Giada Rotunno

Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, and Denothe Excellence Center, Florence, Italy.

View Article and Find Full Text PDF

April 2020

Characteristics and clinical correlates of NFE2 mutations in chronic Myeloproliferative neoplasms.

Authors:

Paola Guglielmelli Annalisa Pacilli Giacomo Coltro Francesco Mannelli Lara Mannelli Elisa Contini Giada Rotunno Niccolò Bartalucci Sara Fiaccabrino Benedetta Sordi Giuseppe Gaetano Loscocco Chiara Paoli Alessandro M Vannucchi

Am J Hematol 2020 01 12;95(1):E23-E26. Epub 2019 Nov 12.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi, Florence, Italy.

View Article and Find Full Text PDF

January 2020

Second primary malignancies in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 2233 patients.

Cancer Med 2019 08 7;8(9):4089-4092. Epub 2019 Jun 7.

Hematology, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

View Article and Find Full Text PDF

August 2019

Spectrum of mutations in primary myelofibrosis: prognostic impact of the p.G646Wfs*12 mutation.

Authors:

Giada Rotunno Carmela Mannarelli Giada Brogi Annalisa Pacilli Francesca Gesullo Francesco Mannelli Sara Fiaccabrino Benedetta Sordi Chiara Paoli Ilaria Marone Elisa Rumi Rossella Manfredini Giovanni Barosi Mario Cazzola Alessandro M Vannucchi Paola Guglielmelli

Blood 2019 06 10;133(26):2802-2808. Epub 2019 May 10.

Centro di Ricerca e Innovazione per le Malattie Mieloproliferative (CRIMM), Dipartimento di Medicina Sperimentale e Clinica, Azienda Ospedaliera Universitaria Careggi, and.

View Article and Find Full Text PDF

June 2019

Myelodysplasia as assessed by multiparameter flow cytometry refines prognostic stratification provided by genotypic risk in systemic mastocytosis.

Authors:

Francesco Mannelli Francesca Gesullo Giada Rotunno Annalisa Pacilli Sara Bencini Francesco Annunziato Roberta Zanotti Luigi Scaffidi Fiorina Giona Michelina Santopietro Federica Grifoni Lisa Pieri Paola Guglielmelli Alessandro M Vannucchi

Am J Hematol 2019 08 21;94(8):845-852. Epub 2019 May 21.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Denothe Excellence Center, Università degli Studi, Firenze, Italy.

View Article and Find Full Text PDF

August 2019

Validation of the Mayo alliance prognostic system for mastocytosis.

Authors:

Francesco Mannelli Francesca Gesullo Giada Rotunno Annalisa Pacilli Lisa Pieri Paola Guglielmelli Alessandro M Vannucchi

Blood Cancer J 2019 02 11;9(2):18. Epub 2019 Feb 11.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi, Firenze, Italy.

View Article and Find Full Text PDF

February 2019

Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea.

Authors:

Annalisa Pacilli Giada Rotunno Carmela Mannarelli Tiziana Fanelli Alessandro Pancrazzi Elisa Contini Francesco Mannelli Francesca Gesullo Niccolò Bartalucci Giuditta Corbizi Fattori Chiara Paoli Alessandro M Vannucchi Paola Guglielmelli

Blood Cancer J 2018 11 22;8(12):122. Epub 2018 Nov 22.

CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi, Firenze, Italy.

View Article and Find Full Text PDF

November 2018

Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project.

Blood Cancer J 2018 09 21;8(10):89. Epub 2018 Sep 21.

Hematology, Department of Medicine and Surgery, University of Insubria & Ospedale di Circolo, ASST Sette Laghi, Varese, Italy.

View Article and Find Full Text PDF

September 2018

Phenotype variability of patients with post polycythemia vera and post essential thrombocythemia myelofibrosis is associated with the time to progression from polycythemia vera and essential thrombocythemia.

Leuk Res 2018 06 23;69:100-102. Epub 2018 Apr 23.

Hematology, Department of Medicine and Surgery, University of Insubria, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy. Electronic address:

View Article and Find Full Text PDF

June 2018

Value of cytogenetic abnormalities in post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a study of the MYSEC project.

Haematologica 2018 09 5;103(9):e392-e394. Epub 2018 Apr 5.

Hematology, Department of Medicine and Surgery, University of Insubria, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy

View Article and Find Full Text PDF

September 2018

MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis.

J Clin Oncol 2018 02 9;36(4):310-318. Epub 2017 Dec 9.

Paola Guglielmelli, Giada Rotunno, Carmela Mannarelli, Annalisa Pacilli, Francesco Mannelli, and Alessandro M. Vannucchi, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence; Elisa Rumi, Vittorio Rosti, Giovanni Barosi, and Mario Cazzola, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo; Elisa Rumi and Mario Cazzola, University of Pavia, Pavia; Alessandro Rambaldi, University of Milan, Milan; Alessandro Rambaldi and Tiziano Barbui, Azienda Socio sanitaria Territoriale Papa Giovanni XXIII, Bergamo; Francesco Passamonti, University of Insubria, Varese, Italy; and Terra L. Lasho, Mythri Mudireddy, Maura Nicolosi, Animesh Pardanani, Curtis A. Hanson, Rhett P. Ketterling, Naseema Gangat, and Ayalew Tefferi, Mayo Clinic, Rochester, MN.

View Article and Find Full Text PDF

February 2018

Clonal architecture of JAK2V617F mutated cells during treatment with ruxolitinib.

Authors:

Annalisa Pacilli Tiziana Fanelli Carmela Mannarelli Giada Rotunno Alessandro Pancrazzi Alessandro Maria Vannucchi Paola Guglielmelli

Hematol Oncol 2018 Feb 5;36(1):357-359. Epub 2017 May 5.

CRIMM-Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Department of Experimental and Clinical medicine, University of Florence, Florence, Italy.

View Article and Find Full Text PDF

February 2018

Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis.

Blood 2017 06 28;129(24):3227-3236. Epub 2017 Mar 28.

Centro Ricerca e Innovazione delle Malattie Mieloproliferative (CRIMM), Azienda Ospedaliera-Universitaria Careggi, Firenze, Italy.

View Article and Find Full Text PDF

June 2017

Targeted deep sequencing in polycythemia vera and essential thrombocythemia.

Authors:

Ayalew Tefferi Terra L Lasho Paola Guglielmelli Christy M Finke Giada Rotunno Yoseph Elala Annalisa Pacilli Curtis A Hanson Alessandro Pancrazzi Rhett P Ketterling Carmela Mannarelli Daniela Barraco Tiziana Fanelli Animesh Pardanani Naseema Gangat Alessandro M Vannucchi

Blood Adv 2016 Nov 22;1(1):21-30. Epub 2016 Nov 22.

Centro Ricerca e Innovazione Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, and Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; and.

View Article and Find Full Text PDF

November 2016

Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients.

Am J Hematol 2016 09 4;91(9):918-22. Epub 2016 Jul 4.

Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, CRIMM-Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence, Florence, Italy.

View Article and Find Full Text PDF

September 2016

Germline transmission of LNKE208Q variant in a family with myeloproliferative neoplasms.

Authors:

Giuseppe Gaetano Loscocco Carmela Mannarelli Annalisa Pacilli Tiziana Fanelli Giada Rotunno Francesca Gesullo Giuditta Corbizi-Fattori Alessandro Maria Vannucchi Paola Guglielmelli

Am J Hematol 2016 09 4;91(9):E356. Epub 2016 Jul 4.

CRIMM, Centro Di Ricerca E Innovazione per Le Malattie Mieloproliferative, Azienda Ospedaliera Universitaria Careggi, Dipartimento di Medicina Sperimentale e Clinica, Università Degli Studi, Firenze, DENOTHE Excellence Center, Italy.

View Article and Find Full Text PDF

September 2016

Feasibility of a workflow for the molecular characterization of single cells by next generation sequencing.

Authors:

Francesca Salvianti Giada Rotunno Francesca Galardi Francesca De Luca Marta Pestrin Alessandro Maria Vannucchi Angelo Di Leo Mario Pazzagli Pamela Pinzani

Biomol Detect Quantif 2015 Sep 12;5:23-9. Epub 2015 Sep 12.

Department of Clinical, Experimental and Biomedical Sciences, University of Florence, Florence, Italy.

View Article and Find Full Text PDF

September 2015

Epidemiology and clinical relevance of mutations in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 359 patients of the AGIMM group.

Am J Hematol 2016 07 11;91(7):681-6. Epub 2016 May 11.

CRIMM-Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, Department of Experimental and Clinical Medicine, DENOTHE Excellence Center, University of Florence, Florence, Italy.

View Article and Find Full Text PDF

July 2016

Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer.

Authors:

Francesca De Luca Giada Rotunno Francesca Salvianti Francesca Galardi Marta Pestrin Stefano Gabellini Lisa Simi Irene Mancini Alessandro Maria Vannucchi Mario Pazzagli Angelo Di Leo Pamela Pinzani

Oncotarget 2016 May;7(18):26107-19

Department of Clinical, Experimental and Biomedical Sciences, University of Florence, 50139, Florence, Italy.

View Article and Find Full Text PDF

May 2016

Integrative analysis of copy number and gene expression data suggests novel pathogenetic mechanisms in primary myelofibrosis.

Int J Cancer 2016 Apr 25;138(7):1657-69. Epub 2015 Nov 25.

Life Sciences Department University of Modena and Reggio Emilia, Centre for Regenerative Medicine, via Gottardi N.100, Modena, 41125, Italy.

View Article and Find Full Text PDF

April 2016

What Do Molecular Tests Add to Prognostic Stratification in MF: Is It Time to Add These to Our Clinical Practice?

Authors:

Paola Guglielmelli Giada Rotunno Annalisa Pacilli Alessandro Maria Vannucchi

Curr Hematol Malig Rep 2015 Dec;10(4):380-7

CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative croniche, Azienda Ospedaliera Universitaria Careggi, Palazzina 27/B, Cubo 3 Largo Brambilla 3, 50134, Florence, Italy.

View Article and Find Full Text PDF

December 2015

Ruxolitinib is an effective treatment for CALR-positive patients with myelofibrosis.

Authors:

Paola Guglielmelli Giada Rotunno Costanza Bogani Carmela Mannarelli Laura Giunti Aldesia Provenzano Sabrina Giglio Matthew Squires Viktoriya Stalbovskaya Prashanth Gopalakrishna Alessandro M Vannucchi

Br J Haematol 2016 06 25;173(6):938-40. Epub 2015 Aug 25.

Laboratorio Congiunto per le Malattie Mieloproliferative, Università degli Studi di Firenze, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

View Article and Find Full Text PDF

June 2016

JAK2V617F complete molecular remission in polycythemia vera/essential thrombocythemia patients treated with ruxolitinib.

Authors:

Lisa Pieri Alessandro Pancrazzi Annalisa Pacilli Claudia Rabuzzi Giada Rotunno Tiziana Fanelli Paola Guglielmelli Rajmonda Fjerza Chiara Paoli Srdan Verstovsek Alessandro M Vannucchi

Blood 2015 May;125(21):3352-3

Laboratorio Congiunto Malattie Mieloproliferative Croniche, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy Hematology Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

View Article and Find Full Text PDF

May 2015

Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis.

Blood 2014 Aug 1;124(7):1062-9. Epub 2014 Jul 1.

Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS] Policlinico San Matteo, and Department of Molecular Medicine, University of Pavia, Pavia, Italy;

View Article and Find Full Text PDF

August 2014

Calreticulin: a new horizon for the testing and treatment of myeloproliferative neoplasms.

Authors:

Paola Guglielmelli Niccolò Bartalucci Giada Rotunno Alessandro M Vannucchi

Expert Rev Hematol 2014 Aug 22;7(4):423-5. Epub 2014 May 22.

Laboratorio Congiunto MMPC, Department of Experimental and Clinical Medicine, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

View Article and Find Full Text PDF

August 2014