Publications by authors named "Giampaolo Merlini"

100Publications

Clarification on the definition of complete haematologic response in light-chain (AL) amyloidosis.

Amyloid 2021 Jan 7:1-2. Epub 2021 Jan 7.

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo", Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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January 2021

Management of AL amyloidosis in 2020.

Hematology Am Soc Hematol Educ Program 2020 12;2020(1):363-371

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo," and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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December 2020

Management of AL amyloidosis in 2020.

Blood 2020 Dec;136(23):2620-2627

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo," and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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December 2020

Fair Pricing of Innovative Medicines: An EHA Position Paper.

Hemasphere 2020 Oct 30;4(5):e488. Epub 2020 Sep 30.

European Hematology Association, The Hague, The Netherlands.

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October 2020

Access to Affordable Orphan Medicines in Europe: An EHA Position Paper.

Hemasphere 2020 Oct 30;4(5):e477. Epub 2020 Sep 30.

European Hematology Association, The Hague, The Netherlands.

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October 2020

Introduction.

Hematol Oncol Clin North Am 2020 Dec 6;34(6):xv-xvi. Epub 2020 Oct 6.

Amyloidosis Center, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 14, Pavia 27100, Italy. Electronic address:

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December 2020

Future Perspectives.

Hematol Oncol Clin North Am 2020 Dec;34(6):1205-1214

Amyloidosis Center, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, Pavia 27100, Italy.

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December 2020

Sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis.

Blood Adv 2020 Sep;4(17):4175-4179

Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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September 2020

Indicators of profound hematologic response in AL amyloidosis: complete response remains the goal of therapy.

Blood Cancer J 2020 09 1;10(8):90. Epub 2020 Sep 1.

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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September 2020

Proteomics Fundamentally Advance the Diagnosis and Management of Amyloidosis.

Mayo Clin Proc 2020 09;95(9):1816-1818

Amyloidosis Research and Treatment Center, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. Electronic address:

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September 2020

Redirecting proteoxicity.

Leukemia 2020 12 24;34(12):3109-3110. Epub 2020 Aug 24.

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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December 2020

Treating Protein Misfolding Diseases: Therapeutic Successes Against Systemic Amyloidoses.

Front Pharmacol 2020 10;11:1024. Epub 2020 Jul 10.

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.

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July 2020

Novel challenges in the management of immunoglobulin light chain amyloidosis: from the bench to the bedside.

Expert Rev Hematol 2020 Sep 11;13(9):1003-1015. Epub 2020 Aug 11.

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia , Pavia, Italy.

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September 2020

Daratumumab in light chain deposition disease: rapid and profound hematologic response preserves kidney function.

Blood Adv 2020 04;4(7):1321-1324

Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

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April 2020

A powerful oral triplet for AL amyloidosis.

Br J Haematol 2020 05 3;189(4):605-606. Epub 2020 Feb 3.

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo", Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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May 2020

Here to Stay: Biosimilars in Hematology.

Hemasphere 2019 Dec 19;3(6):e323. Epub 2019 Nov 19.

Department of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

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December 2019

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy.

Amyloid 2020 Jun 6;27(2):97-102. Epub 2020 Jan 6.

Molecular Neurobiology Group, Instituto de Biologia Molecular e Celular (IBMC) - Instituto de Investigação e Inovação em Saúde (i3S) da Universidade do Porto, Porto, Portugal.

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June 2020

Amyloidosis and Ocular Involvement: an Overview.

Semin Ophthalmol 2020 Jan 12;35(1):7-26. Epub 2019 Dec 12.

Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Medical School, Bari, Italy.

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January 2020

Light Chains With Heavy Effects.

Am J Kidney Dis 2020 02 16;75(2):291-293. Epub 2019 Oct 16.

Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address:

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February 2020

Predicting survival in light chain amyloidosis.

Haematologica 2019 07;104(7):1294-1296

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo", and Department of Molecular Medicine, University of Pavia, Italy.

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July 2019

Differential serum levels of interleukin-37 in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS).

Clin Exp Rheumatol 2019 Nov-Dec;37 Suppl 121(6):159-160. Epub 2019 May 30.

Research Centre of Systemic Autoinflammatory Diseases, Behçet's Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

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January 2020

Treatment of cardiac transthyretin amyloidosis: an update.

Eur Heart J 2019 12;40(45):3699-3706

Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, Pavia, Italy.

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December 2019

Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration.

Am J Physiol Heart Circ Physiol 2019 05 15;316(5):H1158-H1166. Epub 2019 Mar 15.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts.

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May 2019

New Insights Into a Multifaceted Disease.

Mayo Clin Proc 2019 03;94(3):388-390

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address:

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March 2019

When should treatment of AL amyloidosis start at relapse? Early, to prevent organ progression.

Blood Adv 2019 01;3(2):212-215

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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January 2019

Improved outcomes for kidney transplantation in AL amyloidosis: impact on practice.

Kidney Int 2019 02;95(2):258-260

Amyloidosis Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address:

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February 2019

A new genetic variant of hereditary apolipoprotein A-I amyloidosis: a case-report followed by discussion of diagnostic challenges and therapeutic options.

BMC Med Genet 2019 01 21;20(1):23. Epub 2019 Jan 21.

Department of Clinical Therapeutics, Alexandra General Hospital, National and Kapodistrian University of Athens, School of Medicine, 80 Vas Sofias Avenue, 11528, Athens, Greece.

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January 2019

High sensitivity M-protein detection in a case of light-chain cardiac amyloidosis without evidence of plasma cell dyscrasia.

Am J Hematol 2019 05 8;94(5):619-621. Epub 2019 Jan 8.

Division of Clinical Biochemistry & Immunology, Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota.

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May 2019

Seek and You Shall Find: Is Subclinical Amyloid More Common Than Expected?

Mayo Clin Proc 2018 11;93(11):1546-1548

Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy. Electronic address:

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November 2018

Systemic immunoglobulin light chain amyloidosis.

Nat Rev Dis Primers 2018 10 25;4(1):38. Epub 2018 Oct 25.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

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October 2018

Therapies for cardiac light chain amyloidosis: An update.

Int J Cardiol 2018 Nov;271:152-160

Amyloidosis Research and Treatment Centre, IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Italy.

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November 2018

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy.

N Engl J Med 2018 Sep 27;379(11):1007-1016. Epub 2018 Aug 27.

From the Columbia University Vagelos College of Physicians and Surgeons (M.S.M.) and Pfizer (J.H.S., A.I.B., P.H., J.S., M.B.S.), New York; Syneos Health, Raleigh, NC (B.G.); University College London and St. Bartholomew's Hospital, London (P.M.E.); the Amyloidosis Center, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, and the University of Pavia, Pavia (G.M.), and the Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna (C.R.) - both in Italy; the Amyloidosis Center (CEPARM), Federal University of Rio de Janeiro, Rio de Janeiro (M.W-C.); the Amyloidosis Center, Medical University of Heidelberg, Heidelberg, Germany (A.V.K.); the Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (M.G.); Stanford University School of Medicine, Stanford, CA (R.W.); the French Referral Center for Cardiac Amyloidosis, Amyloidosis Mondor Network, GRC Amyloid Research Institute and Department of Cardiology, Assistance Publique-Hôpitaux de Paris, CHU Henri Mondor, and INSERM Unité 955, Clinical Investigation Center 006, and DHU ATVB, Creteil, France (T.D.); Penn Presbyterian Medical Center, University of Pennsylvania Health System, Philadelphia (B.M.D.); the Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S.); Cleveland Clinic, Cleveland (M.H.); the Medical University of South Carolina, Charleston (D.P.J.); and Pfizer, Groton, CT (T.A.P., S.R., M.S.).

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September 2018

Treatment of AL amyloidosis with bendamustine: a study of 122 patients.

Blood 2018 11 14;132(18):1988-1991. Epub 2018 Aug 14.

Department of Internal Medicine V, Hematology/Oncology/Rheumatology, Amyloidosis Center, University of Heidelberg, Heidelberg, Germany.

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November 2018

Outrageous prices of orphan drugs: a call for collaboration.

Lancet 2018 09 20;392(10149):791-794. Epub 2018 Jul 20.

IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy; Unit of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address:

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September 2018

Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications.

Blood 2018 10 16;132(14):1478-1485. Epub 2018 Jul 16.

Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; and.

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October 2018

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis.

N Engl J Med 2018 Jul;379(1):22-31

From the Indiana University School of Medicine, Indianapolis (M.D.B.); Centro de Estudos em Paramiloidose Antônio Rodrigues de Mello, National Amyloidosis Referral Center, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro (M.W.-C.); Amyloidosis Center, Boston University School of Medicine (J.L.B.) and Brigham and Women's Hospital, Harvard Medical School (A.M.S., S.D.S.), Boston; Johns Hopkins University, Baltimore (M.P.); Mayo Clinic, Rochester, MN (P.J.D., W.J.L., M.A.G.); University of California, Irvine, Irvine (A.K.W.); Amyloid Network-Hospital Henri Mondor-Assistance Publique-Hôpitaux de Paris (AP-HP)-Université Paris Est, Créteil, France (V.P.-B.); Institute for Neurologic Research Raúl Carrea, FLENI, Buenos Aires (F.A.B.); Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia (G.M., L.O.), and Unit of Neurology, University Hospital, Messina (G.V.) - both in Italy; Hospital AACD (Associação de Assistência à Criança Deficiente), São Paulo (M.S.); Columbia University Medical Center (T.H.B.) and Mount Sinai Medical Center (P.D.G.), New York; University College London-National Amyloidosis Centre, London (C.W.); Penn Presbyterian Medical Center, University of Pennsylvania Health System, Philadelphia (B.M.D.); Centre Hospitaliere Universitaire Bicêtre, AP-HP, Unité 1195, INSERM, Université Paris-Sud, Paris (D.A.); Oregon Health and Science University, Portland (S.B.H.); Centro Hospitalar Lisboa Norte-Hospital de Santa Maria, Lisbon (I.C.), and Centro Hospitalar do Porto, Porto (T.C.) - both in Portugal; Universitätsklinikum Münster, Münster, Germany (H.H.S.); Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (J.M.C.), and Hospital Universitari Vall d'Hebron (J.G.), Barcelona; Auckland City Hospital, Auckland, New Zealand (E.G.); and Ionis Pharmaceuticals, Carlsbad, CA (B.P.M., S.G.H., T.J.K., B.W.M., S.W.J., B.F.B., E.J.A.).

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July 2018

Novel Therapies in Light Chain Amyloidosis.

Kidney Int Rep 2018 May 28;3(3):530-541. Epub 2017 Nov 28.

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo," and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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May 2018

Management of the elderly patient with AL amyloidosis.

Eur J Intern Med 2018 12 23;58:48-56. Epub 2018 May 23.

Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Italy. Electronic address:

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December 2018

Light Chain Amyloidosis.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018022. Epub 2018 Mar 1.

Amyloidosis Research and Treatment Center, Foundation "Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo" and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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March 2018

The elusive pathogenesis of Schnitzler syndrome.

Blood 2018 03;131(9):944-946

Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo; University of Pavia.

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March 2018

Proteomics with Mass Spectrometry Imaging: Beyond Amyloid Typing.

Proteomics 2018 04 8;18(7):e1700353. Epub 2018 Mar 8.

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

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April 2018

New concepts in the treatment and diagnosis of amyloidosis.

Expert Rev Hematol 2018 02 10;11(2):117-127. Epub 2018 Jan 10.

a Amyloidosis Research and Treatment Center, Foundation 'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo', and Department of Molecular Medicine , University of Pavia , Pavia , Italy.

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February 2018

AL amyloidosis: from molecular mechanisms to targeted therapies.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):1-12

Amyloidosis Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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December 2017

Presentation and outcome with second-line treatment in AL amyloidosis previously sensitive to nontransplant therapies.

Blood 2018 02 3;131(5):525-532. Epub 2017 Nov 3.

Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, and.

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February 2018

Emerging therapeutic targets currently under investigation for the treatment of systemic amyloidosis.

Expert Opin Ther Targets 2017 12;21(12):1095-1110

a Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine , University of Pavia , Pavia , Italy.

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December 2017

Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial.

Br J Haematol 2017 12 19;179(5):748-755. Epub 2017 Oct 19.

Neuromuscular and Neuroimmunology Service, Department of Medical Biotechnology and Translational Medicine, Milan University, Humanitas Clinical and Research Hospital IRCCS, Milan, Italy.

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December 2017

The lung in amyloidosis.

Eur Respir Rev 2017 Sep 6;26(145). Epub 2017 Sep 6.

Amyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy

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September 2017

Attitudes about when and how to treat patients with AL amyloidosis: an international survey.

Amyloid 2017 Dec 31;24(4):213-216. Epub 2017 Aug 31.

a Division of Hematology , Mayo Clinic , Rochester , MN , USA.

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December 2017

Design and Rationale of the Phase 3 ATTR-ACT Clinical Trial (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial).

Circ Heart Fail 2017 Jun;10(6)

From the Center for Advanced Cardiac Care, Columbia University College of Physicians and Surgeons, NY (M.S.M); Cardiovascular Medicine, University College London, United Kingdom (P.E.); IRCCS Policlinico San Matteo, University of Pavia, Italy (G.M.); Division of Cardiology, Northwestern University, Chicago, IL (S.J.S.); National Amyloidosis Referral Center, Centro de Estudos em Paramiloidose Antônio Rodrigues de Mello, Federal University of Rio de Janeiro, Brazil (M.W.C.); Pfizer, Inc, Collegeville, PA (A.F., C.H.); inVentiv Health, Burlington, MA (B.G.); Pfizer, Inc, Groton, CT (S.R., J.S.); Pfizer, Inc, NY (M.B.S.); and Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy (C.R.).

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June 2017

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system.

J Neuroinflammation 2017 06 6;14(1):115. Epub 2017 Jun 6.

i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal.

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June 2017