Gil McVean

Gil McVean

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Gil McVean

Gil McVean

Publications by authors named "Gil McVean"

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HLA*LA - HLA typing from linearly projected graph alignments.

Bioinformatics 2019 Apr 3. Epub 2019 Apr 3.

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, Bethesda, Maryland, USA.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/btz235DOI Listing
April 2019

Ultrafast search of all deposited bacterial and viral genomic data.

Nat Biotechnol 2019 02 4;37(2):152-159. Epub 2019 Feb 4.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41587-018-0010-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420049PMC
February 2019

Integrating long-range connectivity information into de Bruijn graphs.

Bioinformatics 2018 08;34(15):2556-2565

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bioinformatics/bty157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061703PMC
August 2018

Deconvolution of multiple infections in Plasmodium falciparum from high throughput sequencing data.

Bioinformatics 2018 01;34(1):9-15

Wellcome Trust Centre for Human Genetics,University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bioinformatics/btx530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870807PMC
January 2018

Structural and regulatory diversity shape HLA-C protein expression levels.

Nat Commun 2017 06 26;8:15924. Epub 2017 Jun 26.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/ncomms15924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490200PMC
June 2017

Neuroinflammation - using big data to inform clinical practice.

Nat Rev Neurol 2016 12 18;12(12):685-698. Epub 2016 Nov 18.

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/nrneurol.2016.171DOI Listing
December 2016

High-Accuracy HLA Type Inference from Whole-Genome Sequencing Data Using Population Reference Graphs.

PLoS Comput Biol 2016 Oct 28;12(10):e1005151. Epub 2016 Oct 28.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1005151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085092PMC
October 2016

Stable recombination hotspots in birds.

Science 2015 11;350(6263):928-32

Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Department of Systems Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.aad0843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864528PMC
November 2015

Imputation of KIR Types from SNP Variation Data.

Am J Hum Genet 2015 Oct;97(4):593-607

Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596914PMC
October 2015

Where Next for Genetics and Genomics?

PLoS Biol 2015 Jul 30;13(7):e1002216. Epub 2015 Jul 30.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1002216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520474PMC
July 2015

Improved genome inference in the MHC using a population reference graph.

Nat Genet 2015 Jun 27;47(6):682-8. Epub 2015 Apr 27.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449272PMC
June 2015

The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease.

PLoS Genet 2015 Apr 23;11(4):e1005165. Epub 2015 Apr 23.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1005165
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http://dx.doi.org/10.1371/journal.pgen.1005165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407972PMC
April 2015

Demography and the age of rare variants.

PLoS Genet 2014 Aug 7;10(8):e1004528. Epub 2014 Aug 7.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125085PMC
August 2014

Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.

Science 2014 Jun 12;344(6189):1272-5. Epub 2014 Jun 12.

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1126/science.344.6189.1272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746749PMC
June 2014

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Multi-population classical HLA type imputation.

PLoS Comput Biol 2013 14;9(2):e1002877. Epub 2013 Feb 14.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1371/journal.pcbi.1002877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572961PMC
October 2013

Integrating genealogical and dynamical modelling to infer escape and reversion rates in HIV epitopes.

Proc Biol Sci 2013 Jul 15;280(1762):20130696. Epub 2013 May 15.

Department of Statistics, 1 South Parks Road, University of Oxford, Oxford OX1 3TG, UK.

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http://dx.doi.org/10.1098/rspb.2013.0696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673055PMC
July 2013

Hypervariable antigen genes in malaria have ancient roots.

BMC Evol Biol 2013 May 31;13:110. Epub 2013 May 31.

National Institute of Allergy of Infectious Disease, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1186/1471-2148-13-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680017PMC
May 2013

Estimating selection coefficients in spatially structured populations from time series data of allele frequencies.

Genetics 2013 Mar 10;193(3):973-84. Epub 2013 Jan 10.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1534/genetics.112.147611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584010PMC
March 2013

Genomewide association studies and common disease--realizing clinical utility.

N Engl J Med 2012 Dec;367(25):2370-1

Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMp1212285
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http://dx.doi.org/10.1056/NEJMp1212285DOI Listing
December 2012

Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas.

J Clin Endocrinol Metab 2012 Oct 1;97(10):E1995-2005. Epub 2012 Aug 1.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, and Department of Surgery, John Radcliffe Hospital, Oxford University Hospitals Trust, Oxford, UK.

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http://dx.doi.org/10.1210/jc.2012-2303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446457PMC
October 2012

Estimating recombination rates from genetic variation in humans.

Methods Mol Biol 2012 ;856:217-37

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://link.springer.com/10.1007/978-1-61779-585-5_9
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http://dx.doi.org/10.1007/978-1-61779-585-5_9DOI Listing
July 2012

Differential confounding of rare and common variants in spatially structured populations.

Nat Genet 2012 Feb 5;44(3):243-6. Epub 2012 Feb 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://www.nature.com/articles/ng.1074
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http://dx.doi.org/10.1038/ng.1074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303124PMC
February 2012

De novo assembly and genotyping of variants using colored de Bruijn graphs.

Nat Genet 2012 Jan 8;44(2):226-32. Epub 2012 Jan 8.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/ng.1028
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http://dx.doi.org/10.1038/ng.1028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272472PMC
January 2012

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

Experiments with the site frequency spectrum.

Bull Math Biol 2011 Apr 23;73(4):829-72. Epub 2010 Dec 23.

Biomathematics Research Centre, Christchurch, New Zealand.

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http://dx.doi.org/10.1007/s11538-010-9605-5DOI Listing
April 2011

HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes.

Bioinformatics 2011 Apr 7;27(7):968-72. Epub 2011 Feb 7.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/bioinformatics/btr061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065693PMC
April 2011

PRDM9 marks the spot.

Nat Genet 2010 Oct;42(10):821-2

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http://dx.doi.org/10.1038/ng1010-821DOI Listing
October 2010

Integrating common and rare genetic variation in diverse human populations.

Nature 2010 Sep;467(7311):52-8

Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature09298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173859PMC
September 2010

What drives recombination hotspots to repeat DNA in humans?

Authors:
Gil McVean

Philos Trans R Soc Lond B Biol Sci 2010 Apr;365(1544):1213-8

Department of Statistics, University of Oxford, , 1 South Parks Road, Oxford OX1 3TG, UK.

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http://dx.doi.org/10.1098/rstb.2009.0299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871820PMC
April 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.

Science 2010 Feb 31;327(5967):876-9. Epub 2009 Dec 31.

Department of Statistics, Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK.

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http://dx.doi.org/10.1126/science.1182363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828505PMC
February 2010

A genealogical interpretation of principal components analysis.

Authors:
Gil McVean

PLoS Genet 2009 Oct 16;5(10):e1000686. Epub 2009 Oct 16.

Department of Statistics, University of Oxford, Oxford, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1000686
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http://dx.doi.org/10.1371/journal.pgen.1000686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757795PMC
October 2009

A common sequence motif associated with recombination hot spots and genome instability in humans.

Nat Genet 2008 Sep;40(9):1124-9

Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ng.213DOI Listing
September 2008

A statistical method for predicting classical HLA alleles from SNP data.

Am J Hum Genet 2008 Jan;82(1):48-56

Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.

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http://dx.doi.org/10.1016/j.ajhg.2007.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253983PMC
January 2008

Recombination rate estimation in the presence of hotspots.

Genome Res 2007 Aug 10;17(8):1219-27. Epub 2007 Jul 10.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1101/gr.6386707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933511PMC
August 2007

A new multipoint method for genome-wide association studies by imputation of genotypes.

Nat Genet 2007 Jul 17;39(7):906-13. Epub 2007 Jun 17.

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

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http://www.nature.com/articles/ng2088
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http://dx.doi.org/10.1038/ng2088DOI Listing
July 2007

The structure of linkage disequilibrium around a selective sweep.

Authors:
Gil McVean

Genetics 2007 Mar 28;175(3):1395-406. Epub 2006 Dec 28.

Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom.

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http://dx.doi.org/10.1534/genetics.106.062828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1840056PMC
March 2007

Scanning the human genome for signals of selection.

Curr Opin Genet Dev 2006 Dec 27;16(6):624-9. Epub 2006 Sep 27.

Department of Statistics, Oxford University, 1 South Parks Road, Oxford, OX1 3TG, UK.

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http://dx.doi.org/10.1016/j.gde.2006.09.004DOI Listing
December 2006

The influence of recombination on human genetic diversity.

PLoS Genet 2006 Sep 31;2(9):e148. Epub 2006 Jul 31.

Department of Statistics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575889PMC
September 2006

A fine-scale map of recombination rates and hotspots across the human genome.

Science 2005 Oct;310(5746):321-4

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1117196
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http://dx.doi.org/10.1126/science.1117196DOI Listing
October 2005

Perspectives on human genetic variation from the HapMap Project.

PLoS Genet 2005 Oct;1(4):e54

Department of Statistics, University of Oxford, Oxford, United Kingdom.

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