Publications by authors named "Gianni Colotti"

66Publications

Structural basis of ubiquitination mediated by protein splicing in early Eukarya.

Authors:
Valerio Chiarini Annarita Fiorillo Serena Camerini Marco Crescenzi Shin Nakamura Theo Battista Leonardo Guidoni Gianni Colotti Andrea Ilari

Biochim Biophys Acta Gen Subj 2021 Jan 11;1865(5):129844. Epub 2021 Jan 11.

Institute of Molecular Biology and Pathology of The National Research Council of Italy (CNR), P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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January 2021

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming.

Authors:
Luciana Mosca Andrea Ilari Francesco Fazi Yehuda G Assaraf Gianni Colotti

Drug Resist Updat 2021 Jan 9;54:100742. Epub 2021 Jan 9.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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January 2021

Isolation and preliminary characterization of a human 'phage display'-derived antibody against neural adhesion molecule-1 antigen interfering with fibroblast growth factor receptor-1 binding.

Authors:
Michela Flego Gianni Colotti Alessandro Ascione Maria Luisa Dupuis Eleonora Petrucci Roberta Riccioni Mauro Andreotti Carla Raggi Alessandra Boe Stefano Barca Mara Gellini Stefano Vella Alessandra Mallano

Hum Antibodies 2020 Oct 23. Epub 2020 Oct 23.

National Center for Global Health, Istituto Superiore di Sanità, Rome, 00161, Italy.

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October 2020

Sorcin is an early marker of neurodegeneration, Ca dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.

Authors:
Ilaria Genovese Flavia Giamogante Lucia Barazzuol Theo Battista Annarita Fiorillo Mattia Vicario Giuseppina D'Alessandro Raffaela Cipriani Cristina Limatola Daniela Rossi Vincenzo Sorrentino Elena Poser Luciana Mosca Ferdinando Squitieri Marzia Perluigi Andrea Arena Filip van Petegem Claudia Tito Francesco Fazi Carlotta Giorgi Tito Calì Andrea Ilari Gianni Colotti

Cell Death Dis 2020 10 15;11(10):861. Epub 2020 Oct 15.

Institute of Molecular Biology and Pathology, Italian National Research Council, IBPM-CNR, Rome, Italy.

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October 2020

The central role of gut microbiota in drug metabolism and personalized medicine.

Authors:
Gianni Colotti Teresa Rinaldi

Future Med Chem 2020 Jul 29;12(13):1197-1200. Epub 2020 May 29.

Department of Biology & Biotechnology, Sapienza University of Rome, 00185, Rome, Italy.

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July 2020

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Authors:
Lorenzo Turcano Theo Battista Esther Torrente De Haro Antonino Missineo Cristina Alli Giacomo Paonessa Gianni Colotti Steven Harper Annarita Fiorillo Andrea Ilari Alberto Bresciani

PLoS Negl Trop Dis 2020 05 21;14(5):e0008339. Epub 2020 May 21.

Department of Translational and Discovery Research, Pomezia (Roma) Italy.

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May 2020

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Authors:
Theo Battista Gianni Colotti Andrea Ilari Annarita Fiorillo

Molecules 2020 Apr 21;25(8). Epub 2020 Apr 21.

Department of Biochemical Sciences, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy.

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April 2020

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Authors:
Ilaria Genovese Andrea Carotti Andrea Ilari Annarita Fiorillo Theo Battista Gianni Colotti Ylva Ivarsson

Biochim Biophys Acta Gen Subj 2020 08 17;1864(8):129618. Epub 2020 Apr 17.

Department of Chemistry - BMC, Uppsala University, Husargatan 3, 751 23 Uppsala, Sweden.

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August 2020

Exogenous peptides are able to penetrate human cell and mitochondrial membranes, stabilize mitochondrial tRNA structures, and rescue severe mitochondrial defects.

Authors:
Elena Perli Annalinda Pisano Maria Gemma Pignataro Antonio Francesco Campese Maria Pelullo Ilaria Genovese Valeria de Turris Anna Maria Ghelli Bruna Cerbelli Carla Giordano Gianni Colotti Veronica Morea Giulia d'Amati

FASEB J 2020 06 18;34(6):7675-7686. Epub 2020 Apr 18.

Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

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June 2020

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Authors:
Theo Battista Annarita Fiorillo Valerio Chiarini Ilaria Genovese Andrea Ilari Gianni Colotti

Cancers (Basel) 2020 Apr 6;12(4). Epub 2020 Apr 6.

Institute of Molecular Biology and Pathology, Italian National Research Council, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche (IBPM-CNR), c/o Department of Biochemical Sciences, Sapienza University, P.le A.Moro 5, 00185 Rome, Italy.

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April 2020

Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization.

Authors:
Silvia Caroselli Clemens Zwergel Adele Pirolli Manuela Sabatino Zhanjie Xu Gilbert Kirsch Antonello Mai Gianni Colotti Fabio Altieri Rita Canipari Sergio Valente Rino Ragno

ACS Chem Biol 2020 06 14;15(6):1349-1357. Epub 2020 Apr 14.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

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June 2020

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.

Authors:
Miriam Carbo Valentina Brandi Gianmarco Pascarella David Sasah Staid Gianni Colotti Fabio Polticelli Andrea Ilari Veronica Morea

Int J Mol Med 2019 Dec 15;44(6):2223-2233. Epub 2019 Oct 15.

Institute of Molecular Biology and Pathology of The National Research Council of Italy, I‑00185 Rome, Italy.

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December 2019

Use of organoids in medicinal chemistry: challenges on ethics and biosecurity.

Authors:
Teresa Rinaldi Gianni Colotti

Future Med Chem 2019 05;11(10):1087-1090

IBPM-CNR Institute of Molecular Biology & Pathology, Italian National Research Council, 00185, Rome, Italy.

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May 2019

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.

Authors:
Simone Pippa Cecilia Mannironi Valerio Licursi Luca Bombardi Gianni Colotti Enrico Cundari Adriano Mollica Antonio Coluccia Valentina Naccarato Giuseppe La Regina Romano Silvestri Rodolfo Negri

Molecules 2019 May 4;24(9). Epub 2019 May 4.

Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy.

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May 2019

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism.

Authors:
Gianni Colotti Francesco Saccoliti Marina Gramiccia Trentina Di Muccio Jay Prakash Sunita Yadav Vikash Kumar Dubey Giulio Vistoli Theo Battista Stefano Mocci Annarita Fiorillo Aasia Bibi Valentina Noemi Madia Antonella Messore Roberta Costi Roberto Di Santo Andrea Ilari

Amino Acids 2020 Feb 29;52(2):247-259. Epub 2019 Apr 29.

Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, IBPM-CNR, c/o Dip. Scienze Biochimiche Università Sapienza, P.le Aldo Moro 5, 00185, Rome, Italy.

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February 2020

NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus.

Authors:
Valerio Chiarini Helena Tossavainen Vivek Sharma Gianni Colotti

Biochim Biophys Acta Gen Subj 2019 04 25;1863(4):749-759. Epub 2019 Jan 25.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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April 2019

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

Authors:
Lorenzo Turcano Esther Torrente Antonino Missineo Matteo Andreini Marina Gramiccia Trentina Di Muccio Ilaria Genovese Annarita Fiorillo Steven Harper Alberto Bresciani Gianni Colotti Andrea Ilari

PLoS Negl Trop Dis 2018 11 26;12(11):e0006969. Epub 2018 Nov 26.

Istituto di Biologia e Patologia Molecolari-CNR, and Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma P.le A. Moro, Roma, Italy.

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November 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.

Authors:
Andrea Ilari Ilaria Genovese Fabiana Fiorillo Theo Battista Ilenia De Ionna Annarita Fiorillo Gianni Colotti

Mol Pharm 2018 08 27;15(8):3069-3078. Epub 2018 Jun 27.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences , Sapienza University , P.le A. Moro 5 , 00185 Rome , Italy.

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August 2018

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase.

Authors:
Margherita Ortalli Andrea Ilari Gianni Colotti Ilenia De Ionna Theo Battista Alessandra Bisi Silvia Gobbi Angela Rampa Rita M C Di Martino Giovanna A Gentilomi Stefania Varani Federica Belluti

Eur J Med Chem 2018 May 2;152:527-541. Epub 2018 May 2.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy. Electronic address:

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May 2018

The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity.

Authors:
Elisabetta Falvo Francesca Malagrinò Alessandro Arcovito Francesco Fazi Gianni Colotti Elisa Tremante Patrizio Di Micco Aldo Braca Roberta Opri Alessandro Giuffrè Giulio Fracasso Pierpaolo Ceci

J Control Release 2018 04 20;275:177-185. Epub 2018 Feb 20.

Institute of Molecular Biology and Pathology, CNR - National Research Council of Italy, 00185 Rome, Italy. Electronic address:

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April 2018

Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

Authors:
Ilaria Genovese Andrea Ilari Yehuda G Assaraf Francesco Fazi Gianni Colotti

Drug Resist Updat 2017 05 16;32:23-46. Epub 2017 Oct 16.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM-CNR), c/o Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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May 2017

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases.

Authors:
Gianni Colotti Annarita Fiorillo Andrea Ilari

Front Biosci (Landmark Ed) 2018 Jan 1;23:954-966. Epub 2018 Jan 1.

CNR-Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma, Italy,

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January 2018

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

Authors:
Ilaria Genovese Annarita Fiorillo Andrea Ilari Silvia Masciarelli Francesco Fazi Gianni Colotti

Cell Death Dis 2017 07 20;8(7):e2950. Epub 2017 Jul 20.

IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy.

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July 2017

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

Authors:
Veronica Morea Eris Bidollari Gianni Colotti Annarita Fiorillo Jessica Rosati Lidia De Filippis Ferdinando Squitieri Andrea Ilari

Amino Acids 2017 07 10;49(7):1147-1157. Epub 2017 Apr 10.

National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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July 2017

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.

Authors:
Italia Anna Asteriti Frederick Daidone Gianni Colotti Serena Rinaldo Patrizia Lavia Giulia Guarguaglini Alessandro Paiardini

Oncotarget 2017 May;8(19):32117-32133

Department of Biology and Biotechnology, Sapienza University of Rome, 00185, Rome, Italy.

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May 2017

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.

Authors:
Francesco Saccoliti Gabriella Angiulli Giovanni Pupo Luca Pescatori Valentina Noemi Madia Antonella Messore Gianni Colotti Annarita Fiorillo Luigi Scipione Marina Gramiccia Trentina Di Muccio Roberto Di Santo Roberta Costi Andrea Ilari

J Enzyme Inhib Med Chem 2017 Dec;32(1):304-310

b Istituto di Biologia e Patologia Molecolari - CNR , and Dipartimento di Scienze Biochimiche , " Sapienza" Università di Roma , Roma , Italia.

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December 2017

Polyamine-trypanothione pathway: an update.

Authors:
Andrea Ilari Annarita Fiorillo Ilaria Genovese Gianni Colotti

Future Med Chem 2017 01 13;9(1):61-77. Epub 2016 Dec 13.

CNR - National Research Council of Italy, Institute of Molecular Biology & Pathology, c/o Department of Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le Aldo Moro 5, 00185 - Rome, Italy.

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January 2017

Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.

Authors:
Elena Poser Ilaria Genovese Silvia Masciarelli Teresa Bellissimo Francesco Fazi Gianni Colotti

Methods Mol Biol 2017 ;1517:223-237

IBPM - CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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January 2018

Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.

Authors:
Teresa Bellissimo Silvia Masciarelli Elena Poser Ilaria Genovese Alberto Del Rio Gianni Colotti Francesco Fazi

Methods Mol Biol 2017 ;1517:211-221

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14-16, 00161, Rome, Italy.

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January 2018

Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.

Authors:
Giulio Fracasso Elisabetta Falvo Gianni Colotti Francesco Fazi Tiziano Ingegnere Adriana Amalfitano Giovanni Battista Doglietto Sergio Alfieri Alberto Boffi Veronica Morea Giamaica Conti Elisa Tremante Patrizio Giacomini Alessandro Arcovito Pierpaolo Ceci

J Control Release 2016 10 12;239:10-8. Epub 2016 Aug 12.

Institute of Molecular Biology and Pathology, CNR - National Research Council of Italy, 00185 Rome, Italy. Electronic address:

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October 2016

Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.

Authors:
Elena Perli Annarita Fiorillo Carla Giordano Annalinda Pisano Arianna Montanari Paola Grazioli Antonio F Campese Patrizio Di Micco Helen A Tuppen Ilaria Genovese Elena Poser Carmela Preziuso Robert W Taylor Veronica Morea Gianni Colotti Giulia d'Amati

Hum Mol Genet 2016 Mar 31;25(5):903-15. Epub 2015 Dec 31.

Department of Radiology, Oncology and Pathology, Pasteur Institute-Cenci Bolognetti Foundation, Rome 00161, Italy,

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March 2016

Structural basis of Sorcin-mediated calcium-dependent signal transduction.

Authors:
Andrea Ilari Annarita Fiorillo Elena Poser Vasiliki S Lalioti Gustav N Sundell Ylva Ivarsson Ilaria Genovese Gianni Colotti

Sci Rep 2015 Nov 18;5:16828. Epub 2015 Nov 18.

Institute of Molecular Biology and Pathology CNR; Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185, Rome, Italy.

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November 2015

Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase.

Authors:
Gabriella Angiulli Antonella Lantella Elena Forte Francesco Angelucci Gianni Colotti Andrea Ilari Francesco Malatesta

Biochim Biophys Acta 2015 Sep 29;1850(9):1891-7. Epub 2015 May 29.

Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, Rome Italy. Electronic address:

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September 2015

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Authors:
Margherita Brindisi Simone Brogi Nicola Relitti Alessandra Vallone Stefania Butini Sandra Gemma Ettore Novellino Gianni Colotti Gabriella Angiulli Francesco Di Chiaro Annarita Fiorillo Andrea Ilari Giuseppe Campiani

Sci Rep 2015 May 7;5:9705. Epub 2015 May 7.

1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena [2] Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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May 2015

Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.

Authors:
Andrea Ilari Annarita Fiorillo Paola Baiocco Elena Poser Gabriella Angiulli Gianni Colotti

Mini Rev Med Chem 2015 ;15(3):243-52

CNR- Istituto di Biologia e Patologia Molecolari (IBPM), c/o Dipartimento di Scienze Biochimiche, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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December 2015

The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3.

Authors:
Stefano Sechi Anna Frappaolo Giorgio Belloni Gianni Colotti Maria Grazia Giansanti

Oncotarget 2015 Feb;6(6):3493-506

Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.

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February 2015

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

Authors:
Gianni Colotti Elena Poser Annarita Fiorillo Ilaria Genovese Valerio Chiarini Andrea Ilari

Molecules 2014 Sep 5;19(9):13976-89. Epub 2014 Sep 5.

Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy.

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September 2014

A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.

Authors:
Silvia Masciarelli Roberto Quaranta Ilaria Iosue Gianni Colotti Fabrizio Padula Greta Varchi Francesco Fazi Alberto Del Rio

ACS Chem Biol 2014 Aug 11;9(8):1674-9. Epub 2014 Jun 11.

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology and ‡CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences ''A. Rossi Fanelli'', Sapienza University of Rome , 00161 Rome, Italy.

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August 2014

GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.

Authors:
Stefano Sechi Gianni Colotti Giorgio Belloni Vincenzo Mattei Anna Frappaolo Grazia D Raffa Margaret T Fuller Maria Grazia Giansanti

PLoS Genet 2014 May 1;10(5):e1004305. Epub 2014 May 1.

Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Roma, Italy.

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May 2014

Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.

Authors:
Vasiliki S Lalioti Andrea Ilari David J O'Connell Elena Poser Ignacio V Sandoval Gianni Colotti

PLoS One 2014 10;9(1):e85438. Epub 2014 Jan 10.

CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences "A. Rossi Fanelli", University "Sapienza" P.le A.Moro 5, Rome, Italy.

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October 2014

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.

Authors:
Elena Perli Carla Giordano Annalinda Pisano Arianna Montanari Antonio F Campese Aurelio Reyes Daniele Ghezzi Alessia Nasca Helen A Tuppen Maurizia Orlandi Patrizio Di Micco Elena Poser Robert W Taylor Gianni Colotti Silvia Francisci Veronica Morea Laura Frontali Massimo Zeviani Giulia d'Amati

EMBO Mol Med 2014 02 10;6(2):169-82. Epub 2014 Jan 10.

Department of Radiology, Oncology and Pathology, Sapienza University of Rome, Rome, Italy.

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February 2014

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

Authors:
Gianni Colotti Paola Baiocco Annarita Fiorillo Alberto Boffi Elena Poser Francesco Di Chiaro Andrea Ilari

Future Med Chem 2013 Oct;5(15):1861-75

National Research Council of Italy, Institute of Molecular Biology & Pathology, Rome, Italy c/o Department of Biochemical Sciences 'A. Rossi Fanelli', University Sapienza, Rome, Italy.

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October 2013

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.

Authors:
Gianni Colotti Andrea Ilari Annarita Fiorillo Paola Baiocco Maria Agostina Cinellu Laura Maiore Federica Scaletti Chiara Gabbiani Luigi Messori

ChemMedChem 2013 Oct 23;8(10):1634-7. Epub 2013 Aug 23.

Institute of Molecular Biology & Pathology; National Research Council (CNR); Institute Pasteur Fondazione Cenci Bolognetti; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome (Italy).

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October 2013

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.

Authors:
Paola Baiocco Giovanna Poce Salvatore Alfonso Martina Cocozza Giulio Cesare Porretta Gianni Colotti Mariangela Biava Francesca Moraca Maurizio Botta Vanessa Yardley Annarita Fiorillo Antonella Lantella Francesco Malatesta Andrea Ilari

ChemMedChem 2013 Jul 3;8(7):1175-83. Epub 2013 Jun 3.

Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Piazzale A. Moro 5, 00185 Roma, Italy.

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July 2013

Green tea catechins can bind and modify ERp57/PDIA3 activity.

Authors:
Lucie Trnková Daniela Ricci Caterina Grillo Gianni Colotti Fabio Altieri

Biochim Biophys Acta 2013 Mar;1830(3):2671-82

Department of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanského 62, 500 03 Hradec Králové, Czech Republic.

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March 2013

Metals and metal derivatives in medicine.

Authors:
Gianni Colotti Andrea Ilari Alberto Boffi Veronica Morea

Mini Rev Med Chem 2013 Feb;13(2):211-21

CNR-National Research Council of Italy, Institute of Molecular Biology and Pathology, 00185 Rome, Italy.

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February 2013

The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

Authors:
Annarita Fiorillo Gianni Colotti Alberto Boffi Paola Baiocco Andrea Ilari

PLoS Negl Trop Dis 2012 21;6(8):e1781. Epub 2012 Aug 21.

Dipartimento di Scienze Biochimiche, University Sapienza, Rome, Italy.

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January 2013

Metals and Metal derivatives in Medicine.

Authors:
Gianni Colotti Andrea Ilari Alberto Boffi Veronica Morea

Mini Rev Med Chem 2012 Apr 17. Epub 2012 Apr 17.

Gianni Colotti. CNR - National Research Council of Italy, Institute of Molecular Biology and Pathology c/o Dept. of Biochemical Sciences "A. Rossi Fanelli", University "Sapienza" P.le A.Moro 5, 00185, Rome, Italy.

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April 2012

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.

Authors:
Andrea Ilari Paola Baiocco Luigi Messori Annarita Fiorillo Alberto Boffi Marina Gramiccia Trentina Di Muccio Gianni Colotti

Amino Acids 2012 Feb 11;42(2-3):803-11. Epub 2011 Aug 11.

Department of Biochemical Sciences, Institute of Molecular Biology and Pathology CNR, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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February 2012

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation.

Authors:
Paola Baiocco Andrea Ilari Pierpaolo Ceci Stefania Orsini Marina Gramiccia Trentina Di Muccio Gianni Colotti

ACS Med Chem Lett 2011 Mar 29;2(3):230-3. Epub 2010 Dec 29.

Institute of Molecular Biology and Pathology CNR, and Department of Biochemical Sciences, Sapienza University of Roma , P.le A. Moro 5, 00185 Rome, Italy.

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March 2011

Polyamine metabolism in Leishmania: from arginine to trypanothione.

Authors:
Gianni Colotti Andrea Ilari

Amino Acids 2011 Feb 29;40(2):269-85. Epub 2010 May 29.

Institute of Biology and Molecular Pathology, CNR, c/o Department of Biochemical Sciences, University Sapienza, P.le A. Moro 5, 00185, Rome, Italy.

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February 2011

Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains.

Authors:
Carlotta Zamparelli Niall Macquaide Gianni Colotti Daniela Verzili Tim Seidler Godfrey L Smith Emilia Chiancone

J Mol Cell Cardiol 2010 Jul 15;49(1):132-41. Epub 2010 Mar 15.

C.N.R. Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, 00185 Rome, Italy.

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July 2010

Molecular basis of antimony treatment in leishmaniasis.

Authors:
Paola Baiocco Gianni Colotti Stefano Franceschini Andrea Ilari

J Med Chem 2009 Apr;52(8):2603-12

Istituto di Biologia e Patologia MolecolariCNR and Department of Biochemical Sciences, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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April 2009

Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis.

Authors:
Paola Baiocco Stefano Franceschini Andrea Ilari Gianni Colotti

Protein Pept Lett 2009 ;16(2):196-200

Istituto di Biologia e Patologia Molecolari, CNR, and Dipartimento di Scienze Biochimiche, Università "Sapienza" di Roma, P.le A. Moro 5, I-00185 Rome, Italy.

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August 2009

Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes.

Authors:
Mark R Fowler Gianni Colotti Emilia Chiancone Yoshiharu Higuchi Tim Seidler Godfrey L Smith

Pflugers Arch 2009 Mar 2;457(5):1049-60. Epub 2008 Sep 2.

University of Glasgow, UK.

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March 2009

Molecular characterization of nitrite reductase gene (aniA) and gene product in Neisseria meningitidis isolates: is aniA essential for meningococcal survival?

Authors:
Paola Stefanelli Gianni Colotti Arianna Neri Maria Luisa Salucci Roberto Miccoli Luana Di Leandro Rodolfo Ippoliti

IUBMB Life 2008 Sep;60(9):629-36

Deptartment of Infectious, Parasitic and Immune-mediated diseases, Istituto Superiore di Sanità, Rome, Italy.

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September 2008

Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits.

Authors:
Mark R Fowler Gianni Colotti Emilia Chiancone Godfrey L Smith Ian M Fearon

Exp Physiol 2008 Dec 4;93(12):1233-8. Epub 2008 Jul 4.

Faculty of Biomedical & Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK.

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December 2008

The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.

Authors:
Andrea Ilari Alessandra Bonamore Stefano Franceschini Annarita Fiorillo Alberto Boffi Gianni Colotti

Proteins 2008 Jun;71(4):2065-75

Institute of Molecular Biology and Pathology, C.N.R., Rome, Italy.

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June 2008

Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.

Authors:
Stefano Franceschini Andrea Ilari Daniela Verzili Carlotta Zamparelli Anaid Antaramian Angélica Rueda Hector H Valdivia Emilia Chiancone Gianni Colotti

FASEB J 2008 Jan 15;22(1):295-306. Epub 2007 Aug 15.

CNR Institute of Molecular Biology and Pathology, University Sapienza, P.le A.Moro 5, 00185 Rome, Italy.

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January 2008

The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization.

Authors:
Stefano Vernarecci Gianni Colotti Prisca Ornaghi Elmar Schiebel Emilia Chiancone Patrizia Filetici

Mol Microbiol 2007 Aug 19;65(4):1122-38. Epub 2007 Jul 19.

Istituto di Biologia e Patologia Molecolari, CNR, and Dipartemento di Genetica e Biologia Molecolare, Sapienza Università di Roma, P. le A. Moro 5, 00185 Rome, Italy.

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August 2007

The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor.

Authors:
Gianni Colotti Carlotta Zamparelli Daniela Verzili Manuela Mella Christopher M Loughrey Godfrey L Smith Emilia Chiancone

Biochemistry 2006 Oct;45(41):12519-29

Consiglio Nazionale delle Ricerche, Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, 00185 Rome, Italy.

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October 2006

The desaturase from Bacillus subtilis, a promising tool for the selective olefination of phospholipids.

Authors:
Alessandra Bonamore Alberto Macone Gianni Colotti Rosa Marina Matarese Alberto Boffi

J Biotechnol 2006 Jan 18;121(1):49-53. Epub 2005 Aug 18.

Department of Biochemical Sciences, University "La Sapienza", Piazza Aldo Moro 5, 00185 Rome, Italy.

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January 2006

Inventory of the proteins in Neisseria meningitidis serogroup B strain MC58.

Authors:
Giuseppina Mignogna Alessandra Giorgi Paola Stefanelli Arianna Neri Gianni Colotti Bruno Maras M Eugenia Schininà

J Proteome Res 2005 Jul-Aug;4(4):1361-70

Dipartimento di Scienze Biochimiche, Università La Sapienza, Piazzale A. Moro 5, I-00185 Rome, Italy.

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October 2005

What is the future of the CNR?

Authors:
Gianni Colotti Andrea Ilari Veronica Morea

Ital J Biochem 2003 Mar;52(1):6-7

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March 2003

Information transfer in the penta-EF-hand protein sorcin does not operate via the canonical structural/functional pairing. A study with site-specific mutants.

Authors:
Manuela Mella Gianni Colotti Carlotta Zamparelli Daniela Verzili Andrea Ilari Emilia Chiancone

J Biol Chem 2003 Jul 23;278(27):24921-8. Epub 2003 Apr 23.

Consiglio Nazionale delle Ricerche Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza, Italy.

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July 2003

The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein.

Authors:
Andrea Ilari Kenneth A Johnson Vassilios Nastopoulos Daniela Verzili Carlotta Zamparelli Gianni Colotti Demetrius Tsernoglou Emilia Chiancone

J Mol Biol 2002 Mar;317(3):447-58

CNR, Centro Studio sulla Biologia Molecolare and Dipartimento di Scienze Biochimiche, Università La Sapienza, P.le Aldo Moro 5, Roma, 00185, Italy.

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March 2002