Publications by authors named "Gianni Colotti"

66Publications

Structural basis of ubiquitination mediated by protein splicing in early Eukarya.

Biochim Biophys Acta Gen Subj 2021 Jan 11;1865(5):129844. Epub 2021 Jan 11.

Institute of Molecular Biology and Pathology of The National Research Council of Italy (CNR), P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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January 2021

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming.

Drug Resist Updat 2021 Jan 9;54:100742. Epub 2021 Jan 9.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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January 2021

The central role of gut microbiota in drug metabolism and personalized medicine.

Future Med Chem 2020 Jul 29;12(13):1197-1200. Epub 2020 May 29.

Department of Biology & Biotechnology, Sapienza University of Rome, 00185, Rome, Italy.

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July 2020

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Molecules 2020 Apr 21;25(8). Epub 2020 Apr 21.

Department of Biochemical Sciences, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy.

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April 2020

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Biochim Biophys Acta Gen Subj 2020 08 17;1864(8):129618. Epub 2020 Apr 17.

Department of Chemistry - BMC, Uppsala University, Husargatan 3, 751 23 Uppsala, Sweden.

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August 2020

Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.

FASEB J 2020 06 18;34(6):7675-7686. Epub 2020 Apr 18.

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

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June 2020

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Cancers (Basel) 2020 Apr 6;12(4). Epub 2020 Apr 6.

Institute of Molecular Biology and Pathology, Italian National Research Council, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche (IBPM-CNR), c/o Department of Biochemical Sciences, Sapienza University, P.le A.Moro 5, 00185 Rome, Italy.

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April 2020

Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization.

ACS Chem Biol 2020 06 14;15(6):1349-1357. Epub 2020 Apr 14.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

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June 2020

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.

Int J Mol Med 2019 Dec 15;44(6):2223-2233. Epub 2019 Oct 15.

Institute of Molecular Biology and Pathology of The National Research Council of Italy, I‑00185 Rome, Italy.

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December 2019

Use of organoids in medicinal chemistry: challenges on ethics and biosecurity.

Future Med Chem 2019 05;11(10):1087-1090

IBPM-CNR Institute of Molecular Biology & Pathology, Italian National Research Council, 00185, Rome, Italy.

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May 2019

NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.

Biochim Biophys Acta Gen Subj 2019 04 25;1863(4):749-759. Epub 2019 Jan 25.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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April 2019

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

PLoS Negl Trop Dis 2018 11 26;12(11):e0006969. Epub 2018 Nov 26.

Istituto di Biologia e Patologia Molecolari-CNR, and Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma P.le A. Moro, Roma, Italy.

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November 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.

Mol Pharm 2018 08 27;15(8):3069-3078. Epub 2018 Jun 27.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences , Sapienza University , P.le A. Moro 5 , 00185 Rome , Italy.

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August 2018

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

Eur J Med Chem 2018 May 2;152:527-541. Epub 2018 May 2.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address:

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May 2018

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

Drug Resist Updat 2017 05 16;32:23-46. Epub 2017 Oct 16.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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May 2017

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases.

Front Biosci (Landmark Ed) 2018 Jan 1;23:954-966. Epub 2018 Jan 1.

CNR-Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma, Italy,

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January 2018

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

Cell Death Dis 2017 07 20;8(7):e2950. Epub 2017 Jul 20.

IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy.

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July 2017

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

Amino Acids 2017 07 10;49(7):1147-1157. Epub 2017 Apr 10.

National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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July 2017

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.

Oncotarget 2017 May;8(19):32117-32133

Department of Biology and Biotechnology, Sapienza University of Rome, 00185, Rome, Italy.

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May 2017

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.

J Enzyme Inhib Med Chem 2017 Dec;32(1):304-310

b Istituto di Biologia e Patologia Molecolari - CNR , and Dipartimento di Scienze Biochimiche , " Sapienza" Università di Roma , Roma , Italia.

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December 2017

Polyamine-trypanothione pathway: an update.

Future Med Chem 2017 01 13;9(1):61-77. Epub 2016 Dec 13.

CNR - National Research Council of Italy, Institute of Molecular Biology & Pathology, c/o Department of Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le Aldo Moro 5, 00185 - Rome, Italy.

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January 2017

Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.

Methods Mol Biol 2017 ;1517:223-237

IBPM - CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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January 2018

Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.

Methods Mol Biol 2017 ;1517:211-221

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161, Rome, Italy.

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January 2018

Structural basis of Sorcin-mediated calcium-dependent signal transduction.

Sci Rep 2015 Nov 18;5:16828. Epub 2015 Nov 18.

Institute of Molecular Biology and Pathology CNR; Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185, Rome, Italy.

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November 2015

Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.

Biochim Biophys Acta 2015 Sep 29;1850(9):1891-7. Epub 2015 May 29.

Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, Rome Italy. Electronic address:

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September 2015

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Sci Rep 2015 May 7;5:9705. Epub 2015 May 7.

1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena [2] Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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May 2015

Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.

Mini Rev Med Chem 2015 ;15(3):243-52

CNR- Istituto di Biologia e Patologia Molecolari (IBPM), c/o Dipartimento di Scienze Biochimiche, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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December 2015

The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3.

Oncotarget 2015 Feb;6(6):3493-506

Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.

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February 2015

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

Molecules 2014 Sep 5;19(9):13976-89. Epub 2014 Sep 5.

Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy.

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September 2014

A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.

ACS Chem Biol 2014 Aug 11;9(8):1674-9. Epub 2014 Jun 11.

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology and ‡CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences ''A. Rossi Fanelli'', Sapienza University of Rome , 00161 Rome, Italy.

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August 2014

GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.

PLoS Genet 2014 May 1;10(5):e1004305. Epub 2014 May 1.

Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Roma, Italy.

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May 2014

Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.

PLoS One 2014 10;9(1):e85438. Epub 2014 Jan 10.

CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences "A. Rossi Fanelli", University "Sapienza" P.le A.Moro 5, Rome, Italy.

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October 2014

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

Future Med Chem 2013 Oct;5(15):1861-75

National Research Council of Italy, Institute of Molecular Biology & Pathology, Rome, Italy c/o Department of Biochemical Sciences 'A. Rossi Fanelli', University Sapienza, Rome, Italy.

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October 2013

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.

ChemMedChem 2013 Oct 23;8(10):1634-7. Epub 2013 Aug 23.

Institute of Molecular Biology & Pathology; National Research Council (CNR); Institute Pasteur Fondazione Cenci Bolognetti; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome (Italy).

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October 2013

Green tea catechins can bind and modify ERp57/PDIA3 activity.

Biochim Biophys Acta 2013 Mar;1830(3):2671-82

Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanského 62, 500 03 Hradec Králové, Czech Republic.

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March 2013

Metals and metal derivatives in medicine.

Mini Rev Med Chem 2013 Feb;13(2):211-21

CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology, 00185 Rome, Italy.

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February 2013

Metals and Metal derivatives in Medicine.

Mini Rev Med Chem 2012 Apr 17. Epub 2012 Apr 17.

Gianni Colotti. CNR - National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Dept. of Biochemical Sciences "A. Rossi Fanelli", University "Sapienza" P.le A.Moro 5, 00185, Rome, Italy.

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April 2012

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.

Amino Acids 2012 Feb 11;42(2-3):803-11. Epub 2011 Aug 11.

Department of Biochemical Sciences, Institute of Molecular Biology and Pathology CNR, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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February 2012

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation.

ACS Med Chem Lett 2011 Mar 29;2(3):230-3. Epub 2010 Dec 29.

Institute of Molecular Biology and Pathology CNR, and Department of Biochemical Sciences, Sapienza University of Roma , P.le A. Moro 5, 00185 Rome, Italy.

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March 2011

Polyamine metabolism in Leishmania: from arginine to trypanothione.

Amino Acids 2011 Feb 29;40(2):269-85. Epub 2010 May 29.

Institute of Biology and Molecular Pathology, CNR, c/o Department of Biochemical Sciences, University Sapienza, P.le A. Moro 5, 00185, Rome, Italy.

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February 2011

Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains.

J Mol Cell Cardiol 2010 Jul 15;49(1):132-41. Epub 2010 Mar 15.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy.

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July 2010

Molecular basis of antimony treatment in leishmaniasis.

J Med Chem 2009 Apr;52(8):2603-12

Istituto di Biologia e Patologia MolecolariCNR and Department of Biochemical Sciences, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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April 2009

Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis.

Protein Pept Lett 2009 ;16(2):196-200

Istituto di Biologia e Patologia Molecolari, CNR, and Dipartimento di Scienze Biochimiche, Università "Sapienza" di Roma, P.le A. Moro 5, I-00185 Rome, Italy.

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August 2009

Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits.

Exp Physiol 2008 Dec 4;93(12):1233-8. Epub 2008 Jul 4.

Faculty of Biomedical & Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK.

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December 2008

The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization.

Mol Microbiol 2007 Aug 19;65(4):1122-38. Epub 2007 Jul 19.

Istituto di Biologia e Patologia Molecolari, CNR, and Dipartemento di Genetica e Biologia Molecolare, Sapienza Università di Roma, P. le A. Moro 5, 00185 Rome, Italy.

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August 2007

The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor.

Biochemistry 2006 Oct;45(41):12519-29

Consiglio Nazionale delle Ricerche, Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, 00185 Rome, Italy.

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October 2006

The desaturase from Bacillus subtilis, a promising tool for the selective olefination of phospholipids.

J Biotechnol 2006 Jan 18;121(1):49-53. Epub 2005 Aug 18.

Department of Biochemical Sciences, University "La Sapienza", Piazza Aldo Moro 5, 00185 Rome, Italy.

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January 2006

Inventory of the proteins in Neisseria meningitidis serogroup B strain MC58.

J Proteome Res 2005 Jul-Aug;4(4):1361-70

Dipartimento di Scienze Biochimiche, Università La Sapienza, Piazzale A. Moro 5, I-00185 Rome, Italy.

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October 2005

Information transfer in the penta-EF-hand protein sorcin does not operate via the canonical structural/functional pairing. A study with site-specific mutants.

J Biol Chem 2003 Jul 23;278(27):24921-8. Epub 2003 Apr 23.

Consiglio Nazionale delle Ricerche Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, Italy.

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July 2003

The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein.

J Mol Biol 2002 Mar;317(3):447-58

CNR, Centro Studio sulla Biologia Molecolare and Dipartimento di Scienze Biochimiche, Università La Sapienza, P.le Aldo Moro 5, Roma, 00185, Italy.

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March 2002