Gideon M Hirschfield

Gideon M Hirschfield

UNVERIFIED PROFILE

Are you Gideon M Hirschfield?   Register this Author

Register author
Gideon M Hirschfield

Gideon M Hirschfield

Publications by authors named "Gideon M Hirschfield"

Are you Gideon M Hirschfield?   Register this Author

100Publications

3819Reads

50Profile Views

Cirrhosis-associated immune dysfunction: Novel insights in impaired adaptive immunity.

EBioMedicine 2019 Nov 11. Epub 2019 Nov 11.

Toronto Centre for Liver Disease, University Health Network, Canada; Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2019.10.056DOI Listing
November 2019

Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.

Clin Gastroenterol Hepatol 2019 Sep 4;17(10):2076-2084.e2. Epub 2019 Jan 4.

Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15423565193000
Publisher Site
http://dx.doi.org/10.1016/j.cgh.2018.12.028DOI Listing
September 2019

The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review.

Semin Liver Dis 2019 Sep 19. Epub 2019 Sep 19.

Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1697617
Publisher Site
http://dx.doi.org/10.1055/s-0039-1697617DOI Listing
September 2019

Guideline review: British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis treatment and management guidelines.

Frontline Gastroenterol 2019 Jul 9;10(3):316-319. Epub 2019 Jan 9.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/flgastro-2018-101109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583568PMC
July 2019

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom.

Clin Gastroenterol Hepatol 2019 Jun 14;17(7):1379-1387.e3. Epub 2018 Dec 14.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2018.12.007DOI Listing
June 2019

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.

Liver Int 2019 May 25;39(5):967-975. Epub 2019 Feb 25.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14069DOI Listing
May 2019

Grand round: Autoimmune hepatitis.

J Hepatol 2019 Apr 20;70(4):773-784. Epub 2018 Nov 20.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Liver Unit, University Hospitals Birmingham, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University of Toronto and University Health Network, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2018.11.006DOI Listing
April 2019

Response to "Is the hub-and-spoke model of care delivery a possible answer to geographical variation in liver transplant outcomes?"

Am J Transplant 2019 Apr 22;19(4):1248-1249. Epub 2019 Jan 22.

Liver Medicine, University Hospitals Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15226DOI Listing
April 2019

Liver disease in the young adult: the challenges and rewards.

Lancet Gastroenterol Hepatol 2019 Mar;4(3):248-254

Centre for Rare Diseases, Institute for Translational Medicine, University Hospitals Birmingham, Birmingham, UK; National Institute for Health Research Birmingham Biomedical Research Centre, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2468-1253(18)30244-9DOI Listing
March 2019

A Practical Review of Primary Biliary Cholangitis for the Gastroenterologist.

Gastroenterol Hepatol (N Y) 2019 Mar;15(3):145-154

Dr Onofrio is a hepatology fellow in the Division of Gastroenterology at the University of Toronto and the Toronto Centre for Liver Disease at Toronto General Hospital in the University Health Network in Toronto, Canada. Dr Hirschfield is the Lily and Terry Horner Chair in Autoimmune Liver Disease Research in the Toronto Centre for Liver Disease at Toronto General Hospital and a professor of medicine in the Division of Gastroenterology at the University of Toronto. Dr Gulamhusein is an assistant professor at the University of Toronto and a clinician investigator in the Division of Gastroenterology in the Toronto Centre for Liver Disease at Toronto General Hospital.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495411PMC
March 2019

Proximity to transplant center and outcome among liver transplant patients.

Am J Transplant 2019 01 3;19(1):208-220. Epub 2018 Aug 3.

Liver Medicine, University Hospitals Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491997PMC
January 2019

Autoimmune hepatitis and complexities in management.

Frontline Gastroenterol 2019 Jan 12;10(1):77-87. Epub 2018 Aug 12.

Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://fg.bmj.com/lookup/doi/10.1136/flgastro-2018-101015
Publisher Site
http://dx.doi.org/10.1136/flgastro-2018-101015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319158PMC
January 2019

Pathophysiology of primary biliary cholangitis.

Best Pract Res Clin Gastroenterol 2018 Jun - Aug;34-35:17-25. Epub 2018 May 24.

Centre for Liver Research and NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpg.2018.05.012DOI Listing
December 2018

Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells.

J Autoimmun 2018 11 14;94:143-155. Epub 2018 Aug 14.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK; Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183030
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.07.020DOI Listing
November 2018

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom.

Aliment Pharmacol Ther 2018 11 18;48(9):951-960. Epub 2018 Sep 18.

NIHR Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apt.14968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667893PMC
November 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease.

Hepatol Commun 2018 Aug 6;2(8):956-967. Epub 2018 Aug 6.

Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep4.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078219PMC
August 2018

Work in Progress: Drugs in Development.

Clin Liver Dis 2018 08 17;22(3):501-515. Epub 2018 May 17.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10893261183002
Publisher Site
http://dx.doi.org/10.1016/j.cld.2018.03.004DOI Listing
August 2018

Quality of life and primary sclerosing cholangitis: The business of defining what counts.

Hepatology 2018 07 2;68(1):16-18. Epub 2018 May 2.

National Institute for Health Research Birmingham Biomedical Research Centre, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29775DOI Listing
July 2018

Genetic association studies and the risk factors for developing the "Immuno-bile-logic" disease primary biliary cholangitis.

Hepatology 2018 04 19;67(4):1620-1622. Epub 2018 Feb 19.

Centre for Liver Research and NIHR Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29603DOI Listing
April 2018

Deciphering the biology of IgG4-related disease: specific antigens and disease?

Gut 2018 04 3;67(4):602-605. Epub 2017 Nov 3.

Centre for Rare Diseases, Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2017-314861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058063PMC
April 2018

Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.

Hepatol Commun 2018 04 26;2(4):421-436. Epub 2018 Feb 26.

Centre for Liver Research, Institute of Immunology and Immunotherapy and National Institute of Health Research Inflammation Biomedical Research Centre Birmingham University of Birmingham Birmingham United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep4.1163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880196PMC
April 2018

Clinical outcomes of donation after circulatory death liver transplantation in primary sclerosing cholangitis.

J Hepatol 2017 11 8;67(5):957-965. Epub 2017 Jul 8.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Centre (BRC), Institute of Immunology and Immunotherapy, University of Birmingham, UK; Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, UK; Department of Liver Surgery, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2017.06.027DOI Listing
November 2017

Insights into the management of Wilson's disease.

Therap Adv Gastroenterol 2017 Nov 3;10(11):889-905. Epub 2017 Oct 3.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756283X17731520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673017PMC
November 2017

Primary sclerosing cholangitis and the management of uncertainty and complexity.

Frontline Gastroenterol 2017 Oct 25;8(4):260-266. Epub 2017 Jul 25.

Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/flgastro-2017-100815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641853PMC
October 2017

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.

Sci Rep 2017 08 9;7(1):7652. Epub 2017 Aug 9.

Centre for Liver Research and NIHR Birmingham Liver Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-07967-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550460PMC
August 2017

Should we screen for cirrhosis?

BMJ 2017 07 12;358:j3233. Epub 2017 Jul 12.

Centre for Liver Research, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.j3233DOI Listing
July 2017

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

Apical Sodium-Dependent Transporter Inhibitors in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Dig Dis 2017 1;35(3):267-274. Epub 2017 Mar 1.

Institute of Cellular Medicine, NIHR Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000450988DOI Listing
May 2017

Immunogenetics in primary sclerosing cholangitis.

Curr Opin Gastroenterol 2017 03;33(2):93-98

aCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKbNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital RikshospitaletcInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwaydBirmingham Health Partners, Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOG.0000000000000336DOI Listing
March 2017

The gut-adherent microbiota of PSC-IBD is distinct to that of IBD.

Gut 2017 02 19;66(2):386-388. Epub 2016 Apr 19.

National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2016-311915DOI Listing
February 2017

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis.

J Autoimmun 2017 02 24;77:45-54. Epub 2016 Oct 24.

Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Birmingham Health Partners, Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2016.10.003DOI Listing
February 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Primary biliary cholangitis in 2016: High-definition PBC: biology, models and therapeutic advances.

Nat Rev Gastroenterol Hepatol 2017 02 11;14(2):76-78. Epub 2017 Jan 11.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham B15 2TT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2016.201DOI Listing
February 2017

The Pathogenesis of Autoimmune Liver Disease.

Dig Dis 2016;34(4):327-33. Epub 2016 May 11.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000444471DOI Listing
January 2017

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.

J Hepatol 2017 01 17;66(1):116-122. Epub 2016 Sep 17.

Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.09.002DOI Listing
January 2017

New Approaches to Investigate Drug-Induced Hypersensitivity.

Chem Res Toxicol 2017 01 15;30(1):239-259. Epub 2016 Nov 15.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrestox.6b00333DOI Listing
January 2017

Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes.

World J Gastroenterol 2016 Dec;22(45):9966-9973

Neil Rajoriya, Dhiraj Tripathi, Joanna A Leithead, Bridget K Gunson, Sophie Lord, James W Ferguson, Gideon M Hirschfield, Liver Unit, Queen Elizabeth Hospital, Birmingham B152WB, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v22.i45.9966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143763PMC
December 2016

Autoimmune liver disease: evaluating overlapping and cross-over presentations-a case-based discussion.

Frontline Gastroenterol 2016 Oct 8;7(4):240-245. Epub 2016 Jun 8.

NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/flgastro-2016-100698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369510PMC
October 2016

An overview of the diagnosis and management of immunoglobulin G4-related disease.

CMAJ 2016 Sep 20;188(13):953-961. Epub 2016 Jun 20.

Centre for Liver Research (Haldar, Hirschfield), National Institute for Health Research Liver Biomedical Research Unit, University of Birmingham; Department of Renal Medicine (Cockwell), Institute of Translational Medicine, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Edgbaston; Institute of Immunology and Immunotherapy (Haldar, Richter, Hirschfield), College of Medical and Dental Sciences, University of Birmingham; Department of Hepatobiliary Surgery (Roberts), Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Edgbaston, Birmingham, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1503/cmaj.151402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026513PMC
September 2016

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

N Engl J Med 2016 Aug;375(7):631-43

From University Hospitals KU Leuven, Leuven, Belgium (F.N.); University of Bologna, Bologna (P.A., G.M.), Program for Autoimmune Liver Disease, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan (P.I.), Humanitas Clinical and Research Center, Rozzano (P.I.), and University of Padua, Padua (A.F.) - all in Italy; Royal Prince Alfred Hospital, Camperdown, NSW, Australia (S.I.S.); University of California Davis Medical Center, Sacramento (C.B.), Scripps Clinic, La Jolla (P.J.P.), and Intercept Pharmaceuticals, San Diego (R.H.-R., T.M., S.S., R.P., L.M., M.P., D.S.) - all in California; Radboud University Nijmegen Medical Center, Nijmegen (J.P.H.D.), University of Amsterdam, Amsterdam (U.B.), University Medical Center Utrecht, Utrecht (K.J.E.), and University Medical Center Rotterdam, Rotterdam (B.H.) - all in the Netherlands; Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland (J.R.); Medical University of Vienna, Vienna (M.T.); Newcastle University Medical School, Newcastle upon Tyne (D.E.J.), and the Centre for Liver Research, NIHR Biomedical Research Unit, University of Birmingham, Birmingham (G.M.H.) - both in the United Kingdom; Liver Center Munich, Department of Medicine II, University of Munich, Munich, Germany (S.H.); Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond (V.L.), and the Liver Institute of Virginia, Newport News (M.S.) - all in Virginia; the Liver Unit, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas del Instituto de Salud Carlos III, Barcelona (V.V.); Centre Hospitalier de l'Université de Montréal-St. Luc, Montreal (C.V.); University Health Network Toronto Western Hospital, Toronto (H.S.); Arizona State University, Tempe (K.D.L.); Sahlgrenska Academy, University of Gothenburg,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1509840DOI Listing
August 2016

Aspects of the Pathophysiology of Primary Biliary Cirrhosis.

Dig Dis 2015 7;33 Suppl 2:102-8. Epub 2015 Dec 7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000440755DOI Listing
July 2016

OX40, OX40L and Autoimmunity: a Comprehensive Review.

Clin Rev Allergy Immunol 2016 Jun;50(3):312-32

MRC Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-015-8498-3DOI Listing
June 2016

Obeticholic acid for the treatment of primary biliary cirrhosis.

Expert Rev Clin Pharmacol 2016 7;9(1):13-26. Epub 2015 Nov 7.

b Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis , California , Birmingham , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17512433.2015.1092381DOI Listing
June 2016

Factors that Influence Health-Related Quality of Life in Patients with Primary Sclerosing Cholangitis.

Dig Dis Sci 2016 06 7;61(6):1692-9. Epub 2016 Jan 7.

Centre for Liver Research, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-015-4013-1DOI Listing
June 2016

Reply.

Gastroenterology 2016 06 6;150(7):1689-1690. Epub 2016 May 6.

Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.05.001DOI Listing
June 2016

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires.

Hepatology 2016 May 30;63(5):1608-19. Epub 2015 Sep 30.

Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.28116DOI Listing
May 2016

Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease.

J Hepatol 2016 May 23;64(5):1190-1193. Epub 2016 Jan 23.

Centre for Liver Research, University of Birmingham and NIHR Birmingham Liver Biomedical Research Unit, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824751PMC
May 2016

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity.

J Autoimmun 2016 Apr 9;68:98-104. Epub 2016 Feb 9.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU), Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2016.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803021PMC
April 2016

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.

Gut 2016 Feb 7;65(2):321-9. Epub 2015 Jan 7.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) and Centre for Liver Research, University of Birmingham, Birmingham, UK Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2014-308351DOI Listing
February 2016

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists.

Hepatology 2016 Feb 26;63(2):644-59. Epub 2015 Nov 26.

National Institute for Health Research (NIHR), Birmingham Liver Biomedical Research Unit (BRU), and Center for Liver Research, University of Birmingham, Birmingham, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.28128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864755PMC
February 2016

The Immunogenetics of Autoimmune Cholestasis.

Clin Liver Dis 2016 Feb;20(1):15-31

National Institute of Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Wolfson Drive, Birmingham B15 2TT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cld.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681448PMC
February 2016

Serum alkaline phosphatase in multidrug resistance 2 (Mdr2(-/-) ) knockout mice is strain specific.

Hepatology 2016 Jan 26;63(1):346. Epub 2015 Jun 26.

NIHR Biomedical Research Unit and Center for Liver Research, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.27874DOI Listing
January 2016

Primary biliary cirrhosis: Renaming primary biliary cirrhosis-clarity or confusion?

Nat Rev Gastroenterol Hepatol 2015 Dec 10;12(12):678-9. Epub 2015 Nov 10.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Wolfson Drive, Birmingham B15 2TT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2015.187DOI Listing
December 2015

Reply: To PMID 25500425.

Gastroenterology 2015 Aug 29;149(2):508-9. Epub 2015 Jun 29.

Centre for Liver Research, NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.06.039DOI Listing
August 2015

Autoimmune hepatitis: an approach to disease understanding and management.

Br Med Bull 2015 Jun 20;114(1):181-91. Epub 2015 May 20.

NIHR Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bmb/ldv021DOI Listing
June 2015

Genetic Distinctions in Patients With Primary Sclerosing Cholangitis: Immunoglobulin G4 Elevations and HLA Risk.

Gastroenterology 2015 May 21;148(5):886-9. Epub 2015 Mar 21.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.03.021DOI Listing
May 2015

Reply: To PMID 25160979.

Gastroenterology 2015 Apr 26;148(4):860-1. Epub 2015 Feb 26.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.02.047DOI Listing
April 2015

Genetics of autoimmune liver disease: a brief summary for clinicians.

Dig Dis 2014 22;32(5):e1-6. Epub 2014 Aug 22.

National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000366174DOI Listing
March 2015

Novel therapeutic targets in primary biliary cirrhosis.

Nat Rev Gastroenterol Hepatol 2015 Mar 3;12(3):147-58. Epub 2015 Feb 3.

Institute of Cellular Medicine, 3rd Floor William Leech Building, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2015.12DOI Listing
March 2015

Follicles, germinal centers, and immune mechanisms in primary biliary cirrhosis.

Hepatology 2015 Feb;61(2):424-7

Center for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.27552DOI Listing
February 2015

Liver disease in the UK.

Lancet 2015 Feb;385(9967):503

Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(15)60192-1DOI Listing
February 2015

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

Hum Mol Genet 2015 Jan 8;24(2):582-96. Epub 2014 Sep 8.

Division of Rheumatology, Center for Autoimmune Genomics and Etiology and US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275071PMC
January 2015

Unmet clinical need in autoimmune liver diseases.

J Hepatol 2015 Jan 16;62(1):208-18. Epub 2014 Sep 16.

Liver Unit, Freeman Hospital, Newcastle-upon-Tyne, UK; UK-PBC Research Consortium, UK; Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2014.09.010DOI Listing
January 2015

Reply to: "AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary biliary cirrhosis".

J Hepatol 2014 Dec 23;61(6):1445-6. Epub 2014 Aug 23.

NIHR Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2014.08.020DOI Listing
December 2014

Mechanisms of tissue injury in autoimmune liver diseases.

Semin Immunopathol 2014 Sep 1;36(5):553-68. Epub 2014 Aug 1.

NIHR Biomedical Research Unit in Liver Disease and Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK, B15 2TT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00281-014-0439-3DOI Listing
September 2014