Gianluigi Forloni

Gianluigi Forloni

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Gianluigi Forloni

Publications by authors named "Gianluigi Forloni"

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Doxycycline for Alzheimer's Disease: Fighting β-Amyloid Oligomers and Neuroinflammation.

Front Pharmacol 2019 3;10:738. Epub 2019 Jul 3.

Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Milan, Italy.

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http://dx.doi.org/10.3389/fphar.2019.00738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616274PMC
July 2019

miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer's disease.

Neurobiol Aging 2019 Jun 21;82:102-109. Epub 2019 Jun 21.

Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Faculty of Psychology, eCampus University, Novedrate (Como), Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.06.005DOI Listing
June 2019

Alzheimer's Disease, Oligomers, and Inflammation.

J Alzheimers Dis 2018 ;62(3):1261-1276

Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy.

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http://dx.doi.org/10.3233/JAD-170819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869993PMC
May 2019

Corrected QT Interval Prolongation in Psychopharmacological Treatment and Its Modulation by Genetic Variation.

Neuropsychobiology 2019 13;77(2):67-72. Epub 2018 Dec 13.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy,

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http://dx.doi.org/10.1159/000493400DOI Listing
March 2019

Nanovector-Mediated Drug Delivery in Spinal Cord Injury: A Multitarget Approach.

ACS Chem Neurosci 2019 Mar 25;10(3):1173-1182. Epub 2019 Feb 25.

Dipartimento di Neuroscienze , Istituto di Ricerche Farmacologiche Mario Negri IRCCS , via La Masa 19 , 20156 Milan , Italy.

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http://dx.doi.org/10.1021/acschemneuro.8b00700DOI Listing
March 2019

Clinical trials of prion disease therapeutics.

Curr Opin Pharmacol 2019 Feb 17;44:53-60. Epub 2019 May 17.

Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy.

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http://dx.doi.org/10.1016/j.coph.2019.04.019DOI Listing
February 2019

Plasma and Brain Concentrations of Doxycycline after Single and Repeated Doses in Wild-Type and APP23 Mice.

J Pharmacol Exp Ther 2019 Jan 5;368(1):32-40. Epub 2018 Nov 5.

Departments of Molecular Biochemistry and Pharmacology (J.L., C.F., M.S., M.G.), Neuroscience (C.B., G.F.), and Environmental Health Science (A.P.), Instituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.252064DOI Listing
January 2019

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models.

Neurobiol Aging 2018 10 12;70:128-139. Epub 2018 Jun 12.

Department of Neuroscience, IRCCS, Istituto di Ricerhe Farmacologiche Mario Negri, Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.002DOI Listing
October 2018

Exome sequencing in an Italian family with Alzheimer's disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615H.

Alzheimers Res Ther 2018 10 12;10(1):106. Epub 2018 Oct 12.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20156, Milan, Italy.

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http://dx.doi.org/10.1186/s13195-018-0435-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182820PMC
October 2018

A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.

ACS Chem Neurosci 2018 07 16;9(7):1591-1606. Epub 2018 Apr 16.

Department of Medicine, Djavad Mowafaghian Centre for Brain Health , University of British Columbia , 2211 Wesbrook Mall , Vancouver , BC V6T 2B5 , Canada.

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http://dx.doi.org/10.1021/acschemneuro.7b00469DOI Listing
July 2018

Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer's Disease.

Sci Rep 2018 Jun 22;8(1):9576. Epub 2018 Jun 22.

Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, IRCCS, Mario Negri Institute for Pharmacological Research, Milan, (MI), Italy.

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http://dx.doi.org/10.1038/s41598-018-27839-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015016PMC
June 2018

Novel targets in Alzheimer's disease: A special focus on microglia.

Pharmacol Res 2018 04 31;130:402-413. Epub 2018 Jan 31.

Biology of Neurodegenerative Disorders Lab, Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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http://dx.doi.org/10.1016/j.phrs.2018.01.017DOI Listing
April 2018

Alpha-synuclein oligomers impair memory through glial cell activation and via Toll-like receptor 2.

Brain Behav Immun 2018 03 16;69:591-602. Epub 2018 Feb 16.

Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2018.02.012DOI Listing
March 2018

Applicability of [C]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model.

Neurobiol Aging 2017 09 15;57:84-94. Epub 2017 May 15.

PET Preclinical Laboratory, Turku PET Centre, University of Turku, Turku, Finland; Medicity Research Laboratory, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.05.008DOI Listing
September 2017

Current Options for Cell Therapy in Spinal Cord Injury.

Trends Mol Med 2017 09 12;23(9):831-849. Epub 2017 Aug 12.

Dipartimento di Neuroscienze, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.07.005DOI Listing
September 2017

Multifunctional liposomes delay phenotype progression and prevent memory impairment in a presymptomatic stage mouse model of Alzheimer disease.

J Control Release 2017 07 10;258:121-129. Epub 2017 May 10.

School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy; Nanomedicine Center NANOMIB, University of Milano-Bicocca, 20126 Milano, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659173058
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http://dx.doi.org/10.1016/j.jconrel.2017.05.013DOI Listing
July 2017

Electrocardiogram Alterations Associated With Psychotropic Drug Use and CACNA1C Gene Variants in Three Independent Samples.

Basic Clin Pharmacol Toxicol 2017 May 5;120(5):482-490. Epub 2017 Jan 5.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/bcpt.12720DOI Listing
May 2017

The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk.

Genes Genet Syst 2017 May 24;91(6):301-309. Epub 2017 Feb 24.

Laboratory of Neurological Diseases, Department of Neuroscience, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri.

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http://dx.doi.org/10.1266/ggs.16-00023DOI Listing
May 2017

The Continuing Failure of Bexarotene in Alzheimer's Disease Mice.

J Alzheimers Dis 2015 ;46(2):471-82

Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, IRCCS Mario Negri Institute for Pharmacological Research, Milano, Italy.

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http://dx.doi.org/10.3233/JAD-150029DOI Listing
July 2016

The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers.

J Alzheimers Dis 2016 07;53(4):1485-97

Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044783PMC
http://dx.doi.org/10.3233/JAD-150882DOI Listing
July 2016

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.

Mov Disord 2016 06 31;31(6):771-81. Epub 2016 Mar 31.

Departement of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche "Mario Negri,", Milano, Italy.

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http://dx.doi.org/10.1002/mds.26624DOI Listing
June 2016

CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer's Disease Patients.

J Alzheimers Dis 2016 04;52(4):1203-8

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3233/JAD-160074DOI Listing
April 2016

Frontotemporal Lobar Degeneration and MicroRNAs.

Front Aging Neurosci 2016 9;8:17. Epub 2016 Feb 9.

Department of Neuroscience, Istituto Superiore di Sanità Rome, Italy.

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http://dx.doi.org/10.3389/fnagi.2016.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746266PMC
February 2016

Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression.

J Alzheimers Dis 2014 ;42(3):851-64

IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.

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http://dx.doi.org/10.3233/JAD-131430DOI Listing
August 2015

Influence of socio-demographic features and apolipoprotein E epsilon 4 expression on the prevalence of dementia and cognitive impairment in a population of 70-74-year olds: the InveCe.Ab study.

Arch Gerontol Geriatr 2015 Mar-Apr;60(2):334-43. Epub 2014 Nov 25.

Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine - University of Pavia, Via Forlanini 2, 27100 Pavia, Italy.

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http://dx.doi.org/10.1016/j.archger.2014.11.006DOI Listing
July 2015

Nanovector-mediated drug delivery for spinal cord injury treatment.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014 Sep-Oct;6(5):506-15. Epub 2014 May 21.

Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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http://dx.doi.org/10.1002/wnan.1276DOI Listing
March 2015

In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches.

Curr Pharm Des 2014 ;20(15):2491-505

IRCCS Istitituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 2156 Milano, Italy.

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http://dx.doi.org/10.2174/13816128113199990497DOI Listing
February 2015

Genetics of psychotropic medication induced side effects in two independent samples of bipolar patients.

J Neural Transm (Vienna) 2015 Jan 17;122(1):43-58. Epub 2014 Aug 17.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy.

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http://dx.doi.org/10.1007/s00702-014-1290-3DOI Listing
January 2015

Therapy in prion diseases.

Curr Top Med Chem 2013 ;13(19):2465-76

IRCCS Istituto di Ricerche Farmacologiche "Mario Negri" Via La Masa 19, 20156 Milano, Italy.

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http://dx.doi.org/10.2174/15680266113136660173DOI Listing
November 2014

Stress impairs synaptic plasticity in triple-transgenic Alzheimer's disease mice: rescue by ryanodine.

Neurodegener Dis 2014 4;13(2-3):135-8. Epub 2013 Sep 4.

Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1159/000354231DOI Listing
September 2014

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

Synthesis and evaluation of a (18)F-curcumin derivate for β-amyloid plaque imaging.

Bioorg Med Chem 2014 May 18;22(9):2753-62. Epub 2014 Mar 18.

Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Porthaninkatu 3, FI-20500 Turku, Finland; Turku PET Centre, Accelerator Laboratory, Åbo Akademi University, Porthansgatan 3, FI-20500 Turku, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896140018
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http://dx.doi.org/10.1016/j.bmc.2014.03.010DOI Listing
May 2014

Impact of 5-HTTLPR polymorphism on alexithymia in alcoholic patients after detoxification treatment.

J Addict Med 2013 Sep-Oct;7(5):372-3

Department of Biomedical and Neuromotor Sciences (LM, CM, MB, DDR, AS), Institute of Psychiatry, University of Bologna, Bologna, Italy; Department of Psychiatry (IL, EOT), Eginition Hospital, and Laboratory of Biological Chemistry (CP, AZ, AK), University of Athens Medical School, Athens, Greece; and Neuroscience Department (DA, GF, SR, SB, GB), Istituto di ricerche Farmacologiche "Mario Negri," Milan, Italy.

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http://dx.doi.org/10.1097/ADM.0b013e31829c3049DOI Listing
April 2014

Development and analysis of semi-interpenetrating polymer networks for brain injection in neurodegenerative disorders.

Int J Artif Organs 2013 Nov 27;36(11):762-74. Epub 2013 Nov 27.

1 Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano and Unità di Ricerca Consorzio INSTM, Politecnico di Milano, Milan - Italy.

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http://dx.doi.org/10.5301/ijao.5000282DOI Listing
November 2013

The neurodegeneration in Alzheimer disease and the prion protein.

Prion 2013 Jan-Feb;7(1):60-5. Epub 2013 Jan 1.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

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http://dx.doi.org/10.4161/pri.23286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609052PMC
August 2013

Tunable hydrogel-nanoparticles release system for sustained combination therapies in the spinal cord.

Colloids Surf B Biointerfaces 2013 Aug 14;108:169-77. Epub 2013 Mar 14.

Politecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", via Mancinelli 7, 20131 Milano, Italy.

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http://dx.doi.org/10.1016/j.colsurfb.2013.02.046DOI Listing
August 2013

A new face for old antibiotics: tetracyclines in treatment of amyloidoses.

J Med Chem 2013 Aug 8;56(15):5987-6006. Epub 2013 May 8.

IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milano, Italy.

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http://dx.doi.org/10.1021/jm400161pDOI Listing
August 2013

Current options for drug delivery to the spinal cord.

Expert Opin Drug Deliv 2013 Mar 6;10(3):385-96. Epub 2013 Jan 6.

Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy.

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http://dx.doi.org/10.1517/17425247.2013.751372DOI Listing
March 2013

Sporadic human prion diseases: molecular insights and diagnosis.

Lancet Neurol 2012 Jul;11(7):618-28

Division of Neurology, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1016/S1474-4422(12)70063-7DOI Listing
July 2012

Hydrogels in spinal cord injury repair strategies.

ACS Chem Neurosci 2011 Jul 4;2(7):336-45. Epub 2011 May 4.

Department of Chemistry, Materials and Chemical Engineering "Giulio Natta," Politecnico di Milano, via Mancinelli 7, 20131 Milan, Italy; Department of Neuroscience, Mario Negri Institute for Pharmacological Research, via La Masa 19, 20156, Milan, Italy.

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http://dx.doi.org/10.1021/cn200030wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369745PMC
July 2011