Gian Marco Ghiggeri

Gian Marco Ghiggeri

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Gian Marco Ghiggeri

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Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease.

Int J Mol Sci 2019 Nov 5;20(21). Epub 2019 Nov 5.

Renal Unit, Department of Medicine, University/Hospital of Verona, Piazzale A. Stefani 1, 37126 Verona, Italy.

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http://dx.doi.org/10.3390/ijms20215517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862015PMC
November 2019

An Update on Antibodies to Necleosome Components as Biomarkers of Sistemic Lupus Erythematosus and of Lupus Flares.

Int J Mol Sci 2019 Nov 18;20(22). Epub 2019 Nov 18.

Laboratory of Molecular Nephrology, Scientific Institute for Research and Health Care, IRCCS IstitutoGianninaGaslini, 16147 Genoa, Italy.

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http://dx.doi.org/10.3390/ijms20225799DOI Listing
November 2019

Atypical IgM on T cells predict relapse and steroid dependence in idiopathic nephrotic syndrome.

Kidney Int 2019 Oct 7;96(4):971-982. Epub 2019 May 7.

Laboratory of Nephrology, Department of Rare Diseases, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Division of Nephrology, Department of Pediatric Subspecialties, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.1016/j.kint.2019.04.006DOI Listing
October 2019

Post-transplant recurrence of steroid resistant nephrotic syndrome in children: the Italian experience.

J Nephrol 2019 Oct 15. Epub 2019 Oct 15.

Pediatric Nephrology, Dialysis and Transplant Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, University of Milan, via della Commenda, 9, 20122, Milan, Italy.

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http://dx.doi.org/10.1007/s40620-019-00660-9DOI Listing
October 2019

Biological surface properties in extracellular vesicles and their effect on cargo proteins.

Sci Rep 2019 Sep 10;9(1):13048. Epub 2019 Sep 10.

Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

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http://dx.doi.org/10.1038/s41598-019-47598-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736982PMC
September 2019

Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis.

J Rheumatol 2019 May 15. Epub 2019 May 15.

From the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Supported by a grant from Fondazione Lupus Italia 2014. Further support from the Fondazione Malattie Renali del Bambino and grant no. ROL 9849 from Compagnia di San Paolo. PC is the recipient of US National Institutes of Health R01 grant AI132949. M. Bruschi, PhD, Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini; A. Bonanni, MD, Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini; A. Petretto, PhD, Core Facilities- Proteomics Laboratory, IRCCS Istituto Giannina Gaslini; A. Vaglio, MD, Nephrology Unit, University Hospital, University of Parma; F. Pratesi, MD, Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; L. Santucci, PhD, Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini; P. Migliorini, MD, Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; R. Bertelli, PhD, Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini; M. Galetti, PhD, INAIL Research Center at the University of Parma; S. Belletti, MD, S.Bi.Bi.T Department of the University of Parma; L. Cavagna, MD, Division of Rheumatology, University and IRCCS Policlinico S. Matteo; G. Moroni, MD, Division of Nephrology and Dialysis, Fondazione IRCCS Ca' Granda Ospedale Maggiore Milano; F. Franceschini, MD, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia; G. Pazzola, MD, Nephrology and Dialysis, Arciospedale Santa Maria Nuova; L. Allegri, MD, Nephrology Unit, University Hospital, University of Parma; R.A. Sinico, MD, Department of Medicine and Surgery, University of Milan; G. Pesce, PhD, Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; M. Bagnasco, MD, Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; A. Manfredi, MD, Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele; G.A. Ramirez, MD, Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele; P. Ramoino, MD, DISTAV, University of Genoa; P. Bianchini, MD, Department of Nanophysics, IIT; F. Puppo, MD, Department of Internal Medicine, University of Genoa; F. Pupo, MD, Department of Internal Medicine, University of Genoa; S. Negrini, MD, Department of Internal Medicine, University of Genoa; F. Mattana, MD, Division of Nephrology, University of Genoa and Policlinico San Martino; G. Emmi, MD, Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi; G. Garibotto, MD, Division of Nephrology, University of Genoa and Policlinico San Martino; D. Santoro, MD, Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital; F. Scolari, MD, Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari; A. Ravelli, MD, Division of Paediatric Rheumatology, IRCCS Istituto Giannina Gaslini; A. Tincani, MD, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia; P. Cravedi, MD, Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai; S. Volpi, MD, Division of Paediatric Rheumatology, IRCCS Istituto Giannina Gaslini; G. Candiano, PhD, Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini; G.M. Ghiggeri, MD, PhD, Laboratory of Molecular Nephrology, and Division of Nephrology, Dialysis, and Transplantation, IRCCS Istituto Giannina Gaslini. Address correspondence to Dr. G.M. Ghiggeri, Division of Nephrology, Dialysis and Transplantation, Laboratory Molecular Nephrology Science, Istituto G. Gaslini, Largo G. Gaslini 5, Genoa, Italy. E-mail: Accepted for publication April 24, 2019.

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.181232
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http://dx.doi.org/10.3899/jrheum.181232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917988PMC
May 2019

Author Correction: The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

Nat Genet 2019 04;51(4):764

Division of Nephrology, Department of Medicine, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-019-0376-0DOI Listing
April 2019

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation.

Front Immunol 2019 30;10:963. Epub 2019 Apr 30.

UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Genova, Italy.

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http://dx.doi.org/10.3389/fimmu.2019.00963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503056PMC
April 2019

The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

Nat Genet 2019 01 21;51(1):117-127. Epub 2018 Dec 21.

Division of Nephrology, Department of Medicine, Columbia University, New York, NY, USA.

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http://www.nature.com/articles/s41588-018-0281-y
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http://dx.doi.org/10.1038/s41588-018-0281-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668343PMC
January 2019

Drug-induced lupus: Traditional and new concepts.

Autoimmun Rev 2018 Sep 10;17(9):912-918. Epub 2018 Jul 10.

Nephrology Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore, Milano, Italy.

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http://dx.doi.org/10.1016/j.autrev.2018.03.016DOI Listing
September 2018

Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.

Proteomics Clin Appl 2018 05 5;12(3):e1700082. Epub 2017 Dec 5.

Dipartimento di Farmacia, Laboratorio di Biochimica, Università di Genova, Genoa, Italy.

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http://dx.doi.org/10.1002/prca.201700082DOI Listing
May 2018

Annexin A1 and Autoimmunity: From Basic Science to Clinical Applications.

Int J Mol Sci 2018 May 3;19(5). Epub 2018 May 3.

Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS), Istituto Giannina Gaslini, Largo Gaslini n 5, 16148 Genoa, Italy.

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http://dx.doi.org/10.3390/ijms19051348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983684PMC
May 2018

Genetic basis of human congenital anomalies of the kidney and urinary tract.

J Clin Invest 2018 01 2;128(1):4-15. Epub 2018 Jan 2.

Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI95300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749511PMC
January 2018

Randomised controlled trial comparing ofatumumab to rituximab in children with steroid-dependent and calcineurin inhibitor-dependent idiopathic nephrotic syndrome: study protocol.

BMJ Open 2017 03 17;7(3):e013319. Epub 2017 Mar 17.

Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy.

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http://dx.doi.org/10.1136/bmjopen-2016-013319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372102PMC
March 2017

Anti-alpha-enolase antibodies in membranous nephropathy: isotype matters.

Clin Exp Nephrol 2017 02 30;21(1):171-172. Epub 2016 Mar 30.

Division of Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, Largo G. Gaslini 5, 16148, Genoa, Italy.

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http://dx.doi.org/10.1007/s10157-016-1263-yDOI Listing
February 2017

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.

N Engl J Med 2017 02 25;376(8):742-754. Epub 2017 Jan 25.

From the Division of Nephrology (E.L.-R., M.V., V.P.C., Z.Y., A.M., J.M., N.J.S., D.A.F., R.D., M.W., G.S.M., M.B., J.M.B., K.K., A.G.G., S.S.-C.) and the Division of Nephrology in Medicine and Zuckerman Mind Brain Behavior Institute (B.H.), the Departments of Systems Biology (D.S.P., B.H.), Biochemistry and Molecular Biophysics (B.H.), and Pathology (V.D.), and the Howard Hughes Medical Institute (D.S.P., B.H.), Columbia University, and the Department of Genetics and Development, Columbia University Medical Center (Q.L., V.E.P.), New York, and the Department of Genetics, Albert Einstein College of Medicine, Bronx (S.E.R., B.E.M.) - all in New York; the Center for Human Disease Modeling, Duke University, Durham, NC (Y.P.L., B.R.A., N. Katsanis); the Departments of Internal Medicine-Nephrology (E.A.O.) and Pediatrics-Nephrology (M.G.S., C.E.G., V.V.-W.), University of Michigan School of Medicine, Ann Arbor; the Department of Anatomy, Histology, and Embryology, School of Medicine, University of Split (K.V., M.S.-B.), and the Departments of Pediatrics (A.A., M. Saraga) and Pathology (N. Kunac), University Hospital of Split, Split, Croatia; the Department of Pediatric Nephrology, VU University Medical Center, Amsterdam (R.W., J.A.E.W.); the Department of Medicine, Boston Children's Hospital (A.V., F.H.), and Harvard Medical School, Boston (A.V., F.H., I.A.D.), and the Nephrology Division, Massachusetts General Hospital, Charlestown (I.A.D.) - all in Massachusetts; the Division of Nephrology, Dialysis, Transplantation, and Laboratory on Pathophysiology of Uremia, Istituto G. Gaslini, Genoa (M.B., A.C., G.M.G.), the Department of Clinical and Experimental Medicine, University of Parma (M.B., M. Maiorana, L.A.), and the Pediatric Surgery Unit, University Hospital of Parma (E.C.), Parma, the Section of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Bari (L.G.), the Department of Medical Sciences, University of Milano, and Institute of Biomedical Technologies, Italian National Institute of Research ITB-CNR, Milan (D.C.), and Dipartimento Ostetrico-Ginecologico e Seconda Divisione di Nefrologia ASST Spedali Civili e Presidio di Montichiari (C.I.) and Cattedra di Nefrologia, Università di Brescia, Seconda Divisione di Nefrologia Azienda Ospedaliera Spedali Civili di Brescia Presidio di Montichiari (F.S.), Brescia - all in Italy; the Department of General and Transplant Surgery, University Hospital of Heidelberg, Germany (V.J.L.); the Department of Pediatric Nephrology, Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (R.S., L.H., C.J.), INSERM UMR 1163, Laboratory of Hereditary Kidney Diseases (R.S.), Necker-Enfants Malades Hospital, Paris Descartes-Sorbonne Paris Cite University, Imagine Institute (R.S.), Sorbonne Universités, UPMC 06, Plateforme Post-génomique de la Pitié-Salpêtrière, UMS 2 Omique, Inserm US029 (W.C.), Paris, and the Department of Genetics, Centre Hospitalier Universitaire de Reims, Unité de Formation et de Recherche de Médecine, Reims (D.G.) - both in France; the Department of Neurology, University of Washington School of Medicine, and Northwest VA Parkinson's Disease Research, Education and Clinical Centers, Seattle (A. Samii); the Division of Human Genetics, Department of Pediatrics, 22q and You Center, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania (D.M.M.-M., T.B.C., E.H.Z., S.L.F.), Division of Nephrology, Children's Hospital of Philadelphia (S.L.F.), and the Department of Genetics, University of Pennsylvania (H.H.), Philadelphia; the Dialysis Unit, Jagiellonian University Medical College (D.D.), and the Department of Pediatric Nephrology, Jagiellonian University Medical College (M. Miklaszewska), Krakow, the Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz (M.T.), the Department of Pediatric Nephrology Medical University of Lublin, Lublin (P.S.), the Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice (M. Szczepanska), the Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw (M.M.-W., G.K., A. Szmigielska), and Krysiewicza Children's Hospital (M.Z.) and the Department of Medical Genetics, Poznan University of Medical Sciences, and Center for Medical Genetics GENESIS (A.L.-B., A.M.-K.), Poznań - all in Poland; the Department of Clinical Genetics (J.M.D., D.B.), National Children's Research Centre (J.M.D., P.P.), and University College Dublin School of Medicine (D.B.), Our Lady's Children's Hospital Crumlin, and the National Children's Hospital Tallaght (P.P.), Dublin, Ireland; the Division of Pediatric Nephrology, Children's Mercy Hospital, Kansas City, MO (B.A.W.); University Children's Hospital, Medical Faculty of Skopje, Skopje, Macedonia (Z.G., V.T.); Faculty of Medicine, Palacky University, Olomouc, Czech Republic (H.F.); the Division of Pediatric Nephrology, University of New Mexico Children's Hospital, Albuquerque (C.S.W.); Ben May Department for Cancer Research, University of Chicago, Chicago (A.I.); and the Department of Genetics, Howard Hughes Medical Institute, and Yale Center for Mendelian Genomics, Yale University, New Haven, CT (R.P.L.).

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http://dx.doi.org/10.1056/NEJMoa1609009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559731PMC
February 2017

Ofatumumab-associated acute pneumonitis: Not new but still the first case.

Pharmacol Res Perspect 2017 02 26;5(1):e00267. Epub 2016 Dec 26.

Division of Nephrology, Dialysis, Transplantation Giannina Gaslini Children's Hospital Via Gerolamo Gaslini 5 Genoa 16148 Italy.

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http://dx.doi.org/10.1002/prp2.267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461639PMC
February 2017

Post-translational modified proteins are biomarkers of autoimmune-processes: NETosis and the inflammatory-autoimmunity connection.

Clin Chim Acta 2017 Jan 5;464:12-16. Epub 2016 Nov 5.

Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS), Istituto Giannina Gaslini, Genoa, Italy; Laboratory on Pathophysiology of Uremia, Scientific Institute for Research and Health Care (IRCCS), Istituto Giannina Gaslini, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.11.006DOI Listing
January 2017

Clinical trials in minimal change disease.

Nephrol Dial Transplant 2017 01;32(suppl_1):i7-i13

Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy.

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http://dx.doi.org/10.1093/ndt/gfw235DOI Listing
January 2017

Ofatumumab-associated acute respiratory manifestations: clinical characteristics and treatment.

Br J Clin Pharmacol 2016 10 28;82(4):1146-8. Epub 2016 Jun 28.

Division of Nephrology, Dialysis, Transplantation, Giannina Gaslini Children's Hospital, Genoa, 16148, Italy.

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http://dx.doi.org/10.1111/bcp.13029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137839PMC
October 2016

Membranous glomerulonephritis: histological and serological features to differentiate cancer-related and non-related forms.

J Nephrol 2016 Aug 25;29(4):469-78. Epub 2016 Jan 25.

Division of Nephrology Dialysis and Transplantation, Istituto Giannina Gaslini, Genoa, Italy.

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http://dx.doi.org/10.1007/s40620-016-0268-7DOI Listing
August 2016

A Pilot Study of IL2 in Drug-Resistant Idiopathic Nephrotic Syndrome.

PLoS One 2015 28;10(9):e0138343. Epub 2015 Sep 28.

Division of Nephrology, Dialysis, Transplantation and Laboratory on Physiopathology of Uremia, Giannina Gaslini Children Hospital, Genoa, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587361PMC
June 2016

Anti-CD20 Antibodies for Idiopathic Nephrotic Syndrome in Children.

Clin J Am Soc Nephrol 2016 Apr 19;11(4):710-20. Epub 2015 Nov 19.

Division of Nephrology, Dialysis, Transplantation and Laboratory on Pathophysiology of Uremia, Giannina Gaslini Children's Hospital, Genoa, Italy

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http://dx.doi.org/10.2215/CJN.08500815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822672PMC
April 2016

Human urinary exosome proteome unveils its aerobic respiratory ability.

J Proteomics 2016 Mar 2;136:25-34. Epub 2016 Feb 2.

Dipartimento di Farmacia, Laboratorio di Biochimica, Università di Genova, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.02.001DOI Listing
March 2016

Urine Proteome Biomarkers in Kidney Diseases. I. Limits, Perspectives, and First Focus on Normal Urine.

Biomark Insights 2016 16;11:41-8. Epub 2016 Mar 16.

Laboratory on Physiopathology of Uremia, Istituto Giannina Gaslini, Genova, Italy.; Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini, Genova, Italy.

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http://dx.doi.org/10.4137/BMI.S26229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795486PMC
March 2016

Urine proteome analysis in Dent's disease shows high selective changes potentially involved in chronic renal damage.

J Proteomics 2016 Jan 11;130:26-32. Epub 2015 Sep 11.

Nephrology, Dialysis and Transplantation Unit, Istituto Giannina Gaslini, Genova, Italy; Laboratory on Physiopathology of Uremia, Istituto Giannina Gaslini, Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.08.024DOI Listing
January 2016

LPS nephropathy in mice is ameliorated by IL-2 independently of regulatory T cells activity.

PLoS One 2014 24;9(10):e111285. Epub 2014 Oct 24.

Division of Nephrology, Dialysis, Transplantation and Laboratory on Physiopathology of Uremia, Giannina Gaslini Children Hospital, Genoa, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111285PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208845PMC
December 2015

Widening and diversifying the proteome capture by combinatorial peptide ligand libraries via Alcian Blue dye binding.

Anal Chem 2015 23;87(9):4814-20. Epub 2015 Apr 23.

∥Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano, Via Mancinelli 7, Milano 20131, Italy.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b00218
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http://dx.doi.org/10.1021/acs.analchem.5b00218DOI Listing
December 2015

A mild form of rituximab-associated lung injury in two adolescents treated for nephrotic syndrome.

BMJ Case Rep 2015 Dec 9;2015. Epub 2015 Dec 9.

Division of Nephrology, Dialysis and Transplantation, Giannina Gaslini Children's Hospital, Genoa, Italy.

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http://dx.doi.org/10.1136/bcr-2015-212694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680578PMC
December 2015

Low-dose ofatumumab for rituximab-resistant nephrotic syndrome.

BMJ Case Rep 2015 Sep 16;2015. Epub 2015 Sep 16.

Division of Nephrology Dialysis and Transplantation, Istituto G Gaslini, Genoa, Italy.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21020
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http://dx.doi.org/10.1136/bcr-2015-210208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577716PMC
September 2015

Uromodulin: from monogenic to multifactorial diseases.

Nephrol Dial Transplant 2015 Aug 16;30(8):1250-6. Epub 2014 Sep 16.

Division of Nephrology, IRCCS Giannina Gaslini, Genova, Italy.

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http://dx.doi.org/10.1093/ndt/gfu300DOI Listing
August 2015

Multi-antibody composition in lupus nephritis: isotype and antigen specificity make the difference.

Autoimmun Rev 2015 Aug 14;14(8):692-702. Epub 2015 Apr 14.

Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS), Istituto Giannina Gaslini, Genoa, Italy; Laboratory on Pathophysiology of Uremia, Scientific Institute for Research and Health Care (IRCCS), Istituto Giannina Gaslini, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2015.04.004DOI Listing
August 2015

The latest advancements in proteomic two-dimensional gel electrophoresis analysis applied to biological samples.

Methods Mol Biol 2015 ;1243:103-25

Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Largo G. Gaslini 5, Genoa, Italy.

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http://dx.doi.org/10.1007/978-1-4939-1872-0_6DOI Listing
July 2015

2DE maps in the discovery of human autoimmune kidney diseases: the case of membranous glomerulonephritis.

Methods Mol Biol 2015 ;1243:127-38

Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Largo G. Gaslini 5, Genoa, Italy.

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http://dx.doi.org/10.1007/978-1-4939-1872-0_7DOI Listing
July 2015

Combinatorial Peptide Ligand Library and two dimensional electrophoresis: new frontiers in the study of peritoneal dialysis effluent in pediatric patients.

J Proteomics 2015 Feb 10;116:68-80. Epub 2015 Jan 10.

Nephrology and Dialysis Unit and Laboratory on Physiopathology of Uremia, Istituto Giannina Gaslini, Genova, Italy.

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http://dx.doi.org/10.1016/j.jprot.2015.01.003DOI Listing
February 2015

Posttransplant soluble B-cell activating factor kinetics in pediatric recipients of first kidney allograft.

Transplantation 2015 Jan;99(1):243-9

1 Pediatric Hematology and Oncology, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy. 2 Pediatric Nephrology, IRCCS Istituto G. Gaslini, Genova, Italy. 3 Nephrology Unit, Ospedale Presidio di Sestri Levante, Italy. 4 Transplant Immunology, IRCCS Azienda Ospedaliera Universitaria S. Martino-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. 5 Department of Surgery, Kidney Transplantation Unit, IRCCS Azienda Ospedaliera Universitaria S. Martino-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. 6Transplantation Immunology, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. 7 Biometry and Clinical Epidemiology Service, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.

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http://dx.doi.org/10.1097/TP.0000000000000276DOI Listing
January 2015

From hundreds to thousands: Widening the normal human Urinome (1).

J Proteomics 2015 Jan 12;112:53-62. Epub 2014 Aug 12.

Nephrology, Dialysis, Transplantation Unit and Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, 16148 Genova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.07.021DOI Listing
January 2015

From hundreds to thousands: Widening the normal human Urinome.

Data Brief 2014 Dec 22;1:25-8. Epub 2014 Aug 22.

Nephrology, Dialysis, Transplantation Unit and Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, 16148 Genova, Italy.

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http://dx.doi.org/10.1016/j.dib.2014.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459867PMC
December 2014

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.

Nat Genet 2014 Nov 12;46(11):1187-96. Epub 2014 Oct 12.

Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213311PMC
November 2014

Amoxicillin-associated interference in an HPLC-EC assay for urinary fractionated metanephrines: potential pitfall in pheochromocytoma biochemical diagnosis.

Clin Biochem 2014 Oct 16;47(15):119-21. Epub 2014 Jul 16.

U.O. Laboratorio Centrale di Analisi, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00099120140050
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http://dx.doi.org/10.1016/j.clinbiochem.2014.07.009DOI Listing
October 2014

Unexpectedly high prevalence of rare genetic disorders in kidney transplant recipients with an unknown causal nephropathy.

Clin Transplant 2014 Sep 18;28(9):995-1003. Epub 2014 Jul 18.

Department of Translational Medicine and IRCAD, Nephrology and Kidney Transplantation, University of Eastern Piedmont, Novara, Italy.

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http://dx.doi.org/10.1111/ctr.12408DOI Listing
September 2014

Phenotypic expansion of DGKE-associated diseases.

J Am Soc Nephrol 2014 Jul 7;25(7):1408-14. Epub 2014 Feb 7.

Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York;

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http://dx.doi.org/10.1681/ASN.2013080886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073436PMC
July 2014

mRNA sequencing of a novel NPHS2 intronic mutation in a child with focal and segmental glomerulosclerosis.

Saudi J Kidney Dis Transpl 2014 Jul;25(4):854-7

Pediatric Nephrology, Dialysis and Transplant Unit, Department of Pediatrics, University of Padua, Padua, Italy.

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http://dx.doi.org/10.4103/1319-2442.135180DOI Listing
July 2014

Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction Impairment?

Int J Nephrol 2013 24;2013:457490. Epub 2013 Nov 24.

Department of Nephrology, Gaslini Children Hospital, Genoa, Italy ; Laboratorio di Nefrologia, Istituto G. Gaslini, Largo G. Gaslini 5, 16147 Genova, Italy.

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http://dx.doi.org/10.1155/2013/457490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874297PMC
January 2014

Oxidized albumin. The long way of a protein of uncertain function.

Biochim Biophys Acta 2013 Dec 22;1830(12):5473-9. Epub 2013 Apr 22.

Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Genoa, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2013.04.017DOI Listing
December 2013

Albumin heterogeneity in low-abundance fluids. The case of urine and cerebro-spinal fluid.

Biochim Biophys Acta 2013 Dec 26;1830(12):5503-8. Epub 2013 Apr 26.

Division of Nephrology, Dialysis, and Transplantation, Istituto Giannina Gaslini, Genoa, Italy; Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, Genoa, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2013.04.026DOI Listing
December 2013

Urinary proteome in a snapshot: normal urine and glomerulonephritis.

J Nephrol 2013 Jul-Aug;26(4):610-6. Epub 2012 Oct 12.

Nephrology, Dialysis, Transplantation Unit and Laboratory of the Pathophysiology of Uremia, Giannina Gaslini Institute, Genoa, Italy.

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http://www.sin-italy.org/web%5Ceventi%5CSIN%5Carchivio%5Cjn%
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http://www.jnephrol.com/article/urinary-proteome-in-a-snapsh
Publisher Site
http://dx.doi.org/10.5301/jn.5000233DOI Listing
November 2013

Images in vascular medicine. A challenging case of renovascular hypertension.

Vasc Med 2013 Oct 12;18(5):318-9. Epub 2013 Aug 12.

Pediatric Nephrology Unit, IRCCS G. Gaslini, Genoa, Italy.

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http://dx.doi.org/10.1177/1358863X13497528DOI Listing
October 2013

Mutations in DSTYK and dominant urinary tract malformations.

N Engl J Med 2013 Aug 17;369(7):621-9. Epub 2013 Jul 17.

Divisions of Nephrology (S.S.-C., R.V.S., N.P., K.E.B., S.N.N., B.J.P., P.L.W., M.V., F.L., R.S., N.P., N.K., K.K., Q.A.-A., A.G.G.) and Pediatric Nephrology (P.L.W.) and the Department of Pathology (V.D.D.), Columbia University, and the Department of Medicine, St. Luke's-Roosevelt Hospital Center (S.S.-C.), New York; the Department of Genetics, Howard Hughes Medical Institute, and Yale Center for Mendelian Genomics, Yale University, New Haven, CT (M.C., M.S., R.P.L.); the Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea (M.C.); the Division of Nephrology, Dialysis, and Transplantation (M.B., F.L., G.C., A.C., M.D., C.M., G.P., G.M.G.) and Laboratory of Molecular Genetics (G.S., R.R.), Istituto Giannina Gaslini, the Division of Nephrology, Department of Internal Medicine (M.B.), and Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno Infantili (R.R.), University of Genoa, and IRCCS San Martino-IST (M.B.), Genoa; Cattedra di Nefrologia, Università di Brescia, Seconda Divisione di Nefrologia Azienda Ospedaliera Spedali Civili di Brescia Presidio di Montichiari, Brescia (C.I., F.S.); the Department of Clinical Medicine, Nephrology, and Health Sciences, Unit of Nephrology, University of Parma, Parma (B.B., S.G., L.A.); the Department of Medical and Surgical Sciences, University of Foggia, Foggia (M.G.); the Department of Emergency and Organ Transplantation, University of Bari, Bari (L.G.); and the Division of Nephrology and Dialysis, Hospital of Alghero, Alghero (D.C.) - all in Italy; the Nephrology Division, Massachusetts General Hospital (Y.L., I.A.D.), and Department of Genetics, Harvard Medical School (I.A.D.), Charlestown, MA; University Children's Hospital, Medical School of Skopje, Skopje, Macedonia (V.J.L., N.R.-B., Z.G., V.T.); the Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland (A.M.-K., A.L.-B.); and the Department of Pediatrics, University Hospital of Split (D.K.V., M.S.), and the Department of Anatomy, Histology, and Embryology (K.V., M.S.-B.), School of Medicine (M.S.), University of Split, Split, Croatia.

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http://dx.doi.org/10.1056/NEJMoa1214479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846391PMC
August 2013

Circulating antipodocyte antibodies in membranous nephropathy: new findings.

Am J Kidney Dis 2013 Jul 2;62(1):12-5. Epub 2013 May 2.

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http://dx.doi.org/10.1053/j.ajkd.2013.01.030DOI Listing
July 2013

Combinatorial ligand libraries as a two-dimensional method for proteome analysis.

J Chromatogr A 2013 Jul 29;1297:106-12. Epub 2013 Apr 29.

Nephrology, Dialysis, Transplantation Unit and Laboratory on Pathophysiology of Uremia, Istituto Giannina Gaslini, 16148 Genoa, Italy.

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http://dx.doi.org/10.1016/j.chroma.2013.04.065DOI Listing
July 2013

Lupus nephritis in children and adolescents: results of the Italian Collaborative Study.

Nephrol Dial Transplant 2013 Jun 22;28(6):1487-96. Epub 2013 Jan 22.

Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy.

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http://dx.doi.org/10.1093/ndt/gfs589DOI Listing
June 2013

Intraureteral injection of NASHA/Dx gel under direct ureteroscopic visualization for the treatment of primary high-grade vesicoureteral reflux.

J Laparoendosc Adv Surg Tech A 2012 Oct 18;22(8):844-7. Epub 2012 Sep 18.

Paediatric Surgery, Giannina Gaslini Children’s Hospital and Research Institute, Largo G. Gaslini 5, University of Genoa, Italy.

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http://dx.doi.org/10.1089/lap.2012.0114DOI Listing
October 2012

Rituximab in children with resistant idiopathic nephrotic syndrome.

J Am Soc Nephrol 2012 Jun 10;23(6):1117-24. Epub 2012 May 10.

Division of Nephrology, Dialysis and Transplantation and Laboratory on Pathophysiology of Uremia, Istituto G. Gaslini, Largo G. Gaslini 5, Genoa, Italy.

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http://dx.doi.org/10.1681/ASN.2011080775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358759PMC
June 2012

"Cheek-to-cheek" urinary proteome profiling via combinatorial peptide ligand libraries: A novel, unexpected elution system.

J Proteomics 2012 Jan 1;75(3):796-805. Epub 2011 Oct 1.

Laboratory on Pathophysiology of Uremia, G. Gaslini Children Hospital, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jprot.2011.09.018DOI Listing
January 2012

[TRPC6 mutations in children with steroid-resistant nephrotic syndrome].

G Ital Nefrol 2011 Jul-Aug;28(4):350-2

Dipartimento di Scienze Biomediche, Universita' degli Studi di Foggia, Foggia, Italy.

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November 2011

Oxidative stress and galactose-deficient IgA1 as markers of progression in IgA nephropathy.

Clin J Am Soc Nephrol 2011 Aug 22;6(8):1903-11. Epub 2011 Jul 22.

Nephrology, Dialysis and Transplantation Unit, Regina Margherita Children's University Hospital, Piazza Polonia 94, 10127 Torino, Italy.

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http://dx.doi.org/10.2215/CJN.11571210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156425PMC
August 2011

New insights into membranous glomerulonephritis: from bench to bedside.

Nephrol Dial Transplant 2011 Aug;26(8):2428-30

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http://dx.doi.org/10.1093/ndt/gfr336DOI Listing
August 2011

Analysis of the oxido-redox status of plasma proteins. Technology advances for clinical applications.

J Chromatogr B Analyt Technol Biomed Life Sci 2011 May 3;879(17-18):1338-44. Epub 2010 Dec 3.

Laboratory on Pathophysiology of Uremia, Giannina Gaslini Children Hospital, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jchromb.2010.11.030DOI Listing
May 2011

'Congenital solitary functioning kidneys: which ones warrant follow-up into adult life?'.

Nephrol Dial Transplant 2011 May 5;26(5):1458-60. Epub 2011 Apr 5.

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http://dx.doi.org/10.1093/ndt/gfr145DOI Listing
May 2011

Protein-protein interaction heterogeneity of plasma apolipoprotein A1 in nephrotic syndrome.

Mol Biosyst 2011 Mar;7(3):659-66

Divisione di Nefrologia e Laboratorio di Fisiopatologia dell'Uremia, G. Gaslini Children's Hospital, Genova, Italia.

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http://dx.doi.org/10.1039/c0mb00127aDOI Listing
March 2011

In vivo characterization of renal auto-antigens involved in human auto-immune diseases: the case of membranous glomerulonephritis.

Proteomics Clin Appl 2011 Feb 17;5(1-2):90-7. Epub 2011 Jan 17.

Department of Clinical Medicine, Nephrology and Laboratory Medicine, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1002/prca.201000079DOI Listing
February 2011

Urinary proteomics and drug discovery in chronic kidney disease: a new perspective.

J Proteome Res 2011 Jan 2;10(1):126-32. Epub 2010 Sep 2.

Pharma Research Development and Metabolic Disease, Hoffmann-La Roche Ltd., Basel, Switzerland.

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http://dx.doi.org/10.1021/pr100464qDOI Listing
January 2011

Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract.

Hum Mutat 2010 Dec 9;31(12):1352-9. Epub 2010 Nov 9.

Biologia Generale e Genetica Medica, Università di Pavia, Pavia, Italy; Service of Genetic Medicine, University Hospitals of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1002/humu.21378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056145PMC
December 2010

Nephrectomy for multicystic dysplastic kidney and renal hypodysplasia in children: where do we stand?

Pediatr Surg Int 2010 May 26;26(5):523-8. Epub 2010 Mar 26.

Pediatric Surgery Department, Gaslini Research Institute and Children Hospital, University of Genova, Largo G. Gaslini, 16100, Genoa, Italy.

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http://dx.doi.org/10.1007/s00383-010-2592-7DOI Listing
May 2010