Gilbert G Privé

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark; The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address:

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November 2019

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Nat Commun 2019 08 6;10(1):3521. Epub 2019 Aug 6.

Department of Cell Biology, and Department of Pathology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.

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August 2019

Molecular models should not be published without the corresponding atomic coordinates.

Authors:

Stephen C Graham Bhushan Nagar Gilbert G Privé Janet E Deane

Proc Natl Acad Sci U S A 2019 06;116(23):11099-11100

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom

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June 2019

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.

Authors:

Tharu M Fernando Rossella Marullo Benet Pera Gresely Jude M Phillip Shao Ning Yang Geoffrey Lundell-Smith Ingrid Torregroza Haelee Ahn Todd Evans Balázs Győrffy Gilbert G Privé Masayuki Hirano Ari M Melnick Leandro Cerchietti

Cancer Discov 2019 05 18;9(5):662-679. Epub 2019 Feb 18.

Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.

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May 2019

Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.

Authors:

Yong Wei Zi Jian Xiong Jun Li Chunxia Zou Christopher W Cairo John S Klassen Gilbert G Privé

Commun Biol 2019 5;2:52. Epub 2019 Feb 5.

1Princess Margaret Cancer Centre, Toronto, M5G 1L7 ON Canada.

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April 2020

Detecting Protein-Glycolipid Interactions Using CaR-ESI-MS and Model Membranes: Comparison of Pre-loaded and Passively Loaded Picodiscs.

Authors:

Jun Li Ling Han Jianing Li Elena N Kitova Zi Jian Xiong Gilbert G Privé John S Klassen

J Am Soc Mass Spectrom 2018 07 13;29(7):1493-1504. Epub 2018 Apr 13.

Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.

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July 2018

Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.

Authors:

Michael N Ha Sébastien Delpeut Ryan S Noyce Gary Sisson Karen M Black Liang-Tzung Lin Darius Bilimoria Richard K Plemper Gilbert G Privé Christopher D Richardson

J Virol 2017 12 14;91(23). Epub 2017 Nov 14.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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December 2017

Characterizing the Size and Composition of Saposin A Lipoprotein Picodiscs.

Authors:

Jun Li Michele R Richards Dhanashri Bagal Iain D G Campuzano Elena N Kitova Zi Jian Xiong Gilbert G Privé John S Klassen

Anal Chem 2016 10 13;88(19):9524-9531. Epub 2016 Sep 13.

Alberta Glycomics Centre and Department of Chemistry, University of Alberta , Edmonton, Alberta T6G 2G2, Canada.

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October 2016

Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.

Authors:

Zi-Jian Xiong Jingjing Huang Gennady Poda Régis Pomès Gilbert G Privé

J Mol Biol 2016 07 24;428(15):3026-42. Epub 2016 Jun 24.

Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Electronic address:

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July 2016

Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.

Authors:

Melissa R Marzahn Suresh Marada Jihun Lee Amanda Nourse Sophia Kenrick Huaying Zhao Gili Ben-Nissan Regina-Maria Kolaitis Jennifer L Peters Stanley Pounds Wesley J Errington Gilbert G Privé J Paul Taylor Michal Sharon Peter Schuck Stacey K Ogden Tanja Mittag

EMBO J 2016 06 23;35(12):1254-75. Epub 2016 May 23.

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA

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June 2016

Screening Glycolipids Against Proteins in Vitro Using Picodiscs and Catch-and-Release Electrospray Ionization-Mass Spectrometry.

Authors:

Jun Li Xuxin Fan Elena N Kitova Chunxia Zou Christopher W Cairo Luiz Eugenio Kenneth K S Ng Zi Jian Xiong Gilbert G Privé John S Klassen

Anal Chem 2016 05 20;88(9):4742-50. Epub 2016 Apr 20.

Alberta Glycomics Centre, Department of Chemistry, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.

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May 2016

Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.

Authors:

Alan X Ji Anh Chu Tine Kragh Nielsen Samir Benlekbir John L Rubinstein Gilbert G Privé

J Mol Biol 2016 Jan 31;428(1):92-107. Epub 2015 Aug 31.

Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada; Princess Margaret Cancer Centre, Campbell Family Institute for Cancer Research, University Health Network, 101 College Street, Toronto, ON, M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. Electronic address:

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January 2016

Crystal structure of GnsA from Escherichia coli.

Authors:

Yong Wei Lihong Zhan Zengqiang Gao Gilbert G Privé Yuhui Dong

Biochem Biophys Res Commun 2015 Jun 1;462(1):1-7. Epub 2015 Apr 1.

Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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June 2015

Picodiscs for facile protein-glycolipid interaction analysis.

Authors:

Aneika C Leney Reza Rezaei Darestani Jun Li Sanaz Nikjah Elena N Kitova Chunxia Zou Christopher W Cairo Zi Jian Xiong Gilbert G Privé John S Klassen

Anal Chem 2015 Apr 9;87(8):4402-8. Epub 2015 Apr 9.

§Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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April 2015

Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Authors:

Jean-Philippe P Theurillat Namrata D Udeshi Wesley J Errington Tanya Svinkina Sylvan C Baca Marius Pop Peter J Wild Mirjam Blattner Anna C Groner Mark A Rubin Holger Moch Gilbert G Prive Steven A Carr Levi A Garraway

Science 2014 Oct 2;346(6205):85-89. Epub 2014 Oct 2.

The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

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October 2014

The integrated landscape of driver genomic alterations in glioblastoma.

Nat Genet 2013 Oct 5;45(10):1141-9. Epub 2013 Aug 5.

1] Institute for Cancer Genetics, Columbia University Medical Center, New York, New York, USA. [2].

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October 2013

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Cell Rep 2013 Aug 1;4(3):578-88. Epub 2013 Aug 1.

Division of Hematology and Medical Oncology, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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August 2013

Systemic ceramide accumulation leads to severe and varied pathological consequences.

Authors:

Abdulfatah M Alayoubi James C M Wang Bryan C Y Au Stéphane Carpentier Virginie Garcia Shaalee Dworski Samah El-Ghamrasni Kevin N Kirouac Mathilde J Exertier Zi Jian Xiong Gilbert G Privé Calogera M Simonaro Josefina Casas Gemma Fabrias Edward H Schuchman Patricia V Turner Razqallah Hakem Thierry Levade Jeffrey A Medin

EMBO Mol Med 2013 Jun 16;5(6):827-42. Epub 2013 May 16.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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June 2013

Crystal structure of KLHL3 in complex with Cullin3.

Authors:

Alan X Ji Gilbert G Privé

PLoS One 2013 3;8(4):e60445. Epub 2013 Apr 3.

Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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October 2013

Detergent-mediated protein aggregation.

Authors:

Chris Neale Hamed Ghanei John Holyoake Russell E Bishop Gilbert G Privé Régis Pomès

Chem Phys Lipids 2013 Apr 4;169:72-84. Epub 2013 Mar 4.

Molecular Structure and Function, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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April 2013

Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.

Authors:

Wesley J Errington M Qasim Khan Stephanie A Bueler John L Rubinstein Avijit Chakrabartty Gilbert G Privé

Structure 2012 Jul 24;20(7):1141-53. Epub 2012 May 24.

Department of Biochemistry, University of Toronto, 1 Kings College Circle, Toronto, Ontario M5S 1A8, Canada.

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July 2012

Structure of saposin A lipoprotein discs.

Authors:

Konstantin Popovic John Holyoake Régis Pomès Gilbert G Privé

Proc Natl Acad Sci U S A 2012 Feb 2;109(8):2908-12. Epub 2012 Feb 2.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2M9.

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February 2012

PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.

Authors:

Jose Antonio Cuesta-Seijo Chris Neale M Adil Khan Joel Moktar Christopher D Tran Russell E Bishop Régis Pomès Gilbert G Privé

Structure 2010 Sep;18(9):1210-9

Division of Cancer Genomics and Proteomics, Ontario Cancer Institute and Campbell Family Cancer Research Institute, 101 College Street, Toronto, ON M5G 1L7, Canada.

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September 2010