Giannino Del Sal

Giannino Del Sal

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Giannino Del Sal

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Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.

J Biol Chem 2019 03 17;294(13):5060-5073. Epub 2019 Jan 17.

From the Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario 2000, Argentina, the Instituto de Genética Experimental, Facultad de Ciencias Médicas,

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http://dx.doi.org/10.1074/jbc.RA118.006037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442035PMC
March 2019

Oncogenic Hijacking of the PIN1 Signaling Network.

Front Oncol 2019 25;9:94. Epub 2019 Feb 25.

National Laboratory CIB, Trieste, Italy.

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http://dx.doi.org/10.3389/fonc.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401644PMC
February 2019

Mutant p53 as a guardian of the cancer cell.

Cell Death Differ 2019 01 11;26(2):199-212. Epub 2018 Dec 11.

Laboratorio Nazionale CIB (LNCIB), AREA Science Park, Trieste, Italy.

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http://dx.doi.org/10.1038/s41418-018-0246-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329812PMC
January 2019

GDA, a web-based tool for Genomics and Drugs integrated analysis.

Nucleic Acids Res 2018 07;46(W1):W148-W156

Dept. of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi, 287, 41125 Modena, Italy.

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http://dx.doi.org/10.1093/nar/gky434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031047PMC
July 2018

Complexes formed by mutant p53 and their roles in breast cancer.

Breast Cancer (Dove Med Press) 2018 18;10:101-112. Epub 2018 Jun 18.

National Laboratory CIB (LNCIB), AREA Science park, Trieste, Italy.

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http://dx.doi.org/10.2147/BCTT.S145826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011883PMC
June 2018

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells.

Oncotarget 2018 Apr 17;9(29):20508-20523. Epub 2018 Apr 17.

National Laboratory CIB, Area Science Park Padriciano, Trieste 34149, Italy.

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http://dx.doi.org/10.18632/oncotarget.24974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945496PMC
April 2018

MiR-181 family-specific behavior in different cancers: a meta-analysis view.

Cancer Metastasis Rev 2018 03;37(1):17-32

Departments of Experimental Therapeutics and Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/s10555-017-9714-9DOI Listing
March 2018

The stiff RhoAd from mevalonate to mutant p53.

Cell Death Differ 2018 03 6;25(4):645-647. Epub 2018 Mar 6.

Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy.

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http://dx.doi.org/10.1038/s41418-018-0091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864227PMC
March 2018

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.

Mol Cell 2017 12 7;68(6):1134-1146.e6. Epub 2017 Dec 7.

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204219PMC
December 2017

Dynamic regulation of Pin1 expression and function during zebrafish development.

PLoS One 2017 20;12(4):e0175939. Epub 2017 Apr 20.

Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398671PMC
September 2017

Targeting mutant p53 in cancer: a long road to precision therapy.

FEBS J 2017 03 20;284(6):837-850. Epub 2016 Nov 20.

Laboratorio Nazionale CIB (LNCIB), Trieste, Italy.

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http://dx.doi.org/10.1111/febs.13948DOI Listing
March 2017

PIN1 in breast development and cancer: a clinical perspective.

Cell Death Differ 2017 02 11;24(2):200-211. Epub 2016 Nov 11.

National Laboratory CIB (LNCIB), Area Science Park, Padriciano 99, Trieste 34149, Italy.

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http://dx.doi.org/10.1038/cdd.2016.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299711PMC
February 2017

MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer.

Carcinogenesis 2017 01 17;38(1):64-75. Epub 2016 Oct 17.

Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia, via G. Campi 287, 41100 Modena, Italy.

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http://dx.doi.org/10.1093/carcin/bgw110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276925PMC
January 2017

Multi-omics reveals global effects of mutant p53 gain-of-function.

Cell Cycle 2016 11 26;15(22):3009-3010. Epub 2016 Jul 26.

a Laboratorio Nazionale CIB, Area Science Park Padriciano , Trieste , Italy.

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http://dx.doi.org/10.1080/15384101.2016.1215703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134709PMC
November 2016

Mutant p53-Nrf2 axis regulates the proteasome machinery in cancer.

Mol Cell Oncol 2017 2;4(1):e1217967. Epub 2016 Sep 2.

Laboratorio Nazionale CIB, Area Science Park Padriciano, Trieste, Italy; Dipartimento di Scienze della Vita-Università degli Studi di Trieste, Trieste, Italy.

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http://dx.doi.org/10.1080/23723556.2016.1217967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286961PMC
September 2016

p53 orchestrates calcium signaling in vivo.

Cell Cycle 2015 ;14(9):1343-4

a Laboratorio Nazionale CIB ; Trieste , Italy.

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http://dx.doi.org/10.1080/15384101.2015.1024583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614379PMC
February 2016

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.

EMBO Rep 2016 Feb 21;17(2):188-201. Epub 2015 Dec 21.

Translational Oncogenomic Unit, Molecular Medicine Area Regina Elena National Cancer Institute, Rome, Italy

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http://dx.doi.org/10.15252/embr.201540488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290815PMC
February 2016

Mutant p53: One, No One, and One Hundred Thousand.

Front Oncol 2015 21;5:289. Epub 2015 Dec 21.

Laboratorio Nazionale CIB, Area Science Park Padriciano, Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy.

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http://dx.doi.org/10.3389/fonc.2015.00289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685664PMC
January 2016

Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships.

Biochim Biophys Acta 2015 Oct 29;1850(10):2048-60. Epub 2015 Jan 29.

Laboratorio Nazionale CIB (LNCIB), Area Science Park, Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.01.013DOI Listing
October 2015

Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells.

Biochimie 2015 May 3;112:85-95. Epub 2015 Mar 3.

Department of Life Sciences, University of Trieste, Via Giorgieri, 10, 34127 Trieste, Italy; Department of Medical, Surgery and Health Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, 34134, Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2015.02.015DOI Listing
May 2015

Notch is a direct negative regulator of the DNA-damage response.

Nat Struct Mol Biol 2015 May 20;22(5):417-24. Epub 2015 Apr 20.

1] Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, Milan, Italy. [2] Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy.

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http://dx.doi.org/10.1038/nsmb.3013DOI Listing
May 2015

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes.

Eur Heart J 2015 Apr 5;36(13):817-28. Epub 2014 May 5.

Cardiology and Cardiovascular Research, Institute of Physiology and University Hospital, Zürich, Switzerland Cardiology Unit, Department of Medicine, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehu179DOI Listing
April 2015

HIV-1 integrase binding to its cellular partners: a perspective from computational biology.

Curr Pharm Des 2014 ;20(21):3412-21

Computational Biophysics, German Research School for Simulation Sciences, Computational Biomedicine, Institute for Advanced Simulation (IAS-5), Forschungszentrum Jülich, Jülich D-52425, Germany.

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http://dx.doi.org/10.2174/13816128113199990631DOI Listing
March 2015

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1779-84. Epub 2015 Jan 26.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara 44121, Italy;

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http://dx.doi.org/10.1073/pnas.1410723112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330769PMC
February 2015

Cooperation of p53 mutations with other oncogenic alterations in cancer.

Subcell Biochem 2014 ;85:41-70

Molecular Oncology Group, Institute of Molecular and Cell Biology of Rosario, IBR-CONICET, Rosario, Argentina.

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http://dx.doi.org/10.1007/978-94-017-9211-0_3DOI Listing
December 2014

Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP.

Mol Cell 2014 Dec 13;56(5):617-29. Epub 2014 Nov 13.

Laboratorio Nazionale CIB (LNCIB), AREA Science Park, 34149 Trieste, Italy; Dip. Scienze della Vita, Università degli Studi di Trieste, 34127 Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.013DOI Listing
December 2014

Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration.

Mitochondrion 2014 Nov 15;19 Pt A:88-96. Epub 2014 Aug 15.

Laboratorio Nazionale CIB Area Science Park, Trieste Italy; Dipartimento di Scienze della Vita Università degli Studi di Trieste- Trieste Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15677249140011
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http://dx.doi.org/10.1016/j.mito.2014.08.003DOI Listing
November 2014

Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction.

Nat Commun 2014 Oct 9;5:5066. Epub 2014 Oct 9.

Department of Neuroscience, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy.

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http://dx.doi.org/10.1038/ncomms6066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197815PMC
October 2014

The cytoplasmic side of p53's oncosuppressive activities.

FEBS Lett 2014 Aug 18;588(16):2600-9. Epub 2014 Apr 18.

Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.04.015DOI Listing
August 2014

Metabolic control of YAP and TAZ by the mevalonate pathway.

Nat Cell Biol 2014 Apr 23;16(4):357-66. Epub 2014 Mar 23.

1] Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy [2] Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127 Trieste, Italy.

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http://dx.doi.org/10.1038/ncb2936DOI Listing
April 2014

Disarming mutant p53 oncogenic function.

Pharmacol Res 2014 Jan 15;79:75-87. Epub 2013 Nov 15.

Laboratorio Nazionale CIB (LNCIB), Area Science Park, Trieste, Italy; Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127 Trieste, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2013.11.003DOI Listing
January 2014

Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse.

J Toxicol Pathol 2013 Dec 26;26(4):423-7. Epub 2013 Dec 26.

Dipartimento di Scienze Veterinarie e Sanità Pubblica Veterinaria (DIVET), Facolta di Medicina Veterinaria, Università degli Studi di Milano, Via Celoria, 10, 20133 Milano, Italy ; Mouse & Animal Pathology Lab, Fondazione Filarete, Viale Ortles, 22/4, 20139 Milano, Italy.

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http://jlc.jst.go.jp/DN/JST.JSTAGE/tox/2013-0021?lang=en&
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http://dx.doi.org/10.1293/tox.2013-0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921926PMC
December 2013

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):E4203-12. Epub 2013 Oct 21.

German Cancer Research Center, Cellular Senescence Group, Deutsches Krebsforschungszentrum-Zentrum für Molekulare Biologie der Universität Heidelberg Alliance (DKFZ-ZMBH), 69120 Heidelberg, Germany.

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http://www.pnas.org/content/110/45/E4203.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1310001110
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http://dx.doi.org/10.1073/pnas.1310001110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831444PMC
November 2013

Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.

Mol Cell 2013 May 25;50(3):333-43. Epub 2013 Apr 25.

Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.molcel.2013.03.023DOI Listing
May 2013

The rebel angel: mutant p53 as the driving oncogene in breast cancer.

Carcinogenesis 2012 Nov 20;33(11):2007-17. Epub 2012 Jul 20.

Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy.

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http://dx.doi.org/10.1093/carcin/bgs232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483014PMC
November 2012

p73 as a pharmaceutical target for cancer therapy.

Curr Pharm Des 2011 ;17(6):578-90

Laboratorio Nazionale CIB, AREA Science Park, Padriciano 99, Trieste, TS 34149, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267157PMC
http://dx.doi.org/10.2174/138161211795222667DOI Listing
November 2011

Wiring the oncogenic circuitry: Pin1 unleashes mutant p53.

Oncotarget 2011 Sep;2(9):654-6

Laboratorio Nazionale CIB (LNCIB), Area Science Park, Trieste, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248216PMC
http://dx.doi.org/10.18632/oncotarget.329DOI Listing
September 2011

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.

EMBO J 2011 Aug 16;30(20):4211-22. Epub 2011 Aug 16.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/emboj.2011.303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199391PMC
August 2011

Gene regulation and tumor suppression by the bromodomain-containing protein BRD7.

Cell Cycle 2010 Jul 7;9(14):2777-81. Epub 2010 Jul 7.

Laboratorio Nazionale CIB, Area Science Park, Trieste, Italy.

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July 2010

Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells.

J Biol Chem 2010 Jun 15;285(24):18565-74. Epub 2010 Apr 15.

Sector of Neurobiology, International School for Advanced Studies, Giovanni Armenise-Harvard Foundation Laboratory, AREA Science Park, SS 14, Km 163.5, Basovizza, Italy.

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http://dx.doi.org/10.1074/jbc.M109.088294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881782PMC
June 2010

Improving pharmacological rescue of p53 function: RITA targets mutant p53.

Cell Cycle 2010 Jun 1;9(11):2062. Epub 2010 Jun 1.

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June 2010

BRD7 is a candidate tumour suppressor gene required for p53 function.

Nat Cell Biol 2010 Apr 14;12(4):380-9. Epub 2010 Mar 14.

The Netherlands Cancer Institute, Division of Gene Regulation, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://www.nature.com/articles/ncb2038
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http://dx.doi.org/10.1038/ncb2038DOI Listing
April 2010

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6322-7. Epub 2010 Mar 22.

Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie, Area Science Park, 34012 Trieste, Italy.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1002447107
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http://dx.doi.org/10.1073/pnas.1002447107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851947PMC
April 2010

Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes.

Nat Med 2010 Mar 21;16(3):329-33. Epub 2010 Feb 21.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Trieste, Italy.

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http://virion.ucsd.edu/Jclub2010-04-02.pdf
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http://www.nature.com/doifinder/10.1038/nm.2102
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http://dx.doi.org/10.1038/nm.2102DOI Listing
March 2010

The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73.

Biochem Biophys Res Commun 2009 Oct 8;388(2):428-33. Epub 2009 Aug 8.

Laboratorio Nazionale CIB (LNCIB), AREA Science Park, Padriciano 99, 34149 Trieste, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0901587
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http://dx.doi.org/10.1016/j.bbrc.2009.08.027DOI Listing
October 2009

Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease.

J Biol Chem 2009 Jul 11;284(27):18167-73. Epub 2009 May 11.

Sector of Neurobiology, International School for Advanced Studies, Via Beirut 2-4, 34151 Trieste, Italy.

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http://dx.doi.org/10.1074/jbc.M109.018325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709382PMC
July 2009

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.

Nat Cell Biol 2009 Feb 18;11(2):133-42. Epub 2009 Jan 18.

Laboratorio Nazionale CIB (LNCIB), Area Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1038/ncb1822DOI Listing
February 2009

p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.

Int J Biochem Cell Biol 2008 17;40(10):2110-9. Epub 2008 Feb 17.

Dipartimento di Medicina Sperimentale e Clinica "G. Salvatore", Università di Catanzaro "Magna Graecia", Campus Universitario, Germaneto, 88100 Catanzaro, Italy.

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http://dx.doi.org/10.1016/j.biocel.2008.02.010DOI Listing
October 2008

Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells.

Cancer Res 2008 Aug;68(16):6550-8

The National Laboratory CIB, and Dipartimento di Biochimica, Biofisica, e Chimica delle Macromolecole (BBCM), University of Trieste, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0137DOI Listing
August 2008

Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.

J Biol Chem 2008 Jul 20;283(30):20848-56. Epub 2008 May 20.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, AREA Science Park, Padriciano 99, Trieste, Italy.

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http://dx.doi.org/10.1074/jbc.M710186200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258953PMC
July 2008

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.

Nat Struct Mol Biol 2007 Oct 30;14(10):912-20. Epub 2007 Sep 30.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), Area Science Park, Università di Trieste, Trieste, 34100, Italy.

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http://www.nature.com/articles/nsmb1306
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http://dx.doi.org/10.1038/nsmb1306DOI Listing
October 2007

The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.

J Biol Chem 2007 Jul 27;282(27):19685-91. Epub 2007 Apr 27.

Laboratory B, Experimental Research Center and Rome Oncogenomic Center, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy.

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http://dx.doi.org/10.1074/jbc.M610282200DOI Listing
July 2007

Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.

EMBO J 2007 Apr 8;26(7):1761-71. Epub 2007 Mar 8.

International School for Advanced Studies, Neuroscience Programme, Area Science Park, Basovissa SS14, 34012 Trieste, Italy.

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http://dx.doi.org/10.1038/sj.emboj.7601625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847658PMC
April 2007

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

Science 2007 Feb;315(5812):659-63

Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Ferrera, Italy.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1135380
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http://dx.doi.org/10.1126/science.1135380DOI Listing
February 2007

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

Nat Genet 2006 Oct 10;38(10):1133-41. Epub 2006 Sep 10.

Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1038/ng1879DOI Listing
October 2006

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

EMBO J 2006 May 6;25(9):1883-94. Epub 2006 Apr 6.

Department of Chemistry and Biochemistry, University of Bern, Switzerland.

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http://dx.doi.org/10.1038/sj.emboj.7601077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456935PMC
May 2006

HMGA1 inhibits the function of p53 family members in thyroid cancer cells.

Cancer Res 2006 Mar;66(6):2980-9

Endocrinologia, Dipartimento di Medicina Interna, e Medicina Specialistica, Ospedale Garibaldi, Catania, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2637DOI Listing
March 2006

Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage.

Mol Cell Biol 2005 Jul;25(13):5380-8

Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.13.5380-5388.2005
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http://dx.doi.org/10.1128/MCB.25.13.5380-5388.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156984PMC
July 2005

The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.

J Biol Chem 2004 Nov 31;279(46):48013-23. Epub 2004 Aug 31.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), Area Science Park, Padriciano 99, 34012, Trieste, Italy.

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http://dx.doi.org/10.1074/jbc.M310801200DOI Listing
November 2004

KeePin' the p53 family in good shape.

Cell Cycle 2004 Jul 2;3(7):905-11. Epub 2004 Jul 2.

Laboratorio Nazionale C.I.B., Area Science Park, Trieste, Italy.

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July 2004

Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis.

Mol Biol Cell 2004 Jun 9;15(6):2804-18. Epub 2004 Apr 9.

Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Biologia-Università di Udine, 33100 Udine, Italy.

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http://dx.doi.org/10.1091/mbc.e03-08-0624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420104PMC
June 2004

Modification of the erythroid transcription factor GATA-1 by SUMO-1.

Proc Natl Acad Sci U S A 2004 Jun 1;101(24):8870-5. Epub 2004 Jun 1.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, AREA Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1073/pnas.0308605101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC428439PMC
June 2004

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

Mol Cell 2004 Jun;14(5):625-36

Laboratorio Nazionale C.I.B., Area Science Park, Padriciano 99, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1016/j.molcel.2004.05.007DOI Listing
June 2004

hGTSE-1 expression stimulates cytoplasmic localization of p53.

J Biol Chem 2004 Mar 5;279(12):11744-52. Epub 2004 Jan 5.

Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie LNCIB, Area Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1074/jbc.M311123200DOI Listing
March 2004

Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

Mol Cell Biol 2003 Dec;23(24):9104-16

Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole. Centre of Excellence in Biocristallography, University of Trieste, via L. Giorgieri 1, 34127 Trieste, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309667PMC
http://dx.doi.org/10.1128/mcb.23.24.9104-9116.2003DOI Listing
December 2003

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

Oncogene 2003 Nov;22(54):8738-48

Istituto di Tecnologie Biomediche, Sezione di Bari di Bioinformatica e Genomica CNR, Via Amendola, 165/A Bari 70126, Italy.

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http://www.nature.com/articles/1206967
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http://dx.doi.org/10.1038/sj.onc.1206967DOI Listing
November 2003

The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.

J Biol Chem 2003 Aug 15;278(32):30356-64. Epub 2003 May 15.

Laboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie, Area Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302902200
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http://dx.doi.org/10.1074/jbc.M302902200DOI Listing
August 2003

Regulation of p53 functions: let's meet at the nuclear bodies.

Curr Opin Cell Biol 2003 Jun;15(3):351-7

Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie, Area Science Park, Padriciano 99, 34012, Trieste, Italy.

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http://dx.doi.org/10.1016/s0955-0674(03)00038-3DOI Listing
June 2003

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.

Nature 2002 Oct 2;419(6909):853-7. Epub 2002 Oct 2.

Laboratorio Nazionale CIB, AREA Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1038/nature01120DOI Listing
October 2002

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

J Biol Chem 2002 May 13;277(21):18817-26. Epub 2002 Mar 13.

Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome 00158, Italy.

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http://dx.doi.org/10.1074/jbc.M201405200DOI Listing
May 2002