Publications by authors named "Gianpietro Dotti"

166Publications

Extending the Promise of Chimeric Antigen Receptor T-Cell Therapy Beyond Targeting CD19 Tumors.

Authors:
Natalie S Grover Nicholas Tschernia Gianpietro Dotti Barbara Savoldo

J Clin Oncol 2021 Jan 12:JCO2001738. Epub 2021 Jan 12.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

View Article and Find Full Text PDF
January 2021

STING agonist promotes CAR T cell trafficking and persistence in breast cancer.

Authors:
Nuo Xu Douglas C Palmer Alexander C Robeson Peishun Shou Hemamalini Bommiasamy Sonia J Laurie Caryn Willis Gianpietro Dotti Benjamin G Vincent Nicholas P Restifo Jonathan S Serody

J Exp Med 2021 Feb;218(2)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

View Article and Find Full Text PDF
February 2021

Combining Oncolytic Viruses with CAR T Cell Therapy.

Authors:
Kyle McGrath Gianpietro Dotti

Hum Gene Ther 2020 Dec 21. Epub 2020 Dec 21.

University of North Carolina at Chapel Hill School of Medicine, 6797, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States.

View Article and Find Full Text PDF
December 2020

Cryo-shocked cancer cells for targeted drug delivery and vaccination.

Authors:
Tianyuan Ci Hongjun Li Guojun Chen Zejun Wang Jinqiang Wang Peter Abdou Yiming Tu Gianpietro Dotti Zhen Gu

Sci Adv 2020 Dec 9;6(50). Epub 2020 Dec 9.

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

View Article and Find Full Text PDF
December 2020

Long-term remission in multiply relapsed enteropathy-associated T-cell lymphoma following CD30 CAR T-cell therapy.

Authors:
Timothy J Voorhees Nilanjan Ghosh Natalie Grover Jared Block Catherine Cheng Kaitlin Morrison Anastasia Ivanova Gianpietro Dotti Jonathan Serody Barbara Savoldo Anne W Beaven

Blood Adv 2020 Dec;4(23):5925-5928

University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC; and.

View Article and Find Full Text PDF
December 2020

Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.

Authors:
Andras Heczey Amy N Courtney Antonino Montalbano Simon Robinson Ka Liu Mingmei Li Nisha Ghatwai Olga Dakhova Bin Liu Tali Raveh-Sadka Cynthia N Chauvin-Fleurence Xin Xu Ho Ngai Erica J Di Pierro Barbara Savoldo Gianpietro Dotti Leonid S Metelitsa

Nat Med 2020 11 12;26(11):1686-1690. Epub 2020 Oct 12.

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.

View Article and Find Full Text PDF
November 2020

Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces.

Authors:
Qassim Dirar Teal Russell Lumei Liu Sarah Ahn Gianpietro Dotti Shyam Aravamudhan Laura Conforti Yeoheung Yun

PLoS One 2020 25;15(9):e0238819. Epub 2020 Sep 25.

FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America.

View Article and Find Full Text PDF
November 2020

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.

Authors:
Hsiang-Chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A Ramos Gianpietro Dotti Luke Fritzky Jie-Gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu

Nat Commun 2020 09 23;11(1):4810. Epub 2020 Sep 23.

Department of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA.

View Article and Find Full Text PDF
September 2020

CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes.

Authors:
Valeria Leuci Chiara Donini Giovanni Grignani Ramona Rotolo Giulia Mesiano Erika Fiorino Loretta Gammaitoni Lorenzo D'Ambrosio Alessandra Merlini Elisa Landoni Enzo Medico Sonia Capellero Lidia Giraudo Giulia Cattaneo Ilenia Iaia Ymera Pignochino Marco Basiricò Elisa Vigna Alberto Pisacane Franca Fagioli Soldano Ferrone Massimo Aglietta Gianpietro Dotti Dario Sangiolo

Clin Cancer Res 2020 Dec 8;26(23):6321-6334. Epub 2020 Sep 8.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy.

View Article and Find Full Text PDF
December 2020

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy.

Authors:
Dongfang Liu Saiaditya Badeti Gianpietro Dotti Jie-Gen Jiang He Wang James Dermody Patricia Soteropoulos Deanna Streck Raymond B Birge Chen Liu

Cell Commun Signal 2020 08 25;18(1):134. Epub 2020 Aug 25.

Department of Pathology, Immunology and Laboratory Medicine, Rutgers University- New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, USA.

View Article and Find Full Text PDF
August 2020

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma.

Authors:
Carlos A Ramos Natalie S Grover Anne W Beaven Premal D Lulla Meng-Fen Wu Anastasia Ivanova Tao Wang Thomas C Shea Cliona M Rooney Christopher Dittus Steven I Park Adrian P Gee Paul W Eldridge Kathryn L McKay Birju Mehta Catherine J Cheng Faith B Buchanan Bambi J Grilley Kaitlin Morrison Malcolm K Brenner Jonathan S Serody Gianpietro Dotti Helen E Heslop Barbara Savoldo

J Clin Oncol 2020 Nov 23;38(32):3794-3804. Epub 2020 Jul 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

View Article and Find Full Text PDF
November 2020

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma.

Authors:
Meenakshi Hegde Sujith K Joseph Farzana Pashankar Christopher DeRenzo Khaled Sanber Shoba Navai Tiara T Byrd John Hicks Mina L Xu Claudia Gerken Mamta Kalra Catherine Robertson Huimin Zhang Ankita Shree Birju Mehta Olga Dakhova Vita S Salsman Bambi Grilley Adrian Gee Gianpietro Dotti Helen E Heslop Malcolm K Brenner Winfried S Wels Stephen Gottschalk Nabil Ahmed

Nat Commun 2020 07 15;11(1):3549. Epub 2020 Jul 15.

Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

View Article and Find Full Text PDF
July 2020

Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy.

Authors:
Pritha Agarwalla Edikan A Ogunnaike Sarah Ahn Frances S Ligler Gianpietro Dotti Yevgeny Brudno

Adv Healthc Mater 2020 07 11;9(14):e2000275. Epub 2020 Jun 11.

Joint Department of Biomedical Engineering, University of North Carolina - Chapel Hill and North Carolina State University - Raleigh, 1840 Enterpreneur Way, Raleigh, NC, 27695, USA.

View Article and Find Full Text PDF
July 2020

Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy.

Authors:
Guojun Chen Zhitong Chen Di Wen Zejun Wang Hongjun Li Yi Zeng Gianpietro Dotti Richard E Wirz Zhen Gu

Proc Natl Acad Sci U S A 2020 02 6;117(7):3687-3692. Epub 2020 Feb 6.

Department of Bioengineering, University of California, Los Angeles, CA 90095;

View Article and Find Full Text PDF
February 2020

Interleukin-23 engineering improves CAR T cell function in solid tumors.

Authors:
Xingcong Ma Peishun Shou Christof Smith Yuhui Chen Hongwei Du Chuang Sun Nancy Porterfield Kren Daniel Michaud Sarah Ahn Benjamin Vincent Barbara Savoldo Yuliya Pylayeva-Gupta Shuqun Zhang Gianpietro Dotti Yang Xu

Nat Biotechnol 2020 04 3;38(4):448-459. Epub 2020 Feb 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article and Find Full Text PDF
April 2020

Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors.

Authors:
Giovanni Fucà Loic Reppel Elisa Landoni Barbara Savoldo Gianpietro Dotti

Clin Cancer Res 2020 06 3;26(11):2444-2451. Epub 2020 Feb 3.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.

View Article and Find Full Text PDF
June 2020

THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.

Authors:
Chuang Sun Peishun Shou Hongwei Du Koichi Hirabayashi Yuhui Chen Laura E Herring Sarah Ahn Yang Xu Kyogo Suzuki Guangming Li Ourania Tsahouridis Lishan Su Barbara Savoldo Gianpietro Dotti

Cancer Cell 2020 02 30;37(2):216-225.e6. Epub 2020 Jan 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article and Find Full Text PDF
February 2020

A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor.

Authors:
Elisa Landoni Christof C Smith Giovanni Fucá Yuhui Chen Chuang Sun Benjamin G Vincent Leonid S Metelitsa Gianpietro Dotti Barbara Savoldo

Cancer Immunol Res 2020 01 12;8(1):57-69. Epub 2019 Nov 12.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

View Article and Find Full Text PDF
January 2020

Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy.

Authors:
Xiao Han Shufang Shen Qin Fan Guojun Chen Edikan Archibong Gianpietro Dotti Zhuang Liu Zhen Gu Chao Wang

Sci Adv 2019 10 23;5(10):eaaw6870. Epub 2019 Oct 23.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

View Article and Find Full Text PDF
October 2019

Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors.

Authors:
Andrey Krokhotin Hongwei Du Koichi Hirabayashi Konstantin Popov Tomohiro Kurokawa Xinhui Wan Soldano Ferrone Gianpietro Dotti Nikolay V Dokholyan

Mol Ther Oncolytics 2019 Dec 31;15:30-37. Epub 2019 Aug 31.

Departments of Pharmacology and Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA.

View Article and Find Full Text PDF
December 2019