Publications by authors named "Gheorghe Paltanea"

4 Publications

  • Page 1 of 1

Treatment of Knee Osteochondral Fractures.

Healthcare (Basel) 2022 Jun 8;10(6). Epub 2022 Jun 8.

Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, RO-020021 Bucharest, Romania.

Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. When considering this, the term osteochondral fracture is preserved only for an osteochondral defect that combines disruption of the articular cartilage and subchondral bone. These fractures commonly occur after sports practice and are associated with acute lateral patellar dislocations. Many of these lesions are initially diagnosed by plain radiographs; however, a computed tomography (CT) scan or magnetic resonance imaging (MRI) can add significant value to the diagnosis and treatment. Treatment methods may vary depending on the location and size of the fracture, fragment instability, and skeletal maturity. The paper reports a 14-year-old boy case with an osteochondral fracture due to sports trauma. The medical approach involved an arthrotomy of the knee, drainage of the hematoma, two Kirschner wires (K-wires) for temporary fixation to restructure anatomic alignment, and a titanium Herbert screw fixing the fracture permanently. The patient had a favorable postoperative outcome with no residual pain, adequate knee stability, and a normal range of motion. The mobility of the knee was fully recovered.
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http://dx.doi.org/10.3390/healthcare10061061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222836PMC
June 2022

Magnesium-Based Alloys Used in Orthopedic Surgery.

Materials (Basel) 2022 Feb 2;15(3). Epub 2022 Feb 2.

Faculty of Medicine and Pharmacy, University Dunarea de Jos Galati, 35 Alexandru Ioan Cuza Street, 800010 Galati, Romania.

Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval.
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http://dx.doi.org/10.3390/ma15031148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840615PMC
February 2022

Magnetic Nanoparticles Used in Oncology.

Materials (Basel) 2021 Oct 10;14(20). Epub 2021 Oct 10.

Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, RO-060042 Bucharest, Romania.

Recently, magnetic nanoparticles (MNPs) have more and more often been used in experimental studies on cancer treatments, which have become one of the biggest challenges in medical research. The main goal of this research is to treat and to cure advanced or metastatic cancer with minimal side effects through nanotechnology. Drug delivery approaches take into account the fact that MNPs can be bonded to chemotherapeutical drugs, nucleic acids, synthetized antibodies or radionuclide substances. MNPs can be guided, and different treatment therapies can be applied, under the influence of an external magnetic field. This paper reviews the main MNPs' synthesis methods, functionalization with different materials and highlight the applications in cancer therapy. In this review, we describe cancer cell monitorization based on different types of magnetic nanoparticles, chemotherapy, immunotherapy, magnetic hyperthermia, gene therapy and ferroptosis. Examples of applied treatments on murine models or humans are analyzed, and glioblastoma cancer therapy is detailed in the review. MNPs have an important contribution to diagnostics, investigation, and therapy in the so called theranostics domain. The main conclusion of this paper is that MNPs are very useful in different cancer therapies, with limited side effects, and they can increase the life expectancy of patients with cancer drug resistance.
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http://dx.doi.org/10.3390/ma14205948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539633PMC
October 2021

Correlation between Magnetic Properties and Chemical Composition of Non-Oriented Electrical Steels Cut through Different Technologies.

Materials (Basel) 2020 Mar 23;13(6). Epub 2020 Mar 23.

Faculty of Electrical Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, RO-060042 Bucharest, Romania.

Due to worldwide regulations on electric motor manufacturing, the energy efficiency of these devices has to be constantly improved. A solution may reside in the fact that high quality materials and adequate cutting technologies should be carefully chosen. The magnetic properties of non-oriented electrical steels are affected by the cutting methods, through induced plastic, and thermal stresses. There is also an important correlation between chemical composition and different magnetic properties. In this paper, we analyze different industrial grades of non-oriented electrical steels, used in electrical machines' core manufacturing as M800-65A, M800-50A, M400-65A, M400-50A, M300-35A, and NO20. The influence of the cutting methods on the normal magnetization curve, total energy loss and its components, and relative magnetic permeability is investigated in alternating currents using a laboratory single sheet tester. The chemical composition and grain size influence are analyzed and correlated with the magnetic properties. Special attention is devoted to the influence of the increased cutting perimeter on the energy losses and to the way it relates to each chemical alloy constituent. The final decision in what concerns the choice of the proper magnetic material and the specific cutting technology for the motor magnetic cores is imposed by the desired efficiency class and the specific industrial applications.
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http://dx.doi.org/10.3390/ma13061455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142443PMC
March 2020
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