4721-7. Epub 2004 Jul 1.

Department of Medicine, Box 232, Addenbrooke's Hospital, Cambridge CB2 2QR, United Kingdom.

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http://dx.doi.org/10.1210/en.2004-0491DOI Listing
October 2004

Proopiomelanocortin and energy balance: insights from human and murine genetics.

J Clin Endocrinol Metab 2004 Jun;89(6):2557-62

University Departments of Medicine and Clinical Biochemistry,Cambridge Institute of Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom CB2 2QQ.

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http://dx.doi.org/10.1210/jc.2004-0428DOI Listing
June 2004

Melanocortin receptors weigh in.

Nat Med 2004 Apr;10(4):351-2

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http://dx.doi.org/10.1038/nm0404-351DOI Listing
April 2004

Attractin' more attention - new pieces in the obesity puzzle?

Biochem J 2003 Dec;376(Pt 3):e7-8

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, UK.

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http://dx.doi.org/10.1042/BJ20031675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223828PMC
December 2003

Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female.

J Clin Endocrinol Metab 2003 Dec;88(12):5841-5

Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1210/jc.2003-030903DOI Listing
December 2003

Minireview: human obesity-lessons from monogenic disorders.

Endocrinology 2003 Sep;144(9):3757-64

University Department of Medicine, Cambridge Institute of Medical Research, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1210/en.2003-0373DOI Listing
September 2003

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.

Hum Mol Genet 2003 Mar;12(5):561-74

Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1093/hmg/ddg057DOI Listing
March 2003

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

N Engl J Med 2003 Mar;348(12):1085-95

University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa022050DOI Listing
March 2003

Past, present and future strategies to study the genetics of body weight regulation.

Brief Funct Genomic Proteomic 2002 Oct;1(3):290-304

Cambridge Institute for Medical Research, University of Cambridge, UK.

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http://bfg.oxfordjournals.org/content/1/3/290.full.pdf
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http://dx.doi.org/10.1093/bfgp/1.3.290DOI Listing
October 2002

Obesity therapy: altering the energy intake-and-expenditure balance sheet.

Nat Rev Drug Discov 2002 Apr;1(4):276-86

University Departments of Medicine and Clinical Biochemistry, Addenbrooke's Hospital, Cambridge CB2 2QR, UK.

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http://dx.doi.org/10.1038/nrd770DOI Listing
April 2002