Gideon Hirschfield

Gideon Hirschfield

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Gideon Hirschfield

Gideon Hirschfield

Publications by authors named "Gideon Hirschfield"

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Risk stratification in primary sclerosing cholangitis: comparison of biliary stricture severity on MRCP versus liver stiffness by MR elastography and vibration-controlled transient elastography.

Eur Radiol 2020 Mar 4. Epub 2020 Mar 4.

Joint Department of Medical Imaging, University Health Network, Mt. Sinai & WCH, University of Toronto, 610 University Ave., 3-957, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s00330-020-06728-6DOI Listing
March 2020

Primary Sclerosing Cholangitis With Features of Autoimmune Hepatitis: Exploring the Global Variation in Management.

Hepatol Commun 2020 Mar 16;4(3):399-408. Epub 2020 Jan 16.

Department of Cellular Pathology Queen Elizabeth Hospital Birmingham United Kingdom.

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http://dx.doi.org/10.1002/hep4.1467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049681PMC
March 2020

Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis.

Liver Int 2020 Mar 7. Epub 2020 Mar 7.

Toronto Centre for Liver Disease, Toronto General Hospital and Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1111/liv.14429DOI Listing
March 2020

The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review.

Semin Liver Dis 2020 Feb 19;40(1):34-48. Epub 2019 Sep 19.

Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1697617
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http://dx.doi.org/10.1055/s-0039-1697617DOI Listing
February 2020

Primary biliary cholangitis: pathogenesis and therapeutic opportunities.

Nat Rev Gastroenterol Hepatol 2020 Feb 9;17(2):93-110. Epub 2019 Dec 9.

Toronto Centre for Liver Disease, University Health Network and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41575-019-0226-7DOI Listing
February 2020

Reply.

Hepatology 2020 Jan 3;71(1):399-400. Epub 2020 Jan 3.

Norfolk and Norwich University Hospital, Norwich, United Kingdom.

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http://dx.doi.org/10.1002/hep.30963DOI Listing
January 2020

Letter: histology is relevant for risk stratification in primary biliary cholangitis.

Aliment Pharmacol Ther 2020 Jan;51(1):192-193

Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/apt.15583DOI Listing
January 2020

Cirrhosis-associated immune dysfunction: Novel insights in impaired adaptive immunity.

EBioMedicine 2019 Dec 11;50:3-4. Epub 2019 Nov 11.

Toronto Centre for Liver Disease, University Health Network, Canada; Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921234PMC
December 2019

The Complementary Value of Magnetic Resonance Imaging and Vibration-Controlled Transient Elastography for Risk Stratification in Primary Sclerosing Cholangitis.

Am J Gastroenterol 2019 12;114(12):1878-1885

Assistance Publique - Hôpitaux de Paris, Sorbonne University, INSERM, Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis & Saint-Antoine Research Center, Saint-Antoine Hospital, Paris, France.

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http://dx.doi.org/10.14309/ajg.0000000000000461DOI Listing
December 2019

Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.

Clin Gastroenterol Hepatol 2019 Sep 4;17(10):2076-2084.e2. Epub 2019 Jan 4.

Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193000
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http://dx.doi.org/10.1016/j.cgh.2018.12.028DOI Listing
September 2019

Guideline review: British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis treatment and management guidelines.

Frontline Gastroenterol 2019 Jul 9;10(3):316-319. Epub 2019 Jan 9.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/flgastro-2018-101109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583568PMC
July 2019

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom.

Clin Gastroenterol Hepatol 2019 06 14;17(7):1379-1387.e3. Epub 2018 Dec 14.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2018.12.007DOI Listing
June 2019

Barriers to implementation of stratified care in primary biliary cholangitis: a scoping exercise.

BMJ Open Gastroenterol 2019 17;6(1):e000226. Epub 2019 Jun 17.

University of Birmingham, Institute of Applied Health Research, Birmingham, UK.

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http://dx.doi.org/10.1136/bmjgast-2018-000226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596962PMC
June 2019

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus.

Liver Int 2019 May 25;39(5):967-975. Epub 2019 Feb 25.

Institute of Cellular Medicine and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/liv.14069DOI Listing
May 2019

Grand round: Autoimmune hepatitis.

J Hepatol 2019 Apr 20;70(4):773-784. Epub 2018 Nov 20.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Centre for Liver and Gastroenterology Research, University of Birmingham, UK; Liver Unit, University Hospitals Birmingham, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, UK; Toronto Centre for Liver Disease, University of Toronto and University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.006DOI Listing
April 2019

Response to "Is the hub-and-spoke model of care delivery a possible answer to geographical variation in liver transplant outcomes?"

Am J Transplant 2019 04 22;19(4):1248-1249. Epub 2019 Jan 22.

Liver Medicine, University Hospitals Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/ajt.15226DOI Listing
April 2019

Liver disease in the young adult: the challenges and rewards.

Lancet Gastroenterol Hepatol 2019 Mar;4(3):248-254

Centre for Rare Diseases, Institute for Translational Medicine, University Hospitals Birmingham, Birmingham, UK; National Institute for Health Research Birmingham Biomedical Research Centre, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S2468-1253(18)30244-9DOI Listing
March 2019

A Practical Review of Primary Biliary Cholangitis for the Gastroenterologist.

Gastroenterol Hepatol (N Y) 2019 Mar;15(3):145-154

Dr Onofrio is a hepatology fellow in the Division of Gastroenterology at the University of Toronto and the Toronto Centre for Liver Disease at Toronto General Hospital in the University Health Network in Toronto, Canada. Dr Hirschfield is the Lily and Terry Horner Chair in Autoimmune Liver Disease Research in the Toronto Centre for Liver Disease at Toronto General Hospital and a professor of medicine in the Division of Gastroenterology at the University of Toronto. Dr Gulamhusein is an assistant professor at the University of Toronto and a clinician investigator in the Division of Gastroenterology in the Toronto Centre for Liver Disease at Toronto General Hospital.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495411PMC
March 2019

Proximity to transplant center and outcome among liver transplant patients.

Am J Transplant 2019 01 3;19(1):208-220. Epub 2018 Aug 3.

Liver Medicine, University Hospitals Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/ajt.15004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491997PMC
January 2019

Autoimmune hepatitis and complexities in management.

Frontline Gastroenterol 2019 Jan 12;10(1):77-87. Epub 2018 Aug 12.

Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

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http://fg.bmj.com/lookup/doi/10.1136/flgastro-2018-101015
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http://dx.doi.org/10.1136/flgastro-2018-101015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319158PMC
January 2019

Pathophysiology of primary biliary cholangitis.

Best Pract Res Clin Gastroenterol 2018 Jun - Aug;34-35:17-25. Epub 2018 May 24.

Centre for Liver Research and NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2018.05.012DOI Listing
December 2018

Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells.

J Autoimmun 2018 11 14;94:143-155. Epub 2018 Aug 14.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK; Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183030
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http://dx.doi.org/10.1016/j.jaut.2018.07.020DOI Listing
November 2018

Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom.

Aliment Pharmacol Ther 2018 11 18;48(9):951-960. Epub 2018 Sep 18.

NIHR Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/apt.14968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667893PMC
November 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease.

Hepatol Commun 2018 Aug 6;2(8):956-967. Epub 2018 Aug 6.

Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom.

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http://dx.doi.org/10.1002/hep4.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078219PMC
August 2018

Work in Progress: Drugs in Development.

Clin Liver Dis 2018 08 17;22(3):501-515. Epub 2018 May 17.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10893261183002
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http://dx.doi.org/10.1016/j.cld.2018.03.004DOI Listing
August 2018

Quality of life and primary sclerosing cholangitis: The business of defining what counts.

Hepatology 2018 07 2;68(1):16-18. Epub 2018 May 2.

National Institute for Health Research Birmingham Biomedical Research Centre, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.29775DOI Listing
July 2018

Genetic association studies and the risk factors for developing the "Immuno-bile-logic" disease primary biliary cholangitis.

Hepatology 2018 04 19;67(4):1620-1622. Epub 2018 Feb 19.

Centre for Liver Research and NIHR Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.29603DOI Listing
April 2018

Deciphering the biology of IgG4-related disease: specific antigens and disease?

Gut 2018 04 3;67(4):602-605. Epub 2017 Nov 3.

Centre for Rare Diseases, Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2017-314861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058063PMC
April 2018

Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.

Hepatol Commun 2018 04 26;2(4):421-436. Epub 2018 Feb 26.

Centre for Liver Research, Institute of Immunology and Immunotherapy and National Institute of Health Research Inflammation Biomedical Research Centre Birmingham University of Birmingham Birmingham United Kingdom.

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http://dx.doi.org/10.1002/hep4.1163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880196PMC
April 2018

In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma.

Methods Mol Biol 2017 ;1591:195-214

Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1007/978-1-4939-6931-9_14DOI Listing
February 2018

Twenty-Year Comparative Analysis of Patients With Autoimmune Liver Diseases on Transplant Waitlists.

Clin Gastroenterol Hepatol 2018 02 6;16(2):278-287.e7. Epub 2017 Oct 6.

Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Unit, University of Birmingham, Birmingham, United Kingdom; Liver Medicine, University Hospitals Birmingham, Birmingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2017.09.062DOI Listing
February 2018

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Clin Immunol 2018 02 7;187:137-138. Epub 2017 Dec 7.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.11.012DOI Listing
February 2018

Clinical outcomes of donation after circulatory death liver transplantation in primary sclerosing cholangitis.

J Hepatol 2017 11 8;67(5):957-965. Epub 2017 Jul 8.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Centre (BRC), Institute of Immunology and Immunotherapy, University of Birmingham, UK; Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, UK; Department of Liver Surgery, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.06.027DOI Listing
November 2017

Insights into the management of Wilson's disease.

Therap Adv Gastroenterol 2017 Nov 3;10(11):889-905. Epub 2017 Oct 3.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1177/1756283X17731520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673017PMC
November 2017

Primary sclerosing cholangitis and the management of uncertainty and complexity.

Frontline Gastroenterol 2017 Oct 25;8(4):260-266. Epub 2017 Jul 25.

Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/flgastro-2017-100815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641853PMC
October 2017

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.

Sci Rep 2017 08 9;7(1):7652. Epub 2017 Aug 9.

Centre for Liver Research and NIHR Birmingham Liver Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/s41598-017-07967-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550460PMC
August 2017

Should we screen for cirrhosis?

BMJ 2017 07 12;358:j3233. Epub 2017 Jul 12.

Centre for Liver Research, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/bmj.j3233DOI Listing
July 2017

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

Apical Sodium-Dependent Transporter Inhibitors in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

Dig Dis 2017 1;35(3):267-274. Epub 2017 Mar 1.

Institute of Cellular Medicine, NIHR Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1159/000450988DOI Listing
May 2017

Preface.

Dig Dis 2017 3;35(4):303. Epub 2017 May 3.

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http://dx.doi.org/10.1159/000457326DOI Listing
May 2017

Immunogenetics in primary sclerosing cholangitis.

Curr Opin Gastroenterol 2017 03;33(2):93-98

aCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKbNorwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital RikshospitaletcInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwaydBirmingham Health Partners, Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1097/MOG.0000000000000336DOI Listing
March 2017

The gut-adherent microbiota of PSC-IBD is distinct to that of IBD.

Gut 2017 02 19;66(2):386-388. Epub 2016 Apr 19.

National Institute for Health Research (NIHR) Birmingham, Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2016-311915DOI Listing
February 2017

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis.

J Autoimmun 2017 02 24;77:45-54. Epub 2016 Oct 24.

Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Birmingham Health Partners, Institute of Translational Medicine, University Hospitals Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/j.jaut.2016.10.003DOI Listing
February 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Primary biliary cholangitis in 2016: High-definition PBC: biology, models and therapeutic advances.

Nat Rev Gastroenterol Hepatol 2017 02 11;14(2):76-78. Epub 2017 Jan 11.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/nrgastro.2016.201DOI Listing
February 2017

The Pathogenesis of Autoimmune Liver Disease.

Dig Dis 2016;34(4):327-33. Epub 2016 May 11.

Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1159/000444471DOI Listing
January 2017

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.

J Hepatol 2017 01 17;66(1):116-122. Epub 2016 Sep 17.

Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.09.002DOI Listing
January 2017

New Approaches to Investigate Drug-Induced Hypersensitivity.

Chem Res Toxicol 2017 01 15;30(1):239-259. Epub 2016 Nov 15.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00333DOI Listing
January 2017

Mesenchymal stromal cells and liver fibrosis: a complicated relationship.

FASEB J 2016 12 6;30(12):3905-3928. Epub 2016 Sep 6.

National Institute for Health Research, Birmingham Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom;

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http://dx.doi.org/10.1096/fj.201600433RDOI Listing
December 2016

Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes.

World J Gastroenterol 2016 Dec;22(45):9966-9973

Neil Rajoriya, Dhiraj Tripathi, Joanna A Leithead, Bridget K Gunson, Sophie Lord, James W Ferguson, Gideon M Hirschfield, Liver Unit, Queen Elizabeth Hospital, Birmingham B152WB, United Kingdom.

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http://dx.doi.org/10.3748/wjg.v22.i45.9966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143763PMC
December 2016

Autoimmune liver disease: evaluating overlapping and cross-over presentations-a case-based discussion.

Frontline Gastroenterol 2016 Oct 8;7(4):240-245. Epub 2016 Jun 8.

NIHR Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/flgastro-2016-100698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369510PMC
October 2016

An overview of the diagnosis and management of immunoglobulin G4-related disease.

CMAJ 2016 Sep 20;188(13):953-961. Epub 2016 Jun 20.

Centre for Liver Research (Haldar, Hirschfield), National Institute for Health Research Liver Biomedical Research Unit, University of Birmingham; Department of Renal Medicine (Cockwell), Institute of Translational Medicine, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Edgbaston; Institute of Immunology and Immunotherapy (Haldar, Richter, Hirschfield), College of Medical and Dental Sciences, University of Birmingham; Department of Hepatobiliary Surgery (Roberts), Queen Elizabeth Hospital Birmingham, University Hospital Birmingham, Edgbaston, Birmingham, UK

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http://dx.doi.org/10.1503/cmaj.151402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026513PMC
September 2016

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.

N Engl J Med 2016 Aug;375(7):631-43

From University Hospitals KU Leuven, Leuven, Belgium (F.N.); University of Bologna, Bologna (P.A., G.M.), Program for Autoimmune Liver Disease, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Milan (P.I.), Humanitas Clinical and Research Center, Rozzano (P.I.), and University of Padua, Padua (A.F.) - all in Italy; Royal Prince Alfred Hospital, Camperdown, NSW, Australia (S.I.S.); University of California Davis Medical Center, Sacramento (C.B.), Scripps Clinic, La Jolla (P.J.P.), and Intercept Pharmaceuticals, San Diego (R.H.-R., T.M., S.S., R.P., L.M., M.P., D.S.) - all in California; Radboud University Nijmegen Medical Center, Nijmegen (J.P.H.D.), University of Amsterdam, Amsterdam (U.B.), University Medical Center Utrecht, Utrecht (K.J.E.), and University Medical Center Rotterdam, Rotterdam (B.H.) - all in the Netherlands; Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland (J.R.); Medical University of Vienna, Vienna (M.T.); Newcastle University Medical School, Newcastle upon Tyne (D.E.J.), and the Centre for Liver Research, NIHR Biomedical Research Unit, University of Birmingham, Birmingham (G.M.H.) - both in the United Kingdom; Liver Center Munich, Department of Medicine II, University of Munich, Munich, Germany (S.H.); Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond (V.L.), and the Liver Institute of Virginia, Newport News (M.S.) - all in Virginia; the Liver Unit, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas del Instituto de Salud Carlos III, Barcelona (V.V.); Centre Hospitalier de l'Université de Montréal-St. Luc, Montreal (C.V.); University Health Network Toronto Western Hospital, Toronto (H.S.); Arizona State University, Tempe (K.D.L.); Sahlgrenska Academy, University of Gothenburg,

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http://dx.doi.org/10.1056/NEJMoa1509840DOI Listing
August 2016

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Clin Immunol 2016 07 22;168:25-29. Epub 2016 Apr 22.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221PMC
July 2016

Reply.

Gastroenterology 2016 06 6;150(7):1689-1690. Epub 2016 May 6.

Birmingham, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2016.05.001DOI Listing
June 2016

Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease.

J Hepatol 2016 May 23;64(5):1190-1193. Epub 2016 Jan 23.

Centre for Liver Research, University of Birmingham and NIHR Birmingham Liver Biomedical Research Unit, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824751PMC
May 2016

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity.

J Autoimmun 2016 Apr 9;68:98-104. Epub 2016 Feb 9.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU), Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803021PMC
April 2016