Giles Best

Giles Best

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Giles Best

Publications by authors named "Giles Best"

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Molecular pathogenesis of chronic lymphocytic leukaemia.

Br J Haematol 2019 Sep 31;186(5):668-684. Epub 2019 Jul 31.

Northern Blood Research Centre, Kolling Institute of Medical Research, Sydney, NSW, Australia.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.16102
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http://dx.doi.org/10.1111/bjh.16102DOI Listing
September 2019

Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment.

Leuk Lymphoma 2019 Jul 16;60(7):1632-1643. Epub 2019 Jan 16.

a Northern Blood Research Centre, Kolling Institute , Royal North Shore Hospital , St Leonards , NSW , Australia.

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http://dx.doi.org/10.1080/10428194.2018.1542148DOI Listing
July 2019

Expression of Intracellular Reactive Oxygen Species in Hematopoietic Stem Cells Correlates with Time to Neutrophil and Platelet Engraftment in Patients Undergoing Autologous Bone Marrow Transplantation.

Biol Blood Marrow Transplant 2018 10 19;24(10):1997-2002. Epub 2018 Jun 19.

Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia; Cellular Therapeutic Laboratory, Northern Blood Research Centre, Kolling Research Institute, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.bbmt.2018.06.014DOI Listing
October 2018

The dual inhibitor of the phosphoinositol-3 and PIM kinases, IBL-202, is effective against chronic lymphocytic leukaemia cells under conditions that mimic the hypoxic tumour microenvironment.

Br J Haematol 2018 09 5;182(5):654-669. Epub 2018 Jul 5.

Northern Blood Research Centre, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney, Australia.

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http://dx.doi.org/10.1111/bjh.15447DOI Listing
September 2018

Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment.

Leuk Lymphoma 2018 08 22;59(8):1927-1937. Epub 2017 Nov 22.

a School of Life and Environmental Sciences , University of Sydney , Sydney , Australia.

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http://dx.doi.org/10.1080/10428194.2017.1403598DOI Listing
August 2018

MEK1/2 inhibition by binimetinib is effective as a single agent and potentiates the actions of Venetoclax and ABT-737 under conditions that mimic the chronic lymphocytic leukaemia (CLL) tumour microenvironment.

Br J Haematol 2018 08 16;182(3):360-372. Epub 2018 May 16.

Northern Blood Research Centre, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney, Australia.

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http://dx.doi.org/10.1111/bjh.15282DOI Listing
August 2018

Immune failure, infection and survival in chronic lymphocytic leukemia.

Haematologica 2018 07;103(7):e329

Department of Haematology, Royal North Shore Hospital, Kolling Institute, University of Sydney, St Leonards, Australia.

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http://dx.doi.org/10.3324/haematol.2018.196543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029549PMC
July 2018

Lymphoma cell-of-origin assignment by gene expression profiling is clinically meaningful across broad laboratory contexts.

Br J Haematol 2018 04 15;181(2):272-275. Epub 2017 Feb 15.

Northern Blood Research Centre, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/bjh.14556DOI Listing
April 2018

Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia.

Br J Haematol 2018 04 21;181(1):97-101. Epub 2018 Feb 21.

Department of Haematology, Royal North Shore Hospital, Kolling Institute, University of Sydney, St Leonards, Sydney, Australia.

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http://dx.doi.org/10.1111/bjh.15146DOI Listing
April 2018

Modeling the chronic lymphocytic leukemia microenvironment in vitro.

Leuk Lymphoma 2017 02 18;58(2):266-279. Epub 2016 Oct 18.

a Northern Blood Research Centre , Kolling Institute of Medical Research, Royal North Shore Hospital , Sydney , Australia.

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http://dx.doi.org/10.1080/10428194.2016.1204654DOI Listing
February 2017

The MEK1/2 inhibitor, MEKi-1, induces cell death in chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine.

Leuk Lymphoma 2015 26;56(12):3407-17. Epub 2015 Aug 26.

a Northern Blood Research Centre, Kolling Institute of Medical Research, Royal North Shore Hospital , St Leonards, Sydney , NSW , Australia.

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http://dx.doi.org/10.3109/10428194.2015.1032963DOI Listing
September 2016

Protein profiles distinguish stable and progressive chronic lymphocytic leukemia.

Leuk Lymphoma 2016 May 16;57(5):1033-43. Epub 2015 Nov 16.

a School of Molecular Bioscience, University of Sydney , Sydney , NSW , Australia ;

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http://dx.doi.org/10.3109/10428194.2015.1094692DOI Listing
May 2016

Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date.

World J Clin Cases 2015 Aug;3(8):694-704

Kyle Crassini, Stephen P Mulligan, O Giles Best, Northern Blood Research Centre and CLL Australian Research Consortium, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney NSW 2065, Australia.

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http://dx.doi.org/10.12998/wjcc.v3.i8.694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539409PMC
August 2015

Mechanisms of action of fludarabine nucleoside against human Raji lymphoma cells.

Nucleosides Nucleotides Nucleic Acids 2014 ;33(4-6):375-83

a School of Molecular Bioscience , University of Sydney , Sydney , NSW , Australia.

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http://dx.doi.org/10.1080/15257770.2013.863334DOI Listing
February 2015

Chronic lymphocytic leukaemia, monoclonal B-lymphocytosis and pregnancy: five cases, a literature review and discussion of management.

Br J Haematol 2015 Feb 25;168(3):350-60. Epub 2014 Sep 25.

Department of Haematology, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Kolling Institute, University of Sydney, St Leonards, Sydney, NSW, Australia; Chronic Lymphocytic Leukaemia Australian Research Consortium (CLLARC), Sydney, NSW, Australia.

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http://dx.doi.org/10.1111/bjh.13134DOI Listing
February 2015

Profiles of surface mosaics on chronic lymphocytic leukemias distinguish stable and progressive subtypes.

J Pharm Pharm Sci 2013 ;16(2):231-7

School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.18433/j3f01cDOI Listing
March 2014

Protein kinase C isoform expression in chronic lymphocytic leukemia: a potential target for therapy?

Leuk Lymphoma 2013 Oct 19;54(10):2098-9. Epub 2013 Apr 19.

Northern Blood Research Centre, Kolling Institute of Medical Research, Royal North Shore Hospital , NSW , Australia.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2013.77
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http://dx.doi.org/10.3109/10428194.2013.779692DOI Listing
October 2013

The phosphoinositide 3-kinase pathway in chronic lymphocytic leukemia: evidence for phosphatase and tensin homolog deletion on chromosome 10 deregulation.

Leuk Lymphoma 2013 Jun 5;54(6):1123-4. Epub 2012 Dec 5.

Northern Blood Research Centre, Kolling Institute, Royal North Shore Hospital, Sydney, Australia.

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http://dx.doi.org/10.3109/10428194.2012.746685DOI Listing
June 2013

Hsp90 Inhibitor SNX-7081 dysregulates proteins involved with DNA repair and replication and the cell cycle in human chronic lymphocytic leukemia (CLL) cells.

J Proteome Res 2013 Apr 22;12(4):1710-22. Epub 2013 Mar 22.

Cancer Proteomics Laboratory, School of Molecular Bioscience, University of Sydney , Sydney, NSW 2006, Australia.

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http://pubs.acs.org/doi/10.1021/pr301055y
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http://dx.doi.org/10.1021/pr301055yDOI Listing
April 2013

Immunoglobulin G subclass deficiency and infection risk in 150 patients with chronic lymphocytic leukemia.

Leuk Lymphoma 2013 Jan 8;54(1):99-104. Epub 2012 Sep 8.

Department of Haematology, Royal North Shore Hospital, Kolling Institute, University of Sydney, St Leonards, Sydney, Australia.

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http://dx.doi.org/10.3109/10428194.2012.706285DOI Listing
January 2013

Diagnostic techniques and therapeutic challenges in patients with TP53 dysfunctional chronic lymphocytic leukemia.

Leuk Lymphoma 2012 Nov 31;53(11):2105-15. Epub 2012 May 31.

Royal North Shore Hospital, St Leonards, NSW, Australia.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2012.69
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http://dx.doi.org/10.3109/10428194.2012.692088DOI Listing
November 2012

Surface profiles for subclassification of chronic lymphocytic leukemia.

Leuk Lymphoma 2012 Jun 3;53(6):1046-56. Epub 2012 Apr 3.

School of Molecular Bioscience, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.3109/10428194.2011.631370DOI Listing
June 2012

Fludarabine nucleoside modulates nuclear "survival and death" proteins in resistant chronic lymphocytic leukemia cells.

Nucleosides Nucleotides Nucleic Acids 2011 Dec;30(12):1181-9

School of Molecular Bioscience, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1080/15257770.2011.603716DOI Listing
December 2011

Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis.

FEBS Lett 2009 Sep 18;583(17):2789-92. Epub 2009 Jul 18.

Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2009.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741570PMC
September 2009

The precursor of chronic lymphocytic leukemia.

N Engl J Med 2009 Jun;360(24):2575; author reply 2575-6

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http://dx.doi.org/10.1056/NEJMc090559DOI Listing
June 2009

Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site.

J Biol Chem 2007 Apr 8;282(14):10804-13. Epub 2007 Feb 8.

Department of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M610956200DOI Listing
April 2007

NDPK-A (but not NDPK-B) and AMPK alpha1 (but not AMPK alpha2) bind the cystic fibrosis transmembrane conductance regulator in epithelial cell membranes.

Cell Signal 2006 Oct 8;18(10):1595-603. Epub 2006 Feb 8.

Department of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.cellsig.2006.01.001DOI Listing
October 2006

ZAP-70 in B cell malignancies.

Leuk Lymphoma 2005 Dec;46(12):1689-98

Department of Haematology, Royal Bournemouth Hospital, UK.

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http://dx.doi.org/10.1080/09638280500260079DOI Listing
December 2005

A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung.

Biochem J 2005 Nov;392(Pt 1):201-9

Department of Maternal and Child Health Sciences, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1042/BJ20050269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317679PMC
November 2005