Publications by authors named "Gianfranco Delle Fave"

100Publications

Probiotics in COVID-19 pandemic: when evidence lacks, rationale can still ease the way.

Minerva Gastroenterol Dietol 2020 Sep 4. Epub 2020 Sep 4.

Department of Gastroenterology and Digestive Endoscopy, S. Giovanni Addolorata Hospital, Rome, Italy.

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September 2020

The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.

Dig Liver Dis 2019 12 9;51(12):1725-1730. Epub 2019 Aug 9.

University Denis Diderot - Paris VII, Paris, France; Department of Gastroenterology and Pancreatology, Beaujon Hospital, APHP, ENETs Center of Excellence, Clichy, France.

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December 2019

Mucosal adhesion and anti-inflammatory effects of GG in the human colonic mucosa: A proof-of-concept study.

World J Gastroenterol 2018 Nov;24(41):4652-4662

Department of Digestive and Liver Disease, School of Medicine and Psychology, S. Andrea Hospital, Sapienza University, Rome 00189, Italy.

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November 2018

Heterogeneity of Duodenal Neuroendocrine Tumors: An Italian Multi-center Experience.

Ann Surg Oncol 2018 Oct 27;25(11):3200-3206. Epub 2018 Jul 27.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

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October 2018

Results of surveillance in individuals at high-risk of pancreatic cancer: A systematic review and meta-analysis.

United European Gastroenterol J 2018 May 8;6(4):489-499. Epub 2018 Jan 8.

Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy.

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May 2018

Co-treatment with gemcitabine and nab-paclitaxel exerts additive effects on pancreatic cancer cell death.

Oncol Rep 2018 Apr 25;39(4):1984-1990. Epub 2018 Jan 25.

Medical and Surgical Department of Clinical Sciences and Translational Medicine, Digestive and Liver Disease Unit, Sant'Andrea Hospital, 'Sapienza' University, I-00199 Rome, Italy.

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April 2018

Recurrent biliary acute pancreatitis is frequent in a real-world setting.

Dig Liver Dis 2018 Mar 19;50(3):277-282. Epub 2017 Dec 19.

Digestive & Liver Disease Unit, S. Andrea Hospital, University "La Sapienza", Rome, Italy. Electronic address:

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March 2018

The prevalence of pancreatic cystic lesions in patients with liver cirrhosis is double that in controls.

United European Gastroenterol J 2017 Nov 9;5(7):1007-1014. Epub 2017 Feb 9.

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Faculty of Medicine and Psychology, 'Sapienza' University of Rome, Rome, Italy.

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November 2017

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells.

Cell Death Dis 2017 11 9;8(11):e3168. Epub 2017 Nov 9.

Department of Biomedicine and Prevention, Section of Anatomy, University of Rome 'Tor Vergata', Rome, Italy.

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November 2017

Exclusive and Combined Use of Statins and Aspirin and the Risk of Pancreatic Cancer: a Case-Control Study.

Sci Rep 2017 10 12;7(1):13024. Epub 2017 Oct 12.

Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

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October 2017

Hepatitis B in patients with hematological diseases: An update.

World J Hepatol 2017 Sep;9(25):1043-1053

Digestive and Liver Diseases Department, Sant'Andrea Hospital, School of Medicine and Psychology, Sapienza University, 00189 Rome, Italy.

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September 2017

Antiproliferative effect of somatostatin analogs in advanced gastro-entero-pancreatic neuroendocrine tumors: a systematic review and meta-analysis.

Oncotarget 2017 Jul;8(28):46624-46634

Department of Digestive and Liver Diseases, Sapienza University, Sant'Andrea Hospital, Rome, Italy.

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July 2017

The Neutrophil/Lymphocyte Ratio at Diagnosis Is Significantly Associated with Survival in Metastatic Pancreatic Cancer Patients.

Int J Mol Sci 2017 Mar 29;18(4). Epub 2017 Mar 29.

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Faculty of Medicine and Psychology,"Sapienza" University of Rome, 00189 Rome, Italy.

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March 2017

Endoscopy-guided ablation of pancreatic lesions: Technical possibilities and clinical outlook.

World J Gastrointest Endosc 2017 Feb;9(2):41-54

Marianna Signoretti, Roberto Valente, Gianfranco Delle Fave, Gabriele Capurso, Digestive and Liver Disease Unit, S.Andrea Hospital, University Sapienza, 00199 Rome, Italy.

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February 2017

Gut microbiota and pancreatic diseases.

Minerva Gastroenterol Dietol 2017 Dec 24;63(4):399-410. Epub 2017 Feb 24.

Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University, Rome, Italy -

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December 2017

Elevated C-Reactive Protein in Asymptomatic Crohn's Disease Patients: Listen to the Sound of Silence.

Inflamm Bowel Dis 2017 03;23(3):E13

"Sapienza" University of Rome, S. Andrea Hospital, Rome, Italy "Sapienza" University of Rome, S. Andrea Hospital, Rome, Italy "Sapienza" University of Rome Digestive Endoscopy Unit, S. Andrea Hospital, Rome, Italy "Sapienza" University of Rome, S. Andrea Hospital, Rome, Italy.

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March 2017

Everolimus in Pancreatic Neuroendocrine Carcinomas G3.

Pancreas 2017 03;46(3):302-305

From the *Digestive and Liver Diseases, Sant'Andrea Hospital-Sapienza University of Roma, Rome; †Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Milan; ‡Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, and Department of Medical Biotechnologies, University of Siena, Siena; §Osteoncology and Rare Tumors Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC); and ∥Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

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March 2017

 Sarcopenia predicts reduced survival in patients with hepatocellular carcinoma at first diagnosis.

Ann Hepatol 2017 Jan-Feb 2017;16(1):107-114

Digestive and Liver Diseases Department, Sant'Andrea Hospital, School of Medicine and Psychology, Sapienza University, Rome, Italy.

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February 2017

Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD.

J Clin Gastroenterol 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S179-S182

Faculty of Medicine and Psychology, "Sapienza" University of Rome, S. Andrea Hospital, Rome, Italy.

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December 2017

The Use of Complementary and Alternative Medicine is Frequent in Patients With Pancreatic Disorders.

J Clin Gastroenterol 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S161-S163

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Sapienza University, Rome, Italy.

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December 2017

Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis.

United European Gastroenterol J 2016 Oct 3;4(5):697-705. Epub 2016 Feb 3.

Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy.

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October 2016

[Epidemiology, clinical features and treatment of chronic pancreatitis: current knowledge and future perspectives].

Recenti Prog Med 2016 Jun;107(6):328-36

Unità Operativa Complessa di Malattie dell'Apparato Digerente e del Fegato, Ospedale Sant'Andrea, Sapienza Università di Roma.

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June 2016

Digestive neuroendocrine neoplasms: A 2016 overview.

Dig Liver Dis 2016 Aug 30;48(8):829-35. Epub 2016 Apr 30.

Department of Digestive and Liver Disease, S. Andrea Hospital, II Medical School of "Sapienza" University of Rome, Italy. Electronic address:

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August 2016

A Case of Pancreatic Small Cell Neuroendocrine Carcinoma Associated With SIADH.

Pancreas 2016 May-Jun;45(5):e20-2

Digestive and Liver Disease Unit Sant' Andrea Hospital University Sapienza Rome, Italy Department of Clinical and Molecular Medicine Sant' Andrea Hospital University Sapienza Rome, Italy Nuclear Medicine Unit Sant' Andrea Hospital University Sapienza Rome, Italy Digestive and Liver Disease Unit Sant' Andrea Hospital University Sapienza Rome, Italy Nuclear Medicine Unit Sant' Andrea Hospital University Sapienza Rome, Italy Gastroenterology Unit Moscati Hospital Avellino, Italy Radiology Unit Sant' Andrea Hospital University Sapienza Rome, Italy Nephrology Unit Sant' Andrea Hospital University Sapienza Rome, Italy Digestive and Liver Disease Unit Sant' Andrea Hospital University Sapienza Rome, Italy

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January 2017

Statin Use and Survival in Resectable Pancreatic Cancer: Confounders and Mechanisms.

Am J Gastroenterol 2016 Mar;111(3):436

Department of Medicine and Psychology, Digestive and Liver Disease Unit, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

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March 2016

Risk of pancreatic malignancy and mortality in branch-duct IPMNs undergoing surveillance: A systematic review and meta-analysis.

Dig Liver Dis 2016 May 18;48(5):473-479. Epub 2016 Feb 18.

Division of Pancreatic Surgery, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy. Electronic address:

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May 2016

Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals.

World J Gastrointest Endosc 2015 Jul;7(9):833-42

Gabriele Capurso, Marianna Signoretti, Roberto Valente, Gianfranco Delle Fave, Digestive and Liver Disease Unit, S. Andrea Hospital, University Sapienza, 00199 Rome, Italy.

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July 2015

Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment.

Int J Endocrinol 2015 29;2015:595649. Epub 2015 Mar 29.

Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.

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April 2015

Comparison of diffusion-weighted imaging and gadoxetic acid-enhanced MR images in the evaluation of hepatocellular carcinoma and hypovascular hepatocellular nodules.

Clin Imaging 2015 May-Jun;39(3):468-75. Epub 2015 Jan 7.

Radiology Unit, Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy.

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November 2015

Early onset pancreatic cancer: risk factors, presentation and outcome.

Pancreatology 2015 Mar-Apr;15(2):151-5. Epub 2015 Feb 12.

Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy. Electronic address:

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December 2015

Molecular pathogenesis and targeted therapy of sporadic pancreatic neuroendocrine tumors.

J Hepatobiliary Pancreat Sci 2015 Aug 25;22(8):594-601. Epub 2015 Jan 25.

Digestive and Liver Disease Unit, Faculty of Medicine and Psychology, Sapienza University of Rome at S. Andrea Hospital, Rome, Italy.

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August 2015

The role of combined Ga-DOTANOC and (18)FDG PET/CT in the management of patients with pancreatic neuroendocrine tumors.

Neuroendocrinology 2014 3;100(4):293-9. Epub 2014 Oct 3.

Pancreatic Surgery Unit, Clinica Chirurgia del Pancreas, Università Politecnica delle Marche, Ancona, Italy.

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October 2015

Small intestinal bacterial overgrowth in patients with chronic pancreatitis.

J Clin Gastroenterol 2014 Nov-Dec;48 Suppl 1:S52-5

Digestive and Liver Disease Unit, S. Andrea Hospital, University "Sapienza," Rome, Italy.

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June 2015

Acute fulminant hepatitis E virus genotype 3e infection: description of the first case in Europe.

Scand J Infect Dis 2014 Oct 19;46(10):727-31. Epub 2014 Aug 19.

From the Digestive and Liver Disease Unit, School of Medicine and Psychology, Sapienza University of Rome , Sant'Andrea Hospital.

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October 2014

Real-world study of everolimus in advanced progressive neuroendocrine tumors.

Oncologist 2014 Sep 12;19(9):966-74. Epub 2014 Aug 12.

Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy; Departments of Endocrinology and Oncologia Medica, Università Cattolica del S. Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, Italy; Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy

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September 2014

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition.

Oncotarget 2014 Jul;5(14):5381-91

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Laboratory of Neuroembryology, Fondazione Santa Lucia, Rome, Italy.

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July 2014

Liver biopsy: Analysis of results of two specialist teams.

World J Gastrointest Pathophysiol 2014 May;5(2):114-9

Giulia Anania, Elia Gigante, Matteo Piciucchi, Flavia Baccini, Giulio Antonelli, Paola Begini, Gianfranco Delle Fave, Massimo Marignani, Department of Digestive and Liver Disease, School of Medicine and Psychology University "Sapienza", 00189 Rome, Italy.

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May 2014

"Mucosal healing" in ulcerative colitis: Between clinical evidence and market suggestion.

World J Gastrointest Pathophysiol 2014 May;5(2):54-62

Cristiano Pagnini, Francesca Menasci, Stefano Festa, Gianenrico Rizzatti, Gianfranco Delle Fave, "Sapienza" University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy.

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May 2014

Advanced digestive neuroendocrine tumors: metastatic pattern is an independent factor affecting clinical outcome.

Pancreas 2014 Mar;43(2):212-8

From the *Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, Rome; †Dept of Surgery, Pancreatic Surgery Unit, Università Politecnica delle Marche, Ancona; ‡Ospedale Sacro Cuore Don Calabria, Negrar; §Department of Clinical Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna; ∥Radiology, ¶Pathology Unit, and #Surgery 1, Sapienza University of Rome, Sant'Andrea Hospital, Rome; **ARC-NET Center for Applied Research on Cancer and Department of Pathology and Diagnostics, University of Verona, Verona; and ††Medical Oncology, Università Politecnica delle Marche, Ancona, Italy.

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March 2014

Exocrine pancreatic insufficiency in adults: a shared position statement of the Italian Association for the Study of the Pancreas.

World J Gastroenterol 2013 Nov;19(44):7930-46

Raffaele Pezzilli, Angelo Andriulli, Claudio Bassi, Gianpaolo Balzano, Maurizio Cantore, Gianfranco Delle Fave, Massimo Falconi, Luca Frulloni; the Exocrine Pancreatic Insufficiency collaborative (EPIc) Group, Department of Digestive Diseases, Internal Medicine Sant'Orsola-Malpighi Hospital, 40138 Bologna, Italy.

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November 2013

Gadoxetic acid-enhanced MRI for hepatocellular carcinoma and hypointense nodule observed in the hepatobiliary phase.

Radiol Med 2014 Jun 3;119(6):367-76. Epub 2013 Dec 3.

Facoltà di Medicina e Psicologia, Dipartimento di Scienze Medico-Chirurgiche e di Medicina Traslazionale, Istituto di Radiologia, Università di Roma, Sapienza, Rome, Italy,

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June 2014

Critical review of the evidence on 5-aminosalicilate for chemoprevention of colorectal cancer in ulcerative colitis: a methodological question.

Curr Clin Pharmacol 2014 Feb;9(1):84-90

Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "Sapienza" University, Rome, Italy.

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February 2014

Diagnostic and therapeutic role of endoscopy in gastroenteropancreatic neuroendocrine neoplasms.

Dig Liver Dis 2014 Jan 31;46(1):9-17. Epub 2013 May 31.

Digestive Endoscopy Unit, Catholic University, Rome, Italy. Electronic address:

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January 2014

Gastric and duodenal neuroendocrine tumours.

Best Pract Res Clin Gastroenterol 2012 Dec;26(6):719-35

Department of Gastroenterology and Clinical Medicine, St James's Hospital and Trinity College, Dublin, Ireland.

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December 2012

Outcomes of intraductal papillary mucinous neoplasm with "Sendai-positive" criteria for resection undergoing non-operative management.

Dig Liver Dis 2013 Jul 27;45(7):584-8. Epub 2013 Feb 27.

Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy.

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July 2013

Novel molecular targets for the treatment of gastroenteropancreatic endocrine tumors: answers and unsolved problems.

Int J Mol Sci 2012 Dec 20;14(1):30-45. Epub 2012 Dec 20.

Digestive and Liver Disease Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome at S. Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy.

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December 2012

Is proliferative colonic disease presentation changing?

World J Gastroenterol 2012 Dec;18(45):6614-9

Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sant'Andrea Hospital, "Sapienza" University, 00189 Rome, Italy.

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December 2012

Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor.

Biochim Biophys Acta 2013 Mar 4;1833(3):573-82. Epub 2012 Dec 4.

Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, USA.

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March 2013

Role of the gut barrier in acute pancreatitis.

J Clin Gastroenterol 2012 Oct;46 Suppl:S46-51

Faculty of Medicine and Psychology, Digestive and Liver Disease Unit, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy.

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October 2012

No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia.

Dig Liver Dis 2012 Sep 15;44(9):793-7. Epub 2012 May 15.

Department of Digestive and Liver Disease, University Sapienza, Sant'Andrea Hospital, Rome, Italy.

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September 2012

Molecular pathology and genetics of pancreatic endocrine tumours.

J Mol Endocrinol 2012 Aug 26;49(1):R37-50. Epub 2012 Jun 26.

Digestive and Liver Disease Unit, Faculty of Medicine and Psychology, S. Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Rome, Italy.

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August 2012

'Les liaisons dangereuses': Hepatitis C, Rituximab and B-cell non-Hodgkin's lymphomas.

World J Gastrointest Pharmacol Ther 2012 Apr;3(2):21-8

Massimo Marignani, Michela di Fonzo, Paola Begini, Elia Gigante, Ilaria Deli, Sara Gallina, Emanuela de Santis, Gianfranco Delle Fave, Department of Digestive and Liver Disease, School of Medicine and Psychology University "Sapienza", Azienda Ospedaliera S. Andrea, Via Grottarossa, 1035-1039, 00189 Rome, Italy.

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April 2012

Meta-analysis: the placebo rate of abdominal pain remission in clinical trials of chronic pancreatitis.

Pancreas 2012 Oct;41(7):1125-31

Digestive and Liver Disease Unit, S Andrea Hospital, University of Rome Sapienza, Rome, Italy.

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October 2012

HCV infection, B-cell non-Hodgkin's lymphoma and immunochemotherapy: Evidence and open questions.

World J Gastrointest Oncol 2012 Mar;4(3):46-53

Maria Christina Cox, Maria Antonietta Aloe-Spiriti, Elena Cavalieri, Eleonora Alma, Caterina Rebecchini, Department of Haematology, Sant'Andrea Hospital, La Sapienza University, 00139 Rome, Italy.

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March 2012

Patients with hematological malignancies and serological signs of prior resolved hepatitis B.

World J Gastrointest Oncol 2012 Mar;4(3):37-45

Massimo Marignani, Elia Gigante, Paola Begini, Michela di Fonzo, Ilaria Deli, Sara Gallina, Gianfranco Delle Fave, Digestive and Liver Disease Department, School of Medicine and Psychology University "Sapienza", Azienda Ospedaliera S. Andrea, Via Grottarossa, 1035-1039, 00189 Rome, Italy.

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March 2012

Signalling pathways passing Src in pancreatic endocrine tumours: relevance for possible combined targeted therapies.

Neuroendocrinology 2013 21;97(1):67-73. Epub 2012 Mar 21.

Digestive and Liver Disease Unit, II Medical School, University of Rome La Sapienza, Rome, Italy.

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May 2014

Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy.

World J Gastrointest Oncol 2012 Feb;4(2):22-5

Roberto Valente, Gabriele Capurso, Matteo Piciucchi, Emilio Di Giulio, Gianfranco Delle Fave, Digestive and Liver Disease Unit, Second Medical School, "La Sapienza" University, S. Andrea Hospital, 00189 Rome, Italy.

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February 2012