Publications by authors named "Giles E Hardingham"

95Publications

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.

Acta Neuropathol 2021 Jan 4. Epub 2021 Jan 4.

UK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh bioQuarter, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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January 2021

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases.

Int J Mol Sci 2020 Dec 17;21(24). Epub 2020 Dec 17.

UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh EH16 4SB, UK.

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December 2020

Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.

J Neuroinflammation 2020 Dec 1;17(1):367. Epub 2020 Dec 1.

Centre for Discovery Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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December 2020

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.

Cell Rep 2020 08;32(6):107988

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India. Electronic address:

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August 2020

Neuronal Activity and Its Role in Controlling Antioxidant Genes.

Int J Mol Sci 2020 Mar 12;21(6). Epub 2020 Mar 12.

UK Dementia Research Institute, The Medical School, University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UK.

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March 2020

Targeting Synaptic NMDA Receptor Co-agonism as a Therapy for Alzheimer's Disease?

Cell Metab 2020 03;31(3):439-440

UK Dementia Research Institute at the University of Edinburgh, Chancellor's Building, Edinburgh Medical School, Edinburgh EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK. Electronic address:

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March 2020

The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms.

J Cereb Blood Flow Metab 2020 Nov 13;40(11):2225-2239. Epub 2019 Nov 13.

Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg, Germany.

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November 2020

Altered dendritic spine function and integration in a mouse model of fragile X syndrome.

Nat Commun 2019 10 23;10(1):4813. Epub 2019 Oct 23.

Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.

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October 2019

The human NMDA receptor GluN2A variant influences channel blocker potency.

Pharmacol Res Perspect 2019 08 20;7(4):e00495. Epub 2019 Jun 20.

Centre for Discovery Brain Sciences Hugh Robson Building, University of Edinburgh Edinburgh UK.

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August 2019

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy.

J Physiol 2019 03 30;597(6):1691-1704. Epub 2019 Jan 30.

Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, UK.

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March 2019

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.

Cell Rep 2018 10;25(4):841-851.e4

Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; The Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Centre for Clinical Brain Sciences, University of Edinburgh Chancellor's Building, Edinburgh, UK. Electronic address:

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October 2018

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription.

Nat Protoc 2018 10;13(10):2176-2199

Edinburgh Medical School, and UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.

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October 2018

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Nat Rev Neurosci 2018 Jan 23;19(1):9-15. Epub 2017 Nov 23.

Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.

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January 2018

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory.

Biochem Soc Trans 2017 Dec 17;45(6):1295-1303. Epub 2017 Nov 17.

Edinburgh Medical School, University of Edinburgh, Edinburgh EH16 4TJ, U.K.

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December 2017

Transfection in Primary Cultured Neuronal Cells.

Methods Mol Biol 2017 ;1677:137-144

UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.

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June 2018

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.

Neuron 2017 Aug;95(3):550-563.e5

Centre for Integrative Physiology/Patrick Wild Centre, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Electronic address:

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August 2017

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons.

Sci Rep 2017 07 25;7(1):6390. Epub 2017 Jul 25.

Institut de Neurociències and Unitat de Bioquímica, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.

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July 2017

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers.

Org Biomol Chem 2017 Mar;15(9):2086-2096

Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK. and C.N.R. - I.C.R.M., via Mancinelli 7, 20131 Milan, Italy.

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March 2017

Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes.

Free Radic Biol Med 2016 11 27;100:147-152. Epub 2016 Jun 27.

School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address:

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November 2016

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.

EBioMedicine 2016 Jan 12;3:141-154. Epub 2015 Dec 12.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Midlothian EH16 4UU, United Kingdom; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom; The Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, Midlothian EH16 4SB, United Kingdom. Electronic address:

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January 2016

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.

Nat Rev Neurosci 2016 02 14;17(2):125-34. Epub 2016 Jan 14.

Department of Psychiatry, Center of Psychiatric Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1008, Prilly-Lausanne, Switzerland.

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February 2016

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

J Physiol 2016 11 30;594(22):6573-6582. Epub 2015 Dec 30.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.

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November 2016

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.

Nat Commun 2015 Apr 9;6:6761. Epub 2015 Apr 9.

Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.

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April 2015

Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.

Biochim Biophys Acta 2015 Sep 22;1853(9):2066-76. Epub 2014 Dec 22.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address:

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September 2015

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.

J Physiol 2014 Oct 28;592(19):4353-63. Epub 2014 Aug 28.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9XD, UK

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October 2014

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

Proc Natl Acad Sci U S A 2014 May 21;111(18):E1818-20. Epub 2014 Apr 21.

Center for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom.

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May 2014

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.

J Neurosci 2014 Mar;34(11):4070-5

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom; and Euan MacDonald Centre for MND Research, Centre for Clinical Brain Sciences, and MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

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March 2014

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.

PLoS One 2014 17;9(1):e85932. Epub 2014 Jan 17.

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, United Kingdom ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom ; Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom.

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September 2014

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons.

Neurosci Lett 2013 May 18;543:95-100. Epub 2013 Mar 18.

Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 0SZ, United Kingdom.

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May 2013

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure.

Neuropharmacology 2013 Nov 10;74:119-25. Epub 2013 Feb 10.

Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.

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November 2013

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.

Br J Clin Pharmacol 2013 Apr;75(4):907-18

Anne McLaren Laboratory for Regenerative Medicine & Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0SZ, UK.

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April 2013

SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites.

J Neurochem 2013 Jan 15;124(1):26-35. Epub 2012 Nov 15.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.

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January 2013

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.

Exp Neurol 2012 Oct 6;237(2):396-406. Epub 2012 Jul 6.

University of Cambridge Metabolic Research Laboratories, NIHR Cambridge Biomedical Research Centre Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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October 2012

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity.

J Neurosci 2012 May;32(20):6995-7000

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom.

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May 2012

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

Neuron 2012 May;74(3):543-56

Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.

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May 2012

Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning.

Oxid Med Cell Longev 2011 28;2011:689524. Epub 2011 Jun 28.

Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, UK.

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April 2012

In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export.

PLoS One 2011 9;6(6):e21056. Epub 2011 Jun 9.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom.

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October 2011

The influence of synaptic activity on neuronal health.

Curr Opin Neurobiol 2011 Apr 1;21(2):299-305. Epub 2011 Feb 1.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

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April 2011

Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes.

Antioxid Redox Signal 2011 Apr 28;14(8):1421-4. Epub 2011 Feb 28.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom.

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April 2011

CNS peroxiredoxins and their regulation in health and disease.

Antioxid Redox Signal 2011 Apr 25;14(8):1467-77. Epub 2011 Feb 25.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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April 2011

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.

Nat Rev Neurosci 2010 Oct 15;11(10):682-96. Epub 2010 Sep 15.

Centre for Integrative Physiology, University of Edinburgh, School of Biomedical Sciences, Hugh Robson Building, Edinburgh EH8 9XD, UK.

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October 2010

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration.

Mol Neurobiol 2010 Aug 30;42(1):97-102. Epub 2010 Apr 30.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK.

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August 2010

Excitotoxic insults lead to peroxiredoxin hyperoxidation.

Oxid Med Cell Longev 2009 Apr-Jun;2(2):110-3

Center for Integrative Physiology, University of Edinburgh, Edinburgh, UK.

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January 2011

Coupling of the NMDA receptor to neuroprotective and neurodestructive events.

Biochem Soc Trans 2009 Dec;37(Pt 6):1147-60

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

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December 2009

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.

PLoS One 2009 Oct 6;4(10):e7327. Epub 2009 Oct 6.

Anne McLaren Laboratory for Regenerative Medicine & Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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October 2009

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene.

Channels (Austin) 2009 Jul-Aug;3(4):233-8. Epub 2009 Jul 24.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.

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December 2009

Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.

Epigenetics 2009 Apr 12;4(3):152-8. Epub 2009 Apr 12.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh, SCT, UK.

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April 2009

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.

Mol Cells 2009 Mar 19;27(3):279-82. Epub 2009 Mar 19.

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, UK.

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March 2009

The dichotomy of NMDA receptor signaling.

Neuroscientist 2007 Dec;13(6):572-9

Centre for Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom.

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December 2007

Compartmentalized NMDA receptor signalling to survival and death.

J Physiol 2007 Oct 9;584(Pt 2):381-7. Epub 2007 Aug 9.

Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, UK.

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October 2007

Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity.

J Neurophysiol 2007 Apr 31;97(4):2965-75. Epub 2007 Jan 31.

The University Laboratory of Physiology, Oxford University, Oxford, UK.

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April 2007

Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors.

J Neurosci 2006 Jun;26(23):6337-45

The University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, United Kingdom.

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June 2006

Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability.

J Neurosci 2006 Apr;26(17):4509-18

Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom.

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April 2006

2B synaptic or extrasynaptic determines signalling from the NMDA receptor.

J Physiol 2006 May;572(Pt 3):614-5

Centre for Neuroscience Research, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK.

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May 2006

Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.

J Neurosci 2005 Apr;25(17):4279-87

Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom.

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April 2005

The Yin and Yang of NMDA receptor signalling.

Trends Neurosci 2003 Feb;26(2):81-9

Department of Preclinical Veterinary Sciences, Royal School of Veterinary Studies, Edinburgh University, Summerhall, UK.

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February 2003

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated.

Biochim Biophys Acta 2002 Nov;1600(1-2):148-53

Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, Edinburgh University, Summerhall, EH9 1QH, Edinburgh, UK.

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November 2002